REACTOME_ACTIVATION_OF_SMO Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 CSNK1A1 Casein kinase I isoform alpha [1] -0.42[2] -0.48[3] -0.77[4] -0.22[5] -0.23[6] 0.04[7]
2 ARRB2 Beta-arrestin-2 [8] -0.59[9] -0.26[10] -0.36[11] -2.37[12] -1.67[13] -1.53[14]
3 SMO Smoothened homolog [15] 0.41[16] 0.74[17] 0.83[18] 0.09[19] -0.73[20] -0.40[21]
4 GAS8 Growth arrest-specific protein 8 [22] -0.45[23] -0.14[24] -0.69[25] -1.45[26] -1.75[27] -1.34[28]
5 KIF3A Kinesin-like protein KIF3A [29] -0.11[30] 0.87[31] -0.27[32] 1.08[33] 0.70[34] -0.28[35]
6 SHH Sonic hedgehog protein [36] -0.38[37] -0.58[38] -0.56[39] -8.23[40] -8.48[41] -0.52[42]
7 IQCE IQ domain-containing protein E [43] 0.93[44] -0.81[45] 1.89[46] 0.57[47] 1.49[48] 1.24[49]
8 EFCAB7 EF-hand calcium-binding domain-containing protein 7 [50] -0.86[51] 0.17[52] 0.03[53] 0.50[54] 0.31[55] -0.26[56]
9 ARRB1 Beta-arrestin-1 [57] 2.82[58] 2.58[59] 1.82[60] 1.10[61] 0.80[62] 2.62[63]
10 CDON Cell adhesion molecule-related/down-regulated by oncogenes [64] 2.34[65] 1.74[66] 1.49[67] 3.21[68] 1.50[69] 1.64[70]
11 EVC Ellis-van Creveld syndrome protein [71] 1.89[72] -1.13[73] -5.19[74] 3.42[75] 3.85[76] 1.90[77]
12 PTCH1 Protein patched homolog 1 [78] 1.88[79] 2.07[80] 3.37[81] 2.27[82] 1.51[83] 2.19[84]
13 IHH Indian hedgehog protein [85] 0.30[86] -1.70[87] 4.05[88] -5.35[89] -6.32[90] -0.56[91]
14 GAS1 Growth arrest-specific protein 1 [92] -5.37[93] [94] -4.98[95] -0.08[96] 4.86[97] 1.52[98]
15 EVC2 Limbin [99] -3.71[100] -2.69[101] -3.47[102] 3.43[103] 6.77[104] 5.08[105]
16 BOC Brother of CDO [106] 0.76[107] [108] -1.28[109] 6.71[110] 4.39[111] 3.90[112]
17 DHH Desert hedgehog protein [113] [114] [115] [116] [117] [118] [119]
18 GRK2 Beta-adrenergic receptor kinase 1 [120] [121] [122] [123] [124] [125] [126]
[1]
ref_hepatocyte CSNK1A1
Mean 20.7
Standard deviation 9.8
Values 20 24 35 10 14
[2]
HepG2 CSNK1A1
Mean 57.9
Standard deviation 0.1
Values 58 58
[3]
HepG2.C3A CSNK1A1
Mean 51.1
Standard deviation 2
Values 50 53
[4]
HuH.7 CSNK1A1
Mean 41.8
Standard deviation 2.9
Values 45 39 41
[5]
SNU475 CSNK1A1
Mean 67.7
Standard deviation 7.6
Values 73 62
[6]
THLE CSNK1A1
Mean 81.2
Standard deviation 5.1
Values 78 85
[7]
liver CSNK1A1
Mean 47.5
Standard deviation 6.3
Values 41 56 47 47
[8]
ref_hepatocyte ARRB2
Mean 7.58
Standard deviation 4.1
Values 14 4.4 3.6 8.2 7.8
[9]
HepG2 ARRB2
Mean 18.8
Standard deviation 5.4
Values 23 15
[10]
HepG2.C3A ARRB2
Mean 21.9
Standard deviation 3.9
Values 25 19
[11]
HuH.7 ARRB2
Mean 20.3
Standard deviation 3.2
Values 20 17 23
[12]
SNU475 ARRB2
Mean 5.59
Standard deviation 0.33
Values 5.4 5.8
[13]
THLE ARRB2
Mean 10.9
Standard deviation 0.23
Values 11 11
[14]
liver ARRB2
Mean 5.88
Standard deviation 3.8
Values 9.3 2.5 9.1 2.6
[15]
ref_hepatocyte SMO
Mean 3.57
Standard deviation 2.2
Values 5.2 1.6 1.1 3.9 6
[16]
HepG2 SMO
Mean 17.8
Standard deviation 4.5
Values 15 21
[17]
HepG2.C3A SMO
Mean 20.5
Standard deviation 5.7
Values 25 16
[18]
HuH.7 SMO
Mean 21.9
Standard deviation 2.6
Values 24 19 23
[19]
SNU475 SMO
Mean 14.5
Standard deviation 3.9
Values 17 12
[20]
THLE SMO
Mean 9.89
Standard deviation 1.3
Values 9 11
[21]
liver SMO
Mean 6.03
Standard deviation 3.6
Values 5 5.8 2.3 11
[22]
ref_hepatocyte GAS8
Mean 3.06
Standard deviation 0.88
Values 4.2 3.8 2.8 2.2 2.3
[23]
HepG2 GAS8
Mean 8.36
Standard deviation 0.75
Values 8.9 7.8
[24]
HepG2.C3A GAS8
Mean 9.56
Standard deviation 1.2
Values 10 8.7
[25]
HuH.7 GAS8
Mean 6.56
Standard deviation 1.6
Values 6.6 5 8.1
[26]
SNU475 GAS8
Mean 4.28
Standard deviation 0.29
Values 4.5 4.1
[27]
THLE GAS8
Mean 4.19
Standard deviation 0.6
Values 4.6 3.8
[28]
liver GAS8
Mean 2.7
Standard deviation 0.66
Values 2.7 2.5 3.6 2
[29]
ref_hepatocyte KIF3A
Mean 1.18
Standard deviation 1.1
Values 2.7 1.9 0.74 0.33 0.24
[30]
HepG2 KIF3A
Mean 4.09
Standard deviation 0.63
Values 3.6 4.5
[31]
HepG2.C3A KIF3A
Mean 7.45
Standard deviation 0.61
Values 7.9 7
[32]
HuH.7 KIF3A
Mean 3.38
Standard deviation 0.57
Values 4 3 3.1
[33]
SNU475 KIF3A
Mean 9.52
Standard deviation 1.3
Values 10 8.6
[34]
THLE KIF3A
Mean 8.85
Standard deviation 1.2
Values 9.7 8
[35]
liver KIF3A
Mean 2.19
Standard deviation 0.84
Values 1.5 2.7 3.1 1.4
[36]
ref_hepatocyte SHH
Mean 1.15
Standard deviation 1
Values 0.23 0 2.5 1.4 1.6
[37]
HepG2 SHH
Mean 3.31
Standard deviation 2.1
Values 4.8 1.8
[38]
HepG2.C3A SHH
Mean 2.66
Standard deviation 0.92
Values 3.3 2
[39]
HuH.7 SHH
Mean 2.69
Standard deviation 0.5
Values 2.5 3.3 2.3
[40]
SNU475 SHH
Mean 0.0146
Standard deviation 0.00091
Values 0.014 0.015
[41]
THLE SHH
Mean 0.0148
Standard deviation 0.021
Values 0.03 0
[42]
liver SHH
Mean 1.79
Standard deviation 2.1
Values 0.12 2.9 0 4.1
[43]
ref_hepatocyte IQCE
Mean 0.7
Standard deviation 0.43
Values 0.67 1.4 0.67 0.52 0.24
[44]
HepG2 IQCE
Mean 4.97
Standard deviation 0.95
Values 5.6 4.3
[45]
HepG2.C3A IQCE
Mean 1.37
Standard deviation 0.013
Values 1.4 1.4
[46]
HuH.7 IQCE
Mean 8.95
Standard deviation 2
Values 11 6.8 9.4
[47]
SNU475 IQCE
Mean 3.96
Standard deviation 0.22
Values 4.1 3.8
[48]
THLE IQCE
Mean 9.06
Standard deviation 0.94
Values 8.4 9.7
[49]
liver IQCE
Mean 3.71
Standard deviation 1.6
Values 2.4 4.7 2.3 5.4
[50]
ref_hepatocyte EFCAB7
Mean 0.668
Standard deviation 0.69
Values 1.7 0.94 0 0.24 0.41
[51]
HepG2 EFCAB7
Mean 1.37
Standard deviation 0.35
Values 1.1 1.6
[52]
HepG2.C3A EFCAB7
Mean 2.58
Standard deviation 0.97
Values 1.9 3.3
[53]
HuH.7 EFCAB7
Mean 2.35
Standard deviation 0.43
Values 2.3 2 2.8
[54]
SNU475 EFCAB7
Mean 3.6
Standard deviation 0.22
Values 3.5 3.8
[55]
THLE EFCAB7
Mean 3.81
Standard deviation 0.93
Values 4.5 3.2
[56]
liver EFCAB7
Mean 1.25
Standard deviation 0.23
Values 1.3 1.3 1.5 0.94
[57]
ref_hepatocyte ARRB1
Mean 0.644
Standard deviation 0.19
Values 0.65 0.54 0.92 0.69 0.41
[58]
HepG2 ARRB1
Mean 17.1
Standard deviation 1.4
Values 18 16
[59]
HepG2.C3A ARRB1
Mean 13.3
Standard deviation 2.1
Values 15 12
[60]
HuH.7 ARRB1
Mean 7.82
Standard deviation 0.6
Values 7.8 8.4 7.3
[61]
SNU475 ARRB1
Mean 5.26
Standard deviation 0.39
Values 5.5 5
[62]
THLE ARRB1
Mean 5.15
Standard deviation 0.95
Values 4.5 5.8
[63]
liver ARRB1
Mean 8.83
Standard deviation 5.7
Values 5 11 3.6 16
[64]
ref_hepatocyte CDON
Mean 0.452
Standard deviation 0.47
Values 1.3 0.26 0.36 0.16 0.19
[65]
HepG2 CDON
Mean 8.54
Standard deviation 0.057
Values 8.5 8.6
[66]
HepG2.C3A CDON
Mean 5.21
Standard deviation 0.24
Values 5.4 5
[67]
HuH.7 CDON
Mean 4.38
Standard deviation 1.8
Values 4 6.4 2.8
[68]
SNU475 CDON
Mean 16
Standard deviation 6.6
Values 21 11
[69]
THLE CDON
Mean 5.88
Standard deviation 0.097
Values 5.8 6
[70]
liver CDON
Mean 3.14
Standard deviation 2.4
Values 1.6 3.4 1.1 6.5
[71]
ref_hepatocyte EVC
Mean 0.392
Standard deviation 0.37
Values 1 0.47 0.24 0.086 0.16
[72]
HepG2 EVC
Mean 5.41
Standard deviation 1.7
Values 4.2 6.6
[73]
HepG2.C3A EVC
Mean 0.619
Standard deviation 0.05
Values 0.58 0.65
[74]
HuH.7 EVC
Mean 0.037
Standard deviation 0.02
Values 0.016 0.039 0.056
[75]
SNU475 EVC
Mean 16
Standard deviation 7.3
Values 21 11
[76]
THLE EVC
Mean 26
Standard deviation 10
Values 19 33
[77]
liver EVC
Mean 3.27
Standard deviation 1.9
Values 2 5.6 1.4 4.1
[78]
ref_hepatocyte PTCH1
Mean 0.253
Standard deviation 0.18
Values 0.17 0.14 0.51 0.078 0.37
[79]
HepG2 PTCH1
Mean 3.48
Standard deviation 2.7
Values 5.4 1.6
[80]
HepG2.C3A PTCH1
Mean 3.66
Standard deviation 0.94
Values 4.3 3
[81]
HuH.7 PTCH1
Mean 9.01
Standard deviation 1
Values 10 9 7.9
[82]
SNU475 PTCH1
Mean 4.67
Standard deviation 0.47
Values 4.3 5
[83]
THLE PTCH1
Mean 3.31
Standard deviation 0.69
Values 2.8 3.8
[84]
liver PTCH1
Mean 2.58
Standard deviation 0.39
Values 2.9 2 2.8 2.6
[85]
ref_hepatocyte IHH
Mean 0.19
Standard deviation 0.27
Values 0 0.054 0 0.28 0.62
[86]
HepG2 IHH
Mean 0.871
Standard deviation 0.39
Values 0.6 1.1
[87]
HepG2.C3A IHH
Mean 0.201
Standard deviation 0.05
Values 0.17 0.24
[88]
HuH.7 IHH
Mean 10.8
Standard deviation 0.98
Values 9.7 11 11
[89]
SNU475 IHH
Mean 0.0177
Standard deviation 0.025
Values 0 0.035
[90]
THLE IHH
Mean 0.0109
Standard deviation 0.0071
Values 0.0059 0.016
[91]
liver IHH
Mean 0.288
Standard deviation 0.17
Values 0.49 0.17 0.13 0.36
[92]
ref_hepatocyte GAS1
Mean 0.0949
Standard deviation 0.1
Values 0 0 0.13 0.095 0.25
[93]
HepG2 GAS1
Mean 0.0086
Standard deviation 0.012
Values 0.017 0
[94]
HepG2.C3A GAS1
Mean 0
Standard deviation 0
Values 0 0
[95]
HuH.7 GAS1
Mean 0.0103
Standard deviation 0.013
Values 0.025 0.0064 0
[96]
SNU475 GAS1
Mean 0.343
Standard deviation 0.21
Values 0.19 0.49
[97]
THLE GAS1
Mean 12.6
Standard deviation 3.4
Values 10 15
[98]
liver GAS1
Mean 0.608
Standard deviation 0.22
Values 0.63 0.83 0.31 0.66
[99]
ref_hepatocyte EVC2
Mean 0.0101
Standard deviation 0.014
Values 0 0.026 0 0 0.024
[100]
HepG2 EVC2
Mean 0.00287
Standard deviation 0.0041
Values 0.0057 0
[101]
HepG2.C3A EVC2
Mean 0.00536
Standard deviation 0.0076
Values 0 0.011
[102]
HuH.7 EVC2
Mean 0.00312
Standard deviation 0.0054
Values 0 0 0.0094
[103]
SNU475 EVC2
Mean 0.413
Standard deviation 0.2
Values 0.27 0.56
[104]
THLE EVC2
Mean 5.05
Standard deviation 0.92
Values 4.4 5.7
[105]
liver EVC2
Mean 0.759
Standard deviation 0.45
Values 0.54 1.3 0.26 0.95
[106]
ref_hepatocyte BOC
Mean 0.00813
Standard deviation 0.018
Values 0 0 0 0 0.041
[107]
HepG2 BOC
Mean 0.0516
Standard deviation 0.049
Values 0.086 0.017
[108]
HepG2.C3A BOC
Mean 0
Standard deviation 0
Values 0 0
[109]
HuH.7 BOC
Mean 0.0115
Standard deviation 0.015
Values 0 0.0064 0.028
[110]
SNU475 BOC
Mean 3.24
Standard deviation 0.38
Values 3.5 3
[111]
THLE BOC
Mean 0.781
Standard deviation 0.13
Values 0.88 0.69
[112]
liver BOC
Mean 0.271
Standard deviation 0.4
Values 0.024 0.071 0.13 0.86
[113]
ref_hepatocyte DHH
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[114]
HepG2 DHH
Mean 0.00716
Standard deviation 0.002
Values 0.0057 0.0086
[115]
HepG2.C3A DHH
Mean 0.00972
Standard deviation 0.014
Values 0.019 0
[116]
HuH.7 DHH
Mean 0.00214
Standard deviation 0.0037
Values 0 0.0064 0
[117]
SNU475 DHH
Mean 0.00696
Standard deviation 0.0098
Values 0.014 0
[118]
THLE DHH
Mean 0.0225
Standard deviation 0.0017
Values 0.024 0.021
[119]
liver DHH
Mean 0.03
Standard deviation 0.051
Values 0 0.014 0 0.11
[120]
ref_hepatocyte GRK2
Missing
[121]
HepG2 GRK2
Missing
[122]
HepG2.C3A GRK2
Missing
[123]
HuH.7 GRK2
Missing
[124]
SNU475 GRK2
Missing
[125]
THLE GRK2
Missing
[126]
liver GRK2
Missing