REACTOME_ACETYLCHOLINE_REGULATES_INSULIN_SECRETION Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 MARCKS Myristoylated alanine-rich C-kinase substrate [1] -0.39[2] -0.18[3] 0.03[4] 0.37[5] -0.34[6] -1.69[7]
2 GNA11 Guanine nucleotide-binding protein subunit alpha-11 [8] -1.44[9] -2.09[10] -2.39[11] -2.56[12] -1.18[13] -1.49[14]
3 PRKCA Protein kinase C alpha type [15] 2.07[16] 1.53[17] 1.65[18] 0.78[19] 1.72[20] 1.68[21]
4 GNAQ Guanine nucleotide-binding protein G(q) subunit alpha [22] -0.70[23] -0.49[24] -0.23[25] 0.22[26] 1.01[27] 1.20[28]
5 PLCB3 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [29] 1.24[30] 0.14[31] 0.36[32] 1.34[33] 1.56[34] 0.49[35]
6 PLCB1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [36] 2.02[37] 3.07[38] 2.25[39] -0.59[40] 0.48[41] 2.26[42]
7 CHRM3 Muscarinic acetylcholine receptor M3 [43] -4.28[44] -3.67[45] -1.00[46] -1.77[47] -3.96[48] 2.51[49]
8 PLCB2 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [50] -2.39[51] -7.75[52] -9.84[53] -3.31[54] -3.44[55] 2.00[56]
9 GNA15 Guanine nucleotide-binding protein subunit alpha-15 [57] -4.15[58] -6.44[59] [60] -7.40[61] -3.26[62] -0.14[63]
10 GNA14 Guanine nucleotide-binding protein subunit alpha-14 [64] -6.83[65] -7.80[66] -6.89[67] -7.66[68] -3.99[69] 3.00[70]
[1]
ref_hepatocyte MARCKS
Mean 18.8
Standard deviation 16
Values 20 35 35 2.4 2
[2]
HepG2 MARCKS
Mean 54
Standard deviation 10
Values 61 47
[3]
HepG2.C3A MARCKS
Mean 82.9
Standard deviation 25
Values 1e+02 65
[4]
HuH.7 MARCKS
Mean 109
Standard deviation 27
Values 1.1e+02 81 1.4e+02
[5]
SNU475 MARCKS
Mean 115
Standard deviation 37
Values 1.4e+02 89
[6]
THLE MARCKS
Mean 52.8
Standard deviation 6.4
Values 48 57
[7]
liver MARCKS
Mean 9.72
Standard deviation 4.6
Values 15 7.7 12 4.4
[8]
ref_hepatocyte GNA11
Mean 10
Standard deviation 6.7
Values 19 12 12 3.8 2.8
[9]
HepG2 GNA11
Mean 14
Standard deviation 0.12
Values 14 14
[10]
HepG2.C3A GNA11
Mean 11.8
Standard deviation 0.77
Values 11 12
[11]
HuH.7 GNA11
Mean 10.9
Standard deviation 2.1
Values 13 11 8.6
[12]
SNU475 GNA11
Mean 8.12
Standard deviation 0.83
Values 8.7 7.5
[13]
THLE GNA11
Mean 15.8
Standard deviation 3.1
Values 14 18
[14]
liver GNA11
Mean 5.97
Standard deviation 1.7
Values 6.1 7 3.6 7.3
[15]
ref_hepatocyte PRKCA
Mean 2.45
Standard deviation 2.1
Values 2.7 6 1.1 1.2 1.2
[16]
HepG2 PRKCA
Mean 38.7
Standard deviation 5.6
Values 35 43
[17]
HepG2.C3A PRKCA
Mean 35.5
Standard deviation 4.5
Values 32 39
[18]
HuH.7 PRKCA
Mean 43.7
Standard deviation 11
Values 54 44 33
[19]
SNU475 PRKCA
Mean 20
Standard deviation 4.3
Values 17 23
[20]
THLE PRKCA
Mean 28.8
Standard deviation 11
Values 21 36
[21]
liver PRKCA
Mean 13.2
Standard deviation 7.1
Values 11 17 4.7 21
[22]
ref_hepatocyte GNAQ
Mean 1.88
Standard deviation 1
Values 1.6 2 3.6 1.1 1.1
[23]
HepG2 GNAQ
Mean 4.36
Standard deviation 1.2
Values 3.5 5.2
[24]
HepG2.C3A GNAQ
Mean 6.67
Standard deviation 0.93
Values 6 7.3
[25]
HuH.7 GNAQ
Mean 9.12
Standard deviation 3.7
Values 11 11 4.8
[26]
SNU475 GNAQ
Mean 10.4
Standard deviation 1.4
Values 11 9.4
[27]
THLE GNAQ
Mean 13.5
Standard deviation 3.4
Values 11 16
[28]
liver GNAQ
Mean 7.23
Standard deviation 3.8
Values 5.1 11 3 9.6
[29]
ref_hepatocyte PLCB3
Mean 1.72
Standard deviation 1
Values 3.3 2 1.6 0.84 0.87
[30]
HepG2 PLCB3
Mean 15.2
Standard deviation 2.5
Values 13 17
[31]
HepG2.C3A PLCB3
Mean 9.48
Standard deviation 0.28
Values 9.3 9.7
[32]
HuH.7 PLCB3
Mean 12.5
Standard deviation 4.9
Values 15 6.9 16
[33]
SNU475 PLCB3
Mean 20.7
Standard deviation 4.4
Values 24 18
[34]
THLE PLCB3
Mean 18.1
Standard deviation 1.4
Values 17 19
[35]
liver PLCB3
Mean 4.04
Standard deviation 2.9
Values 1.7 5.4 1.5 7.5
[36]
ref_hepatocyte PLCB1
Mean 0.993
Standard deviation 1.3
Values 3.2 0.71 0.37 0.15 0.52
[37]
HepG2 PLCB1
Mean 15.2
Standard deviation 2.6
Values 13 17
[38]
HepG2.C3A PLCB1
Mean 41.8
Standard deviation 4.5
Values 45 39
[39]
HuH.7 PLCB1
Mean 26.9
Standard deviation 8.9
Values 26 36 19
[40]
SNU475 PLCB1
Mean 3.13
Standard deviation 0.39
Values 3.4 2.9
[41]
THLE PLCB1
Mean 4.93
Standard deviation 0.69
Values 5.4 4.4
[42]
liver PLCB1
Mean 7.93
Standard deviation 2.5
Values 8.6 11 6 6
[43]
ref_hepatocyte CHRM3
Mean 0.919
Standard deviation 0.41
Values 0.88 1.5 1.1 0.54 0.54
[44]
HepG2 CHRM3
Mean 0.178
Standard deviation 0.033
Values 0.15 0.2
[45]
HepG2.C3A CHRM3
Mean 0.36
Standard deviation 0.054
Values 0.4 0.32
[46]
HuH.7 CHRM3
Mean 2.61
Standard deviation 0.47
Values 3 2.8 2.1
[47]
SNU475 CHRM3
Mean 1.28
Standard deviation 0.27
Values 1.1 1.5
[48]
THLE CHRM3
Mean 0.211
Standard deviation 0.087
Values 0.27 0.15
[49]
liver CHRM3
Mean 8.78
Standard deviation 6.3
Values 3.5 15 3.3 13
[50]
ref_hepatocyte PLCB2
Mean 0.44
Standard deviation 0.47
Values 0 0.049 0.42 0.57 1.2
[51]
HepG2 PLCB2
Mean 0.316
Standard deviation 0.31
Values 0.53 0.099
[52]
HepG2.C3A PLCB2
Mean 0.0102
Standard deviation 0.00071
Values 0.0097 0.011
[53]
HuH.7 PLCB2
Mean 0.00273
Standard deviation 0.0047
Values 0.0082 0 0
[54]
SNU475 PLCB2
Mean 0.211
Standard deviation 0.062
Values 0.26 0.17
[55]
THLE PLCB2
Mean 0.145
Standard deviation 0.029
Values 0.12 0.16
[56]
liver PLCB2
Mean 2.94
Standard deviation 1.6
Values 1.8 3.5 1.5 4.9
[57]
ref_hepatocyte GNA15
Mean 0.271
Standard deviation 0.31
Values 0 0 0.27 0.33 0.76
[58]
HepG2 GNA15
Mean 0.0573
Standard deviation 0.081
Values 0.11 0
[59]
HepG2.C3A GNA15
Mean 0.0156
Standard deviation 0.0083
Values 0.0097 0.021
[60]
HuH.7 GNA15
Mean 0
Standard deviation 0
Values 0 0 0
[61]
SNU475 GNA15
Mean 0.0076
Standard deviation 0.011
Values 0 0.015
[62]
THLE GNA15
Mean 0.101
Standard deviation 0.0083
Values 0.095 0.11
[63]
liver GNA15
Mean 0.411
Standard deviation 0.3
Values 0.047 0.6 0.28 0.71
[64]
ref_hepatocyte GNA14
Mean 0.216
Standard deviation 0.25
Values 0 0.19 0 0.28 0.61
[65]
HepG2 GNA14
Mean 0.00716
Standard deviation 0.002
Values 0.0057 0.0086
[66]
HepG2.C3A GNA14
Mean 0.00486
Standard deviation 0.0069
Values 0.0097 0
[67]
HuH.7 GNA14
Mean 0.0103
Standard deviation 0.013
Values 0.025 0.0064 0
[68]
SNU475 GNA14
Mean 0.00507
Standard deviation 0.0072
Values 0 0.01
[69]
THLE GNA14
Mean 0.0485
Standard deviation 0.023
Values 0.065 0.032
[70]
liver GNA14
Mean 2.89
Standard deviation 0.64
Values 3.5 2.1 3.3 2.7