REACTOME_ABACAVIR_TRANSPORT_AND_METABOLISM Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 ADH1A Alcohol dehydrogenase 1A [1] -11.39[2] [3] -7.14[4] -14.48[5] [6] -1.85[7]
2 PCK1 Phosphoenolpyruvate carboxykinase, cytosolic [GTP] [8] -5.34[9] -1.84[10] -9.10[11] [12] -12.82[13] 1.14[14]
3 GUK1 Guanylate kinase [15] 1.49[16] 0.99[17] 0.88[18] 2.07[19] 1.64[20] -1.69[21]
4 SLC22A1 Solute carrier family 22 member 1 [22] -7.16[23] -6.33[24] -8.47[25] -6.78[26] -7.24[27] 1.26[28]
5 ABCB1 Multidrug resistance protein 1 [29] 3.12[30] 3.89[31] 2.69[32] -2.33[33] -3.60[34] 0.76[35]
6 NT5C2 Cytosolic purine 5'-nucleotidase [36] 4.28[37] 4.05[38] 5.09[39] 4.28[40] 4.48[41] 0.39[42]
7 SLC22A3 Solute carrier family 22 member 3 [43] 2.88[44] 3.43[45] 0.27[46] 0.40[47] 3.93[48] 1.53[49]
8 ABCG2 ATP-binding cassette sub-family G member 2 [50] 3.76[51] 2.90[52] 4.45[53] 3.17[54] 2.46[55] 0.36[56]
9 ADAL Adenosine deaminase-like protein [57] 3.90[58] 3.77[59] 3.73[60] 4.56[61] 4.49[62] 0.39[63]
10 SLC22A2 Solute carrier family 22 member 2 [64] [65] 0.24[66] 0.53[67] 3.46[68] 3.16[69] [70]
[1]
ref_hepatocyte ADH1A
Mean 362
Standard deviation 6e+02
Values 0 0.45 9.8 4.1e+02 1.4e+03
[2]
HepG2 ADH1A
Mean 0.0229
Standard deviation 0.016
Values 0.011 0.034
[3]
HepG2.C3A ADH1A
Mean 0
Standard deviation 0
Values 0 0
[4]
HuH.7 ADH1A
Mean 0.465
Standard deviation 0.75
Values 0.057 1.3 0.0094
[5]
SNU475 ADH1A
Mean 0.00253
Standard deviation 0.0036
Values 0 0.0051
[6]
THLE ADH1A
Mean 0
Standard deviation 0
Values 0 0
[7]
liver ADH1A
Mean 135
Standard deviation 1.5e+02
Values 3.6e+02 47 93 38
[8]
ref_hepatocyte PCK1
Mean 142
Standard deviation 1.9e+02
Values 30 0.041 5.3 4.4e+02 2.4e+02
[9]
HepG2 PCK1
Mean 0.593
Standard deviation 0.35
Values 0.84 0.34
[10]
HepG2.C3A PCK1
Mean 10.1
Standard deviation 5.7
Values 14 6
[11]
HuH.7 PCK1
Mean 0.0471
Standard deviation 0.082
Values 0 0.14 0
[12]
SNU475 PCK1
Mean 0
Standard deviation 0
Values 0 0
[13]
THLE PCK1
Mean 0.00266
Standard deviation 0.0038
Values 0 0.0053
[14]
liver PCK1
Mean 420
Standard deviation 94
Values 3.7e+02 4.8e+02 5.2e+02 3.2e+02
[15]
ref_hepatocyte GUK1
Mean 109
Standard deviation 36
Values 48 1.1e+02 1.3e+02 1.4e+02 1.3e+02
[16]
HepG2 GUK1
Mean 51.7
Standard deviation 4.9
Values 55 48
[17]
HepG2.C3A GUK1
Mean 54.7
Standard deviation 0.073
Values 55 55
[18]
HuH.7 GUK1
Mean 36.6
Standard deviation 8.8
Values 31 32 47
[19]
SNU475 GUK1
Mean 73.3
Standard deviation 24
Values 90 56
[20]
THLE GUK1
Mean 46.2
Standard deviation 2.9
Values 44 48
[21]
liver GUK1
Mean 45.4
Standard deviation 35
Values 74 14 77 16
[22]
ref_hepatocyte SLC22A1
Mean 98.8
Standard deviation 1.2e+02
Values 0 2.5 42 1.9e+02 2.6e+02
[23]
HepG2 SLC22A1
Mean 0.117
Standard deviation 0.052
Values 0.08 0.15
[24]
HepG2.C3A SLC22A1
Mean 0.311
Standard deviation 0.14
Values 0.41 0.21
[25]
HuH.7 SLC22A1
Mean 0.0506
Standard deviation 0.035
Values 0.025 0.09 0.037
[26]
SNU475 SLC22A1
Mean 0.144
Standard deviation 0.039
Values 0.17 0.12
[27]
THLE SLC22A1
Mean 0.0887
Standard deviation 0.05
Values 0.12 0.053
[28]
liver SLC22A1
Mean 317
Standard deviation 1.8e+02
Values 5.4e+02 2.2e+02 3.7e+02 1.4e+02
[29]
ref_hepatocyte ABCB1
Mean 12.8
Standard deviation 7
Values 17 21 15 5.4 5.6
[30]
HepG2 ABCB1
Mean 18.8
Standard deviation 3.2
Values 17 21
[31]
HepG2.C3A ABCB1
Mean 47.9
Standard deviation 1.3
Values 47 49
[32]
HuH.7 ABCB1
Mean 15
Standard deviation 8.7
Values 11 25 9
[33]
SNU475 ABCB1
Mean 0.405
Standard deviation 0.094
Values 0.34 0.47
[34]
THLE ABCB1
Mean 0.143
Standard deviation 0.0068
Values 0.15 0.14
[35]
liver ABCB1
Mean 29
Standard deviation 14
Values 13 46 26 31
[36]
ref_hepatocyte NT5C2
Mean 10.7
Standard deviation 5.7
Values 14 19 7.1 6.7 6.3
[37]
HepG2 NT5C2
Mean 35
Standard deviation 8.8
Values 29 41
[38]
HepG2.C3A NT5C2
Mean 44.8
Standard deviation 0.63
Values 45 44
[39]
HuH.7 NT5C2
Mean 66
Standard deviation 5.7
Values 62 73 63
[40]
SNU475 NT5C2
Mean 33.1
Standard deviation 12
Values 42 25
[41]
THLE NT5C2
Mean 32.4
Standard deviation 5.7
Values 28 36
[42]
liver NT5C2
Mean 18.8
Standard deviation 2.6
Values 15 21 21 18
[43]
ref_hepatocyte SLC22A3
Mean 7.12
Standard deviation 5.4
Values 16 4.2 2.4 5.8 6.9
[44]
HepG2 SLC22A3
Mean 8.86
Standard deviation 0.53
Values 8.5 9.2
[45]
HepG2.C3A SLC22A3
Mean 19.5
Standard deviation 1.7
Values 21 18
[46]
HuH.7 SLC22A3
Mean 1.57
Standard deviation 0.81
Values 1.1 2.5 1.1
[47]
SNU475 SLC22A3
Mean 1.51
Standard deviation 1
Values 2.2 0.8
[48]
THLE SLC22A3
Mean 14.8
Standard deviation 11
Values 7.1 22
[49]
liver SLC22A3
Mean 27.5
Standard deviation 7.1
Values 37 21 23 29
[50]
ref_hepatocyte ABCG2
Mean 3
Standard deviation 1.8
Values 1.1 5.2 2.9 1.5 4.4
[51]
HepG2 ABCG2
Mean 6.88
Standard deviation 0.34
Values 7.1 6.6
[52]
HepG2.C3A ABCG2
Mean 5.65
Standard deviation 0.97
Values 5 6.3
[53]
HuH.7 ABCG2
Mean 11.9
Standard deviation 1.2
Values 13 11 11
[54]
SNU475 ABCG2
Mean 4.32
Standard deviation 1
Values 3.6 5
[55]
THLE ABCG2
Mean 2.24
Standard deviation 1.1
Values 1.4 3
[56]
liver ABCG2
Mean 5.14
Standard deviation 1.6
Values 3.4 7.3 4.8 5
[57]
ref_hepatocyte ADAL
Mean 1.78
Standard deviation 0.62
Values 2.2 2.5 0.91 1.8 1.5
[58]
HepG2 ADAL
Mean 4.52
Standard deviation 1.5
Values 3.5 5.6
[59]
HepG2.C3A ADAL
Mean 6.17
Standard deviation 0.39
Values 5.9 6.4
[60]
HuH.7 ADAL
Mean 4.3
Standard deviation 0.44
Values 4.7 3.8 4.3
[61]
SNU475 ADAL
Mean 6.74
Standard deviation 0.22
Values 6.9 6.6
[62]
THLE ADAL
Mean 5.43
Standard deviation 0.17
Values 5.5 5.3
[63]
liver ADAL
Mean 3.12
Standard deviation 0.44
Values 2.7 3.1 3.7 2.9
[64]
ref_hepatocyte SLC22A2
Mean 0.0163
Standard deviation 0.036
Values 0 0 0.082 0 0
[65]
HepG2 SLC22A2
Mean 0
Standard deviation 0
Values 0 0
[66]
HepG2.C3A SLC22A2
Mean 0.00486
Standard deviation 0.0069
Values 0.0097 0
[67]
HuH.7 SLC22A2
Mean 0.00428
Standard deviation 0.0074
Values 0 0.013 0
[68]
SNU475 SLC22A2
Mean 0.0287
Standard deviation 0.012
Values 0.037 0.02
[69]
THLE SLC22A2
Mean 0.0198
Standard deviation 0.0054
Values 0.024 0.016
[70]
liver SLC22A2
Mean 0
Standard deviation 0
Values 0 0 0 0