REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 B2M Beta-2-microglobulin [1] -2.19[2] -1.89[3] -2.21[4] -0.58[5] -0.39[6] -0.19[7]
2 CALR Calreticulin [8] 0.13[9] -0.26[10] -0.17[11] -1.43[12] -0.81[13] -0.58[14]
3 HSPA5 78 kDa glucose-regulated protein [15] 0.65[16] 0.80[17] 0.40[18] -0.61[19] -0.18[20] 0.08[21]
4 HLA-A HLA class I histocompatibility antigen, A-68 alpha chain [22] -0.07[23] 0.25[24] -5.38[25] 0.45[26] -0.25[27] -1.67[28]
5 HLA-C HLA class I histocompatibility antigen, Cw-17 alpha chain [29] -0.93[30] -1.52[31] -5.03[32] -0.33[33] 0.04[34] -1.27[35]
6 HLA-B HLA class I histocompatibility antigen, B-73 alpha chain [36] -1.90[37] -3.15[38] -7.14[39] 1.10[40] 0.42[41] -0.93[42]
7 PDIA3 Protein disulfide-isomerase A3 [43] 0.77[44] 0.55[45] 0.27[46] 0.21[47] 0.23[48] -0.34[49]
8 CANX Calnexin [50] 1.34[51] 1.89[52] 2.56[53] 1.32[54] 1.55[55] 1.80[56]
9 HLA-E HLA class I histocompatibility antigen, alpha chain E [57] -0.73[58] -0.80[59] -0.88[60] 0.60[61] -0.44[62] 0.59[63]
10 BCAP31 B-cell receptor-associated protein 31 [64] 0.17[65] 0.27[66] -0.22[67] -0.28[68] -0.07[69] -0.87[70]
11 SEC13 Protein SEC13 homolog [71] 0.15[72] 0.60[73] 1.14[74] -1.03[75] -0.54[76] -1.15[77]
12 SEC23A Protein transport protein Sec23A [78] 3.03[79] 1.90[80] 3.30[81] 1.62[82] 1.21[83] 1.47[84]
13 TAPBP Tapasin [85] 0.82[86] 0.22[87] -0.21[88] 0.78[89] 0.74[90] 1.46[91]
14 SEC31A Protein transport protein Sec31A [92] 2.88[93] 2.95[94] 3.38[95] 1.73[96] 2.00[97] 2.07[98]
15 SEC24C Protein transport protein Sec24C [99] 2.61[100] 3.09[101] 2.74[102] 2.33[103] 2.14[104] 1.71[105]
16 SAR1B GTP-binding protein SAR1b [106] 0.83[107] 2.14[108] 2.33[109] 0.70[110] 1.45[111] 3.27[112]
17 TAP1 Antigen peptide transporter 1 [113] 0.98[114] 0.04[115] -3.31[116] 2.29[117] 0.99[118] -0.26[119]
18 SEC24D Protein transport protein Sec24D [120] 1.43[121] 2.34[122] 2.66[123] 1.69[124] 1.70[125] 2.23[126]
19 TAP2 Antigen peptide transporter 2 [127] 1.45[128] 0.23[129] -0.91[130] 2.71[131] 1.97[132] 0.01[133]
20 HLA-F HLA class I histocompatibility antigen, alpha chain F [134] -1.35[135] -2.73[136] -6.52[137] 1.99[138] 0.44[139] 0.44[140]
21 SEC24A Protein transport protein Sec24A [141] 2.29[142] 2.89[143] 3.86[144] 2.29[145] 1.86[146] 2.82[147]
22 SEC24B Protein transport protein Sec24B [148] 1.28[149] 1.69[150] 2.13[151] 1.16[152] 2.05[153] 2.50[154]
23 ERAP1 Endoplasmic reticulum aminopeptidase 1 [155] 2.02[156] 2.27[157] 2.45[158] 2.11[159] 2.90[160] 3.12[161]
24 HLA-G HLA class I histocompatibility antigen, alpha chain G [162] -1.92[163] -2.85[164] -7.19[165] -0.62[166] -6.42[167] -3.39[168]
25 ERAP2 Endoplasmic reticulum aminopeptidase 2 [169] 3.09[170] 2.35[171] -2.33[172] 0.71[173] 0.75[174] 3.32[175]
[1]
ref_hepatocyte B2M
Mean 1.02e+03
Standard deviation 6.9e+02
Values 3.7e+02 4.4e+02 7.8e+02 1.7e+03 1.8e+03
[2]
HepG2 B2M
Mean 232
Standard deviation 27
Values 2.1e+02 2.5e+02
[3]
HepG2.C3A B2M
Mean 239
Standard deviation 55
Values 2e+02 2.8e+02
[4]
HuH.7 B2M
Mean 145
Standard deviation 20
Values 1.3e+02 1.7e+02 1.4e+02
[5]
SNU475 B2M
Mean 773
Standard deviation 1.4e+02
Values 8.7e+02 6.8e+02
[6]
THLE B2M
Mean 787
Standard deviation 30
Values 7.7e+02 8.1e+02
[7]
liver B2M
Mean 957
Standard deviation 6e+02
Values 1.5e+03 6.1e+02 1.4e+03 3e+02
[8]
ref_hepatocyte CALR
Mean 617
Standard deviation 2.8e+02
Values 7.7e+02 4.7e+02 3.5e+02 1e+03 4.6e+02
[9]
HepG2 CALR
Mean 698
Standard deviation 0.66
Values 7e+02 7e+02
[10]
HepG2.C3A CALR
Mean 448
Standard deviation 1.7e+02
Values 3.3e+02 5.7e+02
[11]
HuH.7 CALR
Mean 360
Standard deviation 34
Values 3.3e+02 3.5e+02 4e+02
[12]
SNU475 CALR
Mean 258
Standard deviation 1.5e+02
Values 3.6e+02 1.6e+02
[13]
THLE CALR
Mean 356
Standard deviation 52
Values 3.2e+02 3.9e+02
[14]
liver CALR
Mean 440
Standard deviation 89
Values 4e+02 3.7e+02 5.7e+02 4.2e+02
[15]
ref_hepatocyte HSPA5
Mean 323
Standard deviation 1.8e+02
Values 2.1e+02 1.7e+02 4.7e+02 5.6e+02 2.1e+02
[16]
HepG2 HSPA5
Mean 522
Standard deviation 17
Values 5.1e+02 5.3e+02
[17]
HepG2.C3A HSPA5
Mean 488
Standard deviation 22
Values 5e+02 4.7e+02
[18]
HuH.7 HSPA5
Mean 279
Standard deviation 1e+02
Values 2.1e+02 4e+02 2.3e+02
[19]
SNU475 HSPA5
Mean 240
Standard deviation 1.2e+02
Values 3.2e+02 1.6e+02
[20]
THLE HSPA5
Mean 287
Standard deviation 62
Values 2.4e+02 3.3e+02
[21]
liver HSPA5
Mean 365
Standard deviation 1.6e+02
Values 2.5e+02 3.1e+02 6.1e+02 2.9e+02
[22]
ref_hepatocyte HLA-A
Mean 230
Standard deviation 75
Values 2e+02 1.6e+02 1.9e+02 3.5e+02 2.5e+02
[23]
HepG2 HLA-A
Mean 225
Standard deviation 68
Values 2.7e+02 1.8e+02
[24]
HepG2.C3A HLA-A
Mean 238
Standard deviation 65
Values 2.8e+02 1.9e+02
[25]
HuH.7 HLA-A
Mean 3.61
Standard deviation 1.9
Values 2.4 5.8 2.7
[26]
SNU475 HLA-A
Mean 354
Standard deviation 9.1
Values 3.5e+02 3.6e+02
[27]
THLE HLA-A
Mean 195
Standard deviation 20
Values 2.1e+02 1.8e+02
[28]
liver HLA-A
Mean 77.2
Standard deviation 46
Values 1.3e+02 45 1e+02 33
[29]
ref_hepatocyte HLA-C
Mean 203
Standard deviation 89
Values 1.4e+02 91 2.1e+02 3.1e+02 2.6e+02
[30]
HepG2 HLA-C
Mean 110
Standard deviation 36
Values 1.4e+02 84
[31]
HepG2.C3A HLA-C
Mean 61.7
Standard deviation 28
Values 81 42
[32]
HuH.7 HLA-C
Mean 4.07
Standard deviation 0.18
Values 3.9 4.2 4.1
[33]
SNU475 HLA-C
Mean 182
Standard deviation 4.5
Values 1.8e+02 1.9e+02
[34]
THLE HLA-C
Mean 210
Standard deviation 6.8
Values 2.2e+02 2.1e+02
[35]
liver HLA-C
Mean 89.7
Standard deviation 52
Values 1.6e+02 34 97 70
[36]
ref_hepatocyte HLA-B
Mean 189
Standard deviation 1.2e+02
Values 99 87 1.7e+02 3.8e+02 2.1e+02
[37]
HepG2 HLA-B
Mean 52.3
Standard deviation 24
Values 70 35
[38]
HepG2.C3A HLA-B
Mean 18.6
Standard deviation 9.9
Values 26 12
[39]
HuH.7 HLA-B
Mean 0.876
Standard deviation 0.42
Values 0.91 1.3 0.44
[40]
SNU475 HLA-B
Mean 459
Standard deviation 16
Values 4.5e+02 4.7e+02
[41]
THLE HLA-B
Mean 256
Standard deviation 42
Values 2.9e+02 2.3e+02
[42]
liver HLA-B
Mean 106
Standard deviation 56
Values 1.7e+02 64 1.4e+02 54
[43]
ref_hepatocyte PDIA3
Mean 173
Standard deviation 1.1e+02
Values 1.6e+02 78 1e+02 3.6e+02 1.7e+02
[44]
HepG2 PDIA3
Mean 304
Standard deviation 33
Values 3.3e+02 2.8e+02
[45]
HepG2.C3A PDIA3
Mean 221
Standard deviation 2.9
Values 2.2e+02 2.2e+02
[46]
HuH.7 PDIA3
Mean 137
Standard deviation 4.5
Values 1.3e+02 1.4e+02 1.4e+02
[47]
SNU475 PDIA3
Mean 227
Standard deviation 79
Values 2.8e+02 1.7e+02
[48]
THLE PDIA3
Mean 205
Standard deviation 43
Values 1.7e+02 2.4e+02
[49]
liver PDIA3
Mean 146
Standard deviation 45
Values 92 1.6e+02 2e+02 1.4e+02
[50]
ref_hepatocyte CANX
Mean 128
Standard deviation 89
Values 2.7e+02 1.4e+02 43 1.1e+02 75
[51]
HepG2 CANX
Mean 335
Standard deviation 37
Values 3.1e+02 3.6e+02
[52]
HepG2.C3A CANX
Mean 411
Standard deviation 40
Values 4.4e+02 3.8e+02
[53]
HuH.7 CANX
Mean 494
Standard deviation 1.9e+02
Values 4.4e+02 7.1e+02 3.4e+02
[54]
SNU475 CANX
Mean 362
Standard deviation 31
Values 3.8e+02 3.4e+02
[55]
THLE CANX
Mean 379
Standard deviation 58
Values 3.4e+02 4.2e+02
[56]
liver CANX
Mean 477
Standard deviation 1.8e+02
Values 2.6e+02 6.9e+02 4.4e+02 5.2e+02
[57]
ref_hepatocyte HLA-E
Mean 108
Standard deviation 1.1e+02
Values 22 47 2.9e+02 1.2e+02 65
[58]
HepG2 HLA-E
Mean 67.1
Standard deviation 19
Values 80 54
[59]
HepG2.C3A HLA-E
Mean 54
Standard deviation 24
Values 71 37
[60]
HuH.7 HLA-E
Mean 38.3
Standard deviation 6.2
Values 36 45 34
[61]
SNU475 HLA-E
Mean 184
Standard deviation 48
Values 2.2e+02 1.5e+02
[62]
THLE HLA-E
Mean 80.2
Standard deviation 0.91
Values 80 81
[63]
liver HLA-E
Mean 174
Standard deviation 64
Values 2.1e+02 1.4e+02 2.5e+02 1e+02
[64]
ref_hepatocyte BCAP31
Mean 78.4
Standard deviation 17
Values 70 96 55 95 76
[65]
HepG2 BCAP31
Mean 91
Standard deviation 20
Values 1e+02 77
[66]
HepG2.C3A BCAP31
Mean 82.2
Standard deviation 13
Values 91 73
[67]
HuH.7 BCAP31
Mean 44
Standard deviation 7.8
Values 47 35 50
[68]
SNU475 BCAP31
Mean 73
Standard deviation 1.1
Values 74 72
[69]
THLE BCAP31
Mean 75.3
Standard deviation 7.8
Values 70 81
[70]
liver BCAP31
Mean 46
Standard deviation 35
Values 82 16 71 15
[71]
ref_hepatocyte SEC13
Mean 63
Standard deviation 21
Values 96 54 59 66 40
[72]
HepG2 SEC13
Mean 72
Standard deviation 13
Values 63 81
[73]
HepG2.C3A SEC13
Mean 83.1
Standard deviation 9.7
Values 90 76
[74]
HuH.7 SEC13
Mean 90.7
Standard deviation 17
Values 95 72 1.1e+02
[75]
SNU475 SEC13
Mean 35
Standard deviation 1.6
Values 36 34
[76]
THLE SEC13
Mean 43.6
Standard deviation 4
Values 41 46
[77]
liver SEC13
Mean 30.4
Standard deviation 16
Values 36 16 51 19
[78]
ref_hepatocyte SEC23A
Mean 31.3
Standard deviation 39
Values 1e+02 22 9.8 7.7 16
[79]
HepG2 SEC23A
Mean 264
Standard deviation 81
Values 2.1e+02 3.2e+02
[80]
HepG2.C3A SEC23A
Mean 101
Standard deviation 10
Values 94 1.1e+02
[81]
HuH.7 SEC23A
Mean 201
Standard deviation 26
Values 2.3e+02 1.9e+02 1.8e+02
[82]
SNU475 SEC23A
Mean 109
Standard deviation 45
Values 1.4e+02 77
[83]
THLE SEC23A
Mean 72.9
Standard deviation 8.2
Values 67 79
[84]
liver SEC23A
Mean 92.4
Standard deviation 21
Values 62 1.1e+02 1e+02 94
[85]
ref_hepatocyte TAPBP
Mean 22.4
Standard deviation 5.1
Values 19 18 20 25 30
[86]
HepG2 TAPBP
Mean 40.9
Standard deviation 0.51
Values 41 41
[87]
HepG2.C3A TAPBP
Mean 22.7
Standard deviation 7.7
Values 28 17
[88]
HuH.7 TAPBP
Mean 12.7
Standard deviation 0.89
Values 14 12 12
[89]
SNU475 TAPBP
Mean 43.4
Standard deviation 17
Values 55 31
[90]
THLE TAPBP
Mean 37.9
Standard deviation 5
Values 34 41
[91]
liver TAPBP
Mean 66
Standard deviation 34
Values 82 34 1.1e+02 42
[92]
ref_hepatocyte SEC31A
Mean 18.1
Standard deviation 6.3
Values 26 12 12 22 18
[93]
HepG2 SEC31A
Mean 138
Standard deviation 38
Values 1.1e+02 1.6e+02
[94]
HepG2.C3A SEC31A
Mean 121
Standard deviation 28
Values 1.4e+02 1e+02
[95]
HuH.7 SEC31A
Mean 123
Standard deviation 33
Values 1.3e+02 1.5e+02 88
[96]
SNU475 SEC31A
Mean 67.8
Standard deviation 14
Values 78 58
[97]
THLE SEC31A
Mean 73.1
Standard deviation 14
Values 63 83
[98]
liver SEC31A
Mean 81.4
Standard deviation 9.1
Values 69 83 90 84
[99]
ref_hepatocyte SEC24C
Mean 11.2
Standard deviation 2.3
Values 8.5 9 13 13 12
[100]
HepG2 SEC24C
Mean 70.4
Standard deviation 12
Values 62 79
[101]
HepG2.C3A SEC24C
Mean 82.5
Standard deviation 13
Values 91 74
[102]
HuH.7 SEC24C
Mean 48.8
Standard deviation 4.2
Values 53 45 49
[103]
SNU475 SEC24C
Mean 63.5
Standard deviation 9.1
Values 70 57
[104]
THLE SEC24C
Mean 49.6
Standard deviation 4.8
Values 46 53
[105]
liver SEC24C
Mean 39.2
Standard deviation 5.1
Values 32 42 43 39
[106]
ref_hepatocyte SAR1B
Mean 11
Standard deviation 6.3
Values 7.8 6.7 4.9 16 19
[107]
HepG2 SAR1B
Mean 20.2
Standard deviation 7.8
Values 15 26
[108]
HepG2.C3A SAR1B
Mean 41.9
Standard deviation 4.9
Values 45 38
[109]
HuH.7 SAR1B
Mean 36.2
Standard deviation 1.4
Values 35 37 37
[110]
SNU475 SAR1B
Mean 20.2
Standard deviation 0.41
Values 20 20
[111]
THLE SAR1B
Mean 30.3
Standard deviation 0.19
Values 30 30
[112]
liver SAR1B
Mean 113
Standard deviation 10
Values 1.3e+02 1e+02 1.1e+02 1.1e+02
[113]
ref_hepatocyte TAP1
Mean 10.3
Standard deviation 5
Values 6.7 17 14 7.8 5.7
[114]
HepG2 TAP1
Mean 21
Standard deviation 2.1
Values 22 19
[115]
HepG2.C3A TAP1
Mean 9.23
Standard deviation 0.066
Values 9.3 9.2
[116]
HuH.7 TAP1
Mean 0.679
Standard deviation 0.4
Values 0.43 1.1 0.46
[117]
SNU475 TAP1
Mean 56.8
Standard deviation 21
Values 71 42
[118]
THLE TAP1
Mean 20.6
Standard deviation 0.4
Values 20 21
[119]
liver TAP1
Mean 9.22
Standard deviation 1.7
Values 8.8 7.3 11 9.3
[120]
ref_hepatocyte SEC24D
Mean 9.48
Standard deviation 3.8
Values 7.2 4.5 9.5 13 13
[121]
HepG2 SEC24D
Mean 26.4
Standard deviation 13
Values 17 35
[122]
HepG2.C3A SEC24D
Mean 41.7
Standard deviation 12
Values 50 33
[123]
HuH.7 SEC24D
Mean 39.2
Standard deviation 6.5
Values 40 45 32
[124]
SNU475 SEC24D
Mean 34.5
Standard deviation 12
Values 43 26
[125]
THLE SEC24D
Mean 31.1
Standard deviation 0.84
Values 31 32
[126]
liver SEC24D
Mean 47.6
Standard deviation 15
Values 29 51 65 45
[127]
ref_hepatocyte TAP2
Mean 8.93
Standard deviation 5
Values 6 15 13 7.8 2.8
[128]
HepG2 TAP2
Mean 25.2
Standard deviation 3.1
Values 27 23
[129]
HepG2.C3A TAP2
Mean 9.08
Standard deviation 0.12
Values 9.2 9
[130]
HuH.7 TAP2
Mean 3.11
Standard deviation 0.55
Values 3.4 2.5 3.4
[131]
SNU475 TAP2
Mean 66.2
Standard deviation 0.18
Values 66 66
[132]
THLE TAP2
Mean 35.2
Standard deviation 2.1
Values 34 37
[133]
liver TAP2
Mean 9.63
Standard deviation 6.3
Values 5.4 15 3 15
[134]
ref_hepatocyte HLA-F
Mean 6.43
Standard deviation 3.7
Values 5.1 2.2 11 9.7 4.2
[135]
HepG2 HLA-F
Mean 2.61
Standard deviation 0.25
Values 2.8 2.4
[136]
HepG2.C3A HLA-F
Mean 0.842
Standard deviation 0.42
Values 1.1 0.55
[137]
HuH.7 HLA-F
Mean 0.046
Standard deviation 0.0075
Values 0.049 0.051 0.037
[138]
SNU475 HLA-F
Mean 28.8
Standard deviation 5.2
Values 32 25
[139]
THLE HLA-F
Mean 8.79
Standard deviation 2.3
Values 10 7.1
[140]
liver HLA-F
Mean 9.29
Standard deviation 3.9
Values 5.2 8.5 15 8.8
[141]
ref_hepatocyte SEC24A
Mean 6.29
Standard deviation 2.4
Values 10 5 6 3.7 6.7
[142]
HepG2 SEC24A
Mean 31.9
Standard deviation 16
Values 20 43
[143]
HepG2.C3A SEC24A
Mean 40.6
Standard deviation 5.1
Values 44 37
[144]
HuH.7 SEC24A
Mean 60
Standard deviation 26
Values 56 88 36
[145]
SNU475 SEC24A
Mean 34.8
Standard deviation 8.6
Values 41 29
[146]
THLE SEC24A
Mean 23.1
Standard deviation 2.6
Values 21 25
[147]
liver SEC24A
Mean 47.4
Standard deviation 13
Values 30 57 44 59
[148]
ref_hepatocyte SEC24B
Mean 5.63
Standard deviation 2.5
Values 3 3.7 6.8 5.3 9.3
[149]
HepG2 SEC24B
Mean 14.1
Standard deviation 4.7
Values 11 17
[150]
HepG2.C3A SEC24B
Mean 15.8
Standard deviation 0.89
Values 16 15
[151]
HuH.7 SEC24B
Mean 16.1
Standard deviation 5.2
Values 15 22 11
[152]
SNU475 SEC24B
Mean 14.2
Standard deviation 1.6
Values 15 13
[153]
THLE SEC24B
Mean 23.5
Standard deviation 0.16
Values 23 24
[154]
liver SEC24B
Mean 34
Standard deviation 9.4
Values 44 25 27 40
[155]
ref_hepatocyte ERAP1
Mean 4.13
Standard deviation 0.95
Values 5.1 2.9 3.4 4.9 4.4
[156]
HepG2 ERAP1
Mean 17.4
Standard deviation 0.18
Values 17 17
[157]
HepG2.C3A ERAP1
Mean 17.4
Standard deviation 2.7
Values 19 15
[158]
HuH.7 ERAP1
Mean 14.8
Standard deviation 4.3
Values 14 19 11
[159]
SNU475 ERAP1
Mean 20.2
Standard deviation 6.6
Values 25 16
[160]
THLE ERAP1
Mean 31.2
Standard deviation 3
Values 29 33
[161]
liver ERAP1
Mean 38.5
Standard deviation 16
Values 26 44 25 58
[162]
ref_hepatocyte HLA-G
Mean 3.74
Standard deviation 0.61
Values 4.4 2.8 3.8 4.1 3.6
[163]
HepG2 HLA-G
Mean 1.02
Standard deviation 0.39
Values 1.3 0.75
[164]
HepG2.C3A HLA-G
Mean 0.451
Standard deviation 0.21
Values 0.6 0.3
[165]
HuH.7 HLA-G
Mean 0.0168
Standard deviation 0.021
Values 0.041 0 0.0094
[166]
SNU475 HLA-G
Mean 2.74
Standard deviation 0.27
Values 2.5 2.9
[167]
THLE HLA-G
Mean 0.0441
Standard deviation 0.055
Values 0.083 0.0053
[168]
liver HLA-G
Mean 0.382
Standard deviation 0.41
Values 0.42 0.13 0.95 0.026
[169]
ref_hepatocyte ERAP2
Mean 1.25
Standard deviation 1
Values 2.9 0.59 1.5 0.7 0.57
[170]
HepG2 ERAP2
Mean 11
Standard deviation 5.4
Values 7.2 15
[171]
HepG2.C3A ERAP2
Mean 5.58
Standard deviation 2.9
Values 3.5 7.6
[172]
HuH.7 ERAP2
Mean 0.163
Standard deviation 0.16
Values 0.049 0.35 0.094
[173]
SNU475 ERAP2
Mean 2.32
Standard deviation 0.26
Values 2.5 2.1
[174]
THLE ERAP2
Mean 2.13
Standard deviation 0.11
Values 2.1 2.2
[175]
liver ERAP2
Mean 13.4
Standard deviation 8.9
Values 2.7 24 16 11