REACTOME_ACTIVATED_NTRK2_SIGNALS_THROUGH_FRS2_AND_FRS3 Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 PTPN11 Tyrosine-protein phosphatase non-receptor type 11 [1] -0.05[2] 0.10[3] -0.13[4] 0.10[5] 0.75[6] 0.67[7]
2 GRB2 Growth factor receptor-bound protein 2 [8] 0.70[9] 0.26[10] 0.20[11] -0.23[12] -0.31[13] -0.29[14]
3 NRAS GTPase NRas [15] 0.13[16] 0.29[17] 0.52[18] 0.21[19] -0.21[20] -0.83[21]
4 HRAS GTPase HRas [22] -1.51[23] -2.49[24] -3.46[25] -1.73[26] -1.94[27] -3.25[28]
5 KRAS GTPase KRas [29] -1.01[30] -1.31[31] 0.11[32] 0.02[33] -0.31[34] 0.09[35]
6 SOS1 Son of sevenless homolog 1 [36] -0.60[37] 0.66[38] -0.02[39] 0.06[40] -0.70[41] -0.05[42]
7 FRS2 Fibroblast growth factor receptor substrate 2 [43] 0.79[44] 1.61[45] 1.92[46] 2.12[47] 1.76[48] 2.76[49]
8 FRS3 Fibroblast growth factor receptor substrate 3 [50] 0.13[51] -0.32[52] -1.52[53] -0.49[54] -0.83[55] -1.49[56]
9 BDNF Brain-derived neurotrophic factor [57] -2.16[58] -5.20[59] -3.46[60] 5.96[61] 4.73[62] 1.51[63]
10 NTRK2 BDNF/NT-3 growth factors receptor [64] [65] [66] [67] [68] [69] [70]
11 NTF4 Neurotrophin-4 [71] [72] [73] [74] [75] [76] [77]
[1]
ref_hepatocyte PTPN11
Mean 22.2
Standard deviation 20
Values 33 53 10 7.5 7.4
[2]
HepG2 PTPN11
Mean 66.7
Standard deviation 12
Values 58 76
[3]
HepG2.C3A PTPN11
Mean 80.2
Standard deviation 17
Values 68 92
[4]
HuH.7 PTPN11
Mean 74.5
Standard deviation 12
Values 86 77 61
[5]
SNU475 PTPN11
Mean 75.4
Standard deviation 0.72
Values 75 76
[6]
THLE PTPN11
Mean 131
Standard deviation 5.1
Values 1.3e+02 1.3e+02
[7]
liver PTPN11
Mean 75.4
Standard deviation 18
Values 60 99 62 80
[8]
ref_hepatocyte GRB2
Mean 20.7
Standard deviation 5.5
Values 27 26 20 14 17
[9]
HepG2 GRB2
Mean 104
Standard deviation 4.7
Values 1e+02 1.1e+02
[10]
HepG2.C3A GRB2
Mean 83.1
Standard deviation 0.44
Values 83 83
[11]
HuH.7 GRB2
Mean 86.7
Standard deviation 7.6
Values 89 78 93
[12]
SNU475 GRB2
Mean 55.7
Standard deviation 1.4
Values 55 57
[13]
THLE GRB2
Mean 58.8
Standard deviation 3.7
Values 56 61
[14]
liver GRB2
Mean 36.1
Standard deviation 16
Values 50 22 50 22
[15]
ref_hepatocyte NRAS
Mean 14.4
Standard deviation 13
Values 32 23 9.3 3.3 4.6
[16]
HepG2 NRAS
Mean 49.3
Standard deviation 10
Values 42 57
[17]
HepG2.C3A NRAS
Mean 59.2
Standard deviation 18
Values 47 72
[18]
HuH.7 NRAS
Mean 75.6
Standard deviation 9.1
Values 86 70 71
[19]
SNU475 NRAS
Mean 52.9
Standard deviation 9.2
Values 59 46
[20]
THLE NRAS
Mean 44
Standard deviation 8.9
Values 38 50
[21]
liver NRAS
Mean 17.2
Standard deviation 2.6
Values 14 21 18 16
[22]
ref_hepatocyte HRAS
Mean 11.6
Standard deviation 9
Values 4 27 11 7.4 8.8
[23]
HepG2 HRAS
Mean 12.7
Standard deviation 1.1
Values 14 12
[24]
HepG2.C3A HRAS
Mean 6.96
Standard deviation 1.3
Values 6 7.9
[25]
HuH.7 HRAS
Mean 3.85
Standard deviation 1.6
Values 3.6 2.4 5.6
[26]
SNU475 HRAS
Mean 11
Standard deviation 0.62
Values 11 11
[27]
THLE HRAS
Mean 10.7
Standard deviation 2.3
Values 9.1 12
[28]
liver HRAS
Mean 2.6
Standard deviation 1.6
Values 4.1 1.1 3.8 1.4
[29]
ref_hepatocyte KRAS
Mean 8.97
Standard deviation 7.9
Values 18 17 5.4 1.7 2.7
[30]
HepG2 KRAS
Mean 13.9
Standard deviation 3.1
Values 12 16
[31]
HepG2.C3A KRAS
Mean 12.2
Standard deviation 2.3
Values 11 14
[32]
HuH.7 KRAS
Mean 35.4
Standard deviation 4.8
Values 40 30 36
[33]
SNU475 KRAS
Mean 28.7
Standard deviation 5.5
Values 33 25
[34]
THLE KRAS
Mean 25.4
Standard deviation 1.5
Values 24 26
[35]
liver KRAS
Mean 20.4
Standard deviation 8.7
Values 33 16 19 14
[36]
ref_hepatocyte SOS1
Mean 6.81
Standard deviation 11
Values 27 1.9 2.2 1.3 1.5
[37]
HepG2 SOS1
Mean 14
Standard deviation 6.5
Values 9.4 19
[38]
HepG2.C3A SOS1
Mean 36.1
Standard deviation 3.7
Values 39 33
[39]
HuH.7 SOS1
Mean 24.6
Standard deviation 11
Values 22 37 15
[40]
SNU475 SOS1
Mean 22.5
Standard deviation 3.3
Values 25 20
[41]
THLE SOS1
Mean 14.8
Standard deviation 1.4
Values 16 14
[42]
liver SOS1
Mean 14.1
Standard deviation 3.8
Values 13 18 9.3 16
[43]
ref_hepatocyte FRS2
Mean 1.15
Standard deviation 0.48
Values 1.3 1.9 0.69 0.74 1.2
[44]
HepG2 FRS2
Mean 6.18
Standard deviation 3
Values 4 8.3
[45]
HepG2.C3A FRS2
Mean 11.7
Standard deviation 4
Values 8.9 15
[46]
HuH.7 FRS2
Mean 15.9
Standard deviation 4.9
Values 16 21 11
[47]
SNU475 FRS2
Mean 15.7
Standard deviation 0.35
Values 16 15
[48]
THLE FRS2
Mean 13.6
Standard deviation 0.96
Values 14 13
[49]
liver FRS2
Mean 16.5
Standard deviation 3.3
Values 18 20 13 15
[50]
ref_hepatocyte FRS3
Mean 0.88
Standard deviation 0.75
Values 2 0.11 0.65 0.39 1.3
[51]
HepG2 FRS3
Mean 3
Standard deviation 0.84
Values 3.6 2.4
[52]
HepG2.C3A FRS3
Mean 2.38
Standard deviation 0.57
Values 2.8 2
[53]
HuH.7 FRS3
Mean 1.13
Standard deviation 0.22
Values 1.1 0.94 1.4
[54]
SNU475 FRS3
Mean 1.98
Standard deviation 0.18
Values 2.1 1.9
[55]
THLE FRS3
Mean 1.75
Standard deviation 0.21
Values 1.9 1.6
[56]
liver FRS3
Mean 0.666
Standard deviation 0.45
Values 1.1 0.26 0.98 0.3
[57]
ref_hepatocyte BDNF
Mean 0.0532
Standard deviation 0.065
Values 0 0 0.095 0.15 0.024
[58]
HepG2 BDNF
Mean 0.0372
Standard deviation 0.0041
Values 0.04 0.034
[59]
HepG2.C3A BDNF
Mean 0.00486
Standard deviation 0.0069
Values 0.0097 0
[60]
HuH.7 BDNF
Mean 0.0177
Standard deviation 0.024
Values 0.0082 0.045 0
[61]
SNU475 BDNF
Mean 10.5
Standard deviation 1.7
Values 9.3 12
[62]
THLE BDNF
Mean 4.97
Standard deviation 1.1
Values 5.7 4.2
[63]
liver BDNF
Mean 0.324
Standard deviation 0.17
Values 0.19 0.57 0.23 0.3
[64]
ref_hepatocyte NTRK2
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[65]
HepG2 NTRK2
Mean 0.0201
Standard deviation 0.028
Values 0.04 0
[66]
HepG2.C3A NTRK2
Mean 0
Standard deviation 0
Values 0 0
[67]
HuH.7 NTRK2
Mean 0
Standard deviation 0
Values 0 0 0
[68]
SNU475 NTRK2
Mean 0.00507
Standard deviation 0.0072
Values 0 0.01
[69]
THLE NTRK2
Mean 0
Standard deviation 0
Values 0 0
[70]
liver NTRK2
Mean 1.46
Standard deviation 0.52
Values 0.89 1.2 1.8 2
[71]
ref_hepatocyte NTF4
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[72]
HepG2 NTF4
Mean 0.0243
Standard deviation 0.022
Values 0.04 0.0086
[73]
HepG2.C3A NTF4
Mean 0
Standard deviation 0
Values 0 0
[74]
HuH.7 NTF4
Mean 0.0204
Standard deviation 0.023
Values 0.016 0.045 0
[75]
SNU475 NTF4
Mean 0.0814
Standard deviation 0.029
Values 0.1 0.061
[76]
THLE NTF4
Mean 0.0683
Standard deviation 0.029
Values 0.089 0.048
[77]
liver NTF4
Mean 0.00357
Standard deviation 0.0071
Values 0 0.014 0 0