REACTOME_PLATELET_AGGREGATION_PLUG_FORMATION | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | FGG | Fibrinogen gamma chain | [1] | -3.50[2] | -2.27[3] | -2.15[4] | -9.72[5] | -11.75[6] | -0.72[7] |
2 | FGA | Fibrinogen alpha chain | [8] | -3.16[9] | -2.52[10] | -2.04[11] | -8.93[12] | -11.77[13] | -0.05[14] |
3 | FGB | Fibrinogen beta chain | [15] | -4.37[16] | -3.29[17] | -1.05[18] | -7.05[19] | -10.40[20] | 0.73[21] |
4 | F2 | Prothrombin | [22] | 0.84[23] | 1.59[24] | 1.84[25] | -6.99[26] | -7.48[27] | 0.16[28] |
5 | FN1 | Fibronectin | [29] | 6.59[30] | 6.32[31] | 6.07[32] | 6.48[33] | 6.54[34] | 2.14[35] |
6 | RAP1B | Ras-related protein Rap-1b | [36] | 0.79[37] | 1.67[38] | 1.31[39] | 3.04[40] | 2.65[41] | -2.05[42] |
7 | AKT1 | RAC-alpha serine/threonine-protein kinase | [43] | 3.17[44] | 3.20[45] | 1.99[46] | 3.51[47] | 3.39[48] | -0.40[49] |
8 | GRB2 | Growth factor receptor-bound protein 2 | [50] | 4.29[51] | 4.39[52] | 4.37[53] | 4.12[54] | 3.89[55] | 0.14[56] |
9 | CRK | Adapter molecule crk | [57] | 2.89[58] | 3.09[59] | 3.01[60] | 3.32[61] | 3.58[62] | 0.68[63] |
10 | RAP1A | Ras-related protein Rap-1A | [64] | 2.04[65] | 2.25[66] | 2.94[67] | 3.35[68] | 2.97[69] | -1.45[70] |
11 | SHC1 | SHC-transforming protein 1 | [71] | 4.26[72] | 4.74[73] | 4.68[74] | 6.22[75] | 5.56[76] | 0.62[77] |
12 | TLN1 | Talin-1 | [78] | 6.09[79] | 4.97[80] | 5.62[81] | 6.67[82] | 6.55[83] | 3.20[84] |
13 | APBB1IP | Amyloid beta A4 precursor protein-binding family B member 1-interacting protein | -5.44[85] | [86] | -3.39[87] | 0.27[88] | -2.64[89] | -0.70[90] | |
14 | BCAR1 | Breast cancer anti-estrogen resistance protein 1 | [91] | 4.22[92] | 4.36[93] | 3.10[94] | 4.94[95] | 4.52[96] | -0.09[97] |
15 | CSK | Tyrosine-protein kinase CSK | [98] | 3.47[99] | 3.23[100] | 3.46[101] | 3.55[102] | 3.00[103] | -1.02[104] |
16 | PTK2 | Focal adhesion kinase 1 | [105] | 3.83[106] | 4.58[107] | 4.82[108] | 5.51[109] | 4.57[110] | 0.60[111] |
17 | PTPN1 | Tyrosine-protein phosphatase non-receptor type 1 | [112] | 4.21[113] | 4.14[114] | 3.52[115] | 5.39[116] | 4.54[117] | -0.47[118] |
18 | SOS1 | Son of sevenless homolog 1 | [119] | 2.99[120] | 4.78[121] | 4.15[122] | 4.41[123] | 3.50[124] | 0.38[125] |
19 | SRC | Proto-oncogene tyrosine-protein kinase Src | [126] | 6.12[127] | 6.36[128] | 5.22[129] | 5.96[130] | 5.00[131] | -1.01[132] |
20 | PDPK1 | 3-phosphoinositide-dependent protein kinase 1 | [133] | 5.43[134] | 6.88[135] | 5.45[136] | 5.00[137] | 5.25[138] | 2.34[139] |
21 | THPO | Thrombopoietin | [140] | 2.15[141] | 2.02[142] | 0.71[143] | -3.95[144] | -7.95[145] | -0.04[146] |
22 | ITGB3 | Integrin beta-3 | [147] | 1.46[148] | -0.99[149] | 2.40[150] | 6.42[151] | 5.94[152] | 1.17[153] |
23 | RAPGEF4 | Rap guanine nucleotide exchange factor 4 | [154] | -0.93[155] | 1.13[156] | 1.91[157] | 1.90[158] | 4.16[159] | 2.74[160] |
24 | ADRA2C | Alpha-2C adrenergic receptor | [161] | 7.11[162] | 0.96[163] | 2.48[164] | 0.33[165] | -1.54[166] | -3.39[167] |
25 | COL1A1 | Collagen alpha-1(I) chain | [168] | 7.83[169] | 0.58[170] | 2.26[171] | 10.57[172] | 11.97[173] | 6.19[174] |
26 | COL1A2 | Collagen alpha-2(I) chain | [175] | -3.06[176] | -2.72[177] | -0.37[178] | 8.54[179] | 8.44[180] | 6.26[181] |
27 | RASGRP2 | RAS guanyl-releasing protein 2 | [182] | -0.99[183] | 1.46[184] | 4.34[185] | 1.03[186] | 1.86[187] | 1.88[188] |
28 | SYK | Tyrosine-protein kinase SYK | [189] | -5.07[190] | 1.06[191] | -2.09[192] | 3.66[193] | 0.01[194] | 3.20[195] |
29 | MPL | Thrombopoietin receptor | [196] | 0.83[197] | 2.00[198] | 1.41[199] | 1.19[200] | 0.73[201] | 0.11[202] |
30 | GP1BA | Platelet glycoprotein Ib alpha chain | [203] | 1.15[204] | 1.70[205] | 4.76[206] | 2.99[207] | 3.07[208] | 0.91[209] |
31 | GP1BB | Platelet glycoprotein Ib beta chain | [210] | [211] | [212] | [213] | [214] | [215] | [216] |
32 | VWF | von Willebrand factor | [217] | 4.07[218] | 2.17[219] | -0.35[220] | 3.72[221] | 0.99[222] | 5.55[223] |
33 | RAPGEF3 | Rap guanine nucleotide exchange factor 3 | [224] | 4.92[225] | 4.86[226] | 4.15[227] | 5.45[228] | 3.96[229] | 3.65[230] |
34 | GP5 | Platelet glycoprotein V | [231] | -0.31[232] | 1.67[233] | -2.46[234] | -1.83[235] | 1.15[236] | 1.26[237] |
35 | ITGA2B | Integrin alpha-IIb | [238] | 6.70[239] | 7.24[240] | 7.10[241] | 6.58[242] | 4.80[243] | 2.46[244] |
36 | ADRA2A | Alpha-2A adrenergic receptor | [245] | -0.06[246] | 1.69[247] | [248] | 4.91[249] | 7.46[250] | 3.83[251] |
37 | RASGRP1 | RAS guanyl-releasing protein 1 | [252] | 4.33[253] | 5.28[254] | 5.79[255] | 7.71[256] | 8.65[257] | 6.65[258] |
38 | ADRA2B | Alpha-2B adrenergic receptor | [259] | [260] | [261] | [262] | [263] | [264] | [265] |
39 | GP9 | Platelet glycoprotein IX | [266] | [267] | [268] | [269] | [270] | [271] | [272] |