REACTOME_ACTIVATED_TAK1_MEDIATES_P38_MAPK_ACTIVATION Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 UBB Polyubiquitin-B [1] -0.52[2] -0.73[3] -0.63[4] -0.77[5] -0.47[6] -0.05[7]
2 RPS27A Ubiquitin-40S ribosomal protein S27a [8] [9] [10] [11] [12] [13] [14]
3 UBC Polyubiquitin-C [15] -0.07[16] 0.02[17] -0.26[18] 0.08[19] -0.09[20] 0.40[21]
4 UBA52 Ubiquitin-60S ribosomal protein L40 [22] 2.36[23] 2.26[24] 3.25[25] 1.48[26] 2.13[27] 1.17[28]
5 MAP2K3 Dual specificity mitogen-activated protein kinase kinase 3 [29] 0.46[30] 0.75[31] -0.40[32] 0.18[33] -0.11[34] 0.39[35]
6 UBE2V1 Ubiquitin-conjugating enzyme E2 variant 1 [36] -2.19[37] -2.40[38] -2.30[39] -1.88[40] -2.69[41] -3.18[42]
7 IKBKG NF-kappa-B essential modulator [43] 0.79[44] 0.93[45] -1.37[46] 1.16[47] -0.21[48] 1.22[49]
8 IRAK1 Interleukin-1 receptor-associated kinase 1 [50] 3.10[51] 2.48[52] 1.41[53] 2.80[54] 3.01[55] 1.14[56]
9 UBE2N Ubiquitin-conjugating enzyme E2 N [57] 2.37[58] 2.83[59] 1.61[60] 2.33[61] 2.06[62] 1.11[63]
10 MAPKAPK2 MAP kinase-activated protein kinase 2 [64] 2.14[65] 1.16[66] 1.53[67] 3.41[68] 2.45[69] 0.88[70]
11 TAB2 TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [71] 2.05[72] 2.20[73] 2.42[74] 3.71[75] 3.01[76] 2.07[77]
12 MAPK14 Mitogen-activated protein kinase 14 [78] 3.16[79] 3.21[80] 2.74[81] 3.69[82] 3.01[83] 3.11[84]
13 MAP3K7 Mitogen-activated protein kinase kinase kinase 7 [85] 1.58[86] 2.64[87] 2.46[88] 2.50[89] 2.52[90] 2.07[91]
14 IRAK2 Interleukin-1 receptor-associated kinase-like 2 [92] 1.60[93] 1.69[94] 1.43[95] -0.42[96] 0.97[97] 0.80[98]
15 MAPKAPK3 MAP kinase-activated protein kinase 3 [99] 2.69[100] 2.62[101] 1.67[102] 0.53[103] 2.09[104] 1.59[105]
16 TAB3 TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 [106] 1.74[107] 3.67[108] 3.72[109] 2.36[110] 3.40[111] 2.65[112]
17 RIPK2 Receptor-interacting serine/threonine-protein kinase 2 [113] 1.11[114] 1.69[115] 1.66[116] 1.81[117] 1.62[118] 0.69[119]
18 TAB1 TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [120] 2.33[121] 2.96[122] 3.00[123] 2.02[124] 2.20[125] 2.05[126]
19 MAP2K6 Dual specificity mitogen-activated protein kinase kinase 6 [127] 1.97[128] -1.25[129] 3.55[130] 3.02[131] -1.18[132] 0.21[133]
20 TRAF6 TNF receptor-associated factor 6 [134] 2.77[135] 2.65[136] 3.17[137] 3.67[138] 2.97[139] 4.73[140]
21 NOD2 Nucleotide-binding oligomerization domain-containing protein 2 [141] -0.22[142] -2.21[143] [144] -1.60[145] 1.79[146] 1.29[147]
22 NOD1 Nucleotide-binding oligomerization domain-containing protein 1 [148] 2.70[149] 2.36[150] 3.12[151] 4.25[152] 3.71[153] 3.91[154]
23 MAPK11 Mitogen-activated protein kinase 11 [155] 1.51[156] 1.39[157] 0.46[158] 2.36[159] 4.20[160] 1.99[161]
[1]
ref_hepatocyte UBB
Mean 764
Standard deviation 4.8e+02
Values 3.8e+02 3.5e+02 5.3e+02 1.2e+03 1.3e+03
[2]
HepG2 UBB
Mean 368
Standard deviation 39
Values 4e+02 3.4e+02
[3]
HepG2.C3A UBB
Mean 285
Standard deviation 14
Values 2.8e+02 3e+02
[4]
HuH.7 UBB
Mean 304
Standard deviation 40
Values 2.9e+02 2.7e+02 3.5e+02
[5]
SNU475 UBB
Mean 204
Standard deviation 3.3
Values 2.1e+02 2e+02
[6]
THLE UBB
Mean 315
Standard deviation 34
Values 2.9e+02 3.4e+02
[7]
liver UBB
Mean 296
Standard deviation 1.3e+02
Values 4.3e+02 2.1e+02 3.9e+02 1.5e+02
[8]
ref_hepatocyte RPS27A
Mean 499
Standard deviation 2.2e+02
Values 6.6e+02 6.1e+02 1.7e+02 6.8e+02 3.8e+02
[9]
HepG2 RPS27A
Missing
[10]
HepG2.C3A RPS27A
Missing
[11]
HuH.7 RPS27A
Missing
[12]
SNU475 RPS27A
Missing
[13]
THLE RPS27A
Missing
[14]
liver RPS27A
Missing
[15]
ref_hepatocyte UBC
Mean 480
Standard deviation 2.8e+02
Values 1.8e+02 3.5e+02 9.1e+02 5.8e+02 3.8e+02
[16]
HepG2 UBC
Mean 314
Standard deviation 38
Values 3.4e+02 2.9e+02
[17]
HepG2.C3A UBC
Mean 302
Standard deviation 41
Values 3.3e+02 2.7e+02
[18]
HuH.7 UBC
Mean 246
Standard deviation 64
Values 2.4e+02 3.1e+02 1.9e+02
[19]
SNU475 UBC
Mean 232
Standard deviation 63
Values 2.8e+02 1.9e+02
[20]
THLE UBC
Mean 257
Standard deviation 41
Values 2.3e+02 2.9e+02
[21]
liver UBC
Mean 254
Standard deviation 78
Values 2.2e+02 3.1e+02 3.3e+02 1.6e+02
[22]
ref_hepatocyte UBA52
Mean 57.3
Standard deviation 43
Values 14 23 49 1.2e+02 81
[23]
HepG2 UBA52
Mean 203
Standard deviation 20
Values 2.2e+02 1.9e+02
[24]
HepG2.C3A UBA52
Mean 169
Standard deviation 3.3
Values 1.7e+02 1.7e+02
[25]
HuH.7 UBA52
Mean 334
Standard deviation 46
Values 3.4e+02 2.8e+02 3.7e+02
[26]
SNU475 UBA52
Mean 72.9
Standard deviation 11
Values 65 81
[27]
THLE UBA52
Mean 144
Standard deviation 15
Values 1.3e+02 1.5e+02
[28]
liver UBA52
Mean 51.7
Standard deviation 26
Values 79 32 68 28
[29]
ref_hepatocyte MAP2K3
Mean 32.7
Standard deviation 39
Values 11 17 1e+02 16 17
[30]
HepG2 MAP2K3
Mean 31
Standard deviation 5.7
Values 27 35
[31]
HepG2.C3A MAP2K3
Mean 34
Standard deviation 1.9
Values 35 33
[32]
HuH.7 MAP2K3
Mean 15.2
Standard deviation 4.8
Values 18 9.6 18
[33]
SNU475 MAP2K3
Mean 16.9
Standard deviation 1.1
Values 16 18
[34]
THLE MAP2K3
Mean 17.3
Standard deviation 3
Values 15 19
[35]
liver MAP2K3
Mean 17.2
Standard deviation 13
Values 30 4.9 26 7.1
[36]
ref_hepatocyte UBE2V1
Mean 30.9
Standard deviation 6.6
Values 41 25 33 29 27
[37]
HepG2 UBE2V1
Mean 4.65
Standard deviation 0.14
Values 4.6 4.7
[38]
HepG2.C3A UBE2V1
Mean 3.63
Standard deviation 0.17
Values 3.8 3.5
[39]
HuH.7 UBE2V1
Mean 3.85
Standard deviation 0.39
Values 4.3 3.8 3.5
[40]
SNU475 UBE2V1
Mean 3.83
Standard deviation 0.48
Values 4.2 3.5
[41]
THLE UBE2V1
Mean 2.74
Standard deviation 0.61
Values 2.3 3.2
[42]
liver UBE2V1
Mean 1.36
Standard deviation 0.64
Values 1.9 0.84 2 0.78
[43]
ref_hepatocyte IKBKG
Mean 22.7
Standard deviation 14
Values 7.4 36 37 24 10
[44]
HepG2 IKBKG
Mean 27.1
Standard deviation 5.7
Values 31 23
[45]
HepG2.C3A IKBKG
Mean 26.7
Standard deviation 4
Values 30 24
[46]
HuH.7 IKBKG
Mean 5.4
Standard deviation 1.3
Values 5.4 4.1 6.7
[47]
SNU475 IKBKG
Mean 23.2
Standard deviation 3.5
Values 21 26
[48]
THLE IKBKG
Mean 11.2
Standard deviation 1
Values 10 12
[49]
liver IKBKG
Mean 21.3
Standard deviation 6.6
Values 20 22 29 13
[50]
ref_hepatocyte IRAK1
Mean 21.3
Standard deviation 13
Values 18 30 38 16 5
[51]
HepG2 IRAK1
Mean 126
Standard deviation 40
Values 1.5e+02 97
[52]
HepG2.C3A IRAK1
Mean 73.4
Standard deviation 2.1
Values 72 75
[53]
HuH.7 IRAK1
Mean 34.7
Standard deviation 4.6
Values 40 31 34
[54]
SNU475 IRAK1
Mean 67.9
Standard deviation 14
Values 58 78
[55]
THLE IRAK1
Mean 98.2
Standard deviation 12
Values 90 1.1e+02
[56]
liver IRAK1
Mean 18.8
Standard deviation 3.7
Values 17 19 15 24
[57]
ref_hepatocyte UBE2N
Mean 19.2
Standard deviation 7.8
Values 19 28 25 11 12
[58]
HepG2 UBE2N
Mean 68.4
Standard deviation 19
Values 55 82
[59]
HepG2.C3A UBE2N
Mean 84.8
Standard deviation 36
Values 60 1.1e+02
[60]
HuH.7 UBE2N
Mean 36
Standard deviation 8.3
Values 38 27 43
[61]
SNU475 UBE2N
Mean 44
Standard deviation 3.7
Values 47 41
[62]
THLE UBE2N
Mean 45.7
Standard deviation 8
Values 40 51
[63]
liver UBE2N
Mean 16.6
Standard deviation 11
Values 25 8.3 27 5.9
[64]
ref_hepatocyte MAPKAPK2
Mean 13.1
Standard deviation 7.6
Values 5.2 10 24 17 8.7
[65]
HepG2 MAPKAPK2
Mean 39.7
Standard deviation 1.4
Values 41 39
[66]
HepG2.C3A MAPKAPK2
Mean 18.1
Standard deviation 4.5
Values 21 15
[67]
HuH.7 MAPKAPK2
Mean 23.2
Standard deviation 2.9
Values 25 20 25
[68]
SNU475 MAPKAPK2
Mean 63.2
Standard deviation 4
Values 66 60
[69]
THLE MAPKAPK2
Mean 40.9
Standard deviation 0.33
Values 41 41
[70]
liver MAPKAPK2
Mean 9.67
Standard deviation 2.5
Values 10 11 6 11
[71]
ref_hepatocyte TAB2
Mean 9.62
Standard deviation 3.5
Values 7.9 8.1 16 8.4 7.8
[72]
HepG2 TAB2
Mean 27.4
Standard deviation 8.1
Values 22 33
[73]
HepG2.C3A TAB2
Mean 27.3
Standard deviation 2.5
Values 29 26
[74]
HuH.7 TAB2
Mean 31.5
Standard deviation 8.5
Values 28 41 25
[75]
SNU475 TAB2
Mean 57.4
Standard deviation 2.2
Values 59 56
[76]
THLE TAB2
Mean 44.2
Standard deviation 0.52
Values 44 45
[77]
liver TAB2
Mean 16.2
Standard deviation 4.7
Values 21 15 10 19
[78]
ref_hepatocyte MAPK14
Mean 8.71
Standard deviation 2
Values 12 8.5 7.2 7.5 8.3
[79]
HepG2 MAPK14
Mean 53.4
Standard deviation 8.7
Values 47 60
[80]
HepG2.C3A MAPK14
Mean 49.9
Standard deviation 0.11
Values 50 50
[81]
HuH.7 MAPK14
Mean 35.7
Standard deviation 1.3
Values 37 36 34
[82]
SNU475 MAPK14
Mean 51.3
Standard deviation 0.4
Values 52 51
[83]
THLE MAPK14
Mean 40
Standard deviation 3.6
Values 37 43
[84]
liver MAPK14
Mean 30.1
Standard deviation 8.3
Values 24 38 22 37
[85]
ref_hepatocyte MAP3K7
Mean 8.64
Standard deviation 6.6
Values 18 13 4.6 4 3.6
[86]
HepG2 MAP3K7
Mean 17.8
Standard deviation 6.7
Values 13 23
[87]
HepG2.C3A MAP3K7
Mean 33.3
Standard deviation 3
Values 31 35
[88]
HuH.7 MAP3K7
Mean 29.2
Standard deviation 2.3
Values 31 27 30
[89]
SNU475 MAP3K7
Mean 22.3
Standard deviation 2.2
Values 24 21
[90]
THLE MAP3K7
Mean 28.3
Standard deviation 1.5
Values 29 27
[91]
liver MAP3K7
Mean 14.6
Standard deviation 1.8
Values 14 16 16 12
[92]
ref_hepatocyte IRAK2
Mean 8.12
Standard deviation 8.7
Values 2.6 12 22 2.3 1.9
[93]
HepG2 IRAK2
Mean 17
Standard deviation 8.7
Values 23 11
[94]
HepG2.C3A IRAK2
Mean 16.3
Standard deviation 5.4
Values 20 12
[95]
HuH.7 IRAK2
Mean 13.4
Standard deviation 4.3
Values 10 18 11
[96]
SNU475 IRAK2
Mean 2.77
Standard deviation 1.6
Values 1.6 3.9
[97]
THLE IRAK2
Mean 9.08
Standard deviation 2
Values 7.7 10
[98]
liver IRAK2
Mean 5.68
Standard deviation 1
Values 4.5 5.2 6.5 6.5
[99]
ref_hepatocyte MAPKAPK3
Mean 8.03
Standard deviation 3.9
Values 5.9 12 13 4.9 4.9
[100]
HepG2 MAPKAPK3
Mean 35.8
Standard deviation 0.92
Values 36 35
[101]
HepG2.C3A MAPKAPK3
Mean 30.6
Standard deviation 0.36
Values 30 31
[102]
HuH.7 MAPKAPK3
Mean 15.7
Standard deviation 2.2
Values 17 13 16
[103]
SNU475 MAPKAPK3
Mean 5.29
Standard deviation 0.058
Values 5.2 5.3
[104]
THLE MAPKAPK3
Mean 19.5
Standard deviation 4.7
Values 16 23
[105]
liver MAPKAPK3
Mean 9.68
Standard deviation 1.8
Values 12 7.4 10 9.3
[106]
ref_hepatocyte TAB3
Mean 6.67
Standard deviation 6.1
Values 17 5.7 5.5 1.9 3.1
[107]
HepG2 TAB3
Mean 15.3
Standard deviation 7.1
Values 10 20
[108]
HepG2.C3A TAB3
Mean 52.5
Standard deviation 9.3
Values 59 46
[109]
HuH.7 TAB3
Mean 53.9
Standard deviation 32
Values 42 90 30
[110]
SNU475 TAB3
Mean 15.6
Standard deviation 5
Values 19 12
[111]
THLE TAB3
Mean 40.2
Standard deviation 2.3
Values 42 39
[112]
liver TAB3
Mean 16.8
Standard deviation 3.6
Values 21 18 15 13
[113]
ref_hepatocyte RIPK2
Mean 4.75
Standard deviation 3.4
Values 4.6 4.7 10 2.7 1.5
[114]
HepG2 RIPK2
Mean 7.05
Standard deviation 1.9
Values 5.7 8.4
[115]
HepG2.C3A RIPK2
Mean 9.51
Standard deviation 0.29
Values 9.3 9.7
[116]
HuH.7 RIPK2
Mean 9.2
Standard deviation 1.4
Values 9.4 10 7.7
[117]
SNU475 RIPK2
Mean 7.59
Standard deviation 1.2
Values 6.7 8.5
[118]
THLE RIPK2
Mean 8.33
Standard deviation 0.54
Values 7.9 8.7
[119]
liver RIPK2
Mean 3.08
Standard deviation 0.94
Values 3.6 2.6 4.1 2
[120]
ref_hepatocyte TAB1
Mean 3.61
Standard deviation 1.3
Values 2.3 2.1 5.1 4.4 4.1
[121]
HepG2 TAB1
Mean 12.5
Standard deviation 0.3
Values 13 12
[122]
HepG2.C3A TAB1
Mean 17.4
Standard deviation 1.8
Values 19 16
[123]
HuH.7 TAB1
Mean 17.6
Standard deviation 2.2
Values 19 15 19
[124]
SNU475 TAB1
Mean 6.68
Standard deviation 1.2
Values 7.5 5.8
[125]
THLE TAB1
Mean 9.45
Standard deviation 1.6
Values 8.3 11
[126]
liver TAB1
Mean 5.99
Standard deviation 1.7
Values 7.6 4.1 7.1 5.1
[127]
ref_hepatocyte MAP2K6
Mean 1.65
Standard deviation 2.1
Values 5.3 0.69 0.17 0.98 1.1
[128]
HepG2 MAP2K6
Mean 4.46
Standard deviation 1.8
Values 3.2 5.7
[129]
HepG2.C3A MAP2K6
Mean 0.428
Standard deviation 0.00091
Values 0.43 0.43
[130]
HuH.7 MAP2K6
Mean 11.9
Standard deviation 2.1
Values 13 9.5 13
[131]
SNU475 MAP2K6
Mean 6.1
Standard deviation 1.1
Values 6.8 5.4
[132]
THLE MAP2K6
Mean 0.418
Standard deviation 0.064
Values 0.37 0.46
[133]
liver MAP2K6
Mean 0.764
Standard deviation 0.64
Values 1.6 0.61 0.051 0.79
[134]
ref_hepatocyte TRAF6
Mean 0.965
Standard deviation 0.32
Values 0.82 1 1.5 0.7 0.8
[135]
HepG2 TRAF6
Mean 4.54
Standard deviation 0.72
Values 4 5
[136]
HepG2.C3A TRAF6
Mean 3.74
Standard deviation 0.086
Values 3.8 3.7
[137]
HuH.7 TRAF6
Mean 5.32
Standard deviation 1
Values 5 6.4 4.5
[138]
SNU475 TRAF6
Mean 5.61
Standard deviation 0.46
Values 5.9 5.3
[139]
THLE TRAF6
Mean 4.31
Standard deviation 0.54
Values 3.9 4.7
[140]
liver TRAF6
Mean 10.3
Standard deviation 0.99
Values 9.7 12 9.8 10
[141]
ref_hepatocyte NOD2
Mean 0.638
Standard deviation 1.3
Values 0 0.1 2.9 0.095 0.065
[142]
HepG2 NOD2
Mean 0.376
Standard deviation 0.25
Values 0.55 0.2
[143]
HepG2.C3A NOD2
Mean 0.0856
Standard deviation 0.03
Values 0.11 0.064
[144]
HuH.7 NOD2
Mean 0
Standard deviation 0
Values 0 0 0
[145]
SNU475 NOD2
Mean 0.0958
Standard deviation 0.044
Values 0.065 0.13
[146]
THLE NOD2
Mean 1.26
Standard deviation 0.96
Values 1.9 0.58
[147]
liver NOD2
Mean 0.628
Standard deviation 0.28
Values 0.82 0.74 0.21 0.74
[148]
ref_hepatocyte NOD1
Mean 0.485
Standard deviation 0.18
Values 0.6 0.52 0.63 0.18 0.5
[149]
HepG2 NOD1
Mean 2.17
Standard deviation 0.27
Values 2.4 2
[150]
HepG2.C3A NOD1
Mean 1.55
Standard deviation 0.59
Values 1.1 2
[151]
HuH.7 NOD1
Mean 2.59
Standard deviation 0.8
Values 3.3 1.7 2.8
[152]
SNU475 NOD1
Mean 4.21
Standard deviation 0.18
Values 4.3 4.1
[153]
THLE NOD1
Mean 3.63
Standard deviation 0.052
Values 3.6 3.7
[154]
liver NOD1
Mean 2.92
Standard deviation 0.79
Values 2.1 3.5 2.4 3.7
[155]
ref_hepatocyte MAPK11
Mean 0.382
Standard deviation 0.29
Values 0 0.34 0.22 0.71 0.64
[156]
HepG2 MAPK11
Mean 0.749
Standard deviation 0.18
Values 0.62 0.88
[157]
HepG2.C3A MAPK11
Mean 0.621
Standard deviation 0.12
Values 0.53 0.71
[158]
HuH.7 MAPK11
Mean 0.322
Standard deviation 0.15
Values 0.28 0.2 0.49
[159]
SNU475 MAPK11
Mean 0.898
Standard deviation 0.33
Values 1.1 0.66
[160]
THLE MAPK11
Mean 4.01
Standard deviation 0.7
Values 4.5 3.5
[161]
liver MAPK11
Mean 0.609
Standard deviation 0.32
Values 0.96 0.49 0.23 0.75