REACTOME_ABC_TRANSPORTER_DISORDERS | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | APOA1 | Apolipoprotein A-I | [1] | -2.26[2] | -1.19[3] | -3.41[4] | -11.52[5] | -11.77[6] | -0.15[7] |
2 | UBB | Polyubiquitin-B | [8] | -0.22[9] | -0.63[10] | -0.07[11] | -0.24[12] | 0.13[13] | -0.88[14] |
3 | RPS27A | Ubiquitin-40S ribosomal protein S27a | [15] | [16] | [17] | [18] | [19] | [20] | [21] |
4 | UBC | Polyubiquitin-C | [22] | 0.22[23] | 0.12[24] | 0.29[25] | 0.61[26] | 0.51[27] | -0.42[28] |
5 | PSME1 | Proteasome activator complex subunit 1 | [29] | 0.45[30] | -1.47[31] | -0.68[32] | -0.11[33] | -0.71[34] | -1.38[35] |
6 | PSME2 | Proteasome activator complex subunit 2 | [36] | 0.63[37] | -1.09[38] | -0.77[39] | 0.11[40] | -0.25[41] | -1.00[42] |
7 | PSMA7 | Proteasome subunit alpha type-7 | [43] | 1.59[44] | 1.37[45] | 0.48[46] | 1.74[47] | 1.22[48] | 0.02[49] |
8 | PSMB1 | Proteasome subunit beta type-1 | [50] | 1.13[51] | 0.93[52] | 0.28[53] | 0.49[54] | 1.18[55] | -0.14[56] |
9 | PSMB3 | Proteasome subunit beta type-3 | [57] | 0.65[58] | -0.46[59] | 1.01[60] | 0.47[61] | 0.28[62] | -0.44[63] |
10 | PSMB4 | Proteasome subunit beta type-4 | [64] | 0.90[65] | 0.74[66] | 1.31[67] | 1.90[68] | 1.82[69] | -0.76[70] |
11 | PSMB7 | Proteasome subunit beta type-7 | [71] | -0.05[72] | -0.36[73] | 0.21[74] | 0.12[75] | 0.50[76] | -1.20[77] |
12 | PSMB5 | Proteasome subunit beta type-5 | [78] | 2.35[79] | 0.60[80] | 0.96[81] | 0.85[82] | 1.06[83] | -0.73[84] |
13 | VCP | Transitional endoplasmic reticulum ATPase | [85] | 2.21[86] | 1.74[87] | 2.08[88] | 2.04[89] | 2.51[90] | 1.24[91] |
14 | PSMA6 | Proteasome subunit alpha type-6 | [92] | 2.48[93] | 0.88[94] | 1.25[95] | 1.38[96] | 1.32[97] | -0.65[98] |
15 | OS9 | Protein OS-9 | [99] | 1.22[100] | 1.42[101] | 1.58[102] | 0.93[103] | 1.08[104] | 0.97[105] |
16 | PSMA4 | Proteasome subunit alpha type-4 | [106] | 0.55[107] | 0.90[108] | 1.13[109] | 1.68[110] | 1.44[111] | -0.72[112] |
17 | PSMC3 | 26S proteasome regulatory subunit 6A | [113] | 0.52[114] | 0.14[115] | 1.19[116] | 0.48[117] | 0.61[118] | -0.25[119] |
18 | PSMA3 | Proteasome subunit alpha type-3 | [120] | -0.07[121] | 0.62[122] | 0.37[123] | 1.22[124] | 0.71[125] | -0.48[126] |
19 | PSMB6 | Proteasome subunit beta type-6 | [127] | 0.48[128] | 0.31[129] | 0.89[130] | 0.68[131] | 0.35[132] | -0.32[133] |
20 | PSMA2 | Proteasome subunit alpha type-2 | [134] | 0.39[135] | 1.04[136] | 1.81[137] | 1.17[138] | 1.48[139] | -0.10[140] |
21 | PSMD4 | 26S proteasome non-ATPase regulatory subunit 4 | [141] | 0.91[142] | 0.61[143] | 1.25[144] | 1.88[145] | 1.28[146] | -0.42[147] |
22 | PSMD7 | 26S proteasome non-ATPase regulatory subunit 7 | [148] | 0.83[149] | 0.89[150] | 1.18[151] | 0.79[152] | 1.20[153] | -0.59[154] |
23 | PSMD8 | 26S proteasome non-ATPase regulatory subunit 8 | [155] | 1.00[156] | 0.92[157] | 1.49[158] | 1.07[159] | 1.76[160] | -0.57[161] |
24 | PSMD2 | 26S proteasome non-ATPase regulatory subunit 2 | [162] | 2.53[163] | 1.39[164] | 1.90[165] | 2.17[166] | 3.41[167] | 0.47[168] |
25 | PSMC1 | 26S proteasome regulatory subunit 4 | [169] | 0.85[170] | 0.60[171] | 0.39[172] | 2.36[173] | 1.82[174] | -0.37[175] |
26 | PSMA1 | Proteasome subunit alpha type-1 | [176] | 1.03[177] | 1.11[178] | 1.61[179] | 1.93[180] | 1.37[181] | 0.12[182] |
27 | UBA52 | Ubiquitin-60S ribosomal protein L40 | [183] | 2.66[184] | 2.35[185] | 3.80[186] | 2.01[187] | 2.74[188] | 0.35[189] |
28 | PSMC5 | 26S proteasome regulatory subunit 8 | [190] | 1.35[191] | 0.93[192] | 1.44[193] | 1.34[194] | 1.69[195] | -0.12[196] |
29 | PSMD3 | 26S proteasome non-ATPase regulatory subunit 3 | [197] | 1.75[198] | 0.93[199] | 1.96[200] | 1.88[201] | 2.03[202] | -0.40[203] |
30 | PSMB8 | Proteasome subunit beta type-8 | [204] | -0.65[205] | -1.55[206] | -8.33[207] | 1.85[208] | 0.48[209] | -1.09[210] |
31 | PSMD14 | 26S proteasome non-ATPase regulatory subunit 14 | [211] | 0.92[212] | 1.22[213] | 1.91[214] | 1.74[215] | 1.71[216] | -0.55[217] |
32 | PSMC4 | 26S proteasome regulatory subunit 6B | [218] | 1.35[219] | 1.07[220] | 1.44[221] | 1.37[222] | 1.42[223] | -0.07[224] |
33 | RNF5 | E3 ubiquitin-protein ligase RNF5 | [225] | -8.38[226] | -7.92[227] | -6.63[228] | -8.28[229] | -9.67[230] | -9.18[231] |
34 | PSMD6 | 26S proteasome non-ATPase regulatory subunit 6 | [232] | 0.20[233] | 0.37[234] | -0.29[235] | 0.74[236] | 1.49[237] | -0.66[238] |
35 | PSMD13 | 26S proteasome non-ATPase regulatory subunit 13 | [239] | 1.40[240] | 1.20[241] | 2.13[242] | 1.80[243] | 1.25[244] | -0.47[245] |
36 | PSMD12 | 26S proteasome non-ATPase regulatory subunit 12 | [246] | 0.57[247] | 0.34[248] | 0.47[249] | 1.42[250] | 1.42[251] | -0.55[252] |
37 | PSMC6 | 26S proteasome regulatory subunit 10B | [253] | 0.87[254] | 2.13[255] | 1.39[256] | 1.78[257] | 1.65[258] | 0.10[259] |
38 | PSMD11 | 26S proteasome non-ATPase regulatory subunit 11 | [260] | 1.75[261] | 1.05[262] | 2.08[263] | 2.19[264] | 2.28[265] | 0.93[266] |
39 | ABCC2 | Canalicular multispecific organic anion transporter 1 | [267] | 2.81[268] | 4.16[269] | 2.99[270] | 2.29[271] | -4.58[272] | 2.95[273] |
40 | PSMC2 | 26S proteasome regulatory subunit 7 | [274] | 1.51[275] | 1.60[276] | 1.81[277] | 2.58[278] | 2.35[279] | 0.98[280] |
41 | DERL2 | Derlin-2 | [281] | -0.25[282] | 0.19[283] | 0.08[284] | 0.83[285] | 0.49[286] | -0.17[287] |
42 | PSME3 | Proteasome activator complex subunit 3 | [288] | 2.74[289] | 2.14[290] | 2.26[291] | 2.61[292] | 2.81[293] | 0.55[294] |
43 | PSMD1 | 26S proteasome non-ATPase regulatory subunit 1 | [295] | 2.50[296] | 2.50[297] | 2.82[298] | 3.41[299] | 3.36[300] | 1.74[301] |
44 | PSMB10 | Proteasome subunit beta type-10 | [302] | -0.23[303] | 0.05[304] | -1.40[305] | 1.20[306] | -0.03[307] | -0.41[308] |
45 | ABCC6 | Multidrug resistance-associated protein 6 | [309] | 1.31[310] | 1.54[311] | 0.61[312] | -1.87[313] | -4.67[314] | 2.52[315] |
46 | PSMA5 | Proteasome subunit alpha type-5 | [316] | 2.82[317] | 2.94[318] | 2.94[319] | 3.46[320] | 2.96[321] | 1.57[322] |
47 | ERLIN1 | Erlin-1 | [323] | 2.25[324] | 3.11[325] | 3.56[326] | 1.28[327] | 2.66[328] | 1.89[329] |
48 | PSMF1 | Proteasome inhibitor PI31 subunit | [330] | 3.20[331] | 2.93[332] | 2.18[333] | 2.47[334] | 2.17[335] | 1.52[336] |
49 | ERLEC1 | Endoplasmic reticulum lectin 1 | [337] | 1.73[338] | 3.05[339] | 3.10[340] | 2.38[341] | 2.18[342] | 0.97[343] |
50 | PSMB2 | Proteasome subunit beta type-2 | [344] | 2.98[345] | 2.40[346] | 3.23[347] | 3.77[348] | 3.69[349] | 2.06[350] |
51 | DERL1 | Derlin-1 | [351] | 1.55[352] | 1.28[353] | 1.79[354] | 2.74[355] | 2.30[356] | 1.76[357] |
52 | LMBRD1 | Probable lysosomal cobalamin transporter | [358] | 0.57[359] | 1.27[360] | 1.13[361] | 0.96[362] | 1.00[363] | 1.58[364] |
53 | SEL1L | Protein sel-1 homolog 1 | [365] | 2.30[366] | 2.52[367] | 2.85[368] | 3.50[369] | 3.11[370] | 3.83[371] |
54 | PSMB9 | Proteasome subunit beta type-9 | [372] | -1.02[373] | -3.96[374] | -5.83[375] | 3.02[376] | 0.69[377] | -0.83[378] |
55 | PSMD9 | 26S proteasome non-ATPase regulatory subunit 9 | [379] | 1.36[380] | 1.54[381] | 0.99[382] | 1.64[383] | 2.02[384] | 0.39[385] |
56 | ABCB6 | ATP-binding cassette sub-family B member 6, mitochondrial | [386] | 2.26[387] | 2.00[388] | 1.62[389] | 1.85[390] | 0.77[391] | 1.51[392] |
57 | RNF185 | E3 ubiquitin-protein ligase RNF185 | [393] | 1.95[394] | 1.57[395] | 2.44[396] | 2.12[397] | 1.91[398] | 1.84[399] |
58 | PSMD10 | 26S proteasome non-ATPase regulatory subunit 10 | [400] | 1.92[401] | 1.93[402] | 2.38[403] | 3.32[404] | 2.57[405] | 0.38[406] |
59 | ABCG8 | ATP-binding cassette sub-family G member 8 | [407] | -0.01[408] | 0.74[409] | -4.40[410] | -10.14[411] | -9.12[412] | 2.79[413] |
60 | ERLIN2 | Erlin-2 | [414] | 2.77[415] | 2.70[416] | 4.08[417] | 2.79[418] | 2.62[419] | 1.72[420] |
61 | ABCB4 | Phosphatidylcholine translocator ABCB4 | [421] | 0.12[422] | 0.75[423] | 1.94[424] | -2.82[425] | -6.73[426] | 4.58[427] |
62 | PSME4 | Proteasome activator complex subunit 4 | [428] | 3.44[429] | 4.04[430] | 4.48[431] | 3.87[432] | 3.77[433] | 2.64[434] |
63 | ABCG5 | ATP-binding cassette sub-family G member 5 | [435] | -0.01[436] | 1.94[437] | -4.76[438] | -9.73[439] | -7.80[440] | 2.83[441] |
64 | PSMD5 | 26S proteasome non-ATPase regulatory subunit 5 | [442] | 2.34[443] | 1.57[444] | 3.57[445] | 3.70[446] | 3.72[447] | 1.82[448] |
65 | ABCD4 | ATP-binding cassette sub-family D member 4 | [449] | 1.91[450] | 3.03[451] | 2.20[452] | 2.71[453] | 2.13[454] | 1.75[455] |
66 | ABCA1 | ATP-binding cassette sub-family A member 1 | [456] | 3.64[457] | 4.34[458] | 4.52[459] | 3.76[460] | 4.23[461] | 6.22[462] |
67 | ABCC9 | ATP-binding cassette sub-family C member 9 | [463] | -0.90[464] | 0.09[465] | 1.64[466] | 2.21[467] | 0.34[468] | 4.95[469] |
68 | ABCD1 | ATP-binding cassette sub-family D member 1 | [470] | 4.81[471] | 3.76[472] | 2.03[473] | 4.01[474] | 3.00[475] | 1.93[476] |
69 | ABCB11 | Bile salt export pump | [477] | -4.81[478] | [479] | -3.31[480] | -2.98[481] | [482] | 5.79[483] |
70 | DERL3 | Derlin-3 | [484] | -5.92[485] | -5.37[486] | -5.06[487] | -0.77[488] | -1.28[489] | 0.36[490] |
71 | ABCA3 | ATP-binding cassette sub-family A member 3 | [491] | 3.17[492] | 4.44[493] | 2.76[494] | 5.69[495] | 2.49[496] | 2.09[497] |
72 | KCNJ11 | ATP-sensitive inward rectifier potassium channel 11 | [498] | 2.28[499] | 1.56[500] | 1.41[501] | 1.33[502] | 0.51[503] | 0.55[504] |
73 | CFTR | Cystic fibrosis transmembrane conductance regulator | [505] | -0.20[506] | -0.93[507] | 3.04[508] | 6.37[509] | -1.32[510] | 8.16[511] |
74 | ABCC8 | ATP-binding cassette sub-family C member 8 | [512] | 1.08[513] | [514] | 0.35[515] | [516] | [517] | 2.49[518] |
75 | PSMB11 | Proteasome subunit beta type-11 | [519] | [520] | [521] | [522] | [523] | [524] | [525] |
76 | ABCA12 | ATP-binding cassette sub-family A member 12 | [526] | [527] | [528] | [529] | [530] | [531] | [532] |
77 | PSMA8 | Proteasome subunit alpha type-7-like | [533] | [534] | [535] | [536] | [537] | [538] | [539] |
78 | SEM1 | Putative protein SEM1, isoform 2 | [540] | [541] | [542] | [543] | [544] | [545] | [546] |