REACTOME_ALK_MUTANTS_BIND_TKIS Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 NPM1 Nucleophosmin [1] -2.97[2] -1.93[3] -1.30[4] -3.06[5] -3.17[6] -4.19[7]
2 FN1 Fibronectin [8] 2.41[9] 2.06[10] 1.90[11] 2.33[12] 2.40[13] 2.05[14]
3 PRKAR1A cAMP-dependent protein kinase type I-alpha regulatory subunit [15] -1.01[16] -0.71[17] -0.62[18] -0.68[19] -0.92[20] 0.34[21]
4 CLTC Clathrin heavy chain 1 [22] 0.53[23] 0.81[24] 0.93[25] 1.09[26] 1.10[27] 2.21[28]
5 PPM1B Protein phosphatase 1B [29] -2.71[30] -1.82[31] -1.91[32] -2.08[33] -1.86[34] -0.37[35]
6 EML4 Echinoderm microtubule-associated protein-like 4 [36] 2.01[37] 3.29[38] 1.77[39] 1.51[40] -0.14[41] 1.88[42]
7 EIF2AK3 Eukaryotic translation initiation factor 2-alpha kinase 3 [43] -0.54[44] 0.46[45] 0.57[46] -0.40[47] 0.00[48] 1.50[49]
8 BIRC6 Baculoviral IAP repeat-containing protein 6 [50] 1.87[51] 2.91[52] 2.80[53] 3.40[54] 2.61[55] 5.31[56]
9 HIP1 Huntingtin-interacting protein 1 [57] 0.49[58] 0.74[59] 1.41[60] 2.41[61] 1.65[62] 2.32[63]
10 STRN Striatin [64] 0.88[65] 2.02[66] 1.59[67] 2.74[68] 2.50[69] 2.65[70]
11 BCL11A B-cell lymphoma/leukemia 11A [71] -1.70[72] [73] -1.67[74] 2.76[75] [76] 2.06[77]
12 ALK ALK tyrosine kinase receptor [78] [79] [80] [81] [82] [83] [84]
[1]
ref_hepatocyte NPM1
Mean 751
Standard deviation 7.3e+02
Values 1.1e+03 1.9e+03 4.5e+02 2.1e+02 1.2e+02
[2]
HepG2 NPM1
Mean 448
Standard deviation 23
Values 4.3e+02 4.6e+02
[3]
HepG2.C3A NPM1
Mean 727
Standard deviation 15
Values 7.2e+02 7.4e+02
[4]
HuH.7 NPM1
Mean 1.12e+03
Standard deviation 1e+02
Values 1e+03 1.2e+03 1.2e+03
[5]
SNU475 NPM1
Mean 248
Standard deviation 24
Values 2.3e+02 2.6e+02
[6]
THLE NPM1
Mean 283
Standard deviation 68
Values 2.3e+02 3.3e+02
[7]
liver NPM1
Mean 69.2
Standard deviation 20
Values 69 85 81 41
[8]
ref_hepatocyte FN1
Mean 152
Standard deviation 1.4e+02
Values 1.3e+02 57 27 1.7e+02 3.8e+02
[9]
HepG2 FN1
Mean 3.78e+03
Standard deviation 3.9e+02
Values 4.1e+03 3.5e+03
[10]
HepG2.C3A FN1
Mean 2.34e+03
Standard deviation 1.3e+03
Values 3.2e+03 1.4e+03
[11]
HuH.7 FN1
Mean 2.08e+03
Standard deviation 9.6e+02
Values 1.8e+03 3.1e+03 1.3e+03
[12]
SNU475 FN1
Mean 2.11e+03
Standard deviation 1.4e+02
Values 2e+03 2.2e+03
[13]
THLE FN1
Mean 2.73e+03
Standard deviation 1.5e+03
Values 1.7e+03 3.8e+03
[14]
liver FN1
Mean 1.06e+03
Standard deviation 3.8e+02
Values 5.9e+02 1.3e+03 9.3e+02 1.4e+03
[15]
ref_hepatocyte PRKAR1A
Mean 51.9
Standard deviation 38
Values 1.1e+02 62 30 19 35
[16]
HepG2 PRKAR1A
Mean 121
Standard deviation 21
Values 1.1e+02 1.4e+02
[17]
HepG2.C3A PRKAR1A
Mean 117
Standard deviation 14
Values 1.1e+02 1.3e+02
[18]
HuH.7 PRKAR1A
Mean 124
Standard deviation 6.6
Values 1.3e+02 1.3e+02 1.2e+02
[19]
SNU475 PRKAR1A
Mean 89.4
Standard deviation 19
Values 1e+02 76
[20]
THLE PRKAR1A
Mean 93.3
Standard deviation 15
Values 83 1e+02
[21]
liver PRKAR1A
Mean 111
Standard deviation 40
Values 89 1.4e+02 1.5e+02 66
[22]
ref_hepatocyte CLTC
Mean 30
Standard deviation 17
Values 53 42 13 19 24
[23]
HepG2 CLTC
Mean 203
Standard deviation 93
Values 1.4e+02 2.7e+02
[24]
HepG2.C3A CLTC
Mean 193
Standard deviation 28
Values 1.7e+02 2.1e+02
[25]
HuH.7 CLTC
Mean 209
Standard deviation 37
Values 2.5e+02 2.1e+02 1.7e+02
[26]
SNU475 CLTC
Mean 176
Standard deviation 18
Values 1.9e+02 1.6e+02
[27]
THLE CLTC
Mean 218
Standard deviation 18
Values 2.1e+02 2.3e+02
[28]
liver CLTC
Mean 234
Standard deviation 1.1e+02
Values 1.2e+02 3.7e+02 1.8e+02 2.7e+02
[29]
ref_hepatocyte PPM1B
Mean 17.5
Standard deviation 14
Values 28 36 5.5 6.7 11
[30]
HepG2 PPM1B
Mean 12.5
Standard deviation 2
Values 11 14
[31]
HepG2.C3A PPM1B
Mean 18.2
Standard deviation 0.67
Values 19 18
[32]
HuH.7 PPM1B
Mean 17.1
Standard deviation 0.25
Values 17 17 17
[33]
SNU475 PPM1B
Mean 11.4
Standard deviation 2.1
Values 13 9.9
[34]
THLE PPM1B
Mean 16.3
Standard deviation 0.77
Values 16 17
[35]
liver PPM1B
Mean 22.8
Standard deviation 5.4
Values 31 21 20 19
[36]
ref_hepatocyte EML4
Mean 7.28
Standard deviation 3.9
Values 14 7.3 5.4 4.5 5.2
[37]
HepG2 EML4
Mean 137
Standard deviation 43
Values 1.1e+02 1.7e+02
[38]
HepG2.C3A EML4
Mean 262
Standard deviation 7.4
Values 2.7e+02 2.6e+02
[39]
HuH.7 EML4
Mean 91
Standard deviation 20
Values 1.1e+02 74 86
[40]
SNU475 EML4
Mean 57.3
Standard deviation 1.7
Values 56 59
[41]
THLE EML4
Mean 22.4
Standard deviation 1.3
Values 21 23
[42]
liver EML4
Mean 45.2
Standard deviation 4.2
Values 41 50 43 46
[43]
ref_hepatocyte EIF2AK3
Mean 3.27
Standard deviation 0.7
Values 3.2 4.1 3.8 2.9 2.3
[44]
HepG2 EIF2AK3
Mean 10.5
Standard deviation 4.8
Values 7.1 14
[45]
HepG2.C3A EIF2AK3
Mean 16.6
Standard deviation 3.7
Values 19 14
[46]
HuH.7 EIF2AK3
Mean 17.9
Standard deviation 5
Values 15 24 15
[47]
SNU475 EIF2AK3
Mean 6.86
Standard deviation 1.2
Values 7.7 6
[48]
THLE EIF2AK3
Mean 11.1
Standard deviation 0.36
Values 11 11
[49]
liver EIF2AK3
Mean 15.7
Standard deviation 9.3
Values 5.8 26 10 21
[50]
ref_hepatocyte BIRC6
Mean 1.97
Standard deviation 1
Values 3.7 2 1.1 1.3 1.7
[51]
HepG2 BIRC6
Mean 33.7
Standard deviation 12
Values 25 42
[52]
HepG2.C3A BIRC6
Mean 54.8
Standard deviation 4.4
Values 52 58
[53]
HuH.7 BIRC6
Mean 50.4
Standard deviation 17
Values 63 58 31
[54]
SNU475 BIRC6
Mean 57.4
Standard deviation 5.8
Values 62 53
[55]
THLE BIRC6
Mean 40.9
Standard deviation 1.9
Values 42 40
[56]
liver BIRC6
Mean 132
Standard deviation 96
Values 56 2.2e+02 42 2.1e+02
[57]
ref_hepatocyte HIP1
Mean 1.84
Standard deviation 0.79
Values 1.4 3.2 1.6 1.5 1.5
[58]
HepG2 HIP1
Mean 12.1
Standard deviation 2.8
Values 14 10
[59]
HepG2.C3A HIP1
Mean 11.4
Standard deviation 0.92
Values 11 12
[60]
HuH.7 HIP1
Mean 18
Standard deviation 6.1
Values 25 15 14
[61]
SNU475 HIP1
Mean 27.1
Standard deviation 6.9
Values 22 32
[62]
THLE HIP1
Mean 19.6
Standard deviation 1.4
Values 21 19
[63]
liver HIP1
Mean 15.5
Standard deviation 4.5
Values 13 22 14 13
[64]
ref_hepatocyte STRN
Mean 1.09
Standard deviation 0.66
Values 1 1.8 1.7 0.36 0.54
[65]
HepG2 STRN
Mean 9.37
Standard deviation 2.4
Values 7.7 11
[66]
HepG2.C3A STRN
Mean 16.3
Standard deviation 1.3
Values 15 17
[67]
HuH.7 STRN
Mean 12
Standard deviation 3.1
Values 14 14 8.4
[68]
SNU475 STRN
Mean 20
Standard deviation 0.35
Values 20 20
[69]
THLE STRN
Mean 20.8
Standard deviation 0.87
Values 20 21
[70]
liver STRN
Mean 11.5
Standard deviation 5
Values 9.4 16 5.4 15
[71]
ref_hepatocyte BCL11A
Mean 0.0244
Standard deviation 0.055
Values 0 0 0 0 0.12
[72]
HepG2 BCL11A
Mean 0.0351
Standard deviation 0.031
Values 0.057 0.013
[73]
HepG2.C3A BCL11A
Mean 0
Standard deviation 0
Values 0 0
[74]
HuH.7 BCL11A
Mean 0.0281
Standard deviation 0.034
Values 0.066 0 0.019
[75]
SNU475 BCL11A
Mean 0.455
Standard deviation 0.23
Values 0.62 0.29
[76]
THLE BCL11A
Mean 0
Standard deviation 0
Values 0 0
[77]
liver BCL11A
Mean 0.172
Standard deviation 0.097
Values 0.31 0.17 0.077 0.13
[78]
ref_hepatocyte ALK
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[79]
HepG2 ALK
Mean 0
Standard deviation 0
Values 0 0
[80]
HepG2.C3A ALK
Mean 0
Standard deviation 0
Values 0 0
[81]
HuH.7 ALK
Mean 0.00642
Standard deviation 0.011
Values 0 0.019 0
[82]
SNU475 ALK
Mean 0.0319
Standard deviation 0.012
Values 0.023 0.041
[83]
THLE ALK
Mean 0.00828
Standard deviation 0.0033
Values 0.0059 0.011
[84]
liver ALK
Mean 0.137
Standard deviation 0.12
Values 0.047 0.19 0.026 0.29