REACTOME_ADENYLATE_CYCLASE_INHIBITORY_PATHWAY Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 GNAI2 Guanine nucleotide-binding protein G(i) subunit alpha-2 [1] -0.41[2] -1.15[3] -1.18[4] -0.92[5] -0.20[6] -1.15[7]
2 GNAI3 Guanine nucleotide-binding protein G(k) subunit alpha [8] -0.35[9] 0.51[10] 0.42[11] 0.36[12] -0.37[13] -0.73[14]
3 GNAI1 Guanine nucleotide-binding protein G(i) subunit alpha-1 [15] -2.12[16] -2.75[17] -0.80[18] 0.47[19] -0.51[20] -0.13[21]
4 ADCY9 Adenylate cyclase type 9 [22] 2.14[23] 1.65[24] 1.88[25] 0.21[26] -0.60[27] 1.45[28]
5 ADCY6 Adenylate cyclase type 6 [29] 1.58[30] 2.35[31] 2.13[32] 1.76[33] 2.07[34] 1.68[35]
6 ADCY1 Adenylate cyclase type 1 [36] -1.31[37] -2.86[38] -3.25[39] -2.86[40] -3.23[41] 4.03[42]
7 ADCY7 Adenylate cyclase type 7 [43] 3.04[44] 2.98[45] 1.74[46] 2.56[47] 1.68[48] 1.96[49]
8 GNAL Guanine nucleotide-binding protein G(olf) subunit alpha [50] 1.37[51] 2.49[52] 2.57[53] 1.36[54] 0.97[55] 1.58[56]
9 ADCY3 Adenylate cyclase type 3 [57] 0.99[58] 0.06[59] 3.19[60] 3.99[61] 5.17[62] 2.56[63]
10 ADCY2 Adenylate cyclase type 2 [64] -5.86[65] -3.61[66] -5.05[67] -3.48[68] -4.96[69] -5.08[70]
11 ADCY5 Adenylate cyclase type 5 [71] -0.32[72] 0.99[73] 1.83[74] -0.10[75] 0.67[76] 5.41[77]
12 ADCY4 Adenylate cyclase type 4 [78] -0.38[79] -1.14[80] 1.31[81] [82] [83] 7.41[84]
13 GNAT3 Guanine nucleotide-binding protein G(t) subunit alpha-3 [85] [86] [87] [88] [89] [90] [91]
14 ADCY8 Adenylate cyclase type 8 [92] [93] [94] [95] [96] [97] [98]
[1]
ref_hepatocyte GNAI2
Mean 32.9
Standard deviation 13
Values 10 31 41 40 42
[2]
HepG2 GNAI2
Mean 76.1
Standard deviation 11
Values 68 84
[3]
HepG2.C3A GNAI2
Mean 32.5
Standard deviation 8.6
Values 26 39
[4]
HuH.7 GNAI2
Mean 34.9
Standard deviation 7.6
Values 41 26 37
[5]
SNU475 GNAI2
Mean 53.7
Standard deviation 11
Values 62 46
[6]
THLE GNAI2
Mean 126
Standard deviation 19
Values 1.1e+02 1.4e+02
[7]
liver GNAI2
Mean 40.9
Standard deviation 20
Values 61 27 54 21
[8]
ref_hepatocyte GNAI3
Mean 15.6
Standard deviation 11
Values 15 35 11 6.9 10
[9]
HepG2 GNAI3
Mean 37.5
Standard deviation 8.9
Values 31 44
[10]
HepG2.C3A GNAI3
Mean 48.7
Standard deviation 8.6
Values 43 55
[11]
HuH.7 GNAI3
Mean 50
Standard deviation 3.6
Values 54 47 49
[12]
SNU475 GNAI3
Mean 61.5
Standard deviation 5.4
Values 65 58
[13]
THLE GNAI3
Mean 53.3
Standard deviation 7.7
Values 48 59
[14]
liver GNAI3
Mean 26
Standard deviation 3.5
Values 26 25 31 23
[15]
ref_hepatocyte GNAI1
Mean 6.48
Standard deviation 1.5
Values 6.5 8.9 6.3 4.7 6
[16]
HepG2 GNAI1
Mean 4.56
Standard deviation 1
Values 5.3 3.9
[17]
HepG2.C3A GNAI1
Mean 2.12
Standard deviation 0.54
Values 1.7 2.5
[18]
HuH.7 GNAI1
Mean 8.95
Standard deviation 1.2
Values 9.3 7.6 10
[19]
SNU475 GNAI1
Mean 27.6
Standard deviation 3.4
Values 30 25
[20]
THLE GNAI1
Mean 20
Standard deviation 0.41
Values 20 20
[21]
liver GNAI1
Mean 16.4
Standard deviation 11
Values 32 8.4 17 9
[22]
ref_hepatocyte ADCY9
Mean 2.69
Standard deviation 0.67
Values 3.5 2.2 1.8 3 2.9
[23]
HepG2 ADCY9
Mean 36.5
Standard deviation 7.3
Values 42 31
[24]
HepG2.C3A ADCY9
Mean 18.5
Standard deviation 4.9
Values 22 15
[25]
HuH.7 ADCY9
Mean 23.8
Standard deviation 5.7
Values 28 26 17
[26]
SNU475 ADCY9
Mean 9.58
Standard deviation 2.4
Values 11 7.9
[27]
THLE ADCY9
Mean 7.83
Standard deviation 1.4
Values 6.8 8.8
[28]
liver ADCY9
Mean 20.3
Standard deviation 12
Values 11 26 9.7 34
[29]
ref_hepatocyte ADCY6
Mean 1.84
Standard deviation 0.33
Values 1.7 2.4 1.9 1.8 1.5
[30]
HepG2 ADCY6
Mean 16.9
Standard deviation 1.2
Values 16 18
[31]
HepG2.C3A ADCY6
Mean 20.7
Standard deviation 1.1
Values 21 20
[32]
HuH.7 ADCY6
Mean 19.3
Standard deviation 0.93
Values 18 20 20
[33]
SNU475 ADCY6
Mean 19.2
Standard deviation 5.6
Values 23 15
[34]
THLE ADCY6
Mean 34.3
Standard deviation 2.1
Values 36 33
[35]
liver ADCY6
Mean 16.3
Standard deviation 9.4
Values 10 21 6.9 27
[36]
ref_hepatocyte ADCY1
Mean 0.753
Standard deviation 0.8
Values 0.18 0.11 0.22 1.6 1.6
[37]
HepG2 ADCY1
Mean 0.932
Standard deviation 0.17
Values 1 0.82
[38]
HepG2.C3A ADCY1
Mean 0.227
Standard deviation 0.064
Values 0.27 0.18
[39]
HuH.7 ADCY1
Mean 0.189
Standard deviation 0.063
Values 0.18 0.26 0.13
[40]
SNU475 ADCY1
Mean 0.321
Standard deviation 0.11
Values 0.25 0.4
[41]
THLE ADCY1
Mean 0.355
Standard deviation 0.017
Values 0.34 0.37
[42]
liver ADCY1
Mean 34
Standard deviation 27
Values 8 57 14 57
[43]
ref_hepatocyte ADCY7
Mean 0.512
Standard deviation 0.32
Values 0.68 0.13 0.92 0.28 0.54
[44]
HepG2 ADCY7
Mean 12.9
Standard deviation 4.7
Values 16 9.6
[45]
HepG2.C3A ADCY7
Mean 8.84
Standard deviation 0.22
Values 8.7 9
[46]
HuH.7 ADCY7
Mean 4.11
Standard deviation 0.66
Values 4.9 3.6 3.9
[47]
SNU475 ADCY7
Mean 9.31
Standard deviation 2.3
Values 11 7.7
[48]
THLE ADCY7
Mean 7.26
Standard deviation 0.034
Values 7.3 7.2
[49]
liver ADCY7
Mean 5.51
Standard deviation 3.3
Values 2.4 7.3 3.2 9.2
[50]
ref_hepatocyte GNAL
Mean 0.186
Standard deviation 0.15
Values 0.066 0.11 0.45 0.2 0.11
[51]
HepG2 GNAL
Mean 1.47
Standard deviation 0.091
Values 1.5 1.4
[52]
HepG2.C3A GNAL
Mean 2.29
Standard deviation 0.072
Values 2.2 2.3
[53]
HuH.7 GNAL
Mean 2.65
Standard deviation 1
Values 1.8 3.8 2.3
[54]
SNU475 GNAL
Mean 1.47
Standard deviation 0.14
Values 1.6 1.4
[55]
THLE GNAL
Mean 1.61
Standard deviation 0.089
Values 1.6 1.7
[56]
liver GNAL
Mean 1.54
Standard deviation 0.3
Values 1.6 1.8 1.1 1.7
[57]
ref_hepatocyte ADCY3
Mean 0.12
Standard deviation 0.15
Values 0 0.11 0.38 0 0.11
[58]
HepG2 ADCY3
Mean 0.726
Standard deviation 0.55
Values 1.1 0.33
[59]
HepG2.C3A ADCY3
Mean 0.273
Standard deviation 0.084
Values 0.21 0.33
[60]
HuH.7 ADCY3
Mean 2.63
Standard deviation 1.3
Values 3.5 1.1 3.3
[61]
SNU475 ADCY3
Mean 5.86
Standard deviation 0.44
Values 5.5 6.2
[62]
THLE ADCY3
Mean 19
Standard deviation 3
Values 17 21
[63]
liver ADCY3
Mean 1.94
Standard deviation 1.2
Values 1.1 2.4 0.82 3.5
[64]
ref_hepatocyte ADCY2
Mean 0.081
Standard deviation 0.073
Values 0.061 0.016 0.2 0.043 0.081
[65]
HepG2 ADCY2
Mean 0.00429
Standard deviation 0.0061
Values 0 0.0086
[66]
HepG2.C3A ADCY2
Mean 0.0146
Standard deviation 0.021
Values 0.029 0
[67]
HuH.7 ADCY2
Mean 0.00586
Standard deviation 0.0051
Values 0.0082 0 0.0094
[68]
SNU475 ADCY2
Mean 0.0224
Standard deviation 0.019
Values 0.0093 0.035
[69]
THLE ADCY2
Mean 0.0115
Standard deviation 0.0088
Values 0.018 0.0053
[70]
liver ADCY2
Mean 0.00662
Standard deviation 0.013
Values 0 0 0 0.026
[71]
ref_hepatocyte ADCY5
Mean 0.0321
Standard deviation 0.047
Values 0 0 0 0.1 0.057
[72]
HepG2 ADCY5
Mean 0.0787
Standard deviation 0.022
Values 0.063 0.094
[73]
HepG2.C3A ADCY5
Mean 0.14
Standard deviation 0.077
Values 0.19 0.086
[74]
HuH.7 ADCY5
Mean 0.274
Standard deviation 0.063
Values 0.21 0.29 0.33
[75]
SNU475 ADCY5
Mean 0.0925
Standard deviation 0.091
Values 0.028 0.16
[76]
THLE ADCY5
Mean 0.226
Standard deviation 0.12
Values 0.31 0.14
[77]
liver ADCY5
Mean 3.77
Standard deviation 2.2
Values 2.5 3.4 2.3 6.9
[78]
ref_hepatocyte ADCY4
Mean 0.00488
Standard deviation 0.011
Values 0 0 0 0 0.024
[79]
HepG2 ADCY4
Mean 0.0115
Standard deviation 0.016
Values 0.023 0
[80]
HepG2.C3A ADCY4
Mean 0.00486
Standard deviation 0.0069
Values 0.0097 0
[81]
HuH.7 ADCY4
Mean 0.0291
Standard deviation 0.017
Values 0.049 0.019 0.019
[82]
SNU475 ADCY4
Mean 0
Standard deviation 0
Values 0 0
[83]
THLE ADCY4
Mean 0
Standard deviation 0
Values 0 0
[84]
liver ADCY4
Mean 2.29
Standard deviation 1.7
Values 4.6 0.78 1.5 2.3
[85]
ref_hepatocyte GNAT3
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[86]
HepG2 GNAT3
Mean 0
Standard deviation 0
Values 0 0
[87]
HepG2.C3A GNAT3
Mean 0
Standard deviation 0
Values 0 0
[88]
HuH.7 GNAT3
Mean 0
Standard deviation 0
Values 0 0 0
[89]
SNU475 GNAT3
Mean 0.0287
Standard deviation 0.012
Values 0.037 0.02
[90]
THLE GNAT3
Mean 0
Standard deviation 0
Values 0 0
[91]
liver GNAT3
Mean 0
Standard deviation 0
Values 0 0 0 0
[92]
ref_hepatocyte ADCY8
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[93]
HepG2 ADCY8
Mean 0.00573
Standard deviation 0.0081
Values 0.011 0
[94]
HepG2.C3A ADCY8
Mean 0
Standard deviation 0
Values 0 0
[95]
HuH.7 ADCY8
Mean 0
Standard deviation 0
Values 0 0 0
[96]
SNU475 ADCY8
Mean 0.0198
Standard deviation 0.015
Values 0.0093 0.03
[97]
THLE ADCY8
Mean 0.0937
Standard deviation 0.035
Values 0.12 0.069
[98]
liver ADCY8
Mean 0.0332
Standard deviation 0.041
Values 0 0.014 0.026 0.093