REACTOME_APC_C_MEDIATED_DEGRADATION_OF_CELL_CYCLE_PROTEINS | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | UBB | Polyubiquitin-B | [1] | -1.24[2] | -1.45[3] | -1.28[4] | -1.57[5] | -1.34[6] | -0.49[7] |
2 | RPS27A | Ubiquitin-40S ribosomal protein S27a | [8] | [9] | [10] | [11] | [12] | [13] | [14] |
3 | UBC | Polyubiquitin-C | [15] | -0.80[16] | -0.69[17] | -0.92[18] | -0.72[19] | -0.96[20] | -0.04[21] |
4 | PSME1 | Proteasome activator complex subunit 1 | [22] | -0.57[23] | -2.28[24] | -1.89[25] | -1.44[26] | -2.18[27] | -0.99[28] |
5 | PSME2 | Proteasome activator complex subunit 2 | [29] | -0.39[30] | -1.91[31] | -1.98[32] | -1.22[33] | -1.72[34] | -0.62[35] |
6 | PSMA7 | Proteasome subunit alpha type-7 | [36] | 0.57[37] | 0.56[38] | -0.73[39] | 0.40[40] | -0.24[41] | 0.41[42] |
7 | PSMB1 | Proteasome subunit beta type-1 | [43] | 0.12[44] | 0.11[45] | -0.93[46] | -0.84[47] | -0.28[48] | 0.24[49] |
8 | PSMB3 | Proteasome subunit beta type-3 | [50] | -0.37[51] | -1.27[52] | -0.20[53] | -0.86[54] | -1.19[55] | -0.05[56] |
9 | PSMB4 | Proteasome subunit beta type-4 | [57] | -0.12[58] | -0.07[59] | 0.10[60] | 0.57[61] | 0.35[62] | -0.38[63] |
10 | PSMB7 | Proteasome subunit beta type-7 | [64] | -1.07[65] | -1.17[66] | -1.00[67] | -1.21[68] | -0.97[69] | -0.82[70] |
11 | PSMB5 | Proteasome subunit beta type-5 | [71] | 1.33[72] | -0.21[73] | -0.25[74] | -0.48[75] | -0.41[76] | -0.35[77] |
12 | PSMA6 | Proteasome subunit alpha type-6 | [78] | 1.46[79] | 0.07[80] | 0.04[81] | 0.04[82] | -0.15[83] | -0.26[84] |
13 | PSMA4 | Proteasome subunit alpha type-4 | [85] | -0.47[86] | 0.09[87] | -0.08[88] | 0.35[89] | -0.03[90] | -0.34[91] |
14 | SKP1 | S-phase kinase-associated protein 1 | [92] | -0.02[93] | 0.37[94] | -0.49[95] | 0.70[96] | 0.70[97] | 0.69[98] |
15 | PSMC3 | 26S proteasome regulatory subunit 6A | [99] | -0.50[100] | -0.68[101] | -0.02[102] | -0.85[103] | -0.86[104] | 0.13[105] |
16 | PSMA3 | Proteasome subunit alpha type-3 | [106] | -1.09[107] | -0.19[108] | -0.83[109] | -0.11[110] | -0.76[111] | -0.10[112] |
17 | PSMB6 | Proteasome subunit beta type-6 | [113] | -0.54[114] | -0.50[115] | -0.32[116] | -0.65[117] | -1.12[118] | 0.06[119] |
18 | PSMA2 | Proteasome subunit alpha type-2 | [120] | -0.62[121] | 0.23[122] | 0.60[123] | -0.16[124] | 0.01[125] | 0.29[126] |
19 | PSMD4 | 26S proteasome non-ATPase regulatory subunit 4 | [127] | -0.11[128] | -0.20[129] | 0.04[130] | 0.55[131] | -0.19[132] | -0.04[133] |
20 | PSMD7 | 26S proteasome non-ATPase regulatory subunit 7 | [134] | -0.19[135] | 0.08[136] | -0.03[137] | -0.54[138] | -0.27[139] | -0.21[140] |
21 | PSMD8 | 26S proteasome non-ATPase regulatory subunit 8 | [141] | -0.02[142] | 0.11[143] | 0.29[144] | -0.27[145] | 0.29[146] | -0.19[147] |
22 | PSMD2 | 26S proteasome non-ATPase regulatory subunit 2 | [148] | 1.51[149] | 0.58[150] | 0.69[151] | 0.84[152] | 1.94[153] | 0.85[154] |
23 | PSMC1 | 26S proteasome regulatory subunit 4 | [155] | -0.17[156] | -0.21[157] | -0.82[158] | 1.03[159] | 0.35[160] | 0.01[161] |
24 | PSMA1 | Proteasome subunit alpha type-1 | [162] | 0.02[163] | 0.30[164] | 0.40[165] | 0.60[166] | -0.09[167] | 0.50[168] |
25 | UBA52 | Ubiquitin-60S ribosomal protein L40 | [169] | 1.64[170] | 1.54[171] | 2.59[172] | 0.68[173] | 1.27[174] | 0.73[175] |
26 | PSMC5 | 26S proteasome regulatory subunit 8 | [176] | 0.33[177] | 0.12[178] | 0.24[179] | 0.01[180] | 0.23[181] | 0.27[182] |
27 | ANAPC11 | Anaphase-promoting complex subunit 11 | [183] | -0.88[184] | -0.44[185] | -0.84[186] | -1.11[187] | -0.95[188] | -0.01[189] |
28 | PSMD3 | 26S proteasome non-ATPase regulatory subunit 3 | [190] | 0.73[191] | 0.12[192] | 0.75[193] | 0.54[194] | 0.57[195] | -0.02[196] |
29 | PSMB8 | Proteasome subunit beta type-8 | [197] | -1.67[198] | -2.36[199] | -9.54[200] | 0.52[201] | -0.99[202] | -0.71[203] |
30 | PSMD14 | 26S proteasome non-ATPase regulatory subunit 14 | [204] | -0.09[205] | 0.41[206] | 0.70[207] | 0.41[208] | 0.24[209] | -0.16[210] |
31 | PSMC4 | 26S proteasome regulatory subunit 6B | [211] | 0.33[212] | 0.26[213] | 0.23[214] | 0.04[215] | -0.05[216] | 0.31[217] |
32 | PSMD6 | 26S proteasome non-ATPase regulatory subunit 6 | [218] | -0.82[219] | -0.44[220] | -1.50[221] | -0.59[222] | 0.02[223] | -0.28[224] |
33 | PSMD13 | 26S proteasome non-ATPase regulatory subunit 13 | [225] | 0.38[226] | 0.38[227] | 0.92[228] | 0.47[229] | -0.22[230] | -0.09[231] |
34 | PSMD12 | 26S proteasome non-ATPase regulatory subunit 12 | [232] | -0.44[233] | -0.47[234] | -0.74[235] | 0.09[236] | -0.04[237] | -0.17[238] |
35 | PSMC6 | 26S proteasome regulatory subunit 10B | [239] | -0.15[240] | 1.32[241] | 0.18[242] | 0.45[243] | 0.18[244] | 0.49[245] |
36 | PSMD11 | 26S proteasome non-ATPase regulatory subunit 11 | [246] | 0.74[247] | 0.24[248] | 0.87[249] | 0.85[250] | 0.81[251] | 1.31[252] |
37 | PSMC2 | 26S proteasome regulatory subunit 7 | [253] | 0.49[254] | 0.79[255] | 0.60[256] | 1.25[257] | 0.88[258] | 1.36[259] |
38 | CDC26 | Anaphase-promoting complex subunit CDC26 | [260] | -1.82[261] | -1.35[262] | -1.37[263] | -1.82[264] | -1.15[265] | -0.82[266] |
39 | PSME3 | Proteasome activator complex subunit 3 | [267] | 1.72[268] | 1.33[269] | 1.05[270] | 1.27[271] | 1.34[272] | 0.93[273] |
40 | UBE2E1 | Ubiquitin-conjugating enzyme E2 E1 | [274] | 0.00[275] | 0.24[276] | 0.96[277] | 0.73[278] | 0.76[279] | -1.43[280] |
41 | PSMD1 | 26S proteasome non-ATPase regulatory subunit 1 | [281] | 1.48[282] | 1.69[283] | 1.61[284] | 2.08[285] | 1.89[286] | 2.12[287] |
42 | BUB3 | Mitotic checkpoint protein BUB3 | [288] | 1.27[289] | 2.15[290] | 1.55[291] | 0.90[292] | 2.13[293] | 0.79[294] |
43 | PSMB10 | Proteasome subunit beta type-10 | [295] | -1.25[296] | -0.76[297] | -2.61[298] | -0.13[299] | -1.49[300] | -0.03[301] |
44 | PSMA5 | Proteasome subunit alpha type-5 | [302] | 1.81[303] | 2.13[304] | 1.73[305] | 2.13[306] | 1.49[307] | 1.96[308] |
45 | PSMF1 | Proteasome inhibitor PI31 subunit | [309] | 2.19[310] | 2.12[311] | 0.97[312] | 1.14[313] | 0.70[314] | 1.90[315] |
46 | ANAPC16 | Anaphase-promoting complex subunit 16 | [316] | 1.14[317] | 1.85[318] | 0.70[319] | 0.78[320] | 0.79[321] | 1.93[322] |
47 | ANAPC5 | Anaphase-promoting complex subunit 5 | [323] | 1.83[324] | 2.49[325] | 2.67[326] | 1.54[327] | 1.78[328] | 2.09[329] |
48 | PSMB2 | Proteasome subunit beta type-2 | [330] | 1.97[331] | 1.59[332] | 2.02[333] | 2.44[334] | 2.22[335] | 2.44[336] |
49 | PSMB9 | Proteasome subunit beta type-9 | [337] | -2.04[338] | -4.77[339] | -7.04[340] | 1.69[341] | -0.78[342] | -0.45[343] |
50 | PSMD9 | 26S proteasome non-ATPase regulatory subunit 9 | [344] | 0.34[345] | 0.73[346] | -0.22[347] | 0.31[348] | 0.55[349] | 0.77[350] |
51 | CUL1 | Cullin-1 | [351] | 0.57[352] | 1.25[353] | 0.81[354] | 1.79[355] | 1.22[356] | 2.13[357] |
52 | CDC27 | Cell division cycle protein 27 homolog | [358] | 1.17[359] | 2.01[360] | 1.37[361] | 2.39[362] | 1.71[363] | 1.53[364] |
53 | CDC16 | Cell division cycle protein 16 homolog | [365] | 0.46[366] | 0.69[367] | 0.05[368] | 0.79[369] | 1.01[370] | 1.26[371] |
54 | CDK2 | Cyclin-dependent kinase 2 | [372] | 0.54[373] | 0.71[374] | 1.09[375] | 1.19[376] | 1.55[377] | -0.80[378] |
55 | UBE2C | Ubiquitin-conjugating enzyme E2 C | [379] | 0.72[380] | 1.10[381] | 1.88[382] | 1.34[383] | 2.00[384] | -2.42[385] |
56 | UBE2S | Ubiquitin-conjugating enzyme E2 S | [386] | 1.40[387] | 0.97[388] | 3.17[389] | 2.17[390] | 3.31[391] | -1.21[392] |
57 | PSMD10 | 26S proteasome non-ATPase regulatory subunit 10 | [393] | 0.90[394] | 1.11[395] | 1.17[396] | 1.98[397] | 1.10[398] | 0.76[399] |
58 | MAD2L1 | Mitotic spindle assembly checkpoint protein MAD2A | [400] | 1.55[401] | 2.67[402] | 2.02[403] | 1.26[404] | 2.15[405] | -1.49[406] |
59 | CCNB1 | G2/mitotic-specific cyclin-B1 | [407] | 2.80[408] | 3.04[409] | 3.23[410] | 2.81[411] | 3.57[412] | -0.96[413] |
60 | PSME4 | Proteasome activator complex subunit 4 | [414] | 2.43[415] | 3.23[416] | 3.27[417] | 2.54[418] | 2.30[419] | 3.02[420] |
61 | AURKA | Aurora kinase A | [421] | 2.67[422] | 2.92[423] | 2.43[424] | 2.83[425] | 2.51[426] | -1.42[427] |
62 | CDC23 | Cell division cycle protein 23 homolog | [428] | 1.33[429] | 1.53[430] | 1.80[431] | 2.24[432] | 1.72[433] | 1.58[434] |
63 | PSMD5 | 26S proteasome non-ATPase regulatory subunit 5 | [435] | 1.32[436] | 0.76[437] | 2.36[438] | 2.37[439] | 2.25[440] | 2.20[441] |
64 | FZR1 | Fizzy-related protein homolog | [442] | 1.71[443] | 1.35[444] | 1.45[445] | 1.24[446] | 1.61[447] | 2.01[448] |
65 | CDK1 | Cyclin-dependent kinase 1 | [449] | 2.21[450] | 4.27[451] | 3.02[452] | 3.48[453] | 4.07[454] | -1.09[455] |
66 | ANAPC7 | Anaphase-promoting complex subunit 7 | [456] | 1.96[457] | 2.35[458] | 1.84[459] | 2.11[460] | 2.14[461] | 1.57[462] |
67 | ANAPC2 | Anaphase-promoting complex subunit 2 | [463] | 1.56[464] | 1.00[465] | 1.63[466] | 1.25[467] | 0.98[468] | 1.43[469] |
68 | AURKB | Aurora kinase B | [470] | 1.55[471] | 1.90[472] | 2.94[473] | 1.55[474] | 1.86[475] | -1.97[476] |
69 | PLK1 | Serine/threonine-protein kinase PLK1 | [477] | 3.45[478] | 3.19[479] | 3.06[480] | 2.45[481] | 3.27[482] | -1.25[483] |
70 | CDC20 | Cell division cycle protein 20 homolog | [484] | 3.31[485] | 3.33[486] | 3.71[487] | 3.71[488] | 4.14[489] | -0.92[490] |
71 | PTTG1 | Securin | [491] | 2.45[492] | 3.11[493] | 3.73[494] | 2.63[495] | 3.69[496] | -0.69[497] |
72 | ANAPC1 | Anaphase-promoting complex subunit 1 | [498] | 3.37[499] | 3.54[500] | 3.44[501] | 3.13[502] | 2.93[503] | 2.84[504] |
73 | SKP2 | S-phase kinase-associated protein 2 | [505] | 2.27[506] | 2.73[507] | 3.88[508] | 2.47[509] | 2.33[510] | 2.46[511] |
74 | CCNA2 | Cyclin-A2 | [512] | 3.16[513] | 4.17[514] | 3.53[515] | 3.21[516] | 4.38[517] | 0.16[518] |
75 | RB1 | Retinoblastoma-associated protein | [519] | 2.18[520] | 2.67[521] | 3.25[522] | 3.48[523] | 3.58[524] | 2.86[525] |
76 | ANAPC4 | Anaphase-promoting complex subunit 4 | [526] | 1.15[527] | 2.07[528] | 2.41[529] | 2.40[530] | 1.65[531] | 2.36[532] |
77 | UBE2D1 | Ubiquitin-conjugating enzyme E2 D1 | [533] | 1.75[534] | 2.61[535] | 2.97[536] | 2.73[537] | 2.27[538] | 1.88[539] |
78 | FBXO5 | F-box only protein 5 | [540] | 1.98[541] | 3.19[542] | 2.77[543] | 3.22[544] | 3.11[545] | 0.31[546] |
79 | ANAPC10 | Anaphase-promoting complex subunit 10 | [547] | 0.72[548] | 1.61[549] | 1.01[550] | 0.98[551] | 1.54[552] | 1.50[553] |
80 | BTRC | F-box/WD repeat-containing protein 1A | [554] | 2.37[555] | 3.16[556] | 2.78[557] | 1.97[558] | 2.28[559] | 2.73[560] |
81 | NEK2 | Serine/threonine-protein kinase Nek2 | [561] | 1.98[562] | 3.04[563] | 3.67[564] | 3.34[565] | 3.58[566] | -0.89[567] |
82 | BUB1B | Mitotic checkpoint serine/threonine-protein kinase BUB1 beta | [568] | 3.10[569] | 3.80[570] | 3.73[571] | 4.27[572] | 4.34[573] | -0.22[574] |
83 | CDC14A | Dual specificity protein phosphatase CDC14A | [575] | 1.80[576] | 2.59[577] | 3.21[578] | 2.85[579] | 2.29[580] | 2.55[581] |
84 | CCNA1 | Cyclin-A1 | [582] | [583] | -2.44[584] | [585] | 0.42[586] | 7.60[587] | [588] |
85 | PSMB11 | Proteasome subunit beta type-11 | [589] | [590] | [591] | [592] | [593] | [594] | [595] |
86 | ANAPC15 | Anaphase-promoting complex subunit 15 | [596] | [597] | [598] | [599] | [600] | [601] | [602] |
87 | SEM1 | Putative protein SEM1, isoform 2 | [603] | [604] | [605] | [606] | [607] | [608] | [609] |
88 | PSMA8 | Proteasome subunit alpha type-7-like | [610] | [611] | [612] | [613] | [614] | [615] | [616] |