REACTOME_ABERRANT_REGULATION_OF_MITOTIC_G1_S_TRANSITION_IN_CANCER_DUE_TO_RB1_DEFECTS Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 CDKN1A Cyclin-dependent kinase inhibitor 1 [1] -0.72[2] -1.39[3] -3.88[4] -2.89[5] -0.43[6] -1.72[7]
2 CCND1 G1/S-specific cyclin-D1 [8] 1.49[9] -0.29[10] 0.74[11] 0.98[12] -0.59[13] 1.17[14]
3 CDK4 Cyclin-dependent kinase 4 [15] -0.23[16] 1.07[17] 0.91[18] -0.72[19] -0.16[20] -0.72[21]
4 TFDP1 Transcription factor Dp-1 [22] -0.90[23] -0.84[24] -0.58[25] -0.30[26] 0.19[27] -1.03[28]
5 CDKN1B Cyclin-dependent kinase inhibitor 1B [29] -1.65[30] -0.48[31] -0.09[32] -2.01[33] -1.64[34] -0.79[35]
6 CDK2 Cyclin-dependent kinase 2 [36] -1.98[37] -1.09[38] -0.51[39] -0.92[40] -0.42[41] -2.08[42]
7 CDK6 Cyclin-dependent kinase 6 [43] 0.48[44] 1.91[45] 0.51[46] 0.02[47] 0.73[48] 2.18[49]
8 CCND3 G1/S-specific cyclin-D3 [50] -0.61[51] -0.95[52] -2.38[53] 2.76[54] 1.84[55] 0.77[56]
9 CCNE1 G1/S-specific cyclin-E1 [57] -0.32[58] 0.51[59] -1.11[60] -1.31[61] -0.80[62] -4.52[63]
10 RB1 Retinoblastoma-associated protein [64] -0.34[65] 0.88[66] 1.64[67] 1.38[68] 1.61[69] 1.59[70]
11 E2F1 Transcription factor E2F1 [71] 0.38[72] 0.96[73] 1.29[74] 0.96[75] 1.31[76] -3.50[77]
12 E2F3 Transcription factor E2F3 [78] 0.15[79] 0.71[80] 0.16[81] 1.73[82] 1.08[83] -0.06[84]
13 TFDP2 Transcription factor Dp-2 [85] 0.35[86] 1.76[87] 1.97[88] 1.49[89] 1.62[90] 2.46[91]
14 CCNE2 G1/S-specific cyclin-E2 [92] -1.14[93] -0.02[94] -0.29[95] 2.14[96] 1.95[97] -0.24[98]
15 CCND2 G1/S-specific cyclin-D2 [99] 1.58[100] 0.89[101] -5.12[102] -5.35[103] -2.53[104] 1.97[105]
16 CDKN1C Cyclin-dependent kinase inhibitor 1C [106] [107] -6.09[108] 0.80[109] 0.27[110] -0.46[111] 1.57[112]
17 E2F2 Transcription factor E2F2 [113] 2.68[114] 4.30[115] 4.01[116] 3.15[117] 3.39[118] 1.53[119]
[1]
ref_hepatocyte CDKN1A
Mean 40.1
Standard deviation 28
Values 19 48 76 52 5.7
[2]
HepG2 CDKN1A
Mean 158
Standard deviation 49
Values 1.9e+02 1.2e+02
[3]
HepG2.C3A CDKN1A
Mean 53.9
Standard deviation 3.9
Values 51 57
[4]
HuH.7 CDKN1A
Mean 8
Standard deviation 1.9
Values 6.5 10 7.3
[5]
SNU475 CDKN1A
Mean 18.6
Standard deviation 7.8
Values 13 24
[6]
THLE CDKN1A
Mean 122
Standard deviation 11
Values 1.3e+02 1.1e+02
[7]
liver CDKN1A
Mean 16
Standard deviation 8.1
Values 16 6.2 26 16
[8]
ref_hepatocyte CCND1
Mean 23
Standard deviation 14
Values 44 28 19 11 12
[9]
HepG2 CCND1
Mean 421
Standard deviation 48
Values 4.5e+02 3.9e+02
[10]
HepG2.C3A CCND1
Mean 66.1
Standard deviation 12
Values 58 74
[11]
HuH.7 CCND1
Mean 113
Standard deviation 31
Values 1.4e+02 79 1.2e+02
[12]
SNU475 CCND1
Mean 155
Standard deviation 66
Values 1.1e+02 2e+02
[13]
THLE CCND1
Mean 62.5
Standard deviation 6.4
Values 67 58
[14]
liver CCND1
Mean 67.8
Standard deviation 49
Values 26 1.1e+02 1.1e+02 25
[15]
ref_hepatocyte CDK4
Mean 18.5
Standard deviation 5.3
Values 18 13 16 27 19
[16]
HepG2 CDK4
Mean 103
Standard deviation 10
Values 96 1.1e+02
[17]
HepG2.C3A CDK4
Mean 137
Standard deviation 38
Values 1.1e+02 1.6e+02
[18]
HuH.7 CDK4
Mean 102
Standard deviation 34
Values 1.1e+02 67 1.3e+02
[19]
SNU475 CDK4
Mean 38.6
Standard deviation 1.1
Values 38 39
[20]
THLE CDK4
Mean 67.8
Standard deviation 14
Values 58 78
[21]
liver CDK4
Mean 14.8
Standard deviation 9.3
Values 21 8.2 24 5.5
[22]
ref_hepatocyte TFDP1
Mean 14.3
Standard deviation 8.3
Values 23 24 5.8 10 9.4
[23]
HepG2 TFDP1
Mean 50.2
Standard deviation 7.6
Values 45 56
[24]
HepG2.C3A TFDP1
Mean 28.1
Standard deviation 13
Values 19 38
[25]
HuH.7 TFDP1
Mean 28.3
Standard deviation 13
Values 35 13 37
[26]
SNU475 TFDP1
Mean 40
Standard deviation 3.2
Values 42 38
[27]
THLE TFDP1
Mean 67
Standard deviation 13
Values 58 76
[28]
liver TFDP1
Mean 9.23
Standard deviation 0.4
Values 9.3 9.6 8.7 9.3
[29]
ref_hepatocyte CDKN1B
Mean 13.8
Standard deviation 6
Values 23 13 7.5 10 15
[30]
HepG2 CDKN1B
Mean 28.7
Standard deviation 3.4
Values 31 26
[31]
HepG2.C3A CDKN1B
Mean 34.7
Standard deviation 1.4
Values 34 36
[32]
HuH.7 CDKN1B
Mean 38.2
Standard deviation 3.7
Values 35 42 37
[33]
SNU475 CDKN1B
Mean 11.8
Standard deviation 2.9
Values 14 9.7
[34]
THLE CDKN1B
Mean 18.2
Standard deviation 3.4
Values 16 21
[35]
liver CDKN1B
Mean 10.5
Standard deviation 3.5
Values 9.9 14 5.8 12
[36]
ref_hepatocyte CDK2
Mean 12.1
Standard deviation 11
Values 19 28 3.3 5.7 4.6
[37]
HepG2 CDK2
Mean 20
Standard deviation 3.4
Values 18 22
[38]
HepG2.C3A CDK2
Mean 20
Standard deviation 9.1
Values 14 26
[39]
HuH.7 CDK2
Mean 24.9
Standard deviation 12
Values 30 11 33
[40]
SNU475 CDK2
Mean 21.8
Standard deviation 2.6
Values 20 24
[41]
THLE CDK2
Mean 36.9
Standard deviation 5.3
Values 33 41
[42]
liver CDK2
Mean 3.76
Standard deviation 1.3
Values 4.4 2.3 5.2 3.2
[43]
ref_hepatocyte CDK6
Mean 4.05
Standard deviation 4.3
Values 11 4 3.6 0.49 1.1
[44]
HepG2 CDK6
Mean 36.9
Standard deviation 11
Values 29 45
[45]
HepG2.C3A CDK6
Mean 53.4
Standard deviation 2.1
Values 55 52
[46]
HuH.7 CDK6
Mean 16.9
Standard deviation 4
Values 21 16 13
[47]
SNU475 CDK6
Mean 14
Standard deviation 3.1
Values 16 12
[48]
THLE CDK6
Mean 27.4
Standard deviation 3.5
Values 30 25
[49]
liver CDK6
Mean 24.2
Standard deviation 8
Values 24 32 13 28
[50]
ref_hepatocyte CCND3
Mean 3.59
Standard deviation 2.1
Values 0.75 3.2 3.5 6.6 3.9
[51]
HepG2 CCND3
Mean 15.4
Standard deviation 1
Values 15 16
[52]
HepG2.C3A CCND3
Mean 6.55
Standard deviation 2.7
Values 4.7 8.4
[53]
HuH.7 CCND3
Mean 2.03
Standard deviation 0.8
Values 2.3 1.1 2.6
[54]
SNU475 CCND3
Mean 83.7
Standard deviation 2.9
Values 82 86
[55]
THLE CCND3
Mean 52.9
Standard deviation 6.7
Values 48 58
[56]
liver CCND3
Mean 8.04
Standard deviation 5
Values 10 3.8 14 4.1
[57]
ref_hepatocyte CCNE1
Mean 3.4
Standard deviation 4.5
Values 11 4.2 1.1 0.65 0.21
[58]
HepG2 CCNE1
Mean 17.7
Standard deviation 1.7
Values 17 19
[59]
HepG2.C3A CCNE1
Mean 17
Standard deviation 7.4
Values 12 22
[60]
HuH.7 CCNE1
Mean 4.65
Standard deviation 2.3
Values 5.5 2 6.5
[61]
SNU475 CCNE1
Mean 4.72
Standard deviation 1.8
Values 3.5 6
[62]
THLE CCNE1
Mean 8.01
Standard deviation 0.79
Values 7.4 8.6
[63]
liver CCNE1
Mean 0.195
Standard deviation 0.1
Values 0.19 0.26 0.28 0.053
[64]
ref_hepatocyte RB1
Mean 3.07
Standard deviation 1.4
Values 5 3.8 3 1.4 2.2
[65]
HepG2 RB1
Mean 15.8
Standard deviation 7.9
Values 10 21
[66]
HepG2.C3A RB1
Mean 19.9
Standard deviation 6.1
Values 16 24
[67]
HuH.7 RB1
Mean 28.2
Standard deviation 3.3
Values 32 25 28
[68]
SNU475 RB1
Mean 27.3
Standard deviation 0.91
Values 28 27
[69]
THLE RB1
Mean 38.3
Standard deviation 1.7
Values 37 40
[70]
liver RB1
Mean 12.1
Standard deviation 2.2
Values 12 14 13 9
[71]
ref_hepatocyte E2F1
Mean 2.5
Standard deviation 3.1
Values 7.9 2.2 0.64 1.2 0.54
[72]
HepG2 E2F1
Mean 21.3
Standard deviation 1.8
Values 20 23
[73]
HepG2.C3A E2F1
Mean 17.2
Standard deviation 4.9
Values 14 21
[74]
HuH.7 E2F1
Mean 18
Standard deviation 12
Values 21 5.1 28
[75]
SNU475 E2F1
Mean 16.7
Standard deviation 4.8
Values 13 20
[76]
THLE E2F1
Mean 25.4
Standard deviation 2.4
Values 24 27
[77]
liver E2F1
Mean 0.29
Standard deviation 0.19
Values 0.12 0.49 0.41 0.15
[78]
ref_hepatocyte E2F3
Mean 2.21
Standard deviation 1.5
Values 2.9 4 2.9 0.72 0.6
[79]
HepG2 E2F3
Mean 16
Standard deviation 1.7
Values 15 17
[80]
HepG2.C3A E2F3
Mean 12.7
Standard deviation 3.5
Values 10 15
[81]
HuH.7 E2F3
Mean 7.25
Standard deviation 0.87
Values 7.9 6.3 7.6
[82]
SNU475 E2F3
Mean 25
Standard deviation 1.3
Values 24 26
[83]
THLE E2F3
Mean 19.2
Standard deviation 2.8
Values 17 21
[84]
liver E2F3
Mean 2.79
Standard deviation 0.85
Values 3 2.8 3.7 1.6
[85]
ref_hepatocyte TFDP2
Mean 1.97
Standard deviation 0.83
Values 3.4 2.1 1.3 1.4 1.7
[86]
HepG2 TFDP2
Mean 16.3
Standard deviation 2.5
Values 15 18
[87]
HepG2.C3A TFDP2
Mean 23.5
Standard deviation 2.1
Values 22 25
[88]
HuH.7 TFDP2
Mean 22.8
Standard deviation 3.1
Values 26 20 22
[89]
SNU475 TFDP2
Mean 18.9
Standard deviation 4.1
Values 22 16
[90]
THLE TFDP2
Mean 24.9
Standard deviation 1.2
Values 24 26
[91]
liver TFDP2
Mean 14.3
Standard deviation 3.4
Values 17 14 9.6 16
[92]
ref_hepatocyte CCNE2
Mean 0.86
Standard deviation 0.73
Values 1.2 2 0.44 0.36 0.28
[93]
HepG2 CCNE2
Mean 2.55
Standard deviation 1.9
Values 1.2 3.9
[94]
HepG2.C3A CCNE2
Mean 2.99
Standard deviation 2.8
Values 1 5
[95]
HuH.7 CCNE2
Mean 2.08
Standard deviation 1
Values 2.8 0.93 2.5
[96]
SNU475 CCNE2
Mean 13
Standard deviation 3.7
Values 10 16
[97]
THLE CCNE2
Mean 13.6
Standard deviation 1.4
Values 13 15
[98]
liver CCNE2
Mean 0.957
Standard deviation 0.34
Values 0.63 1 1.4 0.78
[99]
ref_hepatocyte CCND2
Mean 0.667
Standard deviation 0.74
Values 0.071 0.5 0.095 0.79 1.9
[100]
HepG2 CCND2
Mean 13
Standard deviation 3.2
Values 11 15
[101]
HepG2.C3A CCND2
Mean 4.34
Standard deviation 2.4
Values 6.1 2.6
[102]
HuH.7 CCND2
Mean 0.0563
Standard deviation 0.028
Values 0.057 0.083 0.028
[103]
SNU475 CCND2
Mean 0.0561
Standard deviation 0.014
Values 0.046 0.066
[104]
THLE CCND2
Mean 0.473
Standard deviation 0.28
Values 0.67 0.28
[105]
liver CCND2
Mean 3.43
Standard deviation 1
Values 4.4 2.9 2.2 4.2
[106]
ref_hepatocyte CDKN1C
Mean 0.303
Standard deviation 0.28
Values 0 0 0.54 0.48 0.5
[107]
HepG2 CDKN1C
Mean 0
Standard deviation 0
Values 0 0
[108]
HepG2.C3A CDKN1C
Mean 0.0156
Standard deviation 0.0083
Values 0.0097 0.021
[109]
HuH.7 CDKN1C
Mean 1.55
Standard deviation 0.54
Values 1.2 2.2 1.3
[110]
SNU475 CDKN1C
Mean 1.25
Standard deviation 0.71
Values 1.8 0.75
[111]
THLE CDKN1C
Mean 0.905
Standard deviation 0.14
Values 0.8 1
[112]
liver CDKN1C
Mean 1.18
Standard deviation 0.29
Values 1.6 1.1 1.3 0.87
[113]
ref_hepatocyte E2F2
Mean 0.16
Standard deviation 0.14
Values 0.34 0.25 0.0027 0.15 0.065
[114]
HepG2 E2F2
Mean 6.69
Standard deviation 1.2
Values 5.8 7.5
[115]
HepG2.C3A E2F2
Mean 11.1
Standard deviation 5.8
Values 7 15
[116]
HuH.7 E2F2
Mean 7.58
Standard deviation 4.8
Values 11 2 9.9
[117]
SNU475 E2F2
Mean 4.87
Standard deviation 1.9
Values 3.6 6.2
[118]
THLE E2F2
Mean 6.85
Standard deviation 0.93
Values 6.2 7.5
[119]
liver E2F2
Mean 0.607
Standard deviation 0.45
Values 1.3 0.49 0.41 0.26