REACTOME_ACTIVATION_OF_GENE_EXPRESSION_BY_SREBF_SREBP | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | SCD | Acyl-CoA desaturase | [1] | 0.10[2] | 0.54[3] | 0.89[4] | -1.66[5] | -2.48[6] | -0.17[7] |
2 | FDPS | Farnesyl pyrophosphate synthase | [8] | -2.25[9] | -2.01[10] | -2.14[11] | -1.63[12] | -1.65[13] | -2.27[14] |
3 | HMGCS1 | Hydroxymethylglutaryl-CoA synthase, cytoplasmic | [15] | -3.08[16] | -1.23[17] | -0.27[18] | -2.96[19] | -3.11[20] | -0.91[21] |
4 | FDFT1 | Squalene synthase | [22] | -1.04[23] | -0.47[24] | -1.34[25] | -2.45[26] | -1.30[27] | -1.62[28] |
5 | CYP51A1 | Lanosterol 14-alpha demethylase | [29] | -1.99[30] | -0.97[31] | -1.47[32] | -1.11[33] | -1.35[34] | 0.14[35] |
6 | IDI1 | Isopentenyl-diphosphate Delta-isomerase 1 | [36] | -2.13[37] | -0.02[38] | -1.87[39] | -0.24[40] | -1.36[41] | -0.35[42] |
7 | SQLE | Squalene monooxygenase | [43] | -1.15[44] | 0.05[45] | -0.64[46] | -0.83[47] | -1.31[48] | -0.98[49] |
8 | DHCR7 | 7-dehydrocholesterol reductase | [50] | -0.29[51] | 0.05[52] | -0.12[53] | -1.31[54] | -0.98[55] | 0.45[56] |
9 | SREBF1 | Sterol regulatory element-binding protein 1 | [57] | -0.05[58] | -1.15[59] | -1.03[60] | -0.22[61] | 0.06[62] | -0.18[63] |
10 | TM7SF2 | Delta(14)-sterol reductase | [64] | -0.69[65] | -1.16[66] | -1.93[67] | -1.23[68] | -2.93[69] | -0.63[70] |
11 | PMVK | Phosphomevalonate kinase | [71] | -1.82[72] | -3.13[73] | -2.33[74] | -0.73[75] | -0.88[76] | -2.84[77] |
12 | MVD | Diphosphomevalonate decarboxylase | [78] | -0.53[79] | 0.57[80] | -0.67[81] | -1.08[82] | -0.96[83] | -1.11[84] |
13 | FASN | Fatty acid synthase | [85] | 3.13[86] | 2.38[87] | 2.51[88] | 2.05[89] | 2.18[90] | 1.84[91] |
14 | LSS | Lanosterol synthase | [92] | 0.09[93] | 0.80[94] | -0.68[95] | 0.43[96] | 0.12[97] | 0.39[98] |
15 | GPAM | Glycerol-3-phosphate acyltransferase 1, mitochondrial | [99] | 1.64[100] | 1.73[101] | 0.04[102] | -1.99[103] | 2.25[104] | 2.00[105] |
16 | HMGCR | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | [106] | 0.17[107] | 1.53[108] | 1.37[109] | 1.01[110] | 0.80[111] | 0.70[112] |
17 | MVK | Mevalonate kinase | [113] | -1.59[114] | -0.61[115] | -1.59[116] | -1.90[117] | -2.02[118] | -0.43[119] |
18 | RXRA | Retinoic acid receptor RXR-alpha | [120] | 0.67[121] | -0.92[122] | -0.50[123] | 1.33[124] | 1.10[125] | 1.48[126] |
19 | ELOVL6 | Elongation of very long chain fatty acids protein 6 | [127] | -2.04[128] | -0.36[129] | -0.70[130] | 0.22[131] | 1.03[132] | -0.31[133] |
20 | NFYC | Nuclear transcription factor Y subunit gamma | [134] | 0.43[135] | -1.10[136] | -1.45[137] | 1.07[138] | 0.46[139] | -1.10[140] |
21 | SREBF2 | Sterol regulatory element-binding protein 2 | [141] | 1.99[142] | 1.45[143] | 2.21[144] | 0.99[145] | 1.37[146] | 0.81[147] |
22 | CARM1 | Histone-arginine methyltransferase CARM1 | [148] | 2.18[149] | 0.24[150] | 0.14[151] | 1.07[152] | 1.96[153] | -1.69[154] |
23 | ACACB | Acetyl-CoA carboxylase 2 | [155] | -0.14[156] | -0.56[157] | -0.86[158] | -0.45[159] | -0.06[160] | 3.51[161] |
24 | NFYB | Nuclear transcription factor Y subunit beta | [162] | 0.09[163] | 0.31[164] | -0.75[165] | 1.71[166] | 2.15[167] | -0.68[168] |
25 | TBL1XR1 | F-box-like/WD repeat-containing protein TBL1XR1 | [169] | 1.81[170] | 0.96[171] | 1.17[172] | 3.73[173] | 3.39[174] | 2.20[175] |
26 | TBL1X | F-box-like/WD repeat-containing protein TBL1X | [176] | 2.06[177] | 1.08[178] | 2.22[179] | -3.08[180] | 2.51[181] | 1.08[182] |
27 | PPARA | Peroxisome proliferator-activated receptor alpha | [183] | 1.40[184] | 0.99[185] | 1.42[186] | 1.36[187] | 0.62[188] | 3.48[189] |
28 | NFYA | Nuclear transcription factor Y subunit alpha | [190] | 2.28[191] | 1.11[192] | 0.56[193] | 2.76[194] | 2.31[195] | -0.20[196] |
29 | MED1 | Mediator of RNA polymerase II transcription subunit 1 | [197] | 3.27[198] | 1.21[199] | 1.69[200] | 3.52[201] | 3.77[202] | 0.61[203] |
30 | GGPS1 | Geranylgeranyl pyrophosphate synthase | [204] | 0.94[205] | 0.81[206] | 0.34[207] | 2.93[208] | 1.39[209] | -0.32[210] |
31 | SP1 | Transcription factor Sp1 | [211] | 2.54[212] | 1.40[213] | 2.04[214] | 3.99[215] | 3.77[216] | 1.48[217] |
32 | ACACA | Acetyl-CoA carboxylase 1 | [218] | 3.18[219] | 2.13[220] | 2.62[221] | 3.90[222] | 3.19[223] | 2.68[224] |
33 | NCOA6 | Nuclear receptor coactivator 6 | [225] | 2.93[226] | 1.39[227] | 1.17[228] | 3.88[229] | 3.23[230] | 0.74[231] |
34 | TGS1 | Trimethylguanosine synthase | [232] | 1.32[233] | 0.37[234] | 0.48[235] | 3.04[236] | 2.96[237] | 0.31[238] |
35 | NCOA1 | Nuclear receptor coactivator 1 | [239] | 1.19[240] | 0.37[241] | 0.14[242] | 3.11[243] | 2.66[244] | 1.99[245] |
36 | CREBBP | CREB-binding protein | [246] | 3.62[247] | 1.45[248] | 1.64[249] | 4.08[250] | 4.18[251] | 2.57[252] |
37 | MTF1 | Metal regulatory transcription factor 1 | [253] | 2.24[254] | 0.71[255] | 0.86[256] | 3.47[257] | 3.59[258] | 1.31[259] |
38 | CHD9 | Chromodomain-helicase-DNA-binding protein 9 | [260] | 2.05[261] | 2.76[262] | 1.58[263] | 3.70[264] | 4.81[265] | 4.26[266] |
39 | NCOA2 | Nuclear receptor coactivator 2 | [267] | 2.30[268] | 1.73[269] | 3.13[270] | 4.52[271] | 2.91[272] | 3.93[273] |
40 | SMARCD3 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfa | 2.20[274] | -0.86[275] | 0.77[276] | 4.58[277] | 4.87[278] | 0.69[279] | |
41 | SC5D | Lathosterol oxidase | [280] | [281] | [282] | [283] | [284] | [285] | [286] |
42 | HELZ2 | Helicase with zinc finger domain 2 | [287] | [288] | [289] | [290] | [291] | [292] | [293] |