REACTOME_AFLATOXIN_ACTIVATION_AND_DETOXIFICATION Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 MGST1 Microsomal glutathione S-transferase 1 [1] -0.47[2] -1.18[3] 0.09[4] -0.11[5] 0.32[6] -0.70[7]
2 CYP3A4 Cytochrome P450 3A4 [8] -7.96[9] -8.45[10] -9.79[11] -12.39[12] -11.12[13] 0.91[14]
3 CYP3A5 Cytochrome P450 3A5 [15] -3.03[16] -1.17[17] -3.54[18] -4.96[19] -7.46[20] 1.28[21]
4 CYP1A2 Cytochrome P450 1A2 [22] -7.14[23] -6.21[24] -6.49[25] -5.96[26] -6.65[27] -1.47[28]
5 MGST2 Microsomal glutathione S-transferase 2 [29] 1.70[30] 2.73[31] 1.41[32] 0.15[33] -0.14[34] -1.74[35]
6 ACY1 Aminoacylase-1 [36] -2.26[37] -1.93[38] -0.97[39] -4.51[40] -4.31[41] -5.04[42]
7 AKR7A3 Aflatoxin B1 aldehyde reductase member 3 [43] -5.46[44] -3.35[45] -5.80[46] -4.84[47] -5.32[48] -0.65[49]
8 MGST3 Microsomal glutathione S-transferase 3 [50] 1.59[51] 1.26[52] 2.37[53] 3.28[54] 2.97[55] -0.03[56]
9 GGT1 Glutathione hydrolase 1 proenzyme [57] 3.10[58] 2.47[59] 2.62[60] 1.94[61] -2.87[62] 0.90[63]
10 AKR7A2 Aflatoxin B1 aldehyde reductase member 2 [64] 4.12[65] 4.58[66] 2.72[67] 3.75[68] 3.64[69] 0.70[70]
11 ACY3 N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) 1.33[71] 1.03[72] 2.80[73] 2.14[74] -5.53[75] -0.50[76]
12 GGT7 Glutathione hydrolase 7 [77] 5.56[78] 5.53[79] 5.45[80] 6.09[81] 4.93[82] 0.54[83]
13 DPEP1 Dipeptidase 1 [84] 5.66[85] 3.58[86] -2.74[87] -2.93[88] -5.40[89] -3.95[90]
14 GGT6 Glutathione hydrolase 6 [91] 4.10[92] 4.28[93] 2.92[94] 3.14[95] 2.15[96] 0.17[97]
15 DPEP2 Dipeptidase 2 [98] 0.59[99] 1.33[100] -0.31[101] [102] [103] 1.21[104]
16 GGT5 Glutathione hydrolase 5 proenzyme [105] 8.35[106] 5.37[107] 0.87[108] 8.04[109] 7.90[110] 5.81[111]
17 DPEP3 Dipeptidase 3 [112] [113] [114] -2.42[115] -1.80[116] [117] -0.68[118]
18 CYP2A13 Cytochrome P450 2A13 [119] [120] [121] [122] [123] [124] -0.34[125]
19 AKR7L Aflatoxin B1 aldehyde reductase member 4 [126] [127] [128] [129] [130] [131] [132]
[1]
ref_hepatocyte MGST1
Mean 720
Standard deviation 4.5e+02
Values 2.4e+02 7.2e+02 4.4e+02 7.8e+02 1.4e+03
[2]
HepG2 MGST1
Mean 83.4
Standard deviation 3.7
Values 86 81
[3]
HepG2.C3A MGST1
Mean 58.5
Standard deviation 26
Values 40 77
[4]
HuH.7 MGST1
Mean 105
Standard deviation 17
Values 97 93 1.2e+02
[5]
SNU475 MGST1
Mean 70.5
Standard deviation 6
Values 66 75
[6]
THLE MGST1
Mean 128
Standard deviation 3.8
Values 1.3e+02 1.3e+02
[7]
liver MGST1
Mean 558
Standard deviation 6e+02
Values 9.8e+02 62 1.2e+03 31
[8]
ref_hepatocyte CYP3A4
Mean 259
Standard deviation 4.1e+02
Values 0.24 11 11 3.2e+02 9.6e+02
[9]
HepG2 CYP3A4
Mean 0.167
Standard deviation 0.098
Values 0.097 0.24
[10]
HepG2.C3A CYP3A4
Mean 0.136
Standard deviation 0.096
Values 0.068 0.2
[11]
HuH.7 CYP3A4
Mean 0.0397
Standard deviation 0.029
Values 0.0082 0.064 0.047
[12]
SNU475 CYP3A4
Mean 0.00507
Standard deviation 0.0072
Values 0 0.01
[13]
THLE CYP3A4
Mean 0.0166
Standard deviation 0.0067
Values 0.012 0.021
[14]
liver CYP3A4
Mean 610
Standard deviation 5.3e+02
Values 4.3e+02 6.4e+02 1.3e+03 49
[15]
ref_hepatocyte CYP3A5
Mean 139
Standard deviation 1.6e+02
Values 22 55 35 2e+02 3.9e+02
[16]
HepG2 CYP3A5
Mean 2.75
Standard deviation 2.1
Values 1.3 4.2
[17]
HepG2.C3A CYP3A5
Mean 11.4
Standard deviation 3.8
Values 14 8.7
[18]
HuH.7 CYP3A5
Mean 1.63
Standard deviation 1.6
Values 0.58 3.5 0.83
[19]
SNU475 CYP3A5
Mean 0.471
Standard deviation 0.12
Values 0.56 0.39
[20]
THLE CYP3A5
Mean 0.113
Standard deviation 0.032
Values 0.14 0.09
[21]
liver CYP3A5
Mean 424
Standard deviation 3.2e+02
Values 9e+02 2.7e+02 2.5e+02 2.8e+02
[22]
ref_hepatocyte CYP1A2
Mean 78.9
Standard deviation 1.3e+02
Values 0.4 18 0.97 71 3e+02
[23]
HepG2 CYP1A2
Mean 0.0901
Standard deviation 0.055
Values 0.052 0.13
[24]
HepG2.C3A CYP1A2
Mean 0.197
Standard deviation 0.066
Values 0.24 0.15
[25]
HuH.7 CYP1A2
Mean 0.12
Standard deviation 0.026
Values 0.11 0.1 0.15
[26]
SNU475 CYP1A2
Mean 0.134
Standard deviation 0.091
Values 0.07 0.2
[27]
THLE CYP1A2
Mean 0.112
Standard deviation 0.068
Values 0.16 0.064
[28]
liver CYP1A2
Mean 35.7
Standard deviation 24
Values 55 12 58 19
[29]
ref_hepatocyte MGST2
Mean 73.6
Standard deviation 69
Values 20 29 25 1.2e+02 1.7e+02
[30]
HepG2 MGST2
Mean 38.6
Standard deviation 7.7
Values 33 44
[31]
HepG2.C3A MGST2
Mean 89.8
Standard deviation 3.2
Values 88 92
[32]
HuH.7 MGST2
Mean 26.6
Standard deviation 6.5
Values 24 22 34
[33]
SNU475 MGST2
Mean 8.62
Standard deviation 2.3
Values 10 7
[34]
THLE MGST2
Mean 9.5
Standard deviation 0.2
Values 9.4 9.6
[35]
liver MGST2
Mean 27.6
Standard deviation 24
Values 59 7.8 35 8.6
[36]
ref_hepatocyte ACY1
Mean 72.1
Standard deviation 60
Values 21 45 22 1.2e+02 1.5e+02
[37]
HepG2 ACY1
Mean 2.42
Standard deviation 0.67
Values 2.9 2
[38]
HepG2.C3A ACY1
Mean 3.49
Standard deviation 0.8
Values 2.9 4.1
[39]
HuH.7 ACY1
Mean 5.02
Standard deviation 1.4
Values 6.3 3.5 5.3
[40]
SNU475 ACY1
Mean 0.334
Standard deviation 0.16
Values 0.45 0.22
[41]
THLE ACY1
Mean 0.518
Standard deviation 0.013
Values 0.51 0.53
[42]
liver ACY1
Mean 2.74
Standard deviation 2.8
Values 5.1 0.36 5.2 0.26
[43]
ref_hepatocyte AKR7A3
Mean 38.6
Standard deviation 35
Values 0 23 23 57 90
[44]
HepG2 AKR7A3
Mean 0.141
Standard deviation 0.011
Values 0.15 0.13
[45]
HepG2.C3A AKR7A3
Mean 0.698
Standard deviation 0.47
Values 1 0.36
[46]
HuH.7 AKR7A3
Mean 0.0946
Standard deviation 0.013
Values 0.09 0.11 0.084
[47]
SNU475 AKR7A3
Mean 0.142
Standard deviation 0.036
Values 0.17 0.12
[48]
THLE AKR7A3
Mean 0.138
Standard deviation 0.09
Values 0.2 0.074
[49]
liver AKR7A3
Mean 30.8
Standard deviation 15
Values 47 24 39 13
[50]
ref_hepatocyte MGST3
Mean 29.9
Standard deviation 13
Values 15 35 20 48 33
[51]
HepG2 MGST3
Mean 14.5
Standard deviation 2.5
Values 13 16
[52]
HepG2.C3A MGST3
Mean 13.2
Standard deviation 1.3
Values 12 14
[53]
HuH.7 MGST3
Mean 21
Standard deviation 3.7
Values 19 19 25
[54]
SNU475 MGST3
Mean 30.6
Standard deviation 11
Values 38 23
[55]
THLE MGST3
Mean 33.4
Standard deviation 7.3
Values 28 39
[56]
liver MGST3
Mean 36.8
Standard deviation 33
Values 56 10 73 7.7
[57]
ref_hepatocyte GGT1
Mean 15.1
Standard deviation 12
Values 0.7 20 4.1 29 22
[58]
HepG2 GGT1
Mean 20.9
Standard deviation 6.9
Values 26 16
[59]
HepG2.C3A GGT1
Mean 15.5
Standard deviation 4.3
Values 19 12
[60]
HuH.7 GGT1
Mean 12.7
Standard deviation 3.6
Values 11 17 9.9
[61]
SNU475 GGT1
Mean 6.1
Standard deviation 1.7
Values 7.3 4.9
[62]
THLE GGT1
Mean 0.294
Standard deviation 0.0057
Values 0.29 0.3
[63]
liver GGT1
Mean 35.2
Standard deviation 23
Values 65 15 40 21
[64]
ref_hepatocyte AKR7A2
Mean 11.8
Standard deviation 5.8
Values 10 10 4 15 20
[65]
HepG2 AKR7A2
Mean 33
Standard deviation 5.4
Values 29 37
[66]
HepG2.C3A AKR7A2
Mean 51.9
Standard deviation 2.5
Values 50 54
[67]
HuH.7 AKR7A2
Mean 10.6
Standard deviation 1.8
Values 11 8.7 12
[68]
SNU475 AKR7A2
Mean 16.7
Standard deviation 2.4
Values 18 15
[69]
THLE AKR7A2
Mean 21
Standard deviation 4.1
Values 18 24
[70]
liver AKR7A2
Mean 23.9
Standard deviation 13
Values 27 13 42 14
[71]
ref_hepatocyte ACY3
Mean 4.61
Standard deviation 5.1
Values 1.2 0 1.7 9.2 11
[72]
HepG2 ACY3
Mean 1.86
Standard deviation 0.36
Values 2.1 1.6
[73]
HepG2.C3A ACY3
Mean 1.74
Standard deviation 0.54
Values 2.1 1.4
[74]
HuH.7 ACY3
Mean 4.39
Standard deviation 0.38
Values 4.7 4 4.5
[75]
SNU475 ACY3
Mean 2.14
Standard deviation 1.8
Values 3.4 0.87
[76]
THLE ACY3
Mean 0.0142
Standard deviation 0.005
Values 0.018 0.011
[77]
liver ACY3
Mean 4.09
Standard deviation 2.5
Values 7.2 2 5 2.2
[78]
ref_hepatocyte GGT7
Mean 1.61
Standard deviation 1.1
Values 1.5 0.71 0.35 2.8 2.6
[79]
HepG2 GGT7
Mean 12.2
Standard deviation 0.96
Values 13 12
[80]
HepG2.C3A GGT7
Mean 13.6
Standard deviation 5.5
Values 18 9.8
[81]
HuH.7 GGT7
Mean 9.57
Standard deviation 2.2
Values 7.5 12 9.5
[82]
SNU475 GGT7
Mean 11.5
Standard deviation 1.7
Values 13 10
[83]
THLE GGT7
Mean 7.01
Standard deviation 1.9
Values 8.3 5.7
[84]
liver GGT7
Mean 2.93
Standard deviation 1
Values 2.2 4.2 2.1 3.3
[85]
ref_hepatocyte DPEP1
Mean 1.57
Standard deviation 3.4
Values 7.6 0 0 0.17 0.098
[86]
HepG2 DPEP1
Mean 12.8
Standard deviation 5.1
Values 9.2 16
[87]
HepG2.C3A DPEP1
Mean 3.47
Standard deviation 0.61
Values 3.9 3
[88]
HuH.7 DPEP1
Mean 0.032
Standard deviation 0.0059
Values 0.033 0.026 0.037
[89]
SNU475 DPEP1
Mean 0.0217
Standard deviation 0.0021
Values 0.023 0.02
[90]
THLE DPEP1
Mean 0.00532
Standard deviation 0.0075
Values 0 0.011
[91]
liver DPEP1
Mean 0.127
Standard deviation 0.17
Values 0.38 0.029 0.026 0.079
[92]
ref_hepatocyte GGT6
Mean 0.301
Standard deviation 0.36
Values 0.92 0.06 0.2 0.06 0.28
[93]
HepG2 GGT6
Mean 0.834
Standard deviation 0.027
Values 0.85 0.82
[94]
HepG2.C3A GGT6
Mean 1.08
Standard deviation 0.082
Values 1 1.1
[95]
HuH.7 GGT6
Mean 0.31
Standard deviation 0.14
Values 0.24 0.47 0.22
[96]
SNU475 GGT6
Mean 0.28
Standard deviation 0.044
Values 0.31 0.25
[97]
THLE GGT6
Mean 0.19
Standard deviation 0.077
Values 0.14 0.24
[98]
liver GGT6
Mean 0.426
Standard deviation 0.13
Values 0.61 0.3 0.41 0.38
[99]
ref_hepatocyte DPEP2
Mean 0.216
Standard deviation 0.31
Values 0 0 0 0.41 0.67
[100]
HepG2 DPEP2
Mean 0.0522
Standard deviation 0.0072
Values 0.057 0.047
[101]
HepG2.C3A DPEP2
Mean 0.1
Standard deviation 0.051
Values 0.14 0.064
[102]
HuH.7 DPEP2
Mean 0.0238
Standard deviation 0.015
Values 0.0082 0.026 0.037
[103]
SNU475 DPEP2
Mean 0
Standard deviation 0
Values 0 0
[104]
THLE DPEP2
Mean 0
Standard deviation 0
Values 0 0
[105]
liver DPEP2
Mean 0.626
Standard deviation 0.12
Values 0.59 0.5 0.8 0.62
[106]
ref_hepatocyte GGT5
Mean 0.17
Standard deviation 0.18
Values 0.15 0 0 0.41 0.3
[107]
HepG2 GGT5
Mean 8.97
Standard deviation 6.7
Values 14 4.3
[108]
HepG2.C3A GGT5
Mean 1.3
Standard deviation 0.47
Values 0.97 1.6
[109]
HuH.7 GGT5
Mean 0.0424
Standard deviation 0.034
Values 0.074 0.0064 0.047
[110]
SNU475 GGT5
Mean 4.71
Standard deviation 2.8
Values 2.7 6.7
[111]
THLE GGT5
Mean 5.79
Standard deviation 1.9
Values 4.5 7.1
[112]
liver GGT5
Mean 12
Standard deviation 7.3
Values 13 4.2 21 9.1
[113]
ref_hepatocyte DPEP3
Mean 0.084
Standard deviation 0.13
Values 0 0 0.3 0.078 0.041
[114]
HepG2 DPEP3
Mean 0
Standard deviation 0
Values 0 0
[115]
HepG2.C3A DPEP3
Mean 0
Standard deviation 0
Values 0 0
[116]
HuH.7 DPEP3
Mean 0.00214
Standard deviation 0.0037
Values 0 0.0064 0
[117]
SNU475 DPEP3
Mean 0.00253
Standard deviation 0.0036
Values 0 0.0051
[118]
THLE DPEP3
Mean 0
Standard deviation 0
Values 0 0
[119]
liver DPEP3
Mean 0.0656
Standard deviation 0.079
Values 0 0.043 0.18 0.04
[120]
ref_hepatocyte CYP2A13
Mean 0.0683
Standard deviation 0.12
Values 0 0 0 0.28 0.057
[121]
HepG2 CYP2A13
Mean 0
Standard deviation 0
Values 0 0
[122]
HepG2.C3A CYP2A13
Mean 0
Standard deviation 0
Values 0 0
[123]
HuH.7 CYP2A13
Mean 0
Standard deviation 0
Values 0 0 0
[124]
SNU475 CYP2A13
Mean 0
Standard deviation 0
Values 0 0
[125]
THLE CYP2A13
Mean 0
Standard deviation 0
Values 0 0
[126]
liver CYP2A13
Mean 0.0677
Standard deviation 0.059
Values 0 0.13 0.1 0.04
[127]
ref_hepatocyte AKR7L
Missing
[128]
HepG2 AKR7L
Mean 0.108
Standard deviation 0.023
Values 0.092 0.12
[129]
HepG2.C3A AKR7L
Mean 0.563
Standard deviation 0.098
Values 0.63 0.49
[130]
HuH.7 AKR7L
Mean 0.2
Standard deviation 0.068
Values 0.12 0.22 0.25
[131]
SNU475 AKR7L
Mean 0.157
Standard deviation 0.028
Values 0.18 0.14
[132]
THLE AKR7L
Mean 0.142
Standard deviation 0.05
Values 0.18 0.11
[133]
liver AKR7L
Mean 11.2
Standard deviation 4.5
Values 8.2 14 16 6.5