REACTOME_ANDROGEN_BIOSYNTHESIS Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 HSD17B12 Very-long-chain 3-oxoacyl-CoA reductase [1] 0.18[2] 0.62[3] 0.61[4] -0.40[5] 0.01[6] 0.16[7]
2 SRD5A1 3-oxo-5-alpha-steroid 4-dehydrogenase 1 [8] -0.63[9] -1.33[10] -0.90[11] 0.68[12] 0.48[13] 0.34[14]
3 SRD5A2 3-oxo-5-alpha-steroid 4-dehydrogenase 2 [15] -7.31[16] -7.30[17] -7.96[18] -10.60[19] -11.23[20] -1.11[21]
4 SRD5A3 Polyprenol reductase [22] 2.04[23] 0.84[24] 0.35[25] 1.71[26] 1.26[27] -0.41[28]
5 POMC Pro-opiomelanocortin [29] [30] -7.79[31] [32] [33] -6.04[34] -3.03[35]
6 HSD17B3 Testosterone 17-beta-dehydrogenase 3 [36] -1.82[37] -2.67[38] 1.34[39] 1.67[40] -4.89[41] 0.04[42]
7 CYP17A1 Steroid 17-alpha-hydroxylase/17,20 lyase [43] -1.36[44] 1.88[45] -2.14[46] -4.00[47] -4.61[48] 0.80[49]
8 HSD3B1 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 [50] -3.73[51] -5.20[52] 1.28[53] [54] -1.94[55] -3.78[56]
9 CGA Glycoprotein hormones alpha chain [57] [58] [59] -2.37[60] -1.78[61] -3.75[62] -4.95[63]
10 HSD3B2 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 [64] -2.20[65] [66] -0.85[67] [68] -1.15[69] -0.06[70]
11 LHB Lutropin subunit beta [71] [72] [73] [74] [75] [76] [77]
[1]
ref_hepatocyte HSD17B12
Mean 20.5
Standard deviation 14
Values 5.1 15 13 28 42
[2]
HepG2 HSD17B12
Mean 19.8
Standard deviation 1.3
Values 19 21
[3]
HepG2.C3A HSD17B12
Mean 41.8
Standard deviation 12
Values 50 34
[4]
HuH.7 HSD17B12
Mean 59.9
Standard deviation 5.1
Values 57 66 57
[5]
SNU475 HSD17B12
Mean 8.53
Standard deviation 0.57
Values 8.1 8.9
[6]
THLE HSD17B12
Mean 20.1
Standard deviation 2.8
Values 18 22
[7]
liver HSD17B12
Mean 58.4
Standard deviation 21
Values 56 62 83 32
[8]
ref_hepatocyte SRD5A1
Mean 9.94
Standard deviation 8.7
Values 6.1 6.5 1.9 11 24
[9]
HepG2 SRD5A1
Mean 5.45
Standard deviation 0.84
Values 4.9 6
[10]
HepG2.C3A SRD5A1
Mean 5.22
Standard deviation 0.13
Values 5.3 5.1
[11]
HuH.7 SRD5A1
Mean 10.1
Standard deviation 0.77
Values 10 9.3 11
[12]
SNU475 SRD5A1
Mean 8.73
Standard deviation 0.84
Values 9.3 8.1
[13]
THLE SRD5A1
Mean 13.5
Standard deviation 3.6
Values 16 11
[14]
liver SRD5A1
Mean 32.2
Standard deviation 11
Values 48 26 24 31
[15]
ref_hepatocyte SRD5A2
Mean 6.56
Standard deviation 6.6
Values 0.19 8.5 1.5 5.8 17
[16]
HepG2 SRD5A2
Mean 0.0351
Standard deviation 0.031
Values 0.057 0.013
[17]
HepG2.C3A SRD5A2
Mean 0.055
Standard deviation 0.032
Values 0.078 0.032
[18]
HuH.7 SRD5A2
Mean 0.0502
Standard deviation 0.057
Values 0.016 0.12 0.019
[19]
SNU475 SRD5A2
Mean 0.00232
Standard deviation 0.0033
Values 0.0046 0
[20]
THLE SRD5A2
Mean 0.00266
Standard deviation 0.0038
Values 0 0.0053
[21]
liver SRD5A2
Mean 7.73
Standard deviation 6.8
Values 5.4 3.3 4.4 18
[22]
ref_hepatocyte SRD5A3
Mean 2.79
Standard deviation 1.2
Values 3.1 2.9 1.4 2.1 4.5
[23]
HepG2 SRD5A3
Mean 9.75
Standard deviation 3.5
Values 7.3 12
[24]
HepG2.C3A SRD5A3
Mean 6.61
Standard deviation 1.4
Values 5.6 7.6
[25]
HuH.7 SRD5A3
Mean 6.78
Standard deviation 0.38
Values 7.1 6.8 6.4
[26]
SNU475 SRD5A3
Mean 5.03
Standard deviation 0.79
Values 5.6 4.5
[27]
THLE SRD5A3
Mean 6.51
Standard deviation 1.2
Values 5.7 7.4
[28]
liver SRD5A3
Mean 5.36
Standard deviation 1.4
Values 5.9 3.5 6.9 5.1
[29]
ref_hepatocyte POMC
Mean 0.898
Standard deviation 0.87
Values 0 1.1 0 1.4 2
[30]
HepG2 POMC
Mean 0
Standard deviation 0
Values 0 0
[31]
HepG2.C3A POMC
Mean 0.00536
Standard deviation 0.0076
Values 0 0.011
[32]
HuH.7 POMC
Mean 0
Standard deviation 0
Values 0 0 0
[33]
SNU475 POMC
Mean 0
Standard deviation 0
Values 0 0
[34]
THLE POMC
Mean 0.0133
Standard deviation 0.019
Values 0 0.027
[35]
liver POMC
Mean 0.28
Standard deviation 0.16
Values 0.35 0.17 0.46 0.13
[36]
ref_hepatocyte HSD17B3
Mean 0.262
Standard deviation 0.31
Values 0 0.1 0 0.63 0.58
[37]
HepG2 HSD17B3
Mean 0.063
Standard deviation 0.032
Values 0.04 0.086
[38]
HepG2.C3A HSD17B3
Mean 0.0545
Standard deviation 0.047
Values 0.087 0.021
[39]
HuH.7 HSD17B3
Mean 1.27
Standard deviation 0.54
Values 0.65 1.5 1.6
[40]
SNU475 HSD17B3
Mean 0.46
Standard deviation 0.0054
Values 0.46 0.46
[41]
THLE HSD17B3
Mean 0.00858
Standard deviation 0.0046
Values 0.012 0.0053
[42]
liver HSD17B3
Mean 0.686
Standard deviation 0.23
Values 0.89 0.54 0.44 0.87
[43]
ref_hepatocyte CYP17A1
Mean 0.208
Standard deviation 0.25
Values 0 0 0.31 0.6 0.13
[44]
HepG2 CYP17A1
Mean 0.0687
Standard deviation 0.024
Values 0.086 0.051
[45]
HepG2.C3A CYP17A1
Mean 1.01
Standard deviation 0.19
Values 1.1 0.88
[46]
HuH.7 CYP17A1
Mean 0.0898
Standard deviation 0.047
Values 0.041 0.13 0.094
[47]
SNU475 CYP17A1
Mean 0.00717
Standard deviation 0.003
Values 0.0093 0.0051
[48]
THLE CYP17A1
Mean 0.00828
Standard deviation 0.0033
Values 0.0059 0.011
[49]
liver CYP17A1
Mean 0.926
Standard deviation 1.4
Values 2.9 0.057 0.21 0.5
[50]
ref_hepatocyte HSD3B1
Mean 0.134
Standard deviation 0.3
Values 0 0 0 0.67 0
[51]
HepG2 HSD3B1
Mean 0.0086
Standard deviation 0.012
Values 0.017 0
[52]
HepG2.C3A HSD3B1
Mean 0.00486
Standard deviation 0.0069
Values 0.0097 0
[53]
HuH.7 HSD3B1
Mean 0.62
Standard deviation 0.19
Values 0.68 0.41 0.77
[54]
SNU475 HSD3B1
Mean 0
Standard deviation 0
Values 0 0
[55]
THLE HSD3B1
Mean 0.034
Standard deviation 0.01
Values 0.041 0.027
[56]
liver HSD3B1
Mean 0.025
Standard deviation 0.029
Values 0.047 0 0 0.053
[57]
ref_hepatocyte CGA
Mean 0.0776
Standard deviation 0.17
Values 0 0 0 0.39 0
[58]
HepG2 CGA
Mean 0
Standard deviation 0
Values 0 0
[59]
HepG2.C3A CGA
Mean 0
Standard deviation 0
Values 0 0
[60]
HuH.7 CGA
Mean 0.0287
Standard deviation 0.011
Values 0.016 0.032 0.037
[61]
SNU475 CGA
Mean 0.0125
Standard deviation 0.011
Values 0.0046 0.02
[62]
THLE CGA
Mean 0.00562
Standard deviation 0.00042
Values 0.0059 0.0053
[63]
liver CGA
Mean 0.00642
Standard deviation 0.013
Values 0 0 0.026 0
[64]
ref_hepatocyte HSD3B2
Mean 0.031
Standard deviation 0.065
Values 0 0 0 0.0086 0.15
[65]
HepG2 HSD3B2
Mean 0.00573
Standard deviation 0.0081
Values 0.011 0
[66]
HepG2.C3A HSD3B2
Mean 0
Standard deviation 0
Values 0 0
[67]
HuH.7 HSD3B2
Mean 0.0327
Standard deviation 0.028
Values 0.025 0.064 0.0094
[68]
SNU475 HSD3B2
Mean 0
Standard deviation 0
Values 0 0
[69]
THLE HSD3B2
Mean 0.0136
Standard deviation 0.011
Values 0.0059 0.021
[70]
liver HSD3B2
Mean 0.0756
Standard deviation 0.044
Values 0.14 0.057 0.051 0.053
[71]
ref_hepatocyte LHB
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[72]
HepG2 LHB
Mean 0.0652
Standard deviation 0.062
Values 0.11 0.021
[73]
HepG2.C3A LHB
Mean 0.158
Standard deviation 0.15
Values 0.26 0.054
[74]
HuH.7 LHB
Mean 0.0861
Standard deviation 0.038
Values 0.074 0.13 0.056
[75]
SNU475 LHB
Mean 0.0127
Standard deviation 0.018
Values 0 0.025
[76]
THLE LHB
Mean 0.0313
Standard deviation 0.014
Values 0.041 0.021
[77]
liver LHB
Mean 0.0209
Standard deviation 0.027
Values 0 0.057 0 0.026