REACTOME_ACTIVATION_OF_NMDA_RECEPTORS_AND_POSTSYNAPTIC_EVENTS | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | TUBA1B | Tubulin alpha-1B chain | [1] | -0.49[2] | -0.50[3] | -0.41[4] | -0.75[5] | -0.05[6] | -1.85[7] |
2 | TUBA1C | Tubulin alpha-1C chain | [8] | -1.11[9] | -1.20[10] | -1.84[11] | -1.41[12] | -1.65[13] | -3.08[14] |
3 | TUBB4B | Tubulin beta-4B chain | [15] | -0.44[16] | -0.57[17] | -0.73[18] | -1.44[19] | -0.41[20] | -0.76[21] |
4 | TUBA4A | Tubulin alpha-4A chain | [22] | -3.70[23] | -3.89[24] | -4.80[25] | -1.60[26] | -1.63[27] | -1.92[28] |
5 | TUBB2A | Tubulin beta-2A chain | [29] | -2.88[30] | -3.01[31] | -1.87[32] | -1.93[33] | -4.05[34] | -2.08[35] |
6 | RAC1 | Ras-related C3 botulinum toxin substrate 1 | [36] | -0.05[37] | -0.40[38] | 0.17[39] | 0.21[40] | 0.34[41] | -0.27[42] |
7 | PRKAR1A | cAMP-dependent protein kinase type I-alpha regulatory subunit | [43] | 0.42[44] | 0.52[45] | 0.53[46] | 0.11[47] | 0.15[48] | 1.29[49] |
8 | KPNA2 | Importin subunit alpha-1 | [50] | 1.13[51] | 0.98[52] | 1.37[53] | 0.73[54] | 1.60[55] | -1.09[56] |
9 | CALM1 | Calmodulin-1 | [57] | 0.42[58] | 0.44[59] | 0.76[60] | 1.78[61] | 1.20[62] | 2.32[63] |
10 | PRKAG1 | 5'-AMP-activated protein kinase subunit gamma-1 | [64] | -1.07[65] | -0.56[66] | -0.58[67] | -0.14[68] | -0.29[69] | -0.95[70] |
11 | PRKACA | cAMP-dependent protein kinase catalytic subunit alpha | [71] | 0.18[72] | -0.02[73] | -0.16[74] | -0.27[75] | 0.46[76] | -0.08[77] |
12 | NRAS | GTPase NRas | [78] | 0.98[79] | 1.39[80] | 1.66[81] | 1.20[82] | 0.91[83] | 0.45[84] |
13 | PRKAG2 | 5'-AMP-activated protein kinase subunit gamma-2 | [85] | -3.71[86] | -8.83[87] | -2.54[88] | -1.54[89] | -1.26[90] | 0.22[91] |
14 | HRAS | GTPase HRas | [92] | -0.66[93] | -1.39[94] | -2.32[95] | -0.75[96] | -0.82[97] | -1.96[98] |
15 | TUBB3 | Tubulin beta-3 chain | [99] | 2.71[100] | 1.63[101] | -2.68[102] | 1.23[103] | -1.74[104] | -7.07[105] |
16 | MAPK1 | Mitogen-activated protein kinase 1 | [106] | 2.06[107] | 2.17[108] | 1.86[109] | 2.05[110] | 1.84[111] | 2.47[112] |
17 | TUBB6 | Tubulin beta-6 chain | [113] | 1.15[114] | -0.96[115] | 0.51[116] | 1.92[117] | 2.40[118] | -0.98[119] |
18 | RPS6KA3 | Ribosomal protein S6 kinase alpha-3 | [120] | [121] | [122] | [123] | [124] | [125] | [126] |
19 | CAMK1 | Calcium/calmodulin-dependent protein kinase type 1 | [127] | -0.90[128] | 0.52[129] | 0.30[130] | -1.26[131] | -0.49[132] | -0.26[133] |
20 | KRAS | GTPase KRas | [134] | -0.17[135] | -0.21[136] | 1.25[137] | 1.00[138] | 0.80[139] | 1.37[140] |
21 | CAMKK2 | Calcium/calmodulin-dependent protein kinase kinase 2 | [141] | 0.91[142] | 1.24[143] | 0.27[144] | 0.36[145] | 0.41[146] | 1.65[147] |
22 | PRKAA1 | 5'-AMP-activated protein kinase catalytic subunit alpha-1 | [148] | 0.26[149] | 1.52[150] | 2.90[151] | 1.66[152] | 2.08[153] | 2.76[154] |
23 | PRKAB2 | 5'-AMP-activated protein kinase subunit beta-2 | [155] | 1.23[156] | 2.39[157] | 2.37[158] | 1.22[159] | 0.34[160] | 2.11[161] |
24 | PRKAR2A | cAMP-dependent protein kinase type II-alpha regulatory subunit | [162] | 0.40[163] | 0.06[164] | 1.02[165] | -0.09[166] | -0.08[167] | 0.84[168] |
25 | LIN7A | Protein lin-7 homolog A | [169] | -1.19[170] | -0.94[171] | -0.31[172] | -4.56[173] | -4.72[174] | -0.11[175] |
26 | CAMK2D | Calcium/calmodulin-dependent protein kinase type II subunit delta | [176] | 0.48[177] | 0.76[178] | 2.15[179] | 0.87[180] | 0.21[181] | 2.11[182] |
27 | DLG1 | Disks large homolog 1 | [183] | 1.41[184] | 1.73[185] | 1.46[186] | 1.50[187] | 1.65[188] | 2.01[189] |
28 | PRKAR1B | cAMP-dependent protein kinase type I-beta regulatory subunit | [190] | 1.32[191] | 0.75[192] | -1.18[193] | -3.90[194] | -0.96[195] | 0.52[196] |
29 | TUBB2B | Tubulin beta-2B chain | [197] | 1.01[198] | -0.13[199] | -0.31[200] | -0.23[201] | -4.01[202] | -3.51[203] |
30 | LIN7C | Protein lin-7 homolog C | [204] | -0.03[205] | 1.10[206] | 2.30[207] | 0.03[208] | 0.26[209] | 3.25[210] |
31 | PRKAB1 | 5'-AMP-activated protein kinase subunit beta-1 | [211] | 1.06[212] | 1.57[213] | 0.58[214] | 0.13[215] | 0.38[216] | 0.70[217] |
32 | RPS6KA1 | Ribosomal protein S6 kinase alpha-1 | [218] | [219] | [220] | [221] | [222] | [223] | [224] |
33 | MAPK3 | Mitogen-activated protein kinase 3 | [225] | 2.20[226] | 2.22[227] | 2.12[228] | 0.62[229] | 0.79[230] | -0.34[231] |
34 | SRC | Proto-oncogene tyrosine-protein kinase Src | [232] | 3.37[233] | 3.33[234] | 2.19[235] | 2.60[236] | 1.92[237] | -0.15[238] |
35 | PDPK1 | 3-phosphoinositide-dependent protein kinase 1 | [239] | 2.68[240] | 3.85[241] | 2.42[242] | 1.64[243] | 2.17[244] | 3.20[245] |
36 | TUBA1A | Tubulin alpha-1A chain | [246] | 2.51[247] | -0.89[248] | -4.22[249] | 4.28[250] | 1.95[251] | 0.70[252] |
37 | GIT1 | ARF GTPase-activating protein GIT1 | [253] | 2.32[254] | 2.17[255] | 1.44[256] | 2.16[257] | 2.01[258] | 0.23[259] |
38 | CAMK2G | Calcium/calmodulin-dependent protein kinase type II subunit gamma | 1.12[260] | 2.31[261] | 1.78[262] | 1.88[263] | 1.59[264] | 1.65[265] | |
39 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | [266] | -0.49[267] | 0.27[268] | 1.41[269] | 2.43[270] | 1.43[271] | 2.41[272] |
40 | ARHGEF7 | Rho guanine nucleotide exchange factor 7 | [273] | 1.96[274] | 1.94[275] | 1.65[276] | 2.01[277] | 1.91[278] | 3.05[279] |
41 | PPM1F | Protein phosphatase 1F | [280] | 1.99[281] | 2.07[282] | 1.74[283] | 2.46[284] | 1.61[285] | 1.97[286] |
42 | CASK | Peripheral plasma membrane protein CASK | [287] | 2.15[288] | 2.03[289] | 3.43[290] | 3.11[291] | 2.56[292] | 1.95[293] |
43 | GRIA3 | Glutamate receptor 3 | [294] | -8.10[295] | -6.98[296] | 1.18[297] | -7.74[298] | -2.05[299] | -0.09[300] |
44 | CREB1 | Cyclic AMP-responsive element-binding protein 1 | [301] | 2.07[302] | 3.20[303] | 3.55[304] | 2.74[305] | 2.83[306] | 3.04[307] |
45 | APBA1 | Amyloid-beta A4 precursor protein-binding family A member 1 | [308] | -7.07[309] | -7.33[310] | 1.57[311] | -1.90[312] | -2.36[313] | 3.04[314] |
46 | RPS6KA2 | Ribosomal protein S6 kinase alpha-2 | [315] | [316] | [317] | [318] | [319] | [320] | [321] |
47 | NRG1 | Pro-neuregulin-1, membrane-bound isoform | [322] | 0.68[323] | -5.48[324] | -2.73[325] | 2.25[326] | -5.08[327] | 1.47[328] |
48 | TUBA8 | Tubulin alpha-8 chain | [329] | -3.09[330] | -1.79[331] | -1.28[332] | -1.85[333] | -2.33[334] | -0.03[335] |
49 | LIN7B | Protein lin-7 homolog B | [336] | -0.25[337] | 0.31[338] | -0.43[339] | -0.55[340] | -0.81[341] | -0.98[342] |
50 | RASGRF2 | Ras-specific guanine nucleotide-releasing factor 2 | [343] | 4.19[344] | 3.42[345] | -1.04[346] | -2.74[347] | -0.36[348] | 1.21[349] |
51 | PRKAA2 | 5'-AMP-activated protein kinase catalytic subunit alpha-2 | [350] | 3.38[351] | 3.80[352] | 3.69[353] | 3.24[354] | 1.43[355] | 2.55[356] |
52 | ADCY1 | Adenylate cyclase type 1 | [357] | -0.49[358] | -2.38[359] | -2.72[360] | -1.91[361] | -1.78[362] | 5.69[363] |
53 | PRKX | cAMP-dependent protein kinase catalytic subunit PRKX | [364] | -1.30[365] | -1.55[366] | 3.24[367] | 1.45[368] | 3.13[369] | 2.14[370] |
54 | CAMK2B | Calcium/calmodulin-dependent protein kinase type II subunit beta | [371] | -2.19[372] | -3.53[373] | -6.64[374] | -2.66[375] | -1.88[376] | 1.84[377] |
55 | DLG3 | Disks large homolog 3 | [378] | 3.91[379] | 3.49[380] | -4.59[381] | 2.25[382] | 3.71[383] | 1.24[384] |
56 | MAPT | Microtubule-associated protein tau | [385] | 2.87[386] | 2.79[387] | 1.95[388] | 1.53[389] | -1.38[390] | 1.03[391] |
57 | CAMKK1 | Calcium/calmodulin-dependent protein kinase kinase 1 | [392] | 1.59[393] | 0.87[394] | -0.98[395] | 3.04[396] | 1.63[397] | 0.79[398] |
58 | DLG4 | Disks large homolog 4 | [399] | 3.13[400] | 3.39[401] | 2.01[402] | 2.16[403] | 4.51[404] | 2.40[405] |
59 | RPS6KA6 | Ribosomal protein S6 kinase alpha-6 | [406] | [407] | [408] | [409] | [410] | [411] | [412] |
60 | PPM1E | Protein phosphatase 1E | [413] | -3.02[414] | -2.19[415] | 4.94[416] | -0.58[417] | 1.25[418] | 2.96[419] |
61 | TUBB8 | Tubulin beta-8 chain | [420] | 0.92[421] | -0.15[422] | 2.17[423] | -0.63[424] | -4.35[425] | -4.03[426] |
62 | NRGN | Neurogranin | [427] | 2.02[428] | 2.25[429] | 0.07[430] | 3.43[431] | 4.10[432] | -0.23[433] |
63 | PRKAR2B | cAMP-dependent protein kinase type II-beta regulatory subunit | [434] | -1.99[435] | -0.19[436] | 3.95[437] | 5.28[438] | 3.94[439] | 4.01[440] |
64 | DLG2 | Disks large homolog 2 | [441] | -1.28[442] | -1.04[443] | -0.13[444] | -0.50[445] | -1.27[446] | 3.43[447] |
65 | TUBA3D | [448] | -1.65[449] | -0.93[450] | -1.92[451] | -0.28[452] | -1.44[453] | 0.71[454] | |
66 | TUBB1 | Tubulin beta-1 chain | [455] | 4.92[456] | 6.76[457] | 2.44[458] | 3.00[459] | 1.81[460] | 4.25[461] |
67 | TUBB4A | Tubulin beta-4A chain | [462] | 2.17[463] | -1.97[464] | 4.42[465] | 3.83[466] | 2.54[467] | 2.54[468] |
68 | NBEA | Neurobeachin | [469] | 4.34[470] | 4.00[471] | 1.65[472] | 2.14[473] | 4.63[474] | 5.52[475] |
69 | TUBA3E | Tubulin alpha-3E chain | [476] | [477] | -4.46[478] | -4.37[479] | -4.49[480] | -1.97[481] | 0.26[482] |
70 | GRIN2D | Glutamate receptor ionotropic, NMDA 2D | [483] | 4.83[484] | 4.71[485] | 4.88[486] | 2.98[487] | 2.08[488] | 0.64[489] |
71 | KIF17 | Kinesin-like protein KIF17 | [490] | 4.45[491] | 6.08[492] | 0.77[493] | 3.06[494] | 1.67[495] | 3.97[496] |
72 | TUBA3C | Tubulin alpha-3C/D chain | [497] | [498] | -3.93[499] | [500] | 1.38[501] | -4.85[502] | -3.54[503] |
73 | GRIN3A | Glutamate receptor ionotropic, NMDA 3A | [504] | -0.82[505] | 1.12[506] | 1.17[507] | 1.67[508] | 0.74[509] | 4.27[510] |
74 | NEFL | Neurofilament light polypeptide | [511] | -1.66[512] | [513] | -0.02[514] | 9.87[515] | 2.66[516] | [517] |
75 | CAMK4 | Calcium/calmodulin-dependent protein kinase type IV | [518] | [519] | -1.44[520] | -2.24[521] | 1.64[522] | 3.85[523] | 4.94[524] |
76 | GRIN3B | Glutamate receptor ionotropic, NMDA 3B | [525] | 4.30[526] | 2.99[527] | 3.46[528] | 0.48[529] | 3.50[530] | 2.90[531] |
77 | GRIN2B | Glutamate receptor ionotropic, NMDA 2B | [532] | -2.11[533] | [534] | [535] | 1.29[536] | -1.38[537] | 2.56[538] |
78 | GRIA4 | Glutamate receptor 4 | [539] | [540] | -0.28[541] | 1.25[542] | 1.71[543] | 1.56[544] | 2.35[545] |
79 | ACTN2 | Alpha-actinin-2 | [546] | 0.62[547] | 0.80[548] | -1.64[549] | 2.43[550] | 2.29[551] | 3.61[552] |
80 | PRKAG3 | 5'-AMP-activated protein kinase subunit gamma-3 | [553] | -1.39[554] | [555] | -1.88[556] | -0.82[557] | [558] | 3.82[559] |
81 | RASGRF1 | Ras-specific guanine nucleotide-releasing factor 1 | [560] | 4.57[561] | 5.40[562] | -2.00[563] | 2.91[564] | 0.15[565] | [566] |
82 | GRIA1 | Glutamate receptor 1 | [567] | -1.98[568] | [569] | [570] | -0.45[571] | 0.13[572] | 0.84[573] |
83 | GRIN2C | Glutamate receptor ionotropic, NMDA 2C | [574] | 3.94[575] | 5.57[576] | 4.03[577] | 3.68[578] | 4.46[579] | 4.64[580] |
84 | GRIN2A | Glutamate receptor ionotropic, NMDA 2A | [581] | [582] | [583] | -0.42[584] | 9.25[585] | 1.93[586] | 8.73[587] |
85 | GRIA2 | Glutamate receptor 2 | [588] | [589] | [590] | [591] | [592] | [593] | [594] |
86 | TUBA4B | Putative tubulin-like protein alpha-4B | [595] | [596] | [597] | [598] | [599] | [600] | [601] |
87 | LRRC7 | Leucine-rich repeat-containing protein 7 | [602] | [603] | [604] | [605] | [606] | [607] | [608] |
88 | TUBB8B | [609] | [610] | [611] | [612] | [613] | [614] | [615] | |
89 | ERBB4 | Receptor tyrosine-protein kinase erbB-4 | [616] | [617] | [618] | [619] | [620] | [621] | [622] |
90 | GRIN1 | Glutamate receptor ionotropic, NMDA 1 | [623] | [624] | [625] | [626] | [627] | [628] | [629] |
91 | TUBAL3 | Tubulin alpha chain-like 3 | [630] | [631] | [632] | [633] | [634] | [635] | [636] |
92 | PRKACG | cAMP-dependent protein kinase catalytic subunit gamma | [637] | [638] | [639] | [640] | [641] | [642] | [643] |
93 | ADCY8 | Adenylate cyclase type 8 | [644] | [645] | [646] | [647] | [648] | [649] | [650] |
94 | CAMK2A | Calcium/calmodulin-dependent protein kinase type II subunit alpha | [651] | [652] | [653] | [654] | [655] | [656] | [657] |