REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | YWHAE | 14-3-3 protein epsilon | [1] | -0.79[2] | -0.55[3] | -0.21[4] | -1.05[5] | -0.42[6] | -0.34[7] |
2 | YWHAZ | 14-3-3 protein zeta/delta | [8] | -0.13[9] | -0.14[10] | 0.16[11] | 0.71[12] | -0.11[13] | -0.43[14] |
3 | DYNLL1 | Dynein light chain 1, cytoplasmic | [15] | -0.94[16] | -0.77[17] | -1.00[18] | -1.81[19] | -1.49[20] | -0.88[21] |
4 | YWHAH | 14-3-3 protein eta | [22] | -0.92[23] | -1.20[24] | -1.24[25] | -1.38[26] | -1.19[27] | -0.74[28] |
5 | YWHAQ | 14-3-3 protein theta | [29] | 0.71[30] | 0.66[31] | 0.35[32] | 1.17[33] | 1.09[34] | 0.62[35] |
6 | SFN | 14-3-3 protein sigma | [36] | -1.92[37] | -2.14[38] | -1.76[39] | -8.02[40] | -8.35[41] | -8.88[42] |
7 | YWHAG | 14-3-3 protein gamma | [43] | 0.65[44] | 0.25[45] | 0.29[46] | 0.53[47] | 0.43[48] | -0.12[49] |
8 | YWHAB | 14-3-3 protein beta/alpha | [50] | 1.48[51] | 1.33[52] | 0.60[53] | 1.11[54] | 1.14[55] | 1.12[56] |
9 | AKT1 | RAC-alpha serine/threonine-protein kinase | [57] | 0.52[58] | 0.43[59] | -0.67[60] | -0.24[61] | 0.38[62] | 0.97[63] |
10 | DYNLL2 | Dynein light chain 2, cytoplasmic | [64] | -0.52[65] | -0.94[66] | -0.73[67] | -3.06[68] | -0.88[69] | -1.72[70] |
11 | BAD | Bcl2-associated agonist of cell death | [71] | -1.23[72] | -0.96[73] | -1.92[74] | -1.26[75] | -0.26[76] | -0.20[77] |
12 | TFDP1 | Transcription factor Dp-1 | [78] | 1.11[79] | 0.58[80] | 0.63[81] | 0.41[82] | 1.59[83] | 0.08[84] |
13 | PPP3R1 | Calcineurin subunit B type 1 | [85] | 0.63[86] | 0.95[87] | 0.85[88] | 0.52[89] | 0.87[90] | 0.07[91] |
14 | BID | BH3-interacting domain death agonist | [92] | 0.17[93] | 0.42[94] | 0.02[95] | -0.48[96] | -0.42[97] | 1.39[98] |
15 | AKT2 | RAC-beta serine/threonine-protein kinase | [99] | 1.40[100] | 1.82[101] | 1.93[102] | 0.67[103] | 1.06[104] | 2.35[105] |
16 | MAPK8 | Mitogen-activated protein kinase 8 | [106] | -1.00[107] | 0.55[108] | -0.60[109] | -1.09[110] | -0.64[111] | 0.71[112] |
17 | TP53BP2 | Apoptosis-stimulating of p53 protein 2 | [113] | -0.16[114] | 0.31[115] | 1.87[116] | 1.07[117] | 0.95[118] | 1.28[119] |
18 | TP53 | Cellular tumor antigen p53 | [120] | 2.08[121] | 1.78[122] | 2.52[123] | 1.10[124] | 1.36[125] | 1.18[126] |
19 | BBC3 | Bcl-2-binding component 3 | [127] | 1.18[128] | 1.21[129] | 0.69[130] | -2.99[131] | -1.64[132] | -3.12[133] |
20 | PPP3CC | Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform | -0.26[134] | 0.02[135] | -0.40[136] | -1.28[137] | 0.24[138] | 1.28[139] | |
21 | BMF | Bcl-2-modifying factor | [140] | 1.26[141] | 1.77[142] | 2.82[143] | 3.44[144] | -1.32[145] | 0.42[146] |
22 | E2F1 | Transcription factor E2F1 | [147] | 2.39[148] | 2.38[149] | 2.50[150] | 1.67[151] | 2.71[152] | -2.40[153] |
23 | PMAIP1 | Phorbol-12-myristate-13-acetate-induced protein 1 | [154] | 0.49[155] | -2.73[156] | 0.80[157] | 2.09[158] | 1.91[159] | -3.08[160] |
24 | TFDP2 | Transcription factor Dp-2 | [161] | 2.35[162] | 3.18[163] | 3.18[164] | 2.20[165] | 3.02[166] | 3.57[167] |
25 | PPP1R13B | Apoptosis-stimulating of p53 protein 1 | [168] | 1.99[169] | 1.42[170] | 0.49[171] | 0.76[172] | 1.21[173] | 2.21[174] |
26 | BCL2L11 | Bcl-2-like protein 11 | [175] | 1.95[176] | 2.09[177] | 2.40[178] | 1.68[179] | 1.25[180] | 3.20[181] |
27 | AKT3 | RAC-gamma serine/threonine-protein kinase | [182] | -1.40[183] | -3.82[184] | -3.15[185] | 5.65[186] | 5.20[187] | 4.83[188] |
28 | TP73 | Tumor protein p73 | [189] | 1.17[190] | 3.86[191] | 2.77[192] | 0.49[193] | 2.22[194] | 1.87[195] |
29 | BCL2 | Apoptosis regulator Bcl-2 | [196] | -2.41[197] | 3.13[198] | -4.29[199] | 1.58[200] | 1.89[201] | 4.45[202] |
30 | TP63 | Tumor protein 63 | [203] | [204] | [205] | -1.50[206] | -1.56[207] | -4.55[208] | -0.26[209] |