REACTOME_ACTIVATION_OF_IRF3_IRF7_MEDIATED_BY_TBK1_IKK_EPSILON Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 UBB Polyubiquitin-B [1] -0.09[2] -0.32[3] -0.40[4] -0.35[5] -0.26[6] -0.22[7]
2 RPS27A Ubiquitin-40S ribosomal protein S27a [8] [9] [10] [11] [12] [13] [14]
3 UBC Polyubiquitin-C [15] 0.35[16] 0.43[17] -0.04[18] 0.51[19] 0.12[20] 0.23[21]
4 CD14 Monocyte differentiation antigen CD14 [22] -6.23[23] -6.34[24] -3.75[25] -2.37[26] -3.93[27] 1.15[28]
5 UBA52 Ubiquitin-60S ribosomal protein L40 [29] 2.79[30] 2.66[31] 3.47[32] 1.90[33] 2.34[34] 1.00[35]
6 PTPN11 Tyrosine-protein phosphatase non-receptor type 11 [36] 2.55[37] 2.95[38] 2.68[39] 3.32[40] 3.58[41] 2.91[42]
7 IRF7 Interferon regulatory factor 7 [43] -7.12[44] -6.16[45] -5.29[46] -0.72[47] -1.35[48] 1.58[49]
8 IRF3 Interferon regulatory factor 3 [50] 2.41[51] 2.54[52] 3.04[53] 2.79[54] 2.00[55] 0.47[56]
9 TANK TRAF family member-associated NF-kappa-B activator [57] 0.97[58] 2.92[59] 2.32[60] 2.56[61] 1.42[62] 2.19[63]
10 TBK1 Serine/threonine-protein kinase TBK1 [64] 1.47[65] 3.12[66] 2.03[67] 2.92[68] 2.63[69] 2.13[70]
11 TICAM1 TIR domain-containing adapter molecule 1 [71] 1.40[72] 0.26[73] 0.96[74] 1.21[75] 1.88[76] 1.15[77]
12 LY96 Lymphocyte antigen 96 [78] -0.54[79] -0.97[80] -7.61[81] 1.07[82] -2.92[83] 0.29[84]
13 TRAF3 TNF receptor-associated factor 3 [85] 5.00[86] 4.38[87] 3.76[88] 5.26[89] 5.30[90] 3.58[91]
14 IKBKE Inhibitor of nuclear factor kappa-B kinase subunit epsilon [92] 3.83[93] 3.66[94] 2.33[95] 4.99[96] 4.17[97] 1.42[98]
15 TLR4 Toll-like receptor 4 [99] 2.38[100] -2.81[101] -3.93[102] -2.67[103] 7.38[104] 6.12[105]
16 TICAM2 TIR domain-containing adapter molecule 2 [106] -5.76[107] [108] -5.45[109] 0.94[110] 0.91[111] -0.32[112]
17 SARM1 Sterile alpha and TIR motif-containing protein 1 [113] 0.53[114] 0.77[115] 2.24[116] 1.11[117] 6.03[118] 4.66[119]
[1]
ref_hepatocyte UBB
Mean 764
Standard deviation 4.8e+02
Values 3.8e+02 3.5e+02 5.3e+02 1.2e+03 1.3e+03
[2]
HepG2 UBB
Mean 368
Standard deviation 39
Values 4e+02 3.4e+02
[3]
HepG2.C3A UBB
Mean 285
Standard deviation 14
Values 2.8e+02 3e+02
[4]
HuH.7 UBB
Mean 304
Standard deviation 40
Values 2.9e+02 2.7e+02 3.5e+02
[5]
SNU475 UBB
Mean 204
Standard deviation 3.3
Values 2.1e+02 2e+02
[6]
THLE UBB
Mean 315
Standard deviation 34
Values 2.9e+02 3.4e+02
[7]
liver UBB
Mean 296
Standard deviation 1.3e+02
Values 4.3e+02 2.1e+02 3.9e+02 1.5e+02
[8]
ref_hepatocyte RPS27A
Mean 499
Standard deviation 2.2e+02
Values 6.6e+02 6.1e+02 1.7e+02 6.8e+02 3.8e+02
[9]
HepG2 RPS27A
Missing
[10]
HepG2.C3A RPS27A
Missing
[11]
HuH.7 RPS27A
Missing
[12]
SNU475 RPS27A
Missing
[13]
THLE RPS27A
Missing
[14]
liver RPS27A
Missing
[15]
ref_hepatocyte UBC
Mean 480
Standard deviation 2.8e+02
Values 1.8e+02 3.5e+02 9.1e+02 5.8e+02 3.8e+02
[16]
HepG2 UBC
Mean 314
Standard deviation 38
Values 3.4e+02 2.9e+02
[17]
HepG2.C3A UBC
Mean 302
Standard deviation 41
Values 3.3e+02 2.7e+02
[18]
HuH.7 UBC
Mean 246
Standard deviation 64
Values 2.4e+02 3.1e+02 1.9e+02
[19]
SNU475 UBC
Mean 232
Standard deviation 63
Values 2.8e+02 1.9e+02
[20]
THLE UBC
Mean 257
Standard deviation 41
Values 2.3e+02 2.9e+02
[21]
liver UBC
Mean 254
Standard deviation 78
Values 2.2e+02 3.1e+02 3.3e+02 1.6e+02
[22]
ref_hepatocyte CD14
Mean 148
Standard deviation 1.9e+02
Values 0.7 1.6 16 3.4e+02 3.8e+02
[23]
HepG2 CD14
Mean 1.01
Standard deviation 0.084
Values 1.1 0.95
[24]
HepG2.C3A CD14
Mean 0.856
Standard deviation 0.32
Values 1.1 0.63
[25]
HuH.7 CD14
Mean 5.78
Standard deviation 1.1
Values 5.8 4.7 6.9
[26]
SNU475 CD14
Mean 9.74
Standard deviation 1.9
Values 8.4 11
[27]
THLE CD14
Mean 4.8
Standard deviation 0.97
Values 5.5 4.1
[28]
liver CD14
Mean 148
Standard deviation 88
Values 2.1e+02 68 2.4e+02 77
[29]
ref_hepatocyte UBA52
Mean 57.3
Standard deviation 43
Values 14 23 49 1.2e+02 81
[30]
HepG2 UBA52
Mean 203
Standard deviation 20
Values 2.2e+02 1.9e+02
[31]
HepG2.C3A UBA52
Mean 169
Standard deviation 3.3
Values 1.7e+02 1.7e+02
[32]
HuH.7 UBA52
Mean 334
Standard deviation 46
Values 3.4e+02 2.8e+02 3.7e+02
[33]
SNU475 UBA52
Mean 72.9
Standard deviation 11
Values 65 81
[34]
THLE UBA52
Mean 144
Standard deviation 15
Values 1.3e+02 1.5e+02
[35]
liver UBA52
Mean 51.7
Standard deviation 26
Values 79 32 68 28
[36]
ref_hepatocyte PTPN11
Mean 22.2
Standard deviation 20
Values 33 53 10 7.5 7.4
[37]
HepG2 PTPN11
Mean 66.7
Standard deviation 12
Values 58 76
[38]
HepG2.C3A PTPN11
Mean 80.2
Standard deviation 17
Values 68 92
[39]
HuH.7 PTPN11
Mean 74.5
Standard deviation 12
Values 86 77 61
[40]
SNU475 PTPN11
Mean 75.4
Standard deviation 0.72
Values 75 76
[41]
THLE PTPN11
Mean 131
Standard deviation 5.1
Values 1.3e+02 1.3e+02
[42]
liver PTPN11
Mean 75.4
Standard deviation 18
Values 60 99 62 80
[43]
ref_hepatocyte IRF7
Mean 11.7
Standard deviation 10
Values 0 3.4 11 20 24
[44]
HepG2 IRF7
Mean 0.0429
Standard deviation 0.012
Values 0.034 0.051
[45]
HepG2.C3A IRF7
Mean 0.0764
Standard deviation 0.0019
Values 0.078 0.075
[46]
HuH.7 IRF7
Mean 0.158
Standard deviation 0.13
Values 0.16 0.29 0.028
[47]
SNU475 IRF7
Mean 2.42
Standard deviation 0.34
Values 2.2 2.7
[48]
THLE IRF7
Mean 2.27
Standard deviation 0.44
Values 2 2.6
[49]
liver IRF7
Mean 15.8
Standard deviation 4.5
Values 16 9.6 20 18
[50]
ref_hepatocyte IRF3
Mean 10
Standard deviation 4.1
Values 7.1 4.7 13 15 10
[51]
HepG2 IRF3
Mean 27.2
Standard deviation 6.6
Values 32 23
[52]
HepG2.C3A IRF3
Mean 27.3
Standard deviation 1.4
Values 28 26
[53]
HuH.7 IRF3
Mean 43.3
Standard deviation 14
Values 47 28 54
[54]
SNU475 IRF3
Mean 23.5
Standard deviation 4.3
Values 20 27
[55]
THLE IRF3
Mean 19.9
Standard deviation 0.46
Values 20 20
[56]
liver IRF3
Mean 6.27
Standard deviation 2.8
Values 8.8 3.7 8.7 4
[57]
ref_hepatocyte TANK
Mean 8.63
Standard deviation 3.4
Values 7.4 6.5 5.3 10 14
[58]
HepG2 TANK
Mean 8.65
Standard deviation 2.2
Values 7.1 10
[59]
HepG2.C3A TANK
Mean 30.5
Standard deviation 0.31
Values 31 30
[60]
HuH.7 TANK
Mean 22.6
Standard deviation 1.7
Values 22 21 25
[61]
SNU475 TANK
Mean 17.3
Standard deviation 2.1
Values 19 16
[62]
THLE TANK
Mean 11.4
Standard deviation 0.54
Values 12 11
[63]
liver TANK
Mean 17.8
Standard deviation 10
Values 32 10 20 9.7
[64]
ref_hepatocyte TBK1
Mean 6.94
Standard deviation 1.7
Values 7.8 8.4 8.4 5 5.2
[65]
HepG2 TBK1
Mean 9.87
Standard deviation 3.8
Values 7.2 13
[66]
HepG2.C3A TBK1
Mean 28.1
Standard deviation 7.6
Values 23 33
[67]
HuH.7 TBK1
Mean 14.9
Standard deviation 0.71
Values 14 16 15
[68]
SNU475 TBK1
Mean 17.9
Standard deviation 1.5
Values 19 17
[69]
THLE TBK1
Mean 21.3
Standard deviation 2.3
Values 23 20
[70]
liver TBK1
Mean 13.7
Standard deviation 2.9
Values 13 15 17 10
[71]
ref_hepatocyte TICAM1
Mean 4.75
Standard deviation 6.4
Values 0 1.4 16 3.4 3
[72]
HepG2 TICAM1
Mean 6.41
Standard deviation 2.9
Values 8.5 4.3
[73]
HepG2.C3A TICAM1
Mean 2.66
Standard deviation 0.59
Values 3.1 2.2
[74]
HuH.7 TICAM1
Mean 4.87
Standard deviation 0.33
Values 5.2 4.5 4.9
[75]
SNU475 TICAM1
Mean 3.73
Standard deviation 0.28
Values 3.5 3.9
[76]
THLE TICAM1
Mean 8.64
Standard deviation 1.3
Values 7.7 9.5
[77]
liver TICAM1
Mean 4.77
Standard deviation 3.4
Values 7.9 1.4 7.4 2.3
[78]
ref_hepatocyte LY96
Mean 2.98
Standard deviation 1.7
Values 3 4.2 0 4 3.7
[79]
HepG2 LY96
Mean 1.05
Standard deviation 0.03
Values 1 1.1
[80]
HepG2.C3A LY96
Mean 0.711
Standard deviation 0.08
Values 0.77 0.65
[81]
HuH.7 LY96
Mean 0.008
Standard deviation 0.0015
Values 0.0082 0.0064 0.0094
[82]
SNU475 LY96
Mean 2.13
Standard deviation 0.56
Values 2.5 1.7
[83]
THLE LY96
Mean 0.194
Standard deviation 0.13
Values 0.1 0.29
[84]
liver LY96
Mean 1.65
Standard deviation 1.4
Values 2.6 0.6 3 0.34
[85]
ref_hepatocyte TRAF3
Mean 1.27
Standard deviation 0.83
Values 0.98 2.5 1.7 0.56 0.6
[86]
HepG2 TRAF3
Mean 20.8
Standard deviation 3.9
Values 24 18
[87]
HepG2.C3A TRAF3
Mean 12.4
Standard deviation 0.058
Values 12 12
[88]
HuH.7 TRAF3
Mean 9.05
Standard deviation 1.3
Values 10 8.7 7.9
[89]
SNU475 TRAF3
Mean 16.6
Standard deviation 0.54
Values 17 16
[90]
THLE TRAF3
Mean 24.7
Standard deviation 3.8
Values 22 27
[91]
liver TRAF3
Mean 6.87
Standard deviation 4
Values 4.4 9.3 2.6 11
[92]
ref_hepatocyte IKBKE
Mean 0.818
Standard deviation 0.8
Values 0.91 2.2 0.36 0.25 0.39
[93]
HepG2 IKBKE
Mean 5.94
Standard deviation 0.2
Values 5.8 6.1
[94]
HepG2.C3A IKBKE
Mean 4.84
Standard deviation 0.7
Values 4.3 5.3
[95]
HuH.7 IKBKE
Mean 2.16
Standard deviation 0.28
Values 2.3 1.8 2.3
[96]
SNU475 IKBKE
Mean 8.87
Standard deviation 0.19
Values 8.7 9
[97]
THLE IKBKE
Mean 7.27
Standard deviation 2.9
Values 5.2 9.3
[98]
liver IKBKE
Mean 0.988
Standard deviation 0.21
Values 1.2 0.98 1.1 0.69
[99]
ref_hepatocyte TLR4
Mean 0.547
Standard deviation 0.41
Values 0 1.1 0.33 0.64 0.66
[100]
HepG2 TLR4
Mean 1.46
Standard deviation 0.9
Values 0.82 2.1
[101]
HepG2.C3A TLR4
Mean 0.0365
Standard deviation 0.024
Values 0.019 0.054
[102]
HuH.7 TLR4
Mean 0.0189
Standard deviation 0.019
Values 0 0.019 0.037
[103]
SNU475 TLR4
Mean 0.0293
Standard deviation 0.0087
Values 0.023 0.035
[104]
THLE TLR4
Mean 45
Standard deviation 10
Values 52 38
[105]
liver TLR4
Mean 17.2
Standard deviation 6.3
Values 13 19 11 25
[106]
ref_hepatocyte TICAM2
Mean 0.456
Standard deviation 0.51
Values 0 0.53 0 0.51 1.2
[107]
HepG2 TICAM2
Mean 0.00429
Standard deviation 0.0061
Values 0 0.0086
[108]
HepG2.C3A TICAM2
Mean 0
Standard deviation 0
Values 0 0
[109]
HuH.7 TICAM2
Mean 0.00547
Standard deviation 0.0095
Values 0.016 0 0
[110]
SNU475 TICAM2
Mean 0.297
Standard deviation 0.053
Values 0.26 0.33
[111]
THLE TICAM2
Mean 0.422
Standard deviation 0.036
Values 0.4 0.45
[112]
liver TICAM2
Mean 0.164
Standard deviation 0.11
Values 0.21 0.14 0.026 0.28
[113]
ref_hepatocyte SARM1
Mean 0.16
Standard deviation 0.097
Values 0.066 0.067 0.16 0.29 0.21
[114]
HepG2 SARM1
Mean 0.118
Standard deviation 0.021
Values 0.1 0.13
[115]
HepG2.C3A SARM1
Mean 0.127
Standard deviation 0.013
Values 0.14 0.12
[116]
HuH.7 SARM1
Mean 0.395
Standard deviation 0.092
Values 0.3 0.49 0.39
[117]
SNU475 SARM1
Mean 0.117
Standard deviation 0.028
Values 0.097 0.14
[118]
THLE SARM1
Mean 5.16
Standard deviation 0.78
Values 4.6 5.7
[119]
liver SARM1
Mean 1.82
Standard deviation 0.21
Values 1.6 2 1.7 1.9