REACTOME_ADORA2B_MEDIATED_ANTI_INFLAMMATORY_CYTOKINES_PRODUCTION | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | GNAS | Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas | 0.38[1] | 0.44[2] | 0.05[3] | 0.43[4] | -0.24[5] | -1.17[6] | |
2 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | -1.25[7] | -1.05[8] | -1.96[9] | -2.23[10] | -2.40[11] | -1.42[12] | |
3 | PRKAR1A | cAMP-dependent protein kinase type I-alpha regulatory subunit | [13] | 0.03[14] | 0.17[15] | 0.28[16] | -0.51[17] | -0.52[18] | 0.76[19] |
4 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | [20] | 0.97[21] | 1.00[22] | 0.48[23] | 0.87[24] | 0.75[25] | -1.06[26] |
5 | GNB2 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 | [27] | -0.65[28] | -0.88[29] | -0.59[30] | -0.78[31] | -0.64[32] | -1.43[33] |
6 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | -4.75[34] | -4.44[35] | -4.79[36] | -4.23[37] | -3.32[38] | -4.17[39] | |
7 | GNAI2 | Guanine nucleotide-binding protein G(i) subunit alpha-2 | [40] | 0.02[41] | -1.02[42] | -0.90[43] | -0.59[44] | 0.57[45] | -0.02[46] |
8 | GNG12 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 | -4.80[47] | -7.71[48] | 0.20[49] | 1.46[50] | 1.65[51] | 0.65[52] | |
9 | PRKACA | cAMP-dependent protein kinase catalytic subunit alpha | [53] | -0.21[54] | -0.37[55] | -0.41[56] | -0.89[57] | -0.21[58] | -0.61[59] |
10 | GNAI3 | Guanine nucleotide-binding protein G(k) subunit alpha | [60] | 0.08[61] | 0.64[62] | 0.70[63] | 0.69[64] | 0.41[65] | 0.40[66] |
11 | ADM | ADM | [67] | -0.13[68] | -0.80[69] | -1.47[70] | 0.24[71] | -0.16[72] | -0.64[73] |
12 | RAMP1 | Receptor activity-modifying protein 1 | [74] | -4.60[75] | -9.19[76] | -1.69[77] | -3.88[78] | -3.92[79] | 0.75[80] |
13 | PRKAR2A | cAMP-dependent protein kinase type II-alpha regulatory subunit | [81] | 0.01[82] | -0.29[83] | 0.77[84] | -0.70[85] | -0.75[86] | 0.32[87] |
14 | GNAI1 | Guanine nucleotide-binding protein G(i) subunit alpha-1 | [88] | -1.69[89] | -2.61[90] | -0.52[91] | 0.80[92] | 0.26[93] | 1.00[94] |
15 | PRKAR1B | cAMP-dependent protein kinase type I-beta regulatory subunit | [95] | 0.93[96] | 0.40[97] | -1.43[98] | -4.51[99] | -1.63[100] | 0.00[101] |
16 | CALCA | Calcitonin | [102] | [103] | [104] | -10.50[105] | [106] | -9.48[107] | -0.93[108] |
17 | GNB5 | Guanine nucleotide-binding protein subunit beta-5 | [109] | 0.05[110] | 0.11[111] | 1.09[112] | 0.37[113] | 0.58[114] | 1.06[115] |
18 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | [116] | -0.88[117] | -0.08[118] | 1.16[119] | 1.82[120] | 0.76[121] | 1.88[122] |
19 | ADCY9 | Adenylate cyclase type 9 | [123] | 2.57[124] | 1.78[125] | 2.16[126] | 0.54[127] | 0.17[128] | 2.58[129] |
20 | ADRB2 | Beta-2 adrenergic receptor | [130] | -7.56[131] | [132] | [133] | -3.81[134] | -4.35[135] | 0.38[136] |
21 | ADCY6 | Adenylate cyclase type 6 | [137] | 2.01[138] | 2.49[139] | 2.41[140] | 2.09[141] | 2.85[142] | 2.81[143] |
22 | CREB1 | Cyclic AMP-responsive element-binding protein 1 | [144] | 1.68[145] | 2.85[146] | 3.30[147] | 2.13[148] | 2.16[149] | 2.51[150] |
23 | GNAZ | Guanine nucleotide-binding protein G(z) subunit alpha | [151] | 1.85[152] | 2.33[153] | 1.57[154] | -2.42[155] | -1.90[156] | -3.14[157] |
24 | GNG11 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 | -8.23[158] | -8.21[159] | -7.56[160] | 1.85[161] | 3.26[162] | 2.40[163] | |
25 | IL6 | Interleukin-6 | [164] | -8.49[165] | [166] | -4.90[167] | -1.27[168] | 1.33[169] | [170] |
26 | ADM2 | ADM2 | [171] | 0.98[172] | 1.22[173] | 2.91[174] | -2.28[175] | -0.42[176] | 0.19[177] |
27 | GPR39 | G-protein coupled receptor 39 | [178] | -1.48[179] | -2.16[180] | -1.95[181] | -2.21[182] | -2.64[183] | 0.42[184] |
28 | ADORA2A | Adenosine receptor A2a | [185] | -0.62[186] | -0.14[187] | 1.54[188] | -1.02[189] | -2.74[190] | 1.37[191] |
29 | GPR176 | G-protein coupled receptor 176 | [192] | -3.13[193] | -4.12[194] | 0.72[195] | 2.20[196] | 3.13[197] | -0.42[198] |
30 | GNG7 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 | 1.51[199] | 1.18[200] | 1.94[201] | -2.65[202] | -1.94[203] | 0.19[204] | |
31 | POMC | Pro-opiomelanocortin | [205] | [206] | -8.39[207] | [208] | [209] | -7.45[210] | -2.02[211] |
32 | RAMP3 | Receptor activity-modifying protein 3 | [212] | [213] | [214] | [215] | -9.53[216] | [217] | 3.21[218] |
33 | ADCY1 | Adenylate cyclase type 1 | [219] | -0.88[220] | -2.73[221] | -2.98[222] | -2.52[223] | -2.45[224] | 5.16[225] |
34 | RAMP2 | Receptor activity-modifying protein 2 | [226] | -1.18[227] | -0.93[228] | 1.65[229] | -1.81[230] | -1.77[231] | 1.24[232] |
35 | GNG4 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 | 3.42[233] | 1.21[234] | 4.97[235] | 0.84[236] | -1.19[237] | -2.38[238] | |
36 | PRKX | cAMP-dependent protein kinase catalytic subunit PRKX | [239] | -1.69[240] | -1.90[241] | 2.98[242] | 0.84[243] | 2.46[244] | 1.61[245] |
37 | ADCY7 | Adenylate cyclase type 7 | [246] | 3.47[247] | 3.11[248] | 2.02[249] | 2.89[250] | 2.46[251] | 3.09[252] |
38 | GNB4 | Guanine nucleotide-binding protein subunit beta-4 | [253] | -0.41[254] | 0.10[255] | 1.06[256] | 2.26[257] | 5.09[258] | 4.26[259] |
39 | GNG2 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | -6.32[260] | -7.18[261] | [262] | 2.70[263] | 2.26[264] | 2.95[265] | |
40 | P2RY11 | P2Y purinoceptor 11 | [266] | -1.13[267] | -1.71[268] | -0.92[269] | -3.80[270] | -1.42[271] | -3.12[272] |
41 | ADORA2B | Adenosine receptor A2b | [273] | 4.06[274] | 3.85[275] | 1.41[276] | 2.11[277] | 3.08[278] | -1.04[279] |
42 | IAPP | Islet amyloid polypeptide | [280] | -1.93[281] | -1.20[282] | -1.07[283] | -2.33[284] | -2.16[285] | -1.29[286] |
43 | AVP | Vasopressin-neurophysin 2-copeptin | [287] | -4.10[288] | -1.64[289] | -2.11[290] | [291] | -7.88[292] | -0.89[293] |
44 | GPBAR1 | G-protein coupled bile acid receptor 1 | [294] | -3.25[295] | -3.53[296] | -4.11[297] | -3.69[298] | -3.68[299] | 1.75[300] |
45 | GNGT2 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 | [301] | [302] | [303] | -2.48[304] | -7.07[305] | 0.28[306] | |
46 | SCTR | Secretin receptor | [307] | -1.61[308] | 0.96[309] | 2.07[310] | -0.36[311] | -5.01[312] | 1.42[313] |
47 | PTGER2 | Prostaglandin E2 receptor EP2 subtype | [314] | [315] | [316] | 0.86[317] | 4.38[318] | 3.28[319] | 1.56[320] |
48 | GNG3 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 | -0.90[321] | 0.95[322] | -1.32[323] | -1.12[324] | -1.34[325] | 0.09[326] | |
49 | HTR7 | 5-hydroxytryptamine receptor 7 | [327] | -1.75[328] | -5.68[329] | -4.88[330] | -1.45[331] | 5.33[332] | 0.04[333] |
50 | PTGER4 | Prostaglandin E2 receptor EP4 subtype | [334] | -4.08[335] | -5.65[336] | 3.08[337] | 0.48[338] | -0.18[339] | 3.14[340] |
51 | PRKAR2B | cAMP-dependent protein kinase type II-beta regulatory subunit | [341] | -2.38[342] | -0.54[343] | 3.70[344] | 4.67[345] | 3.27[346] | 3.48[347] |
52 | ADCY3 | Adenylate cyclase type 3 | [348] | 1.41[349] | 0.19[350] | 3.47[351] | 4.32[352] | 5.94[353] | 3.69[354] |
53 | MC1R | Melanocyte-stimulating hormone receptor | [355] | 5.45[356] | 6.04[357] | 2.17[358] | 3.03[359] | 2.64[360] | 1.27[361] |
54 | CRHR1 | Corticotropin-releasing factor receptor 1 | [362] | [363] | -5.50[364] | -6.12[365] | [366] | [367] | [368] |
55 | GPHA2 | Glycoprotein hormone alpha-2 | [369] | 2.84[370] | 5.65[371] | -4.75[372] | [373] | [374] | -2.69[375] |
56 | GLP2R | Glucagon-like peptide 2 receptor | [376] | -1.60[377] | -3.54[378] | [379] | 2.85[380] | -0.54[381] | 1.42[382] |
57 | ADCY2 | Adenylate cyclase type 2 | [383] | -5.43[384] | -3.48[385] | -4.77[386] | -3.15[387] | -4.18[388] | -3.95[389] |
58 | CGA | Glycoprotein hormones alpha chain | [390] | [391] | [392] | -2.42[393] | -3.93[394] | -5.16[395] | -3.93[396] |
59 | PTHLH | Parathyroid hormone-related protein | [397] | 1.85[398] | 1.40[399] | -3.21[400] | 4.08[401] | 1.42[402] | [403] |
60 | VIPR1 | Vasoactive intestinal polypeptide receptor 1 | [404] | -0.01[405] | -0.67[406] | -0.50[407] | -2.82[408] | 3.42[409] | 6.85[410] |
61 | GNB3 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 | [411] | 1.54[412] | 3.82[413] | 3.07[414] | 0.59[415] | 3.39[416] | -1.51[417] |
62 | CALCRL | Calcitonin gene-related peptide type 1 receptor | [418] | -3.05[419] | -2.35[420] | -2.35[421] | 4.09[422] | 3.36[423] | 7.29[424] |
63 | PTGIR | Prostacyclin receptor | [425] | -1.04[426] | -4.06[427] | [428] | -0.97[429] | 3.48[430] | 5.02[431] |
64 | MC2R | Adrenocorticotropic hormone receptor | [432] | -0.23[433] | 0.28[434] | -0.39[435] | 0.07[436] | 0.14[437] | 2.73[438] |
65 | VIP | VIP peptides | [439] | -1.04[440] | -0.98[441] | [442] | -0.09[443] | -2.05[444] | 1.83[445] |
66 | GIPR | Gastric inhibitory polypeptide receptor | [446] | 1.38[447] | 2.30[448] | 4.14[449] | 1.76[450] | 1.44[451] | 0.42[452] |
67 | ADRB1 | Beta-1 adrenergic receptor | [453] | -4.12[454] | [455] | 2.23[456] | 0.11[457] | -2.83[458] | 2.34[459] |
68 | ADCY5 | Adenylate cyclase type 5 | [460] | 0.11[461] | 1.12[462] | 2.11[463] | 0.23[464] | 1.45[465] | 6.54[466] |
69 | TSHR | Thyrotropin receptor | [467] | [468] | -0.29[469] | -2.85[470] | -1.16[471] | -3.92[472] | 6.93[473] |
70 | GPR84 | G-protein coupled receptor 84 | [474] | -4.46[475] | -3.37[476] | -4.68[477] | -2.81[478] | -0.88[479] | -0.78[480] |
71 | ADCYAP1 | Pituitary adenylate cyclase-activating polypeptide | [481] | [482] | [483] | 1.10[484] | 2.61[485] | 1.68[486] | -1.02[487] |
72 | GPR83 | Probable G-protein coupled receptor 83 | [488] | 1.57[489] | 3.45[490] | 1.13[491] | -0.08[492] | 0.15[493] | 2.42[494] |
73 | DRD5 | D(1B) dopamine receptor | [495] | 2.15[496] | 0.16[497] | -0.94[498] | -3.07[499] | -3.08[500] | 0.64[501] |
74 | PTGDR | Prostaglandin D2 receptor | [502] | [503] | [504] | [505] | 1.35[506] | -0.24[507] | 4.62[508] |
75 | PTH1R | Parathyroid hormone/parathyroid hormone-related peptide receptor | -0.42[509] | [510] | -0.33[511] | -1.47[512] | 1.31[513] | 8.40[514] | |
76 | MC5R | Melanocortin receptor 5 | [515] | [516] | [517] | [518] | [519] | -3.36[520] | 0.44[521] |
77 | AVPR2 | Vasopressin V2 receptor | [522] | -0.02[523] | 0.37[524] | -4.00[525] | -0.04[526] | -2.91[527] | 2.31[528] |
78 | HRH2 | Histamine H2 receptor | [529] | 1.60[530] | 0.34[531] | -2.29[532] | 1.13[533] | -1.91[534] | 4.69[535] |
79 | CRHR2 | Corticotropin-releasing factor receptor 2 | [536] | -3.18[537] | [538] | 0.04[539] | -2.52[540] | -0.08[541] | 0.25[542] |
80 | GPR45 | Probable G-protein coupled receptor 45 | [543] | -1.69[544] | 0.25[545] | -0.19[546] | -0.47[547] | -2.83[548] | 3.86[549] |
81 | PTH2R | Parathyroid hormone 2 receptor | [550] | 1.38[551] | 0.26[552] | 10.37[553] | -0.38[554] | 0.53[555] | 2.69[556] |
82 | CYSLTR2 | Cysteinyl leukotriene receptor 2 | [557] | [558] | -1.42[559] | [560] | -2.65[561] | -1.51[562] | 2.61[563] |
83 | ADCYAP1 | Pituitary adenylate cyclase-activating polypeptide type I receptor | [564] | -0.66[565] | [566] | -2.46[567] | 1.93[568] | [569] | 5.66[570] |
84 | VIPR2 | Vasoactive intestinal polypeptide receptor 2 | [571] | -0.37[572] | 1.67[573] | 1.17[574] | 5.39[575] | 1.43[576] | 4.74[577] |
85 | HTR4 | 5-hydroxytryptamine receptor 4 | [578] | -2.37[579] | [580] | [581] | [582] | -0.51[583] | 5.05[584] |
86 | ADCY4 | Adenylate cyclase type 4 | [585] | 0.04[586] | -1.01[587] | 1.59[588] | [589] | [590] | 8.54[591] |
87 | NPS | Neuropeptide S | [592] | [593] | [594] | [595] | [596] | [597] | [598] |
88 | FSHR | Follicle-stimulating hormone receptor | [599] | [600] | [601] | [602] | [603] | [604] | [605] |
89 | MC4R | Melanocortin receptor 4 | [606] | [607] | [608] | [609] | [610] | [611] | [612] |
90 | NPSR1 | Neuropeptide S receptor | [613] | [614] | [615] | [616] | [617] | [618] | [619] |
91 | GPR150 | Probable G-protein coupled receptor 150 | [620] | [621] | [622] | [623] | [624] | [625] | [626] |
92 | GPR25 | Probable G-protein coupled receptor 25 | [627] | [628] | [629] | [630] | [631] | [632] | [633] |
93 | GCG | Glucagon | [634] | [635] | [636] | [637] | [638] | [639] | [640] |
94 | TAAR5 | Trace amine-associated receptor 5 | [641] | [642] | [643] | [644] | [645] | [646] | [647] |
95 | GPR15 | G-protein coupled receptor 15 | [648] | [649] | [650] | [651] | [652] | [653] | [654] |
96 | TAAR8 | Trace amine-associated receptor 8 | [655] | [656] | [657] | [658] | [659] | [660] | [661] |
97 | GPR32 | Probable G-protein coupled receptor 32 | [662] | [663] | [664] | [665] | [666] | [667] | [668] |
98 | CALCB | Calcitonin gene-related peptide 2 | [669] | [670] | [671] | [672] | [673] | [674] | [675] |
99 | GHRH | Somatoliberin | [676] | [677] | [678] | [679] | [680] | [681] | [682] |
100 | LHCGR | Lutropin-choriogonadotropic hormone receptor | [683] | [684] | [685] | [686] | [687] | [688] | [689] |
101 | RLN3 | Relaxin-3 | [690] | [691] | [692] | [693] | [694] | [695] | [696] |
102 | PRKACG | cAMP-dependent protein kinase catalytic subunit gamma | [697] | [698] | [699] | [700] | [701] | [702] | [703] |
103 | ADRB3 | Beta-3 adrenergic receptor | [704] | [705] | [706] | [707] | [708] | [709] | [710] |
104 | FSHB | Follitropin subunit beta | [711] | [712] | [713] | [714] | [715] | [716] | [717] |
105 | INSL3 | Insulin-like 3 | [718] | [719] | [720] | [721] | [722] | [723] | [724] |
106 | GNAT3 | Guanine nucleotide-binding protein G(t) subunit alpha-3 | [725] | [726] | [727] | [728] | [729] | [730] | [731] |
107 | PTH | Parathyroid hormone | [732] | [733] | [734] | [735] | [736] | [737] | [738] |
108 | GIP | Gastric inhibitory polypeptide | [739] | [740] | [741] | [742] | [743] | [744] | [745] |
109 | TSHB | Thyrotropin subunit beta | [746] | [747] | [748] | [749] | [750] | [751] | [752] |
110 | TAAR6 | Trace amine-associated receptor 6 | [753] | [754] | [755] | [756] | [757] | [758] | [759] |
111 | SCT | Secretin | [760] | [761] | [762] | [763] | [764] | [765] | [766] |
112 | PTH2 | Tuberoinfundibular peptide of 39 residues | [767] | [768] | [769] | [770] | [771] | [772] | [773] |
113 | GLP1R | Glucagon-like peptide 1 receptor | [774] | [775] | [776] | [777] | [778] | [779] | [780] |
114 | LHB | Lutropin subunit beta | [781] | [782] | [783] | [784] | [785] | [786] | [787] |
115 | MC3R | Melanocortin receptor 3 | [788] | [789] | [790] | [791] | [792] | [793] | [794] |
116 | GNGT1 | Guanine nucleotide-binding protein G(T) subunit gamma-T1 | [795] | [796] | [797] | [798] | [799] | [800] | [801] |
117 | RLN2 | Prorelaxin H2 | [802] | [803] | [804] | [805] | [806] | [807] | [808] |
118 | RXFP2 | Relaxin receptor 2 | [809] | [810] | [811] | [812] | [813] | [814] | [815] |
119 | GHRHR | Growth hormone-releasing hormone receptor | [816] | [817] | [818] | [819] | [820] | [821] | [822] |
120 | ADCY8 | Adenylate cyclase type 8 | [823] | [824] | [825] | [826] | [827] | [828] | [829] |
121 | GNG13 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 | [830] | [831] | [832] | [833] | [834] | [835] | |
122 | TAAR1 | Trace amine-associated receptor 1 | [836] | [837] | [838] | [839] | [840] | [841] | [842] |
123 | CRH | Corticoliberin | [843] | [844] | [845] | [846] | [847] | [848] | [849] |
124 | TAAR9 | Trace amine-associated receptor 9 | [850] | [851] | [852] | [853] | [854] | [855] | [856] |
125 | HTR6 | 5-hydroxytryptamine receptor 6 | [857] | [858] | [859] | [860] | [861] | [862] | [863] |
126 | GNG8 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 | [864] | [865] | [866] | [867] | [868] | [869] | |
127 | CALCR | Calcitonin receptor | [870] | [871] | [872] | [873] | [874] | [875] | [876] |
128 | GPHB5 | Glycoprotein hormone beta-5 | [877] | [878] | [879] | [880] | [881] | [882] | [883] |
129 | GPR27 | Probable G-protein coupled receptor 27 | [884] | [885] | [886] | [887] | [888] | [889] | [890] |
130 | RXFP1 | Relaxin receptor 1 | [891] | [892] | [893] | [894] | [895] | [896] | [897] |
131 | DRD1 | D(1A) dopamine receptor | [898] | [899] | [900] | [901] | [902] | [903] | [904] |
132 | TAAR2 | Trace amine-associated receptor 2 | [905] | [906] | [907] | [908] | [909] | [910] | [911] |
133 | GPR20 | G-protein coupled receptor 20 | [912] | [913] | [914] | [915] | [916] | [917] | [918] |