REACTOME_PLATELET_HOMEOSTASIS |
Return to index |
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Order |
Gene |
Description |
ref_hepatocyte |
HepG2 |
HepG2.C3A |
HuH.7 |
SNU475 |
THLE |
liver |
1 |
APOB |
Apolipoprotein B-100 |
[1] |
1.08[2] |
1.47[3] |
1.07[4] |
-7.94[5] |
-7.65[6] |
2.02[7] |
2 |
GNAS |
Guanine nucleotide-binding protein
G(s) subunit alpha isoforms XLas |
-0.43[8] |
-0.78[9] |
-0.70[10] |
0.35[11] |
-0.18[12] |
-4.19[13] |
3 |
GNG5 |
Guanine nucleotide-binding protein
G(I)/G(S)/G(O) subunit gamma-5 |
-2.07[14] |
-2.27[15] |
-2.71[16] |
-2.31[17] |
-2.34[18] |
-4.44[19] |
4 |
GNB1 |
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 |
[20] |
0.15[21] |
-0.21[22] |
-0.27[23] |
0.79[24] |
0.81[25] |
-4.09[26] |
5 |
GNB2 |
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 |
[27] |
-1.46[28] |
-2.10[29] |
-1.33[30] |
-0.86[31] |
-0.58[32] |
-4.45[33] |
6 |
GNG10 |
Guanine nucleotide-binding protein
G(I)/G(S)/G(O) subunit gamma-10 |
-5.56[34] |
-5.66[35] |
-5.53[36] |
-4.31[37] |
-3.26[38] |
-7.19[39] |
7 |
CALM1 |
Calmodulin-1 |
[40] |
-0.78[41] |
-1.13[42] |
-0.24[43] |
1.09[44] |
0.59[45] |
-1.23[46] |
8 |
PPP2R1A |
Serine/threonine-protein phosphatase
2A 65 kDa regulatory subunit A alpha isoform |
-0.06[47] |
-0.62[48] |
-0.27[49] |
0.71[50] |
0.27[51] |
-2.70[52] |
9 |
PPP2CA |
Serine/threonine-protein phosphatase
2A catalytic subunit alpha isoform |
-0.59[53] |
-0.88[54] |
-1.08[55] |
0.24[56] |
0.59[57] |
-2.95[58] |
10 |
PPP2CB |
Serine/threonine-protein phosphatase
2A catalytic subunit beta isoform |
-1.25[59] |
-1.98[60] |
-1.47[61] |
-0.95[62] |
-0.83[63] |
-3.84[64] |
11 |
PTPN11 |
Tyrosine-protein phosphatase non-receptor type 11 |
[65] |
-0.42[66] |
-0.37[67] |
0.01[68] |
0.39[69] |
1.25[70] |
-1.59[71] |
12 |
ATP2A2 |
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 |
[72] |
0.72[73] |
0.20[74] |
0.92[75] |
2.32[76] |
1.48[77] |
-1.11[78] |
13 |
GNG12 |
Guanine nucleotide-binding protein
G(I)/G(S)/G(O) subunit gamma-12 |
-5.61[79] |
-8.93[80] |
-0.55[81] |
1.38[82] |
1.71[83] |
-2.37[84] |
14 |
SRI |
Sorcin |
[85] |
-7.76[86] |
-9.61[87] |
-2.08[88] |
-0.98[89] |
-0.76[90] |
-3.72[91] |
15 |
PPP2R5A |
Serine/threonine-protein phosphatase
2A 56 kDa regulatory subunit alpha isoform |
-1.98[92] |
-1.48[93] |
-0.33[94] |
-0.75[95] |
-1.64[96] |
-2.21[97] |
16 |
PPP2R5C |
Serine/threonine-protein phosphatase
2A 56 kDa regulatory subunit gamma isoform |
-1.17[98] |
-0.67[99] |
-0.55[100] |
0.44[101] |
0.48[102] |
-3.05[103] |
17 |
PPP2R1B |
Serine/threonine-protein phosphatase
2A 65 kDa regulatory subunit A beta isoform |
-0.41[104] |
-1.32[105] |
-0.47[106] |
-0.23[107] |
-0.21[108] |
0.08[109] |
18 |
P2RX4 |
P2X purinoceptor 4 |
[110] |
-1.86[111] |
-1.89[112] |
-0.94[113] |
-2.56[114] |
-2.52[115] |
-3.55[116] |
19 |
MAPK14 |
Mitogen-activated protein kinase 14 |
[117] |
0.61[118] |
0.30[119] |
0.30[120] |
1.19[121] |
0.89[122] |
-1.57[123] |
20 |
STIM1 |
Stromal interaction molecule 1 |
[124] |
-0.02[125] |
-0.42[126] |
-0.40[127] |
0.39[128] |
-0.47[129] |
-1.64[130] |
21 |
ORAI1 |
Calcium release-activated calcium channel protein 1 |
[131] |
-1.18[132] |
-2.09[133] |
-2.14[134] |
-1.71[135] |
-1.29[136] |
-4.43[137] |
22 |
PPP2R5D |
Serine/threonine-protein phosphatase
2A 56 kDa regulatory subunit delta isoform |
0.39[138] |
-0.24[139] |
-0.25[140] |
0.79[141] |
0.91[142] |
-3.12[143] |
23 |
ITPR2 |
Inositol 1,4,5-trisphosphate receptor type 2 |
[144] |
0.05[145] |
1.12[146] |
0.01[147] |
-0.49[148] |
-0.13[149] |
1.02[150] |
24 |
PPP2R5E |
Serine/threonine-protein phosphatase
2A 56 kDa regulatory subunit epsilon isoform |
-0.75[151] |
-0.95[152] |
-0.99[153] |
0.36[154] |
0.38[155] |
-2.66[156] |
25 |
PTPN6 |
Tyrosine-protein phosphatase non-receptor type 6 |
[157] |
-1.32[158] |
-1.52[159] |
-0.51[160] |
-7.64[161] |
-2.39[162] |
-3.03[163] |
26 |
GNB5 |
Guanine nucleotide-binding protein subunit beta-5 |
[164] |
-0.76[165] |
-1.11[166] |
0.34[167] |
0.29[168] |
0.64[169] |
-1.96[170] |
27 |
PAFAH2 |
Platelet-activating factor acetylhydrolase 2, cytoplasmic |
[171] |
-0.54[172] |
0.21[173] |
-0.81[174] |
-0.60[175] |
-1.01[176] |
-1.64[177] |
28 |
ATP2B4 |
Plasma membrane calcium-transporting ATPase 4 |
[178] |
-0.69[179] |
-2.83[180] |
0.67[181] |
2.93[182] |
3.53[183] |
0.81[184] |
29 |
ATP2B1 |
Plasma membrane calcium-transporting ATPase 1 |
[185] |
0.34[186] |
1.61[187] |
3.01[188] |
2.65[189] |
2.81[190] |
0.07[191] |
30 |
ITPR3 |
Inositol 1,4,5-trisphosphate receptor type 3 |
[192] |
4.43[193] |
2.90[194] |
1.81[195] |
1.85[196] |
4.26[197] |
-2.62[198] |
31 |
PPP2R5B |
Serine/threonine-protein phosphatase
2A 56 kDa regulatory subunit beta isoform |
-0.08[199] |
-0.71[200] |
-0.92[201] |
-0.21[202] |
1.19[203] |
-2.75[204] |
32 |
GNG11 |
Guanine nucleotide-binding protein
G(I)/G(S)/G(O) subunit gamma-11 |
-9.04[205] |
-9.42[206] |
-8.31[207] |
1.77[208] |
3.32[209] |
-0.62[210] |
33 |
ATP2B2 |
Plasma membrane calcium-transporting ATPase 2 |
[211] |
-0.94[212] |
-0.49[213] |
3.27[214] |
-5.62[215] |
-5.09[216] |
1.12[217] |
34 |
PDE9A |
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A |
[218] |
0.50[219] |
0.86[220] |
0.99[221] |
-4.48[222] |
-4.99[223] |
-3.65[224] |
35 |
KCNMB3 |
Calcium-activated potassium channel subunit beta-3 |
[225] |
-1.30[226] |
0.16[227] |
0.98[228] |
-0.65[229] |
-0.93[230] |
-3.05[231] |
36 |
GNG7 |
Guanine nucleotide-binding protein
G(I)/G(S)/G(O) subunit gamma-7 |
0.69[232] |
-0.04[233] |
1.19[234] |
-2.73[235] |
-1.88[236] |
-2.83[237] |
37 |
KCNMA1 |
Calcium-activated potassium channel subunit alpha-1 |
[238] |
-8.72[239] |
-9.76[240] |
-3.27[241] |
1.17[242] |
-0.95[243] |
-1.36[244] |
38 |
P2RX7 |
P2X purinoceptor 7 |
[245] |
-5.74[246] |
-2.84[247] |
-7.00[248] |
-5.86[249] |
-0.44[250] |
-1.74[251] |
39 |
FGR |
Tyrosine-protein kinase Fgr |
[252] |
[253] |
[254] |
-7.69[255] |
-5.17[256] |
-7.78[257] |
-1.15[258] |
40 |
NOS2 |
Nitric oxide synthase, inducible |
[259] |
-0.84[260] |
[261] |
-7.04[262] |
-5.35[263] |
-6.01[264] |
-10.16[265] |
41 |
GNG4 |
Guanine nucleotide-binding protein
G(I)/G(S)/G(O) subunit gamma-4 |
2.61[266] |
-0.01[267] |
4.22[268] |
0.76[269] |
-1.13[270] |
-5.40[271] |
42 |
ORAI2 |
Protein orai-2 |
[272] |
2.58[273] |
1.11[274] |
0.74[275] |
3.96[276] |
3.46[277] |
-1.03[278] |
43 |
P2RX5 |
P2X purinoceptor 5 |
[279] |
-1.29[280] |
-2.93[281] |
-2.51[282] |
-0.77[283] |
0.44[284] |
-5.29[285] |
44 |
LRP8 |
Low-density lipoprotein receptor-related protein 8 |
[286] |
1.56[287] |
1.95[288] |
2.75[289] |
3.00[290] |
3.17[291] |
-4.89[292] |
45 |
PECAM1 |
Platelet endothelial cell adhesion molecule |
[293] |
-3.22[294] |
-3.85[295] |
1.15[296] |
-3.00[297] |
-3.22[298] |
-0.13[299] |
46 |
ITPR1 |
Inositol 1,4,5-trisphosphate receptor type 1 |
[300] |
2.28[301] |
1.78[302] |
3.36[303] |
2.35[304] |
3.45[305] |
1.80[306] |
47 |
GNB4 |
Guanine nucleotide-binding protein subunit beta-4 |
[307] |
-1.23[308] |
-1.12[309] |
0.31[310] |
2.18[311] |
5.15[312] |
1.24[313] |
48 |
GNG2 |
Guanine nucleotide-binding protein
G(I)/G(S)/G(O) subunit gamma-2 |
-7.14[314] |
-8.40[315] |
[316] |
2.62[317] |
2.32[318] |
-0.07[319] |
49 |
PDE2A |
cGMP-dependent 3',5'-cyclic phosphodiesterase |
[320] |
0.66[321] |
-5.92[322] |
-4.43[323] |
-4.08[324] |
0.46[325] |
2.01[326] |
50 |
KCNMB4 |
Calcium-activated potassium channel subunit beta-4 |
[327] |
1.29[328] |
0.91[329] |
2.33[330] |
0.60[331] |
-0.07[332] |
-1.91[333] |
51 |
PDE11A |
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A |
[334] |
1.27[335] |
0.13[336] |
1.22[337] |
2.55[338] |
-2.95[339] |
1.56[340] |
52 |
PDE5A |
cGMP-specific 3',5'-cyclic phosphodiesterase |
[341] |
-0.97[342] |
-0.05[343] |
2.17[344] |
3.44[345] |
1.94[346] |
0.13[347] |
53 |
NOS3 |
Nitric oxide synthase, endothelial |
[348] |
3.91[349] |
0.63[350] |
0.52[351] |
-0.44[352] |
1.12[353] |
-0.08[354] |
54 |
ATP2A3 |
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 |
[355] |
1.27[356] |
-3.62[357] |
0.64[358] |
0.62[359] |
0.46[360] |
-0.18[361] |
55 |
GNGT2 |
Guanine nucleotide-binding protein
G(I)/G(S)/G(O) subunit gamma-T2 |
[362] |
[363] |
[364] |
-2.56[365] |
-7.01[366] |
-2.74[367] |
56 |
P2RX3 |
P2X purinoceptor 3 |
[368] |
-4.79[369] |
-4.80[370] |
-3.37[371] |
-7.24[372] |
[373] |
-4.27[374] |
57 |
GNG3 |
Guanine nucleotide-binding protein
G(I)/G(S)/G(O) subunit gamma-3 |
-1.72[375] |
-0.27[376] |
-2.07[377] |
-1.20[378] |
-1.28[379] |
-2.93[380] |
58 |
NOS1 |
Nitric oxide synthase, brain |
[381] |
-2.42[382] |
-0.83[383] |
-1.98[384] |
-1.17[385] |
-1.04[386] |
-2.16[387] |
59 |
PDE1B |
Calcium/calmodulin-dependent
3',5'-cyclic nucleotide phosphodiesterase 1B |
-4.54[388] |
-5.90[389] |
[390] |
-1.32[391] |
-2.17[392] |
1.01[393] |
60 |
KCNMB1 |
Calcium-activated potassium channel subunit beta-1 |
[394] |
[395] |
[396] |
[397] |
-0.99[398] |
[399] |
-2.27[400] |
61 |
GNB3 |
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 |
[401] |
0.73[402] |
2.60[403] |
2.32[404] |
0.51[405] |
3.45[406] |
-4.53[407] |
62 |
PTGIR |
Prostacyclin receptor |
[408] |
-1.86[409] |
-5.28[410] |
[411] |
-1.05[412] |
3.54[413] |
2.00[414] |
63 |
ATP2A1 |
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 |
[415] |
3.69[416] |
5.25[417] |
2.11[418] |
1.78[419] |
2.44[420] |
-1.25[421] |
64 |
SLC8A1 |
Sodium/calcium exchanger 1 |
[422] |
0.68[423] |
[424] |
[425] |
4.26[426] |
2.45[427] |
4.75[428] |
65 |
SLC8A3 |
Sodium/calcium exchanger 3 |
[429] |
-1.41[430] |
-3.74[431] |
-4.16[432] |
[433] |
-2.77[434] |
-2.22[435] |
66 |
P2RX1 |
P2X purinoceptor 1 |
[436] |
0.64[437] |
2.39[438] |
-5.10[439] |
-2.33[440] |
1.08[441] |
-0.17[442] |
67 |
PLA2G4A |
Cytosolic phospholipase A2 |
[443] |
-0.59[444] |
-3.53[445] |
5.00[446] |
3.01[447] |
7.00[448] |
1.50[449] |
68 |
PRKG1 |
cGMP-dependent protein kinase 1 |
[450] |
-1.02[451] |
[452] |
0.40[453] |
2.68[454] |
4.82[455] |
3.66[456] |
69 |
PDE1A |
Calcium/calmodulin-dependent
3',5'-cyclic nucleotide phosphodiesterase 1A |
[457] |
-1.96[458] |
3.16[459] |
5.62[460] |
2.31[461] |
3.75[462] |
70 |
SLC8A2 |
Sodium/calcium exchanger 2 |
[463] |
0.15[464] |
-0.87[465] |
-0.80[466] |
0.53[467] |
-0.72[468] |
-2.84[469] |
71 |
KCNMB2 |
Calcium-activated potassium channel subunit beta-2 |
[470] |
[471] |
-0.79[472] |
0.82[473] |
-1.76[474] |
-2.52[475] |
-1.84[476] |
72 |
PRKG2 |
cGMP-dependent protein kinase 2 |
[477] |
2.04[478] |
[479] |
[480] |
6.29[481] |
0.81[482] |
-0.81[483] |
73 |
GUCY1A2 |
Guanylate cyclase soluble subunit alpha-2 |
[484] |
0.39[485] |
1.10[486] |
7.22[487] |
9.73[488] |
4.50[489] |
7.72[490] |
74 |
TRPC6 |
Short transient receptor potential channel 6 |
[491] |
-1.77[492] |
-0.59[493] |
0.54[494] |
0.36[495] |
-1.10[496] |
0.43[497] |
75 |
PDE10A |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A |
[498] |
-1.56[499] |
[500] |
[501] |
1.88[502] |
8.44[503] |
4.69[504] |
76 |
GUCY1B1 |
|
[505] |
[506] |
[507] |
[508] |
[509] |
[510] |
[511] |
77 |
TRPC3 |
Short transient receptor potential channel 3 |
[512] |
[513] |
[514] |
[515] |
[516] |
[517] |
[518] |
78 |
TRPC7 |
Short transient receptor potential channel 7 |
[519] |
[520] |
[521] |
[522] |
[523] |
[524] |
[525] |
79 |
ATP2B3 |
Plasma membrane calcium-transporting ATPase 3 |
[526] |
[527] |
[528] |
[529] |
[530] |
[531] |
[532] |
80 |
IRAG1 |
|
[533] |
[534] |
[535] |
[536] |
[537] |
[538] |
[539] |
81 |
P2RX6 |
P2X purinoceptor 6 |
[540] |
[541] |
[542] |
[543] |
[544] |
[545] |
[546] |
82 |
GNG8 |
Guanine nucleotide-binding protein
G(I)/G(S)/G(O) subunit gamma-8 |
[547] |
[548] |
[549] |
[550] |
[551] |
[552] |
83 |
GNGT1 |
Guanine nucleotide-binding protein G(T) subunit gamma-T1 |
[553] |
[554] |
[555] |
[556] |
[557] |
[558] |
[559] |
84 |
GUCY1A1 |
|
[560] |
[561] |
[562] |
[563] |
[564] |
[565] |
[566] |
85 |
GNG13 |
Guanine nucleotide-binding protein
G(I)/G(S)/G(O) subunit gamma-13 |
[567] |
[568] |
[569] |
[570] |
[571] |
[572] |
86 |
P2RX2 |
P2X purinoceptor 2 |
[573] |
[574] |
[575] |
[576] |
[577] |
[578] |
[579] |
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