REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | UBB | Polyubiquitin-B | [1] | -1.63[2] | -1.70[3] | -1.72[4] | -2.39[5] | -1.65[6] | -0.99[7] |
2 | RPS27A | Ubiquitin-40S ribosomal protein S27a | [8] | [9] | [10] | [11] | [12] | [13] | [14] |
3 | UBC | Polyubiquitin-C | [15] | -1.18[16] | -0.95[17] | -1.35[18] | -1.54[19] | -1.27[20] | -0.54[21] |
4 | EIF4A1 | Eukaryotic initiation factor 4A-I | [22] | [23] | [24] | [25] | [26] | [27] | [28] |
5 | EIF4A2 | Eukaryotic initiation factor 4A-II | [29] | -0.16[30] | 0.49[31] | 1.01[32] | -1.55[33] | -1.04[34] | -0.95[35] |
6 | EIF4G2 | Eukaryotic translation initiation factor 4 gamma 2 | [36] | 1.08[37] | 1.64[38] | 1.58[39] | 1.43[40] | 0.91[41] | 1.41[42] |
7 | SEC13 | Protein SEC13 homolog | [43] | -0.38[44] | 0.12[45] | 0.14[46] | -1.34[47] | -0.90[48] | -0.68[49] |
8 | EIF4G1 | Eukaryotic translation initiation factor 4 gamma 1 | [50] | 1.45[51] | 0.78[52] | 1.02[53] | 0.77[54] | 1.44[55] | 1.93[56] |
9 | UBA52 | Ubiquitin-60S ribosomal protein L40 | [57] | 1.25[58] | 1.29[59] | 2.16[60] | -0.14[61] | 0.95[62] | 0.23[63] |
10 | EIF4E2 | Eukaryotic translation initiation factor 4E type 2 | [64] | -1.99[65] | -1.90[66] | -1.72[67] | -1.92[68] | -1.93[69] | -1.52[70] |
11 | ISG15 | Ubiquitin-like protein ISG15 | [71] | -1.59[72] | -1.21[73] | -2.49[74] | -2.91[75] | -3.77[76] | -1.51[77] |
12 | KPNB1 | Importin subunit beta-1 | [78] | 1.49[79] | 1.77[80] | 1.89[81] | 1.59[82] | 1.48[83] | 0.34[84] |
13 | EIF4A3 | Eukaryotic initiation factor 4A-III | [85] | 0.32[86] | -0.08[87] | -0.01[88] | -0.70[89] | -0.18[90] | -0.87[91] |
14 | UBE2L6 | Ubiquitin/ISG15-conjugating enzyme E2 L6 | [92] | -1.18[93] | -3.54[94] | -2.05[95] | -0.67[96] | -0.95[97] | 0.19[98] |
15 | KPNA2 | Importin subunit alpha-1 | [99] | 1.35[100] | 1.35[101] | 1.72[102] | 0.92[103] | 1.93[104] | -0.91[105] |
16 | FLNB | Filamin-B | [106] | 3.27[107] | 2.36[108] | 1.38[109] | 1.25[110] | 2.46[111] | 2.56[112] |
17 | UBE2E1 | Ubiquitin-conjugating enzyme E2 E1 | [113] | -0.39[114] | -0.02[115] | 0.53[116] | -0.09[117] | 0.45[118] | -1.93[119] |
18 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | [120] | 0.50[121] | -0.29[122] | 0.65[123] | 2.92[124] | 0.93[125] | 1.83[126] |
19 | ABCE1 | ATP-binding cassette sub-family E member 1 | [127] | 0.35[128] | 1.36[129] | 1.00[130] | 0.26[131] | 1.69[132] | 0.71[133] |
20 | UBE2N | Ubiquitin-conjugating enzyme E2 N | [134] | 1.26[135] | 1.86[136] | 0.52[137] | 0.71[138] | 0.88[139] | 0.17[140] |
21 | PIN1 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | [141] | -0.47[142] | -0.28[143] | -0.20[144] | -1.27[145] | 0.15[146] | -0.48[147] |
22 | PPM1B | Protein phosphatase 1B | [148] | -1.05[149] | -0.22[150] | -0.41[151] | -1.11[152] | -0.47[153] | 0.76[154] |
23 | JAK1 | Tyrosine-protein kinase JAK1 | [155] | 1.09[156] | 0.70[157] | 0.71[158] | 1.02[159] | 1.94[160] | 2.41[161] |
24 | FLNA | Filamin-A | [162] | 4.70[163] | 3.29[164] | 0.18[165] | 5.93[166] | 4.85[167] | 3.04[168] |
25 | EIF4E | Eukaryotic translation initiation factor 4E | [169] | 0.71[170] | 1.67[171] | 0.86[172] | 0.11[173] | 1.42[174] | 1.05[175] |
26 | MX1 | Interferon-induced GTP-binding protein Mx1 | [176] | -1.97[177] | -4.59[178] | -6.80[179] | -2.60[180] | -1.70[181] | 0.70[182] |
27 | OAS1 | 2'-5'-oligoadenylate synthase 1 | [183] | -0.05[184] | -2.81[185] | -8.79[186] | -2.36[187] | -3.54[188] | 0.46[189] |
28 | KPNA3 | Importin subunit alpha-4 | [190] | 1.55[191] | 1.28[192] | 1.33[193] | 0.83[194] | 1.11[195] | 1.35[196] |
29 | RAE1 | mRNA export factor | [197] | 1.15[198] | 0.99[199] | -0.30[200] | 0.97[201] | 0.56[202] | -0.13[203] |
30 | NUP88 | Nuclear pore complex protein Nup88 | [204] | 0.52[205] | 1.17[206] | 1.11[207] | 0.06[208] | 0.84[209] | 2.00[210] |
31 | SEH1L | Nucleoporin SEH1 | [211] | 0.80[212] | 1.41[213] | 1.70[214] | 0.96[215] | 0.47[216] | 1.06[217] |
32 | IRF3 | Interferon regulatory factor 3 | [218] | 0.87[219] | 1.17[220] | 1.73[221] | 0.74[222] | 0.62[223] | -0.30[224] |
33 | IFIT1 | Interferon-induced protein with tetratricopeptide repeats 1 | [225] | -2.85[226] | -4.60[227] | -1.56[228] | -1.50[229] | -1.99[230] | 0.26[231] |
34 | NUP35 | Nucleoporin NUP53 | [232] | -0.51[233] | 0.20[234] | 0.01[235] | -0.70[236] | -0.63[237] | -0.34[238] |
35 | NUP62 | Nuclear pore glycoprotein p62 | [239] | 1.74[240] | 1.48[241] | 2.37[242] | 1.60[243] | 1.97[244] | 1.30[245] |
36 | KPNA4 | Importin subunit alpha-3 | [246] | 1.50[247] | 1.66[248] | 1.72[249] | 1.95[250] | 2.31[251] | 2.10[252] |
37 | NUP85 | Nuclear pore complex protein Nup85 | [253] | 1.31[254] | 1.80[255] | 1.87[256] | 0.96[257] | 1.45[258] | 1.10[259] |
38 | AAAS | Aladin | [260] | 0.84[261] | 1.28[262] | 0.71[263] | 0.60[264] | 0.92[265] | 0.70[266] |
39 | TRIM25 | E3 ubiquitin/ISG15 ligase TRIM25 | [267] | 2.71[268] | 2.47[269] | 2.14[270] | 1.27[271] | 2.21[272] | 2.70[273] |
40 | NUP50 | Nuclear pore complex protein Nup50 | [274] | 1.34[275] | 2.15[276] | 2.39[277] | 1.37[278] | 2.15[279] | 2.44[280] |
41 | RANBP2 | E3 SUMO-protein ligase RanBP2 | [281] | 1.05[282] | 2.86[283] | 2.44[284] | 1.92[285] | 2.36[286] | 3.83[287] |
42 | NUP93 | Nuclear pore complex protein Nup93 | [288] | 2.25[289] | 1.90[290] | 1.71[291] | 1.32[292] | 1.91[293] | 0.38[294] |
43 | NUP98 | Nuclear pore complex protein Nup98-Nup96 | [295] | 2.74[296] | 2.56[297] | 2.65[298] | 2.61[299] | 2.45[300] | 2.74[301] |
44 | NUP54 | Nucleoporin p54 | [302] | 0.68[303] | 1.45[304] | 1.28[305] | 0.72[306] | 1.47[307] | 0.90[308] |
45 | EIF2AK2 | Interferon-induced, double-stranded RNA-activated protein kinase | [309] | 0.26[310] | 0.34[311] | -1.80[312] | 1.40[313] | 1.20[314] | 1.67[315] |
46 | KPNA1 | Importin subunit alpha-5 | [316] | 1.62[317] | 1.81[318] | 1.74[319] | 1.97[320] | 2.56[321] | 3.06[322] |
47 | NUP107 | Nuclear pore complex protein Nup107 | [323] | 1.07[324] | 2.31[325] | 2.13[326] | 1.68[327] | 1.88[328] | 0.88[329] |
48 | NUP37 | Nucleoporin Nup37 | [330] | 1.23[331] | 1.64[332] | 1.57[333] | 0.84[334] | 1.11[335] | -0.54[336] |
49 | TPR | Nucleoprotein TPR | [337] | 1.21[338] | 3.20[339] | 3.34[340] | 2.93[341] | 3.44[342] | 3.48[343] |
50 | ARIH1 | E3 ubiquitin-protein ligase ARIH1 | [344] | 1.63[345] | 2.03[346] | 2.28[347] | 2.23[348] | 2.13[349] | 2.22[350] |
51 | EIF4G3 | Eukaryotic translation initiation factor 4 gamma 3 | [351] | 1.88[352] | 2.73[353] | 2.66[354] | 3.21[355] | 2.94[356] | 2.58[357] |
52 | NUP160 | Nuclear pore complex protein Nup160 | [358] | 2.43[359] | 2.70[360] | 3.14[361] | 1.56[362] | 2.14[363] | 2.35[364] |
53 | PDE12 | 2',5'-phosphodiesterase 12 | [365] | 1.17[366] | 1.15[367] | -0.10[368] | 0.43[369] | 1.72[370] | 2.29[371] |
54 | MAPK3 | Mitogen-activated protein kinase 3 | [372] | 2.42[373] | 2.60[374] | 2.47[375] | 0.81[376] | 1.11[377] | -0.16[378] |
55 | POM121 | Nuclear envelope pore membrane protein POM 121 | [379] | 2.02[380] | 2.50[381] | 2.17[382] | 1.93[383] | 1.66[384] | 2.18[385] |
56 | NUP133 | Nuclear pore complex protein Nup133 | [386] | 1.76[387] | 2.23[388] | 3.02[389] | 2.60[390] | 2.22[391] | 1.93[392] |
57 | NUP153 | Nuclear pore complex protein Nup153 | [393] | 2.97[394] | 3.29[395] | 2.77[396] | 3.65[397] | 3.08[398] | 2.82[399] |
58 | USP18 | Ubl carboxyl-terminal hydrolase 18 | [400] | 0.51[401] | 1.10[402] | 0.58[403] | -0.10[404] | -2.28[405] | 0.90[406] |
59 | NUP43 | Nucleoporin Nup43 | [407] | 2.49[408] | 2.79[409] | 2.37[410] | 2.47[411] | 2.48[412] | 1.19[413] |
60 | OASL | 2'-5'-oligoadenylate synthase-like protein | [414] | -3.66[415] | -4.91[416] | -6.93[417] | -4.58[418] | -2.03[419] | 0.34[420] |
61 | NEDD4 | E3 ubiquitin-protein ligase NEDD4 | [421] | 0.11[422] | 2.31[423] | 2.29[424] | 1.39[425] | 1.94[426] | 3.08[427] |
62 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 4.06[428] | 3.81[429] | 2.97[430] | 3.21[431] | 2.98[432] | 1.22[433] | |
63 | NUP205 | Nuclear pore complex protein Nup205 | [434] | 2.76[435] | 2.80[436] | 3.80[437] | 3.17[438] | 3.62[439] | 2.39[440] |
64 | DDX58 | Probable ATP-dependent RNA helicase DDX58 | [441] | -0.13[442] | -0.02[443] | -1.01[444] | -0.40[445] | 0.44[446] | 2.00[447] |
65 | POM121C | Nuclear envelope pore membrane protein POM 121C | [448] | 1.85[449] | 1.25[450] | 0.75[451] | 1.79[452] | 1.50[453] | 1.32[454] |
66 | NUP214 | Nuclear pore complex protein Nup214 | [455] | 2.59[456] | 2.03[457] | 2.99[458] | 2.57[459] | 2.78[460] | 2.64[461] |
67 | UBA7 | Ubiquitin-like modifier-activating enzyme 7 | [462] | 0.34[463] | 0.19[464] | -4.74[465] | 1.45[466] | 1.29[467] | 2.27[468] |
68 | OAS3 | 2'-5'-oligoadenylate synthase 3 | [469] | 2.84[470] | 0.48[471] | -5.96[472] | 1.51[473] | 2.55[474] | 2.20[475] |
69 | NUP188 | Nucleoporin NUP188 homolog | [476] | 3.83[477] | 3.34[478] | 3.81[479] | 2.91[480] | 4.36[481] | 2.71[482] |
70 | NUP210 | Nuclear pore membrane glycoprotein 210 | [483] | 4.27[484] | 4.21[485] | 5.15[486] | 2.49[487] | 1.16[488] | 3.88[489] |
71 | OAS2 | 2'-5'-oligoadenylate synthase 2 | [490] | -1.57[491] | -5.56[492] | -9.98[493] | -0.73[494] | -0.85[495] | 2.06[496] |
72 | NUP155 | Nuclear pore complex protein Nup155 | [497] | 2.69[498] | 2.42[499] | 3.24[500] | 2.86[501] | 4.02[502] | 2.62[503] |
73 | KPNA7 | Importin subunit alpha-8 | [504] | -1.18[505] | -1.88[506] | -3.36[507] | -3.83[508] | -7.65[509] | -3.01[510] |
74 | HERC5 | E3 ISG15--protein ligase HERC5 | [511] | -2.41[512] | -5.25[513] | 0.31[514] | 1.14[515] | 0.64[516] | 2.11[517] |
75 | EIF4E3 | Eukaryotic translation initiation factor 4E type 3 | [518] | -1.71[519] | -3.76[520] | -3.92[521] | 0.35[522] | 1.38[523] | 2.46[524] |
76 | MX2 | Interferon-induced GTP-binding protein Mx2 | [525] | 3.34[526] | 3.40[527] | 4.22[528] | 0.69[529] | -0.31[530] | 0.39[531] |
77 | KPNA5 | Importin subunit alpha-6 | [532] | 0.32[533] | 1.71[534] | 1.14[535] | 0.88[536] | 0.29[537] | 1.12[538] |
78 | RNASEL | 2-5A-dependent ribonuclease | [539] | -2.08[540] | -4.08[541] | -8.59[542] | 2.63[543] | 2.53[544] | 2.51[545] |
79 | USP41 | Putative ubiquitin carboxyl-terminal hydrolase 41 | [546] | [547] | [548] | [549] | [550] | [551] | [552] |
80 | NUP42 | [553] | [554] | [555] | [556] | [557] | [558] | [559] | |
81 | NDC1 | Nucleoporin NDC1 | [560] | [561] | [562] | [563] | [564] | [565] | [566] |
82 | NUP58 | Nucleoporin p58/p45 | [567] | [568] | [569] | [570] | [571] | [572] | [573] |