REACTOME_ADP_SIGNALLING_THROUGH_P2Y_PURINOCEPTOR_1 Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 GNG5 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 -1.10[1] -0.91[2] -1.73[3] -2.13[4] -2.42[5] -0.84[6]
2 GNB1 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [7] 1.11[8] 1.15[9] 0.71[10] 0.96[11] 0.73[12] -0.49[13]
3 GNB2 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [14] -0.50[15] -0.74[16] -0.36[17] -0.69[18] -0.66[19] -0.85[20]
4 GNG10 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 -4.60[21] -4.30[22] -4.56[23] -4.13[24] -3.34[25] -3.60[26]
5 GNG12 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 -4.65[27] -7.56[28] 0.43[29] 1.56[30] 1.63[31] 1.23[32]
6 GNA11 Guanine nucleotide-binding protein subunit alpha-11 [33] -0.57[34] -0.63[35] -0.63[36] -1.50[37] -0.73[38] -0.51[39]
7 MAPK14 Mitogen-activated protein kinase 14 [40] 1.57[41] 1.66[42] 1.28[43] 1.36[44] 0.81[45] 2.03[46]
8 GNB5 Guanine nucleotide-binding protein subunit beta-5 [47] 0.20[48] 0.26[49] 1.32[50] 0.47[51] 0.56[52] 1.64[53]
9 SRC Proto-oncogene tyrosine-protein kinase Src [54] 3.12[55] 3.13[56] 2.17[57] 2.08[58] 1.23[59] -0.10[60]
10 GNAQ Guanine nucleotide-binding protein G(q) subunit alpha [61] 0.17[62] 0.97[63] 1.53[64] 1.27[65] 1.46[66] 2.19[67]
11 GNG11 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 -8.08[68] -8.06[69] -7.33[70] 1.94[71] 3.23[72] 2.98[73]
12 GNG7 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 1.66[74] 1.32[75] 2.17[76] -2.56[77] -1.96[78] 0.77[79]
13 GNG4 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 3.57[80] 1.35[81] 5.20[82] 0.94[83] -1.21[84] -1.80[85]
14 GNB4 Guanine nucleotide-binding protein subunit beta-4 [86] -0.27[87] 0.24[88] 1.29[89] 2.36[90] 5.07[91] 4.84[92]
15 GNG2 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 -6.18[93] -7.04[94] [95] 2.80[96] 2.24[97] 3.53[98]
16 GNA15 Guanine nucleotide-binding protein subunit alpha-15 [99] -3.28[100] -4.98[101] [102] -6.35[103] -2.82[104] 0.84[105]
17 GNA14 Guanine nucleotide-binding protein subunit alpha-14 [106] -5.96[107] -6.33[108] -5.14[109] -6.61[110] -3.55[111] 3.98[112]
18 GNGT2 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [113] [114] [115] -2.39[116] -7.09[117] 0.86[118]
19 GNG3 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 -0.75[119] 1.10[120] -1.09[121] -1.02[122] -1.36[123] 0.66[124]
20 GNB3 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [125] 1.69[126] 3.96[127] 3.30[128] 0.69[129] 3.37[130] -0.93[131]
21 PLA2G4A Cytosolic phospholipase A2 [132] 0.37[133] -2.17[134] 5.98[135] 3.18[136] 6.92[137] 5.10[138]
22 P2RY1 P2Y purinoceptor 1 [139] [140] [141] -0.71[142] 2.14[143] 4.38[144] 6.63[145]
23 GNG13 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [146] [147] [148] [149] [150] [151]
24 GNGT1 Guanine nucleotide-binding protein G(T) subunit gamma-T1 [152] [153] [154] [155] [156] [157] [158]
25 GNG8 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [159] [160] [161] [162] [163] [164]
[1]
ref_hepatocyte GNG5
Mean 71
Standard deviation 24
Values 60 35 85 91 85
[2]
HepG2 GNG5
Mean 68.1
Standard deviation 11
Values 60 76
[3]
HepG2.C3A GNG5
Mean 68.6
Standard deviation 10
Values 61 76
[4]
HuH.7 GNG5
Mean 36.1
Standard deviation 6.8
Values 38 28 42
[5]
SNU475 GNG5
Mean 37.2
Standard deviation 3.1
Values 39 35
[6]
THLE GNG5
Mean 34.8
Standard deviation 0.49
Values 34 35
[7]
liver GNG5
Mean 33.6
Standard deviation 38
Values 75 1.4 56 1.4
[8]
ref_hepatocyte GNB1
Mean 42.7
Standard deviation 15
Values 44 60 53 31 24
[9]
HepG2 GNB1
Mean 190
Standard deviation 15
Values 2e+02 1.8e+02
[10]
HepG2.C3A GNB1
Mean 171
Standard deviation 4.5
Values 1.7e+02 1.7e+02
[11]
HuH.7 GNB1
Mean 118
Standard deviation 23
Values 1.4e+02 93 1.2e+02
[12]
SNU475 GNB1
Mean 191
Standard deviation 19
Values 2e+02 1.8e+02
[13]
THLE GNB1
Mean 185
Standard deviation 12
Values 1.8e+02 1.9e+02
[14]
liver GNB1
Mean 25.7
Standard deviation 5
Values 31 25 19 27
[15]
ref_hepatocyte GNB2
Mean 38.8
Standard deviation 20
Values 15 25 41 67 46
[16]
HepG2 GNB2
Mean 56.5
Standard deviation 6.2
Values 61 52
[17]
HepG2.C3A GNB2
Mean 42.3
Standard deviation 7.9
Values 48 37
[18]
HuH.7 GNB2
Mean 51.2
Standard deviation 3.5
Values 50 49 55
[19]
SNU475 GNB2
Mean 55.4
Standard deviation 5.7
Values 59 51
[20]
THLE GNB2
Mean 64.6
Standard deviation 5.2
Values 61 68
[21]
liver GNB2
Mean 18.2
Standard deviation 7.1
Values 24 11 25 13
[22]
ref_hepatocyte GNG10
Mean 36.1
Standard deviation 25
Values 54 68 12 12 34
[23]
HepG2 GNG10
Mean 3.07
Standard deviation 0.45
Values 2.8 3.4
[24]
HepG2.C3A GNG10
Mean 3.33
Standard deviation 1.3
Values 2.4 4.3
[25]
HuH.7 GNG10
Mean 2.59
Standard deviation 0.11
Values 2.6 2.5 2.7
[26]
SNU475 GNG10
Mean 4.73
Standard deviation 1.4
Values 5.8 3.7
[27]
THLE GNG10
Mean 9.34
Standard deviation 0.66
Values 8.9 9.8
[28]
liver GNG10
Mean 2.53
Standard deviation 1.2
Values 3.6 2.1 3.3 1.1
[29]
ref_hepatocyte GNG12
Mean 16.5
Standard deviation 18
Values 0.58 46 23 5.6 7.3
[30]
HepG2 GNG12
Mean 1.35
Standard deviation 0.72
Values 1.9 0.84
[31]
HepG2.C3A GNG12
Mean 0.158
Standard deviation 0.011
Values 0.17 0.15
[32]
HuH.7 GNG12
Mean 37.3
Standard deviation 6.6
Values 44 36 31
[33]
SNU475 GNG12
Mean 111
Standard deviation 32
Values 1.3e+02 89
[34]
THLE GNG12
Mean 133
Standard deviation 28
Values 1.1e+02 1.5e+02
[35]
liver GNG12
Mean 32.7
Standard deviation 9.9
Values 36 32 43 19
[36]
ref_hepatocyte GNA11
Mean 10
Standard deviation 6.7
Values 19 12 12 3.8 2.8
[37]
HepG2 GNA11
Mean 14
Standard deviation 0.12
Values 14 14
[38]
HepG2.C3A GNA11
Mean 11.8
Standard deviation 0.77
Values 11 12
[39]
HuH.7 GNA11
Mean 10.9
Standard deviation 2.1
Values 13 11 8.6
[40]
SNU475 GNA11
Mean 8.12
Standard deviation 0.83
Values 8.7 7.5
[41]
THLE GNA11
Mean 15.8
Standard deviation 3.1
Values 14 18
[42]
liver GNA11
Mean 5.97
Standard deviation 1.7
Values 6.1 7 3.6 7.3
[43]
ref_hepatocyte MAPK14
Mean 8.71
Standard deviation 2
Values 12 8.5 7.2 7.5 8.3
[44]
HepG2 MAPK14
Mean 53.4
Standard deviation 8.7
Values 47 60
[45]
HepG2.C3A MAPK14
Mean 49.9
Standard deviation 0.11
Values 50 50
[46]
HuH.7 MAPK14
Mean 35.7
Standard deviation 1.3
Values 37 36 34
[47]
SNU475 MAPK14
Mean 51.3
Standard deviation 0.4
Values 52 51
[48]
THLE MAPK14
Mean 40
Standard deviation 3.6
Values 37 43
[49]
liver MAPK14
Mean 30.1
Standard deviation 8.3
Values 24 38 22 37
[50]
ref_hepatocyte GNB5
Mean 4.79
Standard deviation 2.5
Values 6.3 6.9 2 6.5 2.2
[51]
HepG2 GNB5
Mean 11.3
Standard deviation 2.9
Values 13 9.2
[52]
HepG2.C3A GNB5
Mean 10.4
Standard deviation 1.2
Values 11 9.5
[53]
HuH.7 GNB5
Mean 20.1
Standard deviation 2.5
Values 20 23 18
[54]
SNU475 GNB5
Mean 15.2
Standard deviation 0.29
Values 15 15
[55]
THLE GNB5
Mean 18.5
Standard deviation 0.68
Values 18 19
[56]
liver GNB5
Mean 12.6
Standard deviation 4.4
Values 13 12 18 7.3
[57]
ref_hepatocyte SRC
Mean 3.67
Standard deviation 3.6
Values 9.6 4.7 2.2 0.77 1.2
[58]
HepG2 SRC
Mean 66
Standard deviation 21
Values 81 51
[59]
HepG2.C3A SRC
Mean 58.1
Standard deviation 18
Values 71 45
[60]
HuH.7 SRC
Mean 27.9
Standard deviation 2
Values 28 29 26
[61]
SNU475 SRC
Mean 35.6
Standard deviation 3.5
Values 38 33
[62]
THLE SRC
Mean 22.5
Standard deviation 2.7
Values 21 24
[63]
liver SRC
Mean 2.9
Standard deviation 1
Values 4.1 2.5 1.7 3.2
[64]
ref_hepatocyte GNAQ
Mean 1.88
Standard deviation 1
Values 1.6 2 3.6 1.1 1.1
[65]
HepG2 GNAQ
Mean 4.36
Standard deviation 1.2
Values 3.5 5.2
[66]
HepG2.C3A GNAQ
Mean 6.67
Standard deviation 0.93
Values 6 7.3
[67]
HuH.7 GNAQ
Mean 9.12
Standard deviation 3.7
Values 11 11 4.8
[68]
SNU475 GNAQ
Mean 10.4
Standard deviation 1.4
Values 11 9.4
[69]
THLE GNAQ
Mean 13.5
Standard deviation 3.4
Values 11 16
[70]
liver GNAQ
Mean 7.23
Standard deviation 3.8
Values 5.1 11 3 9.6
[71]
ref_hepatocyte GNG11
Mean 1.51
Standard deviation 1.6
Values 0 0 1.3 3.2 3
[72]
HepG2 GNG11
Mean 0.0115
Standard deviation 0.016
Values 0.023 0
[73]
HepG2.C3A GNG11
Mean 0.0102
Standard deviation 0.00071
Values 0.0097 0.011
[74]
HuH.7 GNG11
Mean 0.0158
Standard deviation 0.022
Values 0.041 0.0064 0
[75]
SNU475 GNG11
Mean 13.3
Standard deviation 2
Values 12 15
[76]
THLE GNG11
Mean 37.1
Standard deviation 6.4
Values 33 42
[77]
liver GNG11
Mean 10.1
Standard deviation 8.8
Values 16 3.1 19 2
[78]
ref_hepatocyte GNG7
Mean 0.972
Standard deviation 0.89
Values 2.2 0.22 0.098 0.76 1.6
[79]
HepG2 GNG7
Mean 6.31
Standard deviation 1.2
Values 7.2 5.5
[80]
HepG2.C3A GNG7
Mean 4.41
Standard deviation 1.7
Values 5.6 3.2
[81]
HuH.7 GNG7
Mean 7.39
Standard deviation 1.1
Values 8.1 6.1 7.9
[82]
SNU475 GNG7
Mean 0.379
Standard deviation 0.19
Values 0.51 0.24
[83]
THLE GNG7
Mean 0.654
Standard deviation 0.35
Values 0.9 0.41
[84]
liver GNG7
Mean 1.4
Standard deviation 0.99
Values 2.8 0.53 1.3 1
[85]
ref_hepatocyte GNG4
Mean 0.665
Standard deviation 1.2
Values 2.8 0.17 0.098 0.15 0.11
[86]
HepG2 GNG4
Mean 16.3
Standard deviation 4.5
Values 19 13
[87]
HepG2.C3A GNG4
Mean 3.08
Standard deviation 0.29
Values 2.9 3.3
[88]
HuH.7 GNG4
Mean 41.2
Standard deviation 8.1
Values 48 32 43
[89]
SNU475 GNG4
Mean 2.92
Standard deviation 0.47
Values 3.3 2.6
[90]
THLE GNG4
Mean 0.755
Standard deviation 0.19
Values 0.89 0.62
[91]
liver GNG4
Mean 0.161
Standard deviation 0.098
Values 0.024 0.26 0.18 0.19
[92]
ref_hepatocyte GNB4
Mean 0.389
Standard deviation 0.25
Values 0.16 0.31 0.7 0.17 0.61
[93]
HepG2 GNB4
Mean 0.666
Standard deviation 0.063
Values 0.71 0.62
[94]
HepG2.C3A GNB4
Mean 0.835
Standard deviation 0.043
Values 0.87 0.8
[95]
HuH.7 GNB4
Mean 1.6
Standard deviation 0.14
Values 1.6 1.7 1.5
[96]
SNU475 GNB4
Mean 4.59
Standard deviation 0.038
Values 4.6 4.6
[97]
THLE GNB4
Mean 34.3
Standard deviation 7.5
Values 29 40
[98]
liver GNB4
Mean 9.42
Standard deviation 4.4
Values 4.9 15 7 11
[99]
ref_hepatocyte GNG2
Mean 0.352
Standard deviation 0.41
Values 0 0.06 0.53 0.18 0.99
[100]
HepG2 GNG2
Mean 0.01
Standard deviation 0.002
Values 0.011 0.0086
[101]
HepG2.C3A GNG2
Mean 0.00486
Standard deviation 0.0069
Values 0.0097 0
[102]
HuH.7 GNG2
Mean 0
Standard deviation 0
Values 0 0 0
[103]
SNU475 GNG2
Mean 5.62
Standard deviation 1.4
Values 4.6 6.6
[104]
THLE GNG2
Mean 4.37
Standard deviation 0.87
Values 5 3.8
[105]
liver GNG2
Mean 3.44
Standard deviation 0.91
Values 3.5 3.6 4.4 2.2
[106]
ref_hepatocyte GNA15
Mean 0.271
Standard deviation 0.31
Values 0 0 0.27 0.33 0.76
[107]
HepG2 GNA15
Mean 0.0573
Standard deviation 0.081
Values 0.11 0
[108]
HepG2.C3A GNA15
Mean 0.0156
Standard deviation 0.0083
Values 0.0097 0.021
[109]
HuH.7 GNA15
Mean 0
Standard deviation 0
Values 0 0 0
[110]
SNU475 GNA15
Mean 0.0076
Standard deviation 0.011
Values 0 0.015
[111]
THLE GNA15
Mean 0.101
Standard deviation 0.0083
Values 0.095 0.11
[112]
liver GNA15
Mean 0.411
Standard deviation 0.3
Values 0.047 0.6 0.28 0.71
[113]
ref_hepatocyte GNA14
Mean 0.216
Standard deviation 0.25
Values 0 0.19 0 0.28 0.61
[114]
HepG2 GNA14
Mean 0.00716
Standard deviation 0.002
Values 0.0057 0.0086
[115]
HepG2.C3A GNA14
Mean 0.00486
Standard deviation 0.0069
Values 0.0097 0
[116]
HuH.7 GNA14
Mean 0.0103
Standard deviation 0.013
Values 0.025 0.0064 0
[117]
SNU475 GNA14
Mean 0.00507
Standard deviation 0.0072
Values 0 0.01
[118]
THLE GNA14
Mean 0.0485
Standard deviation 0.023
Values 0.065 0.032
[119]
liver GNA14
Mean 2.89
Standard deviation 0.64
Values 3.5 2.1 3.3 2.7
[120]
ref_hepatocyte GNGT2
Mean 0.154
Standard deviation 0.23
Values 0 0 0.06 0.16 0.54
[121]
HepG2 GNGT2
Mean 0
Standard deviation 0
Values 0 0
[122]
HepG2.C3A GNGT2
Mean 0
Standard deviation 0
Values 0 0
[123]
HuH.7 GNGT2
Mean 0
Standard deviation 0
Values 0 0 0
[124]
SNU475 GNGT2
Mean 0.0673
Standard deviation 0.062
Values 0.023 0.11
[125]
THLE GNGT2
Mean 0.00296
Standard deviation 0.0042
Values 0.0059 0
[126]
liver GNGT2
Mean 0.235
Standard deviation 0.19
Values 0.35 0.086 0.44 0.066
[127]
ref_hepatocyte GNG3
Mean 0.127
Standard deviation 0.2
Values 0 0 0 0.46 0.18
[128]
HepG2 GNG3
Mean 0.155
Standard deviation 0.032
Values 0.18 0.13
[129]
HepG2.C3A GNG3
Mean 0.493
Standard deviation 0.33
Values 0.73 0.26
[130]
HuH.7 GNG3
Mean 0.101
Standard deviation 0.06
Values 0.033 0.15 0.12
[131]
SNU475 GNG3
Mean 0.144
Standard deviation 0.053
Values 0.18 0.11
[132]
THLE GNG3
Mean 0.13
Standard deviation 0.018
Values 0.14 0.12
[133]
liver GNG3
Mean 0.17
Standard deviation 0.089
Values 0.047 0.26 0.21 0.17
[134]
ref_hepatocyte GNB3
Mean 0.0571
Standard deviation 0.11
Values 0.24 0 0 0 0.041
[135]
HepG2 GNB3
Mean 0.379
Standard deviation 0.11
Values 0.3 0.45
[136]
HepG2.C3A GNB3
Mean 1.61
Standard deviation 0.27
Values 1.4 1.8
[137]
HuH.7 GNB3
Mean 0.95
Standard deviation 0.47
Values 0.98 0.47 1.4
[138]
SNU475 GNB3
Mean 0.211
Standard deviation 0.003
Values 0.21 0.21
[139]
THLE GNB3
Mean 1.55
Standard deviation 0.56
Values 1.9 1.1
[140]
liver GNB3
Mean 0.0253
Standard deviation 0.019
Values 0.047 0.029 0.026 0
[141]
ref_hepatocyte PLA2G4A
Mean 0.0266
Standard deviation 0.038
Values 0 0 0 0.052 0.081
[142]
HepG2 PLA2G4A
Mean 0.0708
Standard deviation 0.027
Values 0.052 0.09
[143]
HepG2.C3A PLA2G4A
Mean 0.0107
Standard deviation 0.015
Values 0 0.021
[144]
HuH.7 PLA2G4A
Mean 2.84
Standard deviation 0.53
Values 2.5 2.6 3.4
[145]
SNU475 PLA2G4A
Mean 0.554
Standard deviation 0.44
Values 0.25 0.86
[146]
THLE PLA2G4A
Mean 8.43
Standard deviation 1.4
Values 9.4 7.5
[147]
liver PLA2G4A
Mean 0.772
Standard deviation 0.24
Values 0.56 1.1 0.64 0.77
[148]
ref_hepatocyte P2RY1
Mean 0.0201
Standard deviation 0.045
Values 0 0 0.1 0 0
[149]
HepG2 P2RY1
Mean 0
Standard deviation 0
Values 0 0
[150]
HepG2.C3A P2RY1
Mean 0
Standard deviation 0
Values 0 0
[151]
HuH.7 P2RY1
Mean 0.0207
Standard deviation 0.026
Values 0.049 0.013 0
[152]
SNU475 P2RY1
Mean 0.203
Standard deviation 0.064
Values 0.16 0.25
[153]
THLE P2RY1
Mean 1.1
Standard deviation 0.15
Values 0.99 1.2
[154]
liver P2RY1
Mean 1.69
Standard deviation 1
Values 0.8 2.1 0.9 2.9
[155]
ref_hepatocyte GNG13
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[156]
HepG2 GNG13
Mean 0
Standard deviation 0
Values 0 0
[157]
HepG2.C3A GNG13
Mean 0
Standard deviation 0
Values 0 0
[158]
HuH.7 GNG13
Mean 0.0152
Standard deviation 0.017
Values 0.033 0.013 0
[159]
SNU475 GNG13
Mean 0.00507
Standard deviation 0.0072
Values 0 0.01
[160]
THLE GNG13
Mean 0.0142
Standard deviation 0.005
Values 0.018 0.011
[161]
liver GNG13
Mean 0
Standard deviation 0
Values 0 0 0 0
[162]
ref_hepatocyte GNGT1
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[163]
HepG2 GNGT1
Mean 0
Standard deviation 0
Values 0 0
[164]
HepG2.C3A GNGT1
Mean 0
Standard deviation 0
Values 0 0
[165]
HuH.7 GNGT1
Mean 0.0409
Standard deviation 0.035
Values 0.0082 0.077 0.037
[166]
SNU475 GNGT1
Mean 0.0679
Standard deviation 0.0043
Values 0.065 0.071
[167]
THLE GNGT1
Mean 0
Standard deviation 0
Values 0 0
[168]
liver GNGT1
Mean 0
Standard deviation 0
Values 0 0 0 0
[169]
ref_hepatocyte GNG8
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[170]
HepG2 GNG8
Mean 0
Standard deviation 0
Values 0 0
[171]
HepG2.C3A GNG8
Mean 0
Standard deviation 0
Values 0 0
[172]
HuH.7 GNG8
Mean 0
Standard deviation 0
Values 0 0 0
[173]
SNU475 GNG8
Mean 0.00507
Standard deviation 0.0072
Values 0 0.01
[174]
THLE GNG8
Mean 0
Standard deviation 0
Values 0 0
[175]
liver GNG8
Mean 0
Standard deviation 0
Values 0 0 0 0