REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 CDKN1A Cyclin-dependent kinase inhibitor 1 [1] 0.35[2] -1.08[3] -3.21[4] -2.00[5] 0.14[6] -1.79[7]
2 AKT1 RAC-alpha serine/threonine-protein kinase [8] -0.41[9] -0.68[10] -1.20[11] -0.06[12] -0.46[13] -0.20[14]
3 BAD Bcl2-associated agonist of cell death [15] -2.16[16] -2.07[17] -2.45[18] -1.08[19] -1.09[20] -1.38[21]
4 AKT1S1 Proline-rich AKT1 substrate 1 [22] -0.96[23] -1.14[24] -0.23[25] -0.76[26] -0.56[27] -1.15[28]
5 CDKN1B Cyclin-dependent kinase inhibitor 1B [29] -0.58[30] -0.17[31] 0.59[32] -1.12[33] -1.07[34] -0.86[35]
6 MKRN1 E3 ubiquitin-protein ligase makorin-1 [36] -0.27[37] -0.60[38] 0.73[39] 0.39[40] -0.54[41] 0.15[42]
7 AKT2 RAC-beta serine/threonine-protein kinase [43] 0.47[44] 0.71[45] 1.40[46] 0.85[47] 0.22[48] 1.17[49]
8 GSK3A Glycogen synthase kinase-3 alpha [50] 0.13[51] -0.16[52] 0.49[53] 0.07[54] 0.42[55] -1.79[56]
9 MDM2 E3 ubiquitin-protein ligase Mdm2 [57] 1.62[58] 3.00[59] 0.80[60] 0.50[61] 0.96[62] 2.21[63]
10 GSK3B Glycogen synthase kinase-3 beta [64] 0.77[65] 0.38[66] 1.51[67] 1.80[68] 1.22[69] 1.21[70]
11 CHUK Inhibitor of nuclear factor kappa-B kinase subunit alpha [71] 0.41[72] 1.60[73] 2.12[74] 0.64[75] 1.04[76] 1.56[77]
12 TSC2 Tuberin [78] 1.32[79] 0.82[80] 2.06[81] 1.19[82] 1.30[83] 2.12[84]
13 CASP9 Caspase-9 [85] -0.34[86] 0.59[87] 0.27[88] 0.23[89] -0.87[90] -0.49[91]
14 AKT3 RAC-gamma serine/threonine-protein kinase [92] -2.34[93] -4.93[94] -3.68[95] 5.83[96] 4.37[97] 3.65[98]
[1]
ref_hepatocyte CDKN1A
Mean 40.1
Standard deviation 28
Values 19 48 76 52 5.7
[2]
HepG2 CDKN1A
Mean 158
Standard deviation 49
Values 1.9e+02 1.2e+02
[3]
HepG2.C3A CDKN1A
Mean 53.9
Standard deviation 3.9
Values 51 57
[4]
HuH.7 CDKN1A
Mean 8
Standard deviation 1.9
Values 6.5 10 7.3
[5]
SNU475 CDKN1A
Mean 18.6
Standard deviation 7.8
Values 13 24
[6]
THLE CDKN1A
Mean 122
Standard deviation 11
Values 1.3e+02 1.1e+02
[7]
liver CDKN1A
Mean 16
Standard deviation 8.1
Values 16 6.2 26 16
[8]
ref_hepatocyte AKT1
Mean 37.6
Standard deviation 15
Values 55 50 19 31 32
[9]
HepG2 AKT1
Mean 87.8
Standard deviation 2.3
Values 89 86
[10]
HepG2.C3A AKT1
Mean 66.6
Standard deviation 2.4
Values 65 68
[11]
HuH.7 AKT1
Mean 30.2
Standard deviation 6.6
Values 33 23 35
[12]
SNU475 AKT1
Mean 66.6
Standard deviation 14
Values 76 57
[13]
THLE AKT1
Mean 75.8
Standard deviation 6.1
Values 72 80
[14]
liver AKT1
Mean 45.1
Standard deviation 25
Values 34 48 20 79
[15]
ref_hepatocyte BAD
Mean 16.7
Standard deviation 11
Values 5.4 16 6.7 28 27
[16]
HepG2 BAD
Mean 11.6
Standard deviation 0.78
Values 11 12
[17]
HepG2.C3A BAD
Mean 11.3
Standard deviation 1.1
Values 10 12
[18]
HuH.7 BAD
Mean 5.61
Standard deviation 0.7
Values 5 6.4 5.5
[19]
SNU475 BAD
Mean 14.6
Standard deviation 2.5
Values 16 13
[20]
THLE BAD
Mean 21.6
Standard deviation 1.3
Values 21 23
[21]
liver BAD
Mean 8.85
Standard deviation 6.2
Values 16 3.7 12 3.7
[22]
ref_hepatocyte AKT1S1
Mean 16.3
Standard deviation 7.1
Values 9.3 9.6 22 25 16
[23]
HepG2 AKT1S1
Mean 26.1
Standard deviation 2.4
Values 24 28
[24]
HepG2.C3A AKT1S1
Mean 20.9
Standard deviation 0.11
Values 21 21
[25]
HuH.7 AKT1S1
Mean 25.6
Standard deviation 5
Values 30 20 27
[26]
SNU475 AKT1S1
Mean 17.8
Standard deviation 0.54
Values 18 17
[27]
THLE AKT1S1
Mean 30.7
Standard deviation 8
Values 25 36
[28]
liver AKT1S1
Mean 10.2
Standard deviation 7
Values 14 4.3 18 4.2
[29]
ref_hepatocyte CDKN1B
Mean 13.8
Standard deviation 6
Values 23 13 7.5 10 15
[30]
HepG2 CDKN1B
Mean 28.7
Standard deviation 3.4
Values 31 26
[31]
HepG2.C3A CDKN1B
Mean 34.7
Standard deviation 1.4
Values 34 36
[32]
HuH.7 CDKN1B
Mean 38.2
Standard deviation 3.7
Values 35 42 37
[33]
SNU475 CDKN1B
Mean 11.8
Standard deviation 2.9
Values 14 9.7
[34]
THLE CDKN1B
Mean 18.2
Standard deviation 3.4
Values 16 21
[35]
liver CDKN1B
Mean 10.5
Standard deviation 3.5
Values 9.9 14 5.8 12
[36]
ref_hepatocyte MKRN1
Mean 13.8
Standard deviation 5.1
Values 13 13 22 10 9.7
[37]
HepG2 MKRN1
Mean 35.5
Standard deviation 5.9
Values 40 31
[38]
HepG2.C3A MKRN1
Mean 25.8
Standard deviation 7.4
Values 31 21
[39]
HuH.7 MKRN1
Mean 42
Standard deviation 7.5
Values 38 51 38
[40]
SNU475 MKRN1
Mean 33.4
Standard deviation 8.1
Values 39 28
[41]
THLE MKRN1
Mean 26.2
Standard deviation 1.3
Values 25 27
[42]
liver MKRN1
Mean 21.1
Standard deviation 4.1
Values 24 17 25 18
[43]
ref_hepatocyte AKT2
Mean 10.6
Standard deviation 2.8
Values 7.2 8.4 11 13 14
[44]
HepG2 AKT2
Mean 45.6
Standard deviation 3.3
Values 48 43
[45]
HepG2.C3A AKT2
Mean 49.1
Standard deviation 8.9
Values 55 43
[46]
HuH.7 AKT2
Mean 51.5
Standard deviation 9.8
Values 59 41 55
[47]
SNU475 AKT2
Mean 35.3
Standard deviation 5.9
Values 39 31
[48]
THLE AKT2
Mean 34.2
Standard deviation 3.5
Values 32 37
[49]
liver AKT2
Mean 33
Standard deviation 9.4
Values 24 36 27 45
[50]
ref_hepatocyte GSK3A
Mean 9.38
Standard deviation 5.1
Values 7.5 3.9 17 12 6.4
[51]
HepG2 GSK3A
Mean 31.9
Standard deviation 3.3
Values 34 30
[52]
HepG2.C3A GSK3A
Mean 23.7
Standard deviation 0.26
Values 24 24
[53]
HuH.7 GSK3A
Mean 24.3
Standard deviation 3.3
Values 26 21 26
[54]
SNU475 GSK3A
Mean 18.2
Standard deviation 1.9
Values 17 20
[55]
THLE GSK3A
Mean 34.6
Standard deviation 4.3
Values 32 38
[56]
liver GSK3A
Mean 3.74
Standard deviation 0.84
Values 4.7 3.1 3 4.2
[57]
ref_hepatocyte MDM2
Mean 6.36
Standard deviation 2.9
Values 11 7.6 5 3.6 4.8
[58]
HepG2 MDM2
Mean 60.6
Standard deviation 13
Values 51 70
[59]
HepG2.C3A MDM2
Mean 145
Standard deviation 52
Values 1.1e+02 1.8e+02
[60]
HuH.7 MDM2
Mean 20.4
Standard deviation 0.31
Values 21 20 20
[61]
SNU475 MDM2
Mean 16.7
Standard deviation 1.8
Values 18 15
[62]
THLE MDM2
Mean 34.2
Standard deviation 0.86
Values 35 34
[63]
liver MDM2
Mean 40.5
Standard deviation 11
Values 29 54 35 45
[64]
ref_hepatocyte GSK3B
Mean 4.16
Standard deviation 1.7
Values 5.2 5.9 4.9 2.7 2.1
[65]
HepG2 GSK3B
Mean 22.1
Standard deviation 6
Values 18 26
[66]
HepG2.C3A GSK3B
Mean 15.3
Standard deviation 2.3
Values 14 17
[67]
HuH.7 GSK3B
Mean 21.8
Standard deviation 5.6
Values 24 26 15
[68]
SNU475 GSK3B
Mean 26.9
Standard deviation 2.6
Values 29 25
[69]
THLE GSK3B
Mean 26.7
Standard deviation 2.9
Values 25 29
[70]
liver GSK3B
Mean 13.2
Standard deviation 3.2
Values 14 15 8.6 16
[71]
ref_hepatocyte CHUK
Mean 3.93
Standard deviation 1.2
Values 4.2 5.7 2.3 3.4 4.1
[72]
HepG2 CHUK
Mean 16.2
Standard deviation 6.4
Values 12 21
[73]
HepG2.C3A CHUK
Mean 33.6
Standard deviation 13
Values 25 43
[74]
HuH.7 CHUK
Mean 31.4
Standard deviation 3.3
Values 34 28 32
[75]
SNU475 CHUK
Mean 11.3
Standard deviation 1.1
Values 11 12
[76]
THLE CHUK
Mean 22.3
Standard deviation 0.15
Values 22 22
[77]
liver CHUK
Mean 16
Standard deviation 3.3
Values 13 21 15 15
[78]
ref_hepatocyte TSC2
Mean 3.2
Standard deviation 0.13
Values 3.1 3.1 3.2 3.2 3.4
[79]
HepG2 TSC2
Mean 24.9
Standard deviation 3.4
Values 27 22
[80]
HepG2.C3A TSC2
Mean 16
Standard deviation 4.7
Values 19 13
[81]
HuH.7 TSC2
Mean 24.6
Standard deviation 4
Values 29 24 21
[82]
SNU475 TSC2
Mean 13.5
Standard deviation 5
Values 17 10
[83]
THLE TSC2
Mean 21.8
Standard deviation 1.7
Values 21 23
[84]
liver TSC2
Mean 19.2
Standard deviation 2.2
Values 17 19 18 22
[85]
ref_hepatocyte CASP9
Mean 2.59
Standard deviation 1
Values 1.9 1.9 2 2.7 4.4
[86]
HepG2 CASP9
Mean 6.38
Standard deviation 0.81
Values 5.8 7
[87]
HepG2.C3A CASP9
Mean 11.1
Standard deviation 0.21
Values 11 11
[88]
HuH.7 CASP9
Mean 5.76
Standard deviation 1.5
Values 6.7 4.1 6.6
[89]
SNU475 CASP9
Mean 5.65
Standard deviation 0.92
Values 6.3 5
[90]
THLE CASP9
Mean 3.94
Standard deviation 0.43
Values 3.6 4.2
[91]
liver CASP9
Mean 2.54
Standard deviation 1.2
Values 2.4 1.9 4.2 1.6
[92]
ref_hepatocyte AKT3
Mean 0.387
Standard deviation 0.32
Values 0 0.53 0.83 0.16 0.41
[93]
HepG2 AKT3
Mean 0.238
Standard deviation 0.15
Values 0.34 0.13
[94]
HepG2.C3A AKT3
Mean 0.036
Standard deviation 0.0097
Values 0.029 0.043
[95]
HuH.7 AKT3
Mean 0.0557
Standard deviation 0.031
Values 0.049 0.09 0.028
[96]
SNU475 AKT3
Mean 40.8
Standard deviation 10
Values 48 34
[97]
THLE AKT3
Mean 22.1
Standard deviation 4.4
Values 25 19
[98]
liver AKT3
Mean 6.71
Standard deviation 4.9
Values 2.8 12 2.3 9.4