KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION |
Return to index |
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Order |
Gene |
Description |
ref_hepatocyte |
HepG2 |
HepG2.C3A |
HuH.7 |
SNU475 |
THLE |
liver |
1 |
ALDH2 |
Aldehyde dehydrogenase, mitochondrial |
[1] |
-0.91[2] |
-2.31[3] |
-2.00[4] |
-1.73[5] |
-1.81[6] |
-1.03[7] |
2 |
ECHS1 |
Enoyl-CoA hydratase, mitochondrial |
[8] |
-0.65[9] |
-0.61[10] |
-0.86[11] |
-1.30[12] |
-1.19[13] |
-0.76[14] |
3 |
HMGCS2 |
Hydroxymethylglutaryl-CoA synthase, mitochondrial |
[15] |
-11.44[16] |
-9.61[17] |
-2.71[18] |
-7.87[19] |
-12.39[20] |
0.25[21] |
4 |
ACAA2 |
3-ketoacyl-CoA thiolase, mitochondrial |
[22] |
-1.12[23] |
-1.59[24] |
-1.84[25] |
-1.05[26] |
-0.90[27] |
0.23[28] |
5 |
ACAT1 |
Acetyl-CoA acetyltransferase, mitochondrial |
[29] |
-0.48[30] |
-1.12[31] |
-2.32[32] |
-0.18[33] |
-1.38[34] |
0.00[35] |
6 |
AOX1 |
Aldehyde oxidase |
[36] |
-1.67[37] |
-2.37[38] |
-8.79[39] |
-2.60[40] |
-1.06[41] |
1.67[42] |
7 |
HMGCS1 |
Hydroxymethylglutaryl-CoA synthase, cytoplasmic |
[43] |
-1.81[44] |
0.91[45] |
2.27[46] |
-1.57[47] |
-1.91[48] |
-0.83[49] |
8 |
ACAA1 |
3-ketoacyl-CoA thiolase, peroxisomal |
[50] |
-0.46[51] |
0.52[52] |
-1.38[53] |
-1.62[54] |
-1.42[55] |
-0.45[56] |
9 |
HSD17B10 |
3-hydroxyacyl-CoA dehydrogenase type-2 |
[57] |
-0.72[58] |
-1.50[59] |
-1.28[60] |
0.15[61] |
0.83[62] |
-1.55[63] |
10 |
HADHA |
Trifunctional enzyme subunit alpha, mitochondrial |
[64] |
1.81[65] |
1.60[66] |
1.59[67] |
1.47[68] |
1.64[69] |
0.05[70] |
11 |
HMGCL |
Hydroxymethylglutaryl-CoA lyase, mitochondrial |
[71] |
-0.92[72] |
0.12[73] |
-0.62[74] |
-0.51[75] |
-1.11[76] |
-0.84[77] |
12 |
ACAT2 |
Acetyl-CoA acetyltransferase, cytosolic |
[78] |
-0.15[79] |
1.35[80] |
0.84[81] |
-0.89[82] |
-0.46[83] |
-1.31[84] |
13 |
HADHB |
Trifunctional enzyme subunit beta, mitochondrial |
[85] |
1.72[86] |
1.27[87] |
0.76[88] |
1.38[89] |
1.34[90] |
0.55[91] |
14 |
ABAT |
4-aminobutyrate aminotransferase, mitochondrial |
[92] |
1.45[93] |
0.66[94] |
-1.10[95] |
-6.65[96] |
-4.93[97] |
0.59[98] |
15 |
ACADS |
Short-chain specific acyl-CoA dehydrogenase, mitochondrial |
[99] |
-0.79[100] |
-0.34[101] |
-1.63[102] |
-0.91[103] |
-2.27[104] |
-0.85[105] |
16 |
ALDH1B1 |
Aldehyde dehydrogenase X, mitochondrial |
[106] |
1.34[107] |
0.78[108] |
-1.12[109] |
0.58[110] |
-0.04[111] |
-0.82[112] |
17 |
HIBADH |
3-hydroxyisobutyrate dehydrogenase, mitochondrial |
[113] |
0.93[114] |
0.10[115] |
0.58[116] |
1.34[117] |
0.10[118] |
-0.99[119] |
18 |
ALDH9A1 |
4-trimethylaminobutyraldehyde dehydrogenase |
[120] |
-0.87[121] |
-0.61[122] |
0.61[123] |
1.16[124] |
1.22[125] |
-0.54[126] |
19 |
ALDH3A2 |
Fatty aldehyde dehydrogenase |
[127] |
1.99[128] |
1.38[129] |
0.82[130] |
2.00[131] |
1.05[132] |
-0.17[133] |
20 |
PCCB |
Propionyl-CoA carboxylase beta chain, mitochondrial |
[134] |
0.68[135] |
0.09[136] |
-1.22[137] |
0.78[138] |
0.70[139] |
-0.69[140] |
21 |
HADH |
Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial |
[141] |
-0.39[142] |
-0.06[143] |
-0.30[144] |
-0.18[145] |
0.11[146] |
-0.47[147] |
22 |
ACADM |
Medium-chain specific acyl-CoA dehydrogenase, mitochondrial |
[148] |
0.02[149] |
0.94[150] |
0.19[151] |
1.34[152] |
0.32[153] |
0.25[154] |
23 |
ACADSB |
Short/branched chain specific
acyl-CoA dehydrogenase, mitochondrial |
0.30[155] |
2.31[156] |
1.83[157] |
-0.81[158] |
-1.11[159] |
1.47[160] |
24 |
ALDH6A1 |
Methylmalonate-semialdehyde
dehydrogenase [acylating], mitochondrial |
-1.93[161] |
-0.77[162] |
-0.97[163] |
-2.13[164] |
-1.96[165] |
0.46[166] |
25 |
EHHADH |
Peroxisomal bifunctional enzyme |
[167] |
-0.88[168] |
-0.63[169] |
-0.06[170] |
-0.52[171] |
-1.31[172] |
1.06[173] |
26 |
DLD |
Dihydrolipoyl dehydrogenase, mitochondrial |
[174] |
0.86[175] |
1.05[176] |
0.87[177] |
2.44[178] |
1.81[179] |
-0.49[180] |
27 |
MCCC2 |
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial |
[181] |
2.13[182] |
1.57[183] |
1.78[184] |
1.62[185] |
1.65[186] |
0.24[187] |
28 |
BCKDHA |
2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial |
[188] |
0.19[189] |
0.00[190] |
1.30[191] |
0.82[192] |
0.86[193] |
-0.18[194] |
29 |
IVD |
Isovaleryl-CoA dehydrogenase, mitochondrial |
[195] |
2.33[196] |
1.95[197] |
0.26[198] |
2.15[199] |
1.94[200] |
1.21[201] |
30 |
HIBCH |
3-hydroxyisobutyryl-CoA hydrolase, mitochondrial |
[202] |
-0.22[203] |
0.42[204] |
-0.55[205] |
0.23[206] |
-0.06[207] |
-0.41[208] |
31 |
ALDH7A1 |
Alpha-aminoadipic semialdehyde dehydrogenase |
[209] |
2.65[210] |
2.07[211] |
1.84[212] |
2.65[213] |
2.92[214] |
-0.30[215] |
32 |
PCCA |
Propionyl-CoA carboxylase alpha chain, mitochondrial |
[216] |
0.43[217] |
0.01[218] |
-0.20[219] |
-0.73[220] |
-0.74[221] |
0.55[222] |
33 |
MCCC1 |
Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial |
[223] |
0.41[224] |
-0.08[225] |
0.85[226] |
0.30[227] |
0.54[228] |
-0.06[229] |
34 |
MCEE |
Methylmalonyl-CoA epimerase, mitochondrial |
[230] |
-0.59[231] |
0.28[232] |
-0.37[233] |
-1.13[234] |
-0.92[235] |
-1.60[236] |
35 |
BCKDHB |
2-oxoisovalerate dehydrogenase subunit beta, mitochondrial |
[237] |
-0.44[238] |
-0.38[239] |
0.77[240] |
0.99[241] |
0.19[242] |
0.34[243] |
36 |
AUH |
Methylglutaconyl-CoA hydratase, mitochondrial |
[244] |
0.42[245] |
1.68[246] |
0.76[247] |
0.00[248] |
1.08[249] |
-0.92[250] |
37 |
ACAD8 |
Isobutyryl-CoA dehydrogenase, mitochondrial |
[251] |
1.28[252] |
0.38[253] |
0.02[254] |
1.57[255] |
1.67[256] |
0.17[257] |
38 |
BCAT2 |
Branched-chain-amino-acid aminotransferase, mitochondrial |
[258] |
-0.70[259] |
-0.25[260] |
2.81[261] |
3.63[262] |
2.96[263] |
-0.35[264] |
39 |
DBT |
Lipoamide acyltransferase component
of branched-chain alpha-keto acid dehydrogenase
complex, mitochondrial |
2.51[265] |
2.72[266] |
4.18[267] |
4.39[268] |
4.00[269] |
2.47[270] |
40 |
BCAT1 |
Branched-chain-amino-acid aminotransferase, cytosolic |
[271] |
5.45[272] |
4.69[273] |
7.04[274] |
6.93[275] |
8.26[276] |
-0.53[277] |
41 |
OXCT2 |
Succinyl-CoA:3-ketoacid coenzyme A transferase 2, mitochondrial |
[278] |
1.08[279] |
1.65[280] |
1.64[281] |
0.99[282] |
1.20[283] |
-2.50[284] |
42 |
OXCT1 |
Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial |
[285] |
2.91[286] |
1.47[287] |
5.75[288] |
6.74[289] |
8.00[290] |
0.01[291] |
43 |
IL4I1 |
L-amino-acid oxidase |
[292] |
-2.76[293] |
-4.18[294] |
-1.07[295] |
2.62[296] |
0.44[297] |
-1.90[298] |
44 |
MMUT |
|
[299] |
[300] |
[301] |
[302] |
[303] |
[304] |
[305] |
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