REACTOME_ADP_SIGNALLING_THROUGH_P2Y_PURINOCEPTOR_12 Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 GNG5 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 -0.87[1] -0.58[2] -1.59[3] -2.05[4] -2.46[5] -0.88[6]
2 GNB1 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [7] 1.35[8] 1.47[9] 0.86[10] 1.04[11] 0.69[12] -0.53[13]
3 GNB2 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [14] -0.27[15] -0.41[16] -0.21[17] -0.61[18] -0.70[19] -0.89[20]
4 GNG10 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 -4.37[21] -3.97[22] -4.41[23] -4.05[24] -3.38[25] -3.64[26]
5 GNAI2 Guanine nucleotide-binding protein G(i) subunit alpha-2 [27] 0.40[28] -0.55[29] -0.52[30] -0.41[31] 0.51[32] 0.51[33]
6 GNG12 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 -4.42[34] -7.24[35] 0.57[36] 1.64[37] 1.59[38] 1.19[39]
7 GNAI3 Guanine nucleotide-binding protein G(k) subunit alpha [40] 0.46[41] 1.11[42] 1.08[43] 0.86[44] 0.35[45] 0.94[46]
8 GNAI1 Guanine nucleotide-binding protein G(i) subunit alpha-1 [47] -1.32[48] -2.15[49] -0.14[50] 0.97[51] 0.20[52] 1.54[53]
9 GNB5 Guanine nucleotide-binding protein subunit beta-5 [54] 0.43[55] 0.58[56] 1.46[57] 0.55[58] 0.52[59] 1.59[60]
10 GNG11 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 -7.85[61] -7.74[62] -7.18[63] 2.02[64] 3.20[65] 2.94[66]
11 GNG7 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 1.89[67] 1.65[68] 2.32[69] -2.48[70] -2.00[71] 0.73[72]
12 GNG4 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 3.80[73] 1.68[74] 5.34[75] 1.02[76] -1.25[77] -1.84[78]
13 GNB4 Guanine nucleotide-binding protein subunit beta-4 [79] -0.04[80] 0.57[81] 1.43[82] 2.44[83] 5.03[84] 4.80[85]
14 GNG2 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 -5.95[86] -6.71[87] [88] 2.88[89] 2.20[90] 3.49[91]
15 GNGT2 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [92] [93] [94] -2.31[95] -7.13[96] 0.82[97]
16 GNG3 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 -0.52[98] 1.42[99] -0.94[100] -0.94[101] -1.40[102] 0.62[103]
17 P2RY12 P2Y purinoceptor 12 [104] [105] [106] [107] -4.42[108] [109] 3.42[110]
18 GNB3 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [111] 1.92[112] 4.28[113] 3.45[114] 0.77[115] 3.33[116] -0.97[117]
19 GNG8 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [118] [119] [120] [121] [122] [123]
20 GNGT1 Guanine nucleotide-binding protein G(T) subunit gamma-T1 [124] [125] [126] [127] [128] [129] [130]
21 GNG13 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [131] [132] [133] [134] [135] [136]
22 GNAT3 Guanine nucleotide-binding protein G(t) subunit alpha-3 [137] [138] [139] [140] [141] [142] [143]
[1]
ref_hepatocyte GNG5
Mean 71
Standard deviation 24
Values 60 35 85 91 85
[2]
HepG2 GNG5
Mean 68.1
Standard deviation 11
Values 60 76
[3]
HepG2.C3A GNG5
Mean 68.6
Standard deviation 10
Values 61 76
[4]
HuH.7 GNG5
Mean 36.1
Standard deviation 6.8
Values 38 28 42
[5]
SNU475 GNG5
Mean 37.2
Standard deviation 3.1
Values 39 35
[6]
THLE GNG5
Mean 34.8
Standard deviation 0.49
Values 34 35
[7]
liver GNG5
Mean 33.6
Standard deviation 38
Values 75 1.4 56 1.4
[8]
ref_hepatocyte GNB1
Mean 42.7
Standard deviation 15
Values 44 60 53 31 24
[9]
HepG2 GNB1
Mean 190
Standard deviation 15
Values 2e+02 1.8e+02
[10]
HepG2.C3A GNB1
Mean 171
Standard deviation 4.5
Values 1.7e+02 1.7e+02
[11]
HuH.7 GNB1
Mean 118
Standard deviation 23
Values 1.4e+02 93 1.2e+02
[12]
SNU475 GNB1
Mean 191
Standard deviation 19
Values 2e+02 1.8e+02
[13]
THLE GNB1
Mean 185
Standard deviation 12
Values 1.8e+02 1.9e+02
[14]
liver GNB1
Mean 25.7
Standard deviation 5
Values 31 25 19 27
[15]
ref_hepatocyte GNB2
Mean 38.8
Standard deviation 20
Values 15 25 41 67 46
[16]
HepG2 GNB2
Mean 56.5
Standard deviation 6.2
Values 61 52
[17]
HepG2.C3A GNB2
Mean 42.3
Standard deviation 7.9
Values 48 37
[18]
HuH.7 GNB2
Mean 51.2
Standard deviation 3.5
Values 50 49 55
[19]
SNU475 GNB2
Mean 55.4
Standard deviation 5.7
Values 59 51
[20]
THLE GNB2
Mean 64.6
Standard deviation 5.2
Values 61 68
[21]
liver GNB2
Mean 18.2
Standard deviation 7.1
Values 24 11 25 13
[22]
ref_hepatocyte GNG10
Mean 36.1
Standard deviation 25
Values 54 68 12 12 34
[23]
HepG2 GNG10
Mean 3.07
Standard deviation 0.45
Values 2.8 3.4
[24]
HepG2.C3A GNG10
Mean 3.33
Standard deviation 1.3
Values 2.4 4.3
[25]
HuH.7 GNG10
Mean 2.59
Standard deviation 0.11
Values 2.6 2.5 2.7
[26]
SNU475 GNG10
Mean 4.73
Standard deviation 1.4
Values 5.8 3.7
[27]
THLE GNG10
Mean 9.34
Standard deviation 0.66
Values 8.9 9.8
[28]
liver GNG10
Mean 2.53
Standard deviation 1.2
Values 3.6 2.1 3.3 1.1
[29]
ref_hepatocyte GNAI2
Mean 32.9
Standard deviation 13
Values 10 31 41 40 42
[30]
HepG2 GNAI2
Mean 76.1
Standard deviation 11
Values 68 84
[31]
HepG2.C3A GNAI2
Mean 32.5
Standard deviation 8.6
Values 26 39
[32]
HuH.7 GNAI2
Mean 34.9
Standard deviation 7.6
Values 41 26 37
[33]
SNU475 GNAI2
Mean 53.7
Standard deviation 11
Values 62 46
[34]
THLE GNAI2
Mean 126
Standard deviation 19
Values 1.1e+02 1.4e+02
[35]
liver GNAI2
Mean 40.9
Standard deviation 20
Values 61 27 54 21
[36]
ref_hepatocyte GNG12
Mean 16.5
Standard deviation 18
Values 0.58 46 23 5.6 7.3
[37]
HepG2 GNG12
Mean 1.35
Standard deviation 0.72
Values 1.9 0.84
[38]
HepG2.C3A GNG12
Mean 0.158
Standard deviation 0.011
Values 0.17 0.15
[39]
HuH.7 GNG12
Mean 37.3
Standard deviation 6.6
Values 44 36 31
[40]
SNU475 GNG12
Mean 111
Standard deviation 32
Values 1.3e+02 89
[41]
THLE GNG12
Mean 133
Standard deviation 28
Values 1.1e+02 1.5e+02
[42]
liver GNG12
Mean 32.7
Standard deviation 9.9
Values 36 32 43 19
[43]
ref_hepatocyte GNAI3
Mean 15.6
Standard deviation 11
Values 15 35 11 6.9 10
[44]
HepG2 GNAI3
Mean 37.5
Standard deviation 8.9
Values 31 44
[45]
HepG2.C3A GNAI3
Mean 48.7
Standard deviation 8.6
Values 43 55
[46]
HuH.7 GNAI3
Mean 50
Standard deviation 3.6
Values 54 47 49
[47]
SNU475 GNAI3
Mean 61.5
Standard deviation 5.4
Values 65 58
[48]
THLE GNAI3
Mean 53.3
Standard deviation 7.7
Values 48 59
[49]
liver GNAI3
Mean 26
Standard deviation 3.5
Values 26 25 31 23
[50]
ref_hepatocyte GNAI1
Mean 6.48
Standard deviation 1.5
Values 6.5 8.9 6.3 4.7 6
[51]
HepG2 GNAI1
Mean 4.56
Standard deviation 1
Values 5.3 3.9
[52]
HepG2.C3A GNAI1
Mean 2.12
Standard deviation 0.54
Values 1.7 2.5
[53]
HuH.7 GNAI1
Mean 8.95
Standard deviation 1.2
Values 9.3 7.6 10
[54]
SNU475 GNAI1
Mean 27.6
Standard deviation 3.4
Values 30 25
[55]
THLE GNAI1
Mean 20
Standard deviation 0.41
Values 20 20
[56]
liver GNAI1
Mean 16.4
Standard deviation 11
Values 32 8.4 17 9
[57]
ref_hepatocyte GNB5
Mean 4.79
Standard deviation 2.5
Values 6.3 6.9 2 6.5 2.2
[58]
HepG2 GNB5
Mean 11.3
Standard deviation 2.9
Values 13 9.2
[59]
HepG2.C3A GNB5
Mean 10.4
Standard deviation 1.2
Values 11 9.5
[60]
HuH.7 GNB5
Mean 20.1
Standard deviation 2.5
Values 20 23 18
[61]
SNU475 GNB5
Mean 15.2
Standard deviation 0.29
Values 15 15
[62]
THLE GNB5
Mean 18.5
Standard deviation 0.68
Values 18 19
[63]
liver GNB5
Mean 12.6
Standard deviation 4.4
Values 13 12 18 7.3
[64]
ref_hepatocyte GNG11
Mean 1.51
Standard deviation 1.6
Values 0 0 1.3 3.2 3
[65]
HepG2 GNG11
Mean 0.0115
Standard deviation 0.016
Values 0.023 0
[66]
HepG2.C3A GNG11
Mean 0.0102
Standard deviation 0.00071
Values 0.0097 0.011
[67]
HuH.7 GNG11
Mean 0.0158
Standard deviation 0.022
Values 0.041 0.0064 0
[68]
SNU475 GNG11
Mean 13.3
Standard deviation 2
Values 12 15
[69]
THLE GNG11
Mean 37.1
Standard deviation 6.4
Values 33 42
[70]
liver GNG11
Mean 10.1
Standard deviation 8.8
Values 16 3.1 19 2
[71]
ref_hepatocyte GNG7
Mean 0.972
Standard deviation 0.89
Values 2.2 0.22 0.098 0.76 1.6
[72]
HepG2 GNG7
Mean 6.31
Standard deviation 1.2
Values 7.2 5.5
[73]
HepG2.C3A GNG7
Mean 4.41
Standard deviation 1.7
Values 5.6 3.2
[74]
HuH.7 GNG7
Mean 7.39
Standard deviation 1.1
Values 8.1 6.1 7.9
[75]
SNU475 GNG7
Mean 0.379
Standard deviation 0.19
Values 0.51 0.24
[76]
THLE GNG7
Mean 0.654
Standard deviation 0.35
Values 0.9 0.41
[77]
liver GNG7
Mean 1.4
Standard deviation 0.99
Values 2.8 0.53 1.3 1
[78]
ref_hepatocyte GNG4
Mean 0.665
Standard deviation 1.2
Values 2.8 0.17 0.098 0.15 0.11
[79]
HepG2 GNG4
Mean 16.3
Standard deviation 4.5
Values 19 13
[80]
HepG2.C3A GNG4
Mean 3.08
Standard deviation 0.29
Values 2.9 3.3
[81]
HuH.7 GNG4
Mean 41.2
Standard deviation 8.1
Values 48 32 43
[82]
SNU475 GNG4
Mean 2.92
Standard deviation 0.47
Values 3.3 2.6
[83]
THLE GNG4
Mean 0.755
Standard deviation 0.19
Values 0.89 0.62
[84]
liver GNG4
Mean 0.161
Standard deviation 0.098
Values 0.024 0.26 0.18 0.19
[85]
ref_hepatocyte GNB4
Mean 0.389
Standard deviation 0.25
Values 0.16 0.31 0.7 0.17 0.61
[86]
HepG2 GNB4
Mean 0.666
Standard deviation 0.063
Values 0.71 0.62
[87]
HepG2.C3A GNB4
Mean 0.835
Standard deviation 0.043
Values 0.87 0.8
[88]
HuH.7 GNB4
Mean 1.6
Standard deviation 0.14
Values 1.6 1.7 1.5
[89]
SNU475 GNB4
Mean 4.59
Standard deviation 0.038
Values 4.6 4.6
[90]
THLE GNB4
Mean 34.3
Standard deviation 7.5
Values 29 40
[91]
liver GNB4
Mean 9.42
Standard deviation 4.4
Values 4.9 15 7 11
[92]
ref_hepatocyte GNG2
Mean 0.352
Standard deviation 0.41
Values 0 0.06 0.53 0.18 0.99
[93]
HepG2 GNG2
Mean 0.01
Standard deviation 0.002
Values 0.011 0.0086
[94]
HepG2.C3A GNG2
Mean 0.00486
Standard deviation 0.0069
Values 0.0097 0
[95]
HuH.7 GNG2
Mean 0
Standard deviation 0
Values 0 0 0
[96]
SNU475 GNG2
Mean 5.62
Standard deviation 1.4
Values 4.6 6.6
[97]
THLE GNG2
Mean 4.37
Standard deviation 0.87
Values 5 3.8
[98]
liver GNG2
Mean 3.44
Standard deviation 0.91
Values 3.5 3.6 4.4 2.2
[99]
ref_hepatocyte GNGT2
Mean 0.154
Standard deviation 0.23
Values 0 0 0.06 0.16 0.54
[100]
HepG2 GNGT2
Mean 0
Standard deviation 0
Values 0 0
[101]
HepG2.C3A GNGT2
Mean 0
Standard deviation 0
Values 0 0
[102]
HuH.7 GNGT2
Mean 0
Standard deviation 0
Values 0 0 0
[103]
SNU475 GNGT2
Mean 0.0673
Standard deviation 0.062
Values 0.023 0.11
[104]
THLE GNGT2
Mean 0.00296
Standard deviation 0.0042
Values 0.0059 0
[105]
liver GNGT2
Mean 0.235
Standard deviation 0.19
Values 0.35 0.086 0.44 0.066
[106]
ref_hepatocyte GNG3
Mean 0.127
Standard deviation 0.2
Values 0 0 0 0.46 0.18
[107]
HepG2 GNG3
Mean 0.155
Standard deviation 0.032
Values 0.18 0.13
[108]
HepG2.C3A GNG3
Mean 0.493
Standard deviation 0.33
Values 0.73 0.26
[109]
HuH.7 GNG3
Mean 0.101
Standard deviation 0.06
Values 0.033 0.15 0.12
[110]
SNU475 GNG3
Mean 0.144
Standard deviation 0.053
Values 0.18 0.11
[111]
THLE GNG3
Mean 0.13
Standard deviation 0.018
Values 0.14 0.12
[112]
liver GNG3
Mean 0.17
Standard deviation 0.089
Values 0.047 0.26 0.21 0.17
[113]
ref_hepatocyte P2RY12
Mean 0.0726
Standard deviation 0.12
Values 0 0 0 0.095 0.27
[114]
HepG2 P2RY12
Mean 0
Standard deviation 0
Values 0 0
[115]
HepG2.C3A P2RY12
Mean 0
Standard deviation 0
Values 0 0
[116]
HuH.7 P2RY12
Mean 0
Standard deviation 0
Values 0 0 0
[117]
SNU475 P2RY12
Mean 0.00739
Standard deviation 0.0039
Values 0.0046 0.01
[118]
THLE P2RY12
Mean 0
Standard deviation 0
Values 0 0
[119]
liver P2RY12
Mean 0.676
Standard deviation 0.42
Values 0.28 1.2 0.72 0.46
[120]
ref_hepatocyte GNB3
Mean 0.0571
Standard deviation 0.11
Values 0.24 0 0 0 0.041
[121]
HepG2 GNB3
Mean 0.379
Standard deviation 0.11
Values 0.3 0.45
[122]
HepG2.C3A GNB3
Mean 1.61
Standard deviation 0.27
Values 1.4 1.8
[123]
HuH.7 GNB3
Mean 0.95
Standard deviation 0.47
Values 0.98 0.47 1.4
[124]
SNU475 GNB3
Mean 0.211
Standard deviation 0.003
Values 0.21 0.21
[125]
THLE GNB3
Mean 1.55
Standard deviation 0.56
Values 1.9 1.1
[126]
liver GNB3
Mean 0.0253
Standard deviation 0.019
Values 0.047 0.029 0.026 0
[127]
ref_hepatocyte GNG8
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[128]
HepG2 GNG8
Mean 0
Standard deviation 0
Values 0 0
[129]
HepG2.C3A GNG8
Mean 0
Standard deviation 0
Values 0 0
[130]
HuH.7 GNG8
Mean 0
Standard deviation 0
Values 0 0 0
[131]
SNU475 GNG8
Mean 0.00507
Standard deviation 0.0072
Values 0 0.01
[132]
THLE GNG8
Mean 0
Standard deviation 0
Values 0 0
[133]
liver GNG8
Mean 0
Standard deviation 0
Values 0 0 0 0
[134]
ref_hepatocyte GNGT1
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[135]
HepG2 GNGT1
Mean 0
Standard deviation 0
Values 0 0
[136]
HepG2.C3A GNGT1
Mean 0
Standard deviation 0
Values 0 0
[137]
HuH.7 GNGT1
Mean 0.0409
Standard deviation 0.035
Values 0.0082 0.077 0.037
[138]
SNU475 GNGT1
Mean 0.0679
Standard deviation 0.0043
Values 0.065 0.071
[139]
THLE GNGT1
Mean 0
Standard deviation 0
Values 0 0
[140]
liver GNGT1
Mean 0
Standard deviation 0
Values 0 0 0 0
[141]
ref_hepatocyte GNG13
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[142]
HepG2 GNG13
Mean 0
Standard deviation 0
Values 0 0
[143]
HepG2.C3A GNG13
Mean 0
Standard deviation 0
Values 0 0
[144]
HuH.7 GNG13
Mean 0.0152
Standard deviation 0.017
Values 0.033 0.013 0
[145]
SNU475 GNG13
Mean 0.00507
Standard deviation 0.0072
Values 0 0.01
[146]
THLE GNG13
Mean 0.0142
Standard deviation 0.005
Values 0.018 0.011
[147]
liver GNG13
Mean 0
Standard deviation 0
Values 0 0 0 0
[148]
ref_hepatocyte GNAT3
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[149]
HepG2 GNAT3
Mean 0
Standard deviation 0
Values 0 0
[150]
HepG2.C3A GNAT3
Mean 0
Standard deviation 0
Values 0 0
[151]
HuH.7 GNAT3
Mean 0
Standard deviation 0
Values 0 0 0
[152]
SNU475 GNAT3
Mean 0.0287
Standard deviation 0.012
Values 0.037 0.02
[153]
THLE GNAT3
Mean 0
Standard deviation 0
Values 0 0
[154]
liver GNAT3
Mean 0
Standard deviation 0
Values 0 0 0 0