REACTOME_APC_C_CDC20_MEDIATED_DEGRADATION_OF_CYCLIN_B Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 UBB Polyubiquitin-B [1] -0.56[2] -0.96[3] -0.96[4] -0.89[5] -0.84[6] -0.07[7]
2 RPS27A Ubiquitin-40S ribosomal protein S27a [8] [9] [10] [11] [12] [13] [14]
3 UBC Polyubiquitin-C [15] -0.12[16] -0.21[17] -0.60[18] -0.04[19] -0.47[20] 0.38[21]
4 UBA52 Ubiquitin-60S ribosomal protein L40 [22] 2.32[23] 2.02[24] 2.91[25] 1.36[26] 1.76[27] 1.15[28]
5 ANAPC11 Anaphase-promoting complex subunit 11 [29] -0.19[30] 0.04[31] -0.53[32] -0.43[33] -0.46[34] 0.41[35]
6 CDC26 Anaphase-promoting complex subunit CDC26 [36] -1.14[37] -0.86[38] -1.05[39] -1.14[40] -0.66[41] -0.40[42]
7 UBE2E1 Ubiquitin-conjugating enzyme E2 E1 [43] 0.68[44] 0.72[45] 1.28[46] 1.40[47] 1.26[48] -1.00[49]
8 ANAPC16 Anaphase-promoting complex subunit 16 [50] 1.83[51] 2.33[52] 1.02[53] 1.46[54] 1.28[55] 2.35[56]
9 ANAPC5 Anaphase-promoting complex subunit 5 [57] 2.51[58] 2.98[59] 2.99[60] 2.22[61] 2.27[62] 2.52[63]
10 CDC27 Cell division cycle protein 27 homolog [64] 1.86[65] 2.49[66] 1.69[67] 3.07[68] 2.20[69] 1.95[70]
11 CDC16 Cell division cycle protein 16 homolog [71] 1.15[72] 1.17[73] 0.37[74] 1.46[75] 1.50[76] 1.68[77]
12 UBE2C Ubiquitin-conjugating enzyme E2 C [78] 1.41[79] 1.58[80] 2.19[81] 2.01[82] 2.50[83] -2.00[84]
13 UBE2S Ubiquitin-conjugating enzyme E2 S [85] 2.09[86] 1.45[87] 3.49[88] 2.85[89] 3.80[90] -0.79[91]
14 CCNB1 G2/mitotic-specific cyclin-B1 [92] 3.49[93] 3.52[94] 3.55[95] 3.49[96] 4.06[97] -0.54[98]
15 CDC23 Cell division cycle protein 23 homolog [99] 2.02[100] 2.01[101] 2.12[102] 2.92[103] 2.22[104] 2.00[105]
16 CDK1 Cyclin-dependent kinase 1 [106] 2.89[107] 4.75[108] 3.33[109] 4.15[110] 4.56[111] -0.66[112]
17 ANAPC7 Anaphase-promoting complex subunit 7 [113] 2.64[114] 2.84[115] 2.16[116] 2.79[117] 2.63[118] 1.99[119]
18 ANAPC2 Anaphase-promoting complex subunit 2 [120] 2.25[121] 1.48[122] 1.94[123] 1.92[124] 1.48[125] 1.85[126]
19 CDC20 Cell division cycle protein 20 homolog [127] 4.00[128] 3.81[129] 4.03[130] 4.39[131] 4.63[132] -0.50[133]
20 ANAPC1 Anaphase-promoting complex subunit 1 [134] 4.05[135] 4.03[136] 3.76[137] 3.81[138] 3.42[139] 3.26[140]
21 ANAPC4 Anaphase-promoting complex subunit 4 [141] 1.84[142] 2.56[143] 2.73[144] 3.07[145] 2.14[146] 2.78[147]
22 UBE2D1 Ubiquitin-conjugating enzyme E2 D1 [148] 2.43[149] 3.10[150] 3.29[151] 3.40[152] 2.76[153] 2.31[154]
23 ANAPC10 Anaphase-promoting complex subunit 10 [155] 1.40[156] 2.09[157] 1.32[158] 1.66[159] 2.03[160] 1.92[161]
24 ANAPC15 Anaphase-promoting complex subunit 15 [162] [163] [164] [165] [166] [167] [168]
[1]
ref_hepatocyte UBB
Mean 764
Standard deviation 4.8e+02
Values 3.8e+02 3.5e+02 5.3e+02 1.2e+03 1.3e+03
[2]
HepG2 UBB
Mean 368
Standard deviation 39
Values 4e+02 3.4e+02
[3]
HepG2.C3A UBB
Mean 285
Standard deviation 14
Values 2.8e+02 3e+02
[4]
HuH.7 UBB
Mean 304
Standard deviation 40
Values 2.9e+02 2.7e+02 3.5e+02
[5]
SNU475 UBB
Mean 204
Standard deviation 3.3
Values 2.1e+02 2e+02
[6]
THLE UBB
Mean 315
Standard deviation 34
Values 2.9e+02 3.4e+02
[7]
liver UBB
Mean 296
Standard deviation 1.3e+02
Values 4.3e+02 2.1e+02 3.9e+02 1.5e+02
[8]
ref_hepatocyte RPS27A
Mean 499
Standard deviation 2.2e+02
Values 6.6e+02 6.1e+02 1.7e+02 6.8e+02 3.8e+02
[9]
HepG2 RPS27A
Missing
[10]
HepG2.C3A RPS27A
Missing
[11]
HuH.7 RPS27A
Missing
[12]
SNU475 RPS27A
Missing
[13]
THLE RPS27A
Missing
[14]
liver RPS27A
Missing
[15]
ref_hepatocyte UBC
Mean 480
Standard deviation 2.8e+02
Values 1.8e+02 3.5e+02 9.1e+02 5.8e+02 3.8e+02
[16]
HepG2 UBC
Mean 314
Standard deviation 38
Values 3.4e+02 2.9e+02
[17]
HepG2.C3A UBC
Mean 302
Standard deviation 41
Values 3.3e+02 2.7e+02
[18]
HuH.7 UBC
Mean 246
Standard deviation 64
Values 2.4e+02 3.1e+02 1.9e+02
[19]
SNU475 UBC
Mean 232
Standard deviation 63
Values 2.8e+02 1.9e+02
[20]
THLE UBC
Mean 257
Standard deviation 41
Values 2.3e+02 2.9e+02
[21]
liver UBC
Mean 254
Standard deviation 78
Values 2.2e+02 3.1e+02 3.3e+02 1.6e+02
[22]
ref_hepatocyte UBA52
Mean 57.3
Standard deviation 43
Values 14 23 49 1.2e+02 81
[23]
HepG2 UBA52
Mean 203
Standard deviation 20
Values 2.2e+02 1.9e+02
[24]
HepG2.C3A UBA52
Mean 169
Standard deviation 3.3
Values 1.7e+02 1.7e+02
[25]
HuH.7 UBA52
Mean 334
Standard deviation 46
Values 3.4e+02 2.8e+02 3.7e+02
[26]
SNU475 UBA52
Mean 72.9
Standard deviation 11
Values 65 81
[27]
THLE UBA52
Mean 144
Standard deviation 15
Values 1.3e+02 1.5e+02
[28]
liver UBA52
Mean 51.7
Standard deviation 26
Values 79 32 68 28
[29]
ref_hepatocyte ANAPC11
Mean 54.5
Standard deviation 27
Values 63 82 10 54 64
[30]
HepG2 ANAPC11
Mean 33.8
Standard deviation 7.4
Values 39 29
[31]
HepG2.C3A ANAPC11
Mean 40.9
Standard deviation 8.3
Values 35 47
[32]
HuH.7 ANAPC11
Mean 29.3
Standard deviation 14
Values 30 15 43
[33]
SNU475 ANAPC11
Mean 20.1
Standard deviation 5.4
Values 24 16
[34]
THLE ANAPC11
Mean 29.3
Standard deviation 0.86
Values 30 29
[35]
liver ANAPC11
Mean 29.4
Standard deviation 28
Values 60 5.9 47 5.7
[36]
ref_hepatocyte CDC26
Mean 30
Standard deviation 5.8
Values 24 31 34 37 24
[37]
HepG2 CDC26
Mean 9.65
Standard deviation 1.5
Values 8.6 11
[38]
HepG2.C3A CDC26
Mean 12
Standard deviation 3.9
Values 9.2 15
[39]
HuH.7 CDC26
Mean 11.2
Standard deviation 1.9
Values 10 10 13
[40]
SNU475 CDC26
Mean 6.75
Standard deviation 0.98
Values 7.4 6.1
[41]
THLE CDC26
Mean 14
Standard deviation 0.81
Values 13 15
[42]
liver CDC26
Mean 9.23
Standard deviation 6.7
Values 14 4.5 15 2.6
[43]
ref_hepatocyte UBE2E1
Mean 24.2
Standard deviation 20
Values 24 60 11 13 14
[44]
HepG2 UBE2E1
Mean 27.5
Standard deviation 0.51
Values 28 27
[45]
HepG2.C3A UBE2E1
Mean 29
Standard deviation 6
Values 25 33
[46]
HuH.7 UBE2E1
Mean 45.6
Standard deviation 10
Values 42 37 57
[47]
SNU475 UBE2E1
Mean 31.8
Standard deviation 1
Values 31 33
[48]
THLE UBE2E1
Mean 42.8
Standard deviation 1.4
Values 42 44
[49]
liver UBE2E1
Mean 4.91
Standard deviation 1.6
Values 3.9 6.7 3.3 5.7
[50]
ref_hepatocyte ANAPC16
Mean 18.3
Standard deviation 8.8
Values 23 15 4.6 22 27
[51]
HepG2 ANAPC16
Mean 45.9
Standard deviation 1.7
Values 47 45
[52]
HepG2.C3A ANAPC16
Mean 66.9
Standard deviation 9.3
Values 60 74
[53]
HuH.7 ANAPC16
Mean 28.7
Standard deviation 4.9
Values 27 25 34
[54]
SNU475 ANAPC16
Mean 25
Standard deviation 5
Values 29 21
[55]
THLE ANAPC16
Mean 32.9
Standard deviation 0.68
Values 32 33
[56]
liver ANAPC16
Mean 37.9
Standard deviation 22
Values 61 20 52 18
[57]
ref_hepatocyte ANAPC5
Mean 17.3
Standard deviation 3.4
Values 12 20 18 20 17
[58]
HepG2 ANAPC5
Mean 70
Standard deviation 5.4
Values 66 74
[59]
HepG2.C3A ANAPC5
Mean 99.1
Standard deviation 8.6
Values 93 1.1e+02
[60]
HuH.7 ANAPC5
Mean 106
Standard deviation 32
Values 1.2e+02 70 1.3e+02
[61]
SNU475 ANAPC5
Mean 40.1
Standard deviation 6.5
Values 45 36
[62]
THLE ANAPC5
Mean 61.8
Standard deviation 4.4
Values 59 65
[63]
liver ANAPC5
Mean 40.2
Standard deviation 5.8
Values 42 37 47 34
[64]
ref_hepatocyte CDC27
Mean 13.6
Standard deviation 15
Values 38 16 8.3 2.9 3.1
[65]
HepG2 CDC27
Mean 35
Standard deviation 19
Values 22 48
[66]
HepG2.C3A CDC27
Mean 55.7
Standard deviation 20
Values 42 70
[67]
HuH.7 CDC27
Mean 34.1
Standard deviation 3.9
Values 39 32 31
[68]
SNU475 CDC27
Mean 56.9
Standard deviation 0.87
Values 56 58
[69]
THLE CDC27
Mean 46.4
Standard deviation 3.2
Values 44 49
[70]
liver CDC27
Mean 21.5
Standard deviation 3.1
Values 20 26 20 21
[71]
ref_hepatocyte CDC16
Mean 12.3
Standard deviation 3.1
Values 8.9 13 15 15 9.1
[72]
HepG2 CDC16
Mean 19.3
Standard deviation 0.027
Values 19 19
[73]
HepG2.C3A CDC16
Mean 20.2
Standard deviation 2.9
Values 22 18
[74]
HuH.7 CDC16
Mean 12.3
Standard deviation 2
Values 11 12 15
[75]
SNU475 CDC16
Mean 16.9
Standard deviation 3.3
Values 19 15
[76]
THLE CDC16
Mean 25.8
Standard deviation 4.3
Values 23 29
[77]
liver CDC16
Mean 16
Standard deviation 5.4
Values 17 16 22 9
[78]
ref_hepatocyte UBE2C
Mean 11
Standard deviation 13
Values 28 21 2.1 1.8 1.8
[79]
HepG2 UBE2C
Mean 20.7
Standard deviation 2
Values 22 19
[80]
HepG2.C3A UBE2C
Mean 24
Standard deviation 9.1
Values 18 30
[81]
HuH.7 UBE2C
Mean 39
Standard deviation 20
Values 45 17 55
[82]
SNU475 UBE2C
Mean 22.1
Standard deviation 5.8
Values 18 26
[83]
THLE UBE2C
Mean 46
Standard deviation 12
Values 38 54
[84]
liver UBE2C
Mean 1.12
Standard deviation 1.5
Values 0.89 0.3 3.3 0.013
[85]
ref_hepatocyte UBE2S
Mean 9.88
Standard deviation 5.6
Values 4.4 13 17 11 4.4
[86]
HepG2 UBE2S
Mean 29.7
Standard deviation 11
Values 38 22
[87]
HepG2.C3A UBE2S
Mean 19.7
Standard deviation 0.91
Values 19 20
[88]
HuH.7 UBE2S
Mean 86.1
Standard deviation 32
Values 86 54 1.2e+02
[89]
SNU475 UBE2S
Mean 35.4
Standard deviation 5.6
Values 31 39
[90]
THLE UBE2S
Mean 102
Standard deviation 13
Values 92 1.1e+02
[91]
liver UBE2S
Mean 2.33
Standard deviation 0.97
Values 3.1 1.7 3.2 1.3
[92]
ref_hepatocyte CCNB1
Mean 8.2
Standard deviation 8.6
Values 15 20 1.8 3.1 1.3
[93]
HepG2 CCNB1
Mean 65.1
Standard deviation 21
Values 50 80
[94]
HepG2.C3A CCNB1
Mean 68.3
Standard deviation 39
Values 41 96
[95]
HuH.7 CCNB1
Mean 74.2
Standard deviation 37
Values 87 33 1e+02
[96]
SNU475 CCNB1
Mean 45.8
Standard deviation 3.3
Values 48 44
[97]
THLE CCNB1
Mean 101
Standard deviation 30
Values 80 1.2e+02
[98]
liver CCNB1
Mean 2.29
Standard deviation 1.6
Values 2.3 2.4 4.2 0.28
[99]
ref_hepatocyte CDC23
Mean 7.24
Standard deviation 2.5
Values 8.6 11 6.9 4.9 4.9
[100]
HepG2 CDC23
Mean 20.7
Standard deviation 3.9
Values 18 24
[101]
HepG2.C3A CDC23
Mean 21.2
Standard deviation 4.4
Values 18 24
[102]
HuH.7 CDC23
Mean 24.3
Standard deviation 6
Values 26 18 29
[103]
SNU475 CDC23
Mean 27.2
Standard deviation 0.72
Values 27 28
[104]
THLE CDC23
Mean 24.9
Standard deviation 1.5
Values 24 26
[105]
liver CDC23
Mean 11.8
Standard deviation 3.1
Values 13 11 15 8
[106]
ref_hepatocyte CDK1
Mean 5.78
Standard deviation 6.9
Values 13 14 0.06 1.6 0.72
[107]
HepG2 CDK1
Mean 30.4
Standard deviation 14
Values 21 40
[108]
HepG2.C3A CDK1
Mean 113
Standard deviation 85
Values 53 1.7e+02
[109]
HuH.7 CDK1
Mean 45.1
Standard deviation 21
Values 55 21 60
[110]
SNU475 CDK1
Mean 51.1
Standard deviation 5
Values 48 55
[111]
THLE CDK1
Mean 101
Standard deviation 11
Values 93 1.1e+02
[112]
liver CDK1
Mean 1.48
Standard deviation 1.4
Values 1 1.4 3.4 0.013
[113]
ref_hepatocyte ANAPC7
Mean 5.77
Standard deviation 1.7
Values 4.5 7.7 7.4 5.2 4
[114]
HepG2 ANAPC7
Mean 25.5
Standard deviation 4
Values 23 28
[115]
HepG2.C3A ANAPC7
Mean 30
Standard deviation 1.6
Values 29 31
[116]
HuH.7 ANAPC7
Mean 20
Standard deviation 6.2
Values 23 13 24
[117]
SNU475 ANAPC7
Mean 19.8
Standard deviation 0.8
Values 19 20
[118]
THLE ANAPC7
Mean 26.5
Standard deviation 2.3
Values 25 28
[119]
liver ANAPC7
Mean 9.34
Standard deviation 1.7
Values 9 10 11 7.1
[120]
ref_hepatocyte ANAPC2
Mean 5.57
Standard deviation 3.1
Values 1.7 3.8 5.3 7.8 9.3
[121]
HepG2 ANAPC2
Mean 18.7
Standard deviation 2.4
Values 17 20
[122]
HepG2.C3A ANAPC2
Mean 11.3
Standard deviation 0.75
Values 11 12
[123]
HuH.7 ANAPC2
Mean 16.6
Standard deviation 4.5
Values 18 12 20
[124]
SNU475 ANAPC2
Mean 10.5
Standard deviation 0.9
Values 11 9.9
[125]
THLE ANAPC2
Mean 11.5
Standard deviation 2.7
Values 9.6 13
[126]
liver ANAPC2
Mean 8.17
Standard deviation 1.9
Values 7.8 8.5 5.9 10
[127]
ref_hepatocyte CDC20
Mean 3.72
Standard deviation 3.7
Values 3.7 10 2 1.1 1.7
[128]
HepG2 CDC20
Mean 42
Standard deviation 5.7
Values 38 46
[129]
HepG2.C3A CDC20
Mean 37.9
Standard deviation 18
Values 25 51
[130]
HuH.7 CDC20
Mean 47
Standard deviation 20
Values 58 24 59
[131]
SNU475 CDC20
Mean 38.7
Standard deviation 5.5
Values 35 43
[132]
THLE CDC20
Mean 68.2
Standard deviation 16
Values 57 79
[133]
liver CDC20
Mean 1.07
Standard deviation 0.91
Values 0.99 0.83 2.3 0.15
[134]
ref_hepatocyte ANAPC1
Mean 3.66
Standard deviation 1.4
Values 5.4 4.5 3.9 2.3 2.2
[135]
HepG2 ANAPC1
Mean 42.9
Standard deviation 9.5
Values 36 50
[136]
HepG2.C3A ANAPC1
Mean 43.4
Standard deviation 8.5
Values 37 49
[137]
HuH.7 ANAPC1
Mean 38.4
Standard deviation 12
Values 51 27 38
[138]
SNU475 ANAPC1
Mean 25.5
Standard deviation 0.94
Values 26 25
[139]
THLE ANAPC1
Mean 28.9
Standard deviation 5.8
Values 25 33
[140]
liver ANAPC1
Mean 14.2
Standard deviation 7.2
Values 7.4 22 8.8 19
[141]
ref_hepatocyte ANAPC4
Mean 2.72
Standard deviation 1
Values 2.7 4.2 3 2 1.7
[142]
HepG2 ANAPC4
Mean 6.87
Standard deviation 3
Values 4.8 9
[143]
HepG2.C3A ANAPC4
Mean 11.6
Standard deviation 1.5
Values 11 13
[144]
HuH.7 ANAPC4
Mean 14
Standard deviation 1.6
Values 14 12 16
[145]
SNU475 ANAPC4
Mean 11.4
Standard deviation 1.7
Values 13 10
[146]
THLE ANAPC4
Mean 8.86
Standard deviation 1.3
Values 7.9 9.8
[147]
liver ANAPC4
Mean 7.61
Standard deviation 3
Values 11 5.6 9 4.7
[148]
ref_hepatocyte UBE2D1
Mean 2.43
Standard deviation 1.1
Values 2.2 1.2 4.1 1.7 2.8
[149]
HepG2 UBE2D1
Mean 9.29
Standard deviation 2.7
Values 7.4 11
[150]
HepG2.C3A UBE2D1
Mean 15.1
Standard deviation 2.9
Values 13 17
[151]
HuH.7 UBE2D1
Mean 18.4
Standard deviation 3.8
Values 21 14 20
[152]
SNU475 UBE2D1
Mean 12.8
Standard deviation 0.14
Values 13 13
[153]
THLE UBE2D1
Mean 12.2
Standard deviation 0.065
Values 12 12
[154]
liver UBE2D1
Mean 4.88
Standard deviation 2.6
Values 6.8 2.9 7.4 2.4
[155]
ref_hepatocyte ANAPC10
Mean 2.16
Standard deviation 0.77
Values 1.8 2 1.3 2.2 3.4
[156]
HepG2 ANAPC10
Mean 4.04
Standard deviation 0.5
Values 3.7 4.4
[157]
HepG2.C3A ANAPC10
Mean 6.67
Standard deviation 1.5
Values 5.6 7.7
[158]
HuH.7 ANAPC10
Mean 4.18
Standard deviation 0.77
Values 3.7 3.8 5.1
[159]
SNU475 ANAPC10
Mean 3.39
Standard deviation 0.1
Values 3.5 3.3
[160]
THLE ANAPC10
Mean 6.54
Standard deviation 0.14
Values 6.4 6.6
[161]
liver ANAPC10
Mean 3.33
Standard deviation 2.2
Values 5.8 1.8 4.5 1.1
[162]
ref_hepatocyte ANAPC15
Missing
[163]
HepG2 ANAPC15
Mean 3.23
Standard deviation 0.75
Values 2.7 3.8
[164]
HepG2.C3A ANAPC15
Mean 2.36
Standard deviation 0.71
Values 1.9 2.9
[165]
HuH.7 ANAPC15
Mean 2.08
Standard deviation 0.91
Values 2.1 1.2 3
[166]
SNU475 ANAPC15
Mean 3.3
Standard deviation 1.3
Values 4.2 2.4
[167]
THLE ANAPC15
Mean 2.63
Standard deviation 1.1
Values 1.9 3.4
[168]
liver ANAPC15
Mean 1.17
Standard deviation 0.99
Values 2.1 0.37 1.9 0.25