KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | RHOA | Transforming protein RhoA | [1] | -1.04[2] | -1.65[3] | -1.34[4] | -1.15[5] | -0.76[6] | -1.35[7] |
2 | CDC42 | Cell division control protein 42 homolog | [8] | -0.92[9] | -0.32[10] | -1.24[11] | -0.46[12] | -1.25[13] | -2.11[14] |
3 | NFKBIA | NF-kappa-B inhibitor alpha | [15] | -1.15[16] | -3.06[17] | -3.35[18] | -3.44[19] | -1.63[20] | -1.16[21] |
4 | JUN | Transcription factor AP-1 | [22] | -0.59[23] | -2.24[24] | -1.88[25] | -1.63[26] | -1.12[27] | -1.83[28] |
5 | FOS | Proto-oncogene c-Fos | [29] | -6.11[30] | -4.96[31] | -5.53[32] | -6.09[33] | -5.09[34] | -1.33[35] |
6 | AKT1 | RAC-alpha serine/threonine-protein kinase | [36] | -0.02[37] | -0.36[38] | -1.35[39] | 0.03[40] | -0.02[41] | -0.27[42] |
7 | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1 | [43] | -1.03[44] | -1.47[45] | -0.80[46] | -0.47[47] | -0.02[48] | -1.21[49] |
8 | MAP2K2 | Dual specificity mitogen-activated protein kinase kinase 2 | [50] | -0.04[51] | -0.48[52] | 0.48[53] | -0.77[54] | -0.35[55] | -1.72[56] |
9 | IKBKG | NF-kappa-B essential modulator | [57] | -0.99[58] | -0.95[59] | -3.11[60] | -0.77[61] | -2.05[62] | -0.63[63] |
10 | GRB2 | Growth factor receptor-bound protein 2 | [64] | 1.10[65] | 0.82[66] | 1.03[67] | 0.63[68] | 0.48[69] | 0.28[70] |
11 | CDK4 | Cyclin-dependent kinase 4 | [71] | 1.24[72] | 1.71[73] | 1.42[74] | 0.26[75] | 0.84[76] | -0.86[77] |
12 | RELA | Transcription factor p65 | [78] | 0.04[79] | -0.58[80] | -0.36[81] | 0.02[82] | -0.14[83] | -0.90[84] |
13 | RAF1 | RAF proto-oncogene serine/threonine-protein kinase | [85] | -0.16[86] | 0.13[87] | 1.49[88] | -0.11[89] | 0.69[90] | 1.07[91] |
14 | CD4 | T-cell surface glycoprotein CD4 | [92] | -5.85[93] | -3.78[94] | -6.32[95] | -7.38[96] | -9.50[97] | -0.11[98] |
15 | NRAS | GTPase NRas | [99] | 0.53[100] | 0.85[101] | 1.35[102] | 1.07[103] | 0.58[104] | -0.27[105] |
16 | NFKBIB | NF-kappa-B inhibitor beta | [106] | -1.26[107] | -1.55[108] | -1.13[109] | -1.74[110] | -1.46[111] | -1.75[112] |
17 | PPP3R1 | Calcineurin subunit B type 1 | [113] | 0.09[114] | 0.16[115] | 0.16[116] | 0.78[117] | 0.48[118] | -1.17[119] |
18 | HRAS | GTPase HRas | [120] | -1.10[121] | -1.92[122] | -2.63[123] | -0.87[124] | -1.15[125] | -2.68[126] |
19 | NCK1 | Cytoplasmic protein NCK1 | [127] | -1.69[128] | -1.70[129] | -1.50[130] | -0.49[131] | -0.44[132] | -0.49[133] |
20 | PAK2 | Serine/threonine-protein kinase PAK 2 | [134] | 1.35[135] | 0.98[136] | 1.37[137] | 0.83[138] | 1.31[139] | 1.34[140] |
21 | MAPK1 | Mitogen-activated protein kinase 1 | [141] | 1.61[142] | 1.64[143] | 1.55[144] | 1.93[145] | 1.51[146] | 1.75[147] |
22 | AKT2 | RAC-beta serine/threonine-protein kinase | [148] | 0.86[149] | 1.03[150] | 1.24[151] | 0.93[152] | 0.66[153] | 1.11[154] |
23 | KRAS | GTPase KRas | [155] | -0.61[156] | -0.74[157] | 0.94[158] | 0.88[159] | 0.47[160] | 0.65[161] |
24 | MAPK14 | Mitogen-activated protein kinase 14 | [162] | 1.38[163] | 1.33[164] | 1.00[165] | 1.76[166] | 1.17[167] | 1.26[168] |
25 | MAP3K7 | Mitogen-activated protein kinase kinase kinase 7 | [169] | -0.20[170] | 0.76[171] | 0.72[172] | 0.56[173] | 0.68[174] | 0.23[175] |
26 | VAV2 | Guanine nucleotide exchange factor VAV2 | [176] | 1.20[177] | 1.34[178] | 0.92[179] | -0.46[180] | -0.10[181] | 0.49[182] |
27 | PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha | [183] | -0.57[184] | -0.56[185] | 0.62[186] | 2.14[187] | 1.58[188] | 2.98[189] |
28 | CBLC | E3 ubiquitin-protein ligase CBL-C | [190] | -2.12[191] | -1.11[192] | -9.36[193] | -11.45[194] | -10.01[195] | -1.11[196] |
29 | SOS1 | Son of sevenless homolog 1 | [197] | -0.20[198] | 1.22[199] | 0.82[200] | 0.92[201] | 0.09[202] | 0.52[203] |
30 | NFKB1 | Nuclear factor NF-kappa-B p105 subunit | [204] | 0.57[205] | 0.14[206] | 0.02[207] | -0.17[208] | 0.67[209] | 0.43[210] |
31 | DLG1 | Disks large homolog 1 | [211] | 0.97[212] | 1.20[213] | 1.16[214] | 1.38[215] | 1.32[216] | 1.29[217] |
32 | MAPK13 | Mitogen-activated protein kinase 13 | [218] | 2.25[219] | 2.54[220] | -0.06[221] | -1.81[222] | -0.36[223] | -1.74[224] |
33 | PTPN6 | Tyrosine-protein phosphatase non-receptor type 6 | [225] | -0.56[226] | -0.48[227] | 0.18[228] | -7.06[229] | -2.11[230] | -0.20[231] |
34 | PIK3R2 | Phosphatidylinositol 3-kinase regulatory subunit beta | [232] | 1.78[233] | 1.89[234] | 2.59[235] | 0.78[236] | 1.28[237] | -0.31[238] |
35 | NCK2 | Cytoplasmic protein NCK2 | [239] | 0.70[240] | 0.17[241] | -1.32[242] | -0.25[243] | 0.43[244] | -0.85[245] |
36 | PAK4 | Serine/threonine-protein kinase PAK 4 | [246] | 0.80[247] | 0.73[248] | 1.51[249] | 1.10[250] | 0.76[251] | -0.35[252] |
37 | PPP3CB | Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform | 0.39[253] | 1.07[254] | 0.67[255] | 0.83[256] | 0.51[257] | -0.17[258] | |
38 | MAPK9 | Mitogen-activated protein kinase 9 | [259] | 1.13[260] | 1.24[261] | 1.39[262] | 1.79[263] | 1.18[264] | 0.49[265] |
39 | NFATC3 | Nuclear factor of activated T-cells, cytoplasmic 3 | [266] | 1.37[267] | 2.04[268] | 2.02[269] | 0.94[270] | 1.25[271] | 2.38[272] |
40 | MAPK3 | Mitogen-activated protein kinase 3 | [273] | 1.75[274] | 1.69[275] | 1.81[276] | 0.50[277] | 0.45[278] | -1.06[279] |
41 | GSK3B | Glycogen synthase kinase-3 beta | [280] | 1.17[281] | 0.69[282] | 1.35[283] | 1.89[284] | 1.65[285] | 1.14[286] |
42 | NFKBIE | NF-kappa-B inhibitor epsilon | [287] | -0.06[288] | 0.75[289] | -1.02[290] | -0.71[291] | -0.31[292] | -1.29[293] |
43 | CHUK | Inhibitor of nuclear factor kappa-B kinase subunit alpha | [294] | 0.81[295] | 1.91[296] | 1.96[297] | 0.73[298] | 1.47[299] | 1.49[300] |
44 | MAP2K7 | Dual specificity mitogen-activated protein kinase kinase 7 | [301] | 0.87[302] | 0.90[303] | 1.56[304] | 0.36[305] | 0.85[306] | -0.78[307] |
45 | PPP3CC | Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform | -0.80[308] | -0.77[309] | -1.08[310] | -1.01[311] | -0.16[312] | 0.04[313] | |
46 | PDPK1 | 3-phosphoinositide-dependent protein kinase 1 | [314] | 2.24[315] | 3.31[316] | 2.11[317] | 1.51[318] | 1.84[319] | 2.48[320] |
47 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 3.39[321] | 2.90[322] | 2.32[323] | 2.90[324] | 2.33[325] | 0.32[326] | |
48 | IKBKB | Inhibitor of nuclear factor kappa-B kinase subunit beta | [327] | 0.42[328] | 0.37[329] | 0.56[330] | 0.33[331] | 0.36[332] | 1.16[333] |
49 | PPP3CA | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | 0.63[334] | 0.28[335] | 0.17[336] | 2.02[337] | 1.70[338] | 1.78[339] | |
50 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 1.11[340] | 1.51[341] | 1.76[342] | 1.13[343] | 1.22[344] | 1.13[345] | |
51 | BCL10 | B-cell lymphoma/leukemia 10 | [346] | -0.01[347] | -0.62[348] | 0.46[349] | 0.61[350] | 0.59[351] | 0.51[352] |
52 | SOS2 | Son of sevenless homolog 2 | [353] | -0.12[354] | 0.89[355] | 0.21[356] | 1.77[357] | 1.56[358] | 1.82[359] |
53 | PAK1 | Serine/threonine-protein kinase PAK 1 | [360] | -0.11[361] | -0.98[362] | 1.52[363] | -1.78[364] | 1.93[365] | 0.25[366] |
54 | FYN | Tyrosine-protein kinase Fyn | [367] | 0.85[368] | -7.87[369] | 0.79[370] | 1.55[371] | 3.01[372] | 0.95[373] |
55 | CBLB | E3 ubiquitin-protein ligase CBL-B | [374] | -0.74[375] | 0.39[376] | 0.91[377] | 0.85[378] | 1.65[379] | 1.35[380] |
56 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | 2.76[381] | 2.49[382] | 2.00[383] | 2.12[384] | 1.33[385] | 2.24[386] | |
57 | MAP3K14 | Mitogen-activated protein kinase kinase kinase 14 | [387] | -0.49[388] | -0.15[389] | -1.23[390] | 2.15[391] | 1.07[392] | 0.86[393] |
58 | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | -0.48[394] | 1.05[395] | 1.32[396] | 1.20[397] | 1.34[398] | 1.89[399] | |
59 | PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | 1.79[400] | 2.77[401] | -0.96[402] | 0.36[403] | 1.06[404] | 0.28[405] | |
60 | MAP3K8 | Mitogen-activated protein kinase kinase kinase 8 | [406] | 1.65[407] | 1.54[408] | 0.82[409] | 0.18[410] | 1.44[411] | 0.46[412] |
61 | PTPRC | Receptor-type tyrosine-protein phosphatase C | [413] | [414] | [415] | [416] | 0.45[417] | -8.54[418] | 3.12[419] |
62 | NFAT5 | Nuclear factor of activated T-cells 5 | [420] | 3.49[421] | 4.16[422] | 4.26[423] | 3.97[424] | 3.52[425] | 4.61[426] |
63 | MAPK12 | Mitogen-activated protein kinase 12 | [427] | 2.72[428] | 2.27[429] | 3.47[430] | 1.56[431] | 2.75[432] | -0.93[433] |
64 | LCP2 | Lymphocyte cytosolic protein 2 | [434] | [435] | [436] | [437] | -3.64[438] | [439] | 1.12[440] |
65 | TEC | Tyrosine-protein kinase Tec | [441] | -2.25[442] | -2.76[443] | -2.08[444] | 1.42[445] | -0.23[446] | 1.57[447] |
66 | LAT | Linker for activation of T-cells family member 1 | [448] | -1.55[449] | -0.12[450] | -1.63[451] | -1.29[452] | -0.78[453] | -0.44[454] |
67 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | [455] | -8.96[456] | [457] | -5.51[458] | [459] | [460] | -0.63[461] |
68 | VAV3 | Guanine nucleotide exchange factor VAV3 | [462] | 1.71[463] | -0.11[464] | 2.15[465] | 3.76[466] | -2.28[467] | 1.33[468] |
69 | CBL | E3 ubiquitin-protein ligase CBL | [469] | 4.35[470] | 3.18[471] | 3.49[472] | 5.21[473] | 4.63[474] | 3.73[475] |
70 | IL10 | Interleukin-10 | [476] | -1.97[477] | -2.33[478] | -2.06[479] | -1.91[480] | -2.44[481] | -1.61[482] |
71 | VAV1 | Proto-oncogene vav | [483] | -8.59[484] | -3.88[485] | -5.50[486] | -6.01[487] | -7.34[488] | 1.16[489] |
72 | PIK3R3 | Phosphatidylinositol 3-kinase regulatory subunit gamma | [490] | 1.63[491] | 1.52[492] | 2.46[493] | 3.24[494] | 2.20[495] | 2.65[496] |
73 | NFATC1 | Nuclear factor of activated T-cells, cytoplasmic 1 | [497] | -2.05[498] | -4.67[499] | 2.01[500] | -5.90[501] | 2.44[502] | 0.70[503] |
74 | AKT3 | RAC-gamma serine/threonine-protein kinase | [504] | -1.94[505] | -4.61[506] | -3.83[507] | 5.92[508] | 4.81[509] | 3.59[510] |
75 | MAPK11 | Mitogen-activated protein kinase 11 | [511] | -0.27[512] | -0.48[513] | -1.29[514] | 0.43[515] | 2.36[516] | 0.14[517] |
76 | PIK3R5 | Phosphoinositide 3-kinase regulatory subunit 5 | [518] | -7.26[519] | [520] | -2.65[521] | -3.85[522] | -3.57[523] | 2.32[524] |
77 | CD247 | T-cell surface glycoprotein CD3 zeta chain | [525] | -4.96[526] | -5.75[527] | -7.17[528] | -3.44[529] | -4.89[530] | -0.04[531] |
78 | CD3D | T-cell surface glycoprotein CD3 delta chain | [532] | 1.30[533] | -0.82[534] | -3.10[535] | -6.43[536] | -4.50[537] | -0.35[538] |
79 | NFATC2 | Nuclear factor of activated T-cells, cytoplasmic 2 | [539] | 2.49[540] | 3.64[541] | 3.13[542] | 0.26[543] | 1.15[544] | 3.26[545] |
80 | LCK | Tyrosine-protein kinase Lck | [546] | 2.68[547] | 2.65[548] | -7.26[549] | -5.01[550] | -5.27[551] | 1.21[552] |
81 | CD8A | T-cell surface glycoprotein CD8 alpha chain | [553] | -0.72[554] | -4.59[555] | 0.63[556] | -4.60[557] | -3.31[558] | 0.82[559] |
82 | CD3G | T-cell surface glycoprotein CD3 gamma chain | [560] | -3.69[561] | -3.04[562] | -4.02[563] | -4.54[564] | -4.01[565] | -0.36[566] |
83 | ZAP70 | Tyrosine-protein kinase ZAP-70 | [567] | 0.91[568] | 1.01[569] | -5.13[570] | -5.47[571] | -4.19[572] | 2.14[573] |
84 | IFNG | Interferon gamma | [574] | [575] | [576] | [577] | -0.62[578] | [579] | -2.32[580] |
85 | CHP2 | Calcineurin B homologous protein 2 | [581] | -0.64[582] | -1.19[583] | -1.96[584] | -1.52[585] | -1.98[586] | -1.92[587] |
86 | ITK | Tyrosine-protein kinase ITK/TSK | [588] | -7.00[589] | -4.13[590] | [591] | -0.09[592] | -4.89[593] | 2.17[594] |
87 | TNF | Tumor necrosis factor | [595] | 1.00[596] | -1.24[597] | -5.75[598] | -2.14[599] | -5.43[600] | -1.91[601] |
88 | CARD11 | Caspase recruitment domain-containing protein 11 | [602] | 1.04[603] | -5.59[604] | -6.27[605] | 1.32[606] | 5.77[607] | 2.25[608] |
89 | CD40LG | CD40 ligand | [609] | -4.87[610] | [611] | -6.55[612] | -4.16[613] | [614] | -0.60[615] |
90 | CD28 | T-cell-specific surface glycoprotein CD28 | [616] | -4.10[617] | -3.34[618] | -3.22[619] | -2.27[620] | -2.39[621] | 1.10[622] |
91 | PAK3 | Serine/threonine-protein kinase PAK 3 | [623] | -6.51[624] | [625] | [626] | -1.52[627] | 0.13[628] | 0.76[629] |
92 | GRAP2 | GRB2-related adapter protein 2 | [630] | -5.94[631] | [632] | -2.35[633] | -1.90[634] | -0.93[635] | 0.81[636] |
93 | PAK6 | Serine/threonine-protein kinase PAK 6 | [637] | -1.77[638] | [639] | 0.93[640] | 2.28[641] | 1.32[642] | -1.10[643] |
94 | PRKCQ | Protein kinase C theta type | [644] | 0.81[645] | -2.87[646] | [647] | 2.20[648] | 3.64[649] | 2.07[650] |
95 | PIK3CG | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | [651] | [652] | [653] | 1.42[654] | -3.53[655] | 4.08[656] | |
96 | CSF2 | Granulocyte-macrophage colony-stimulating factor | [657] | 0.37[658] | -3.70[659] | -2.97[660] | -1.64[661] | 6.19[662] | -1.50[663] |
97 | ICOS | Inducible T-cell costimulator | [664] | [665] | -3.58[666] | [667] | [668] | [669] | -0.58[670] |
98 | NFATC4 | Nuclear factor of activated T-cells, cytoplasmic 4 | [671] | 2.56[672] | -0.28[673] | 2.79[674] | 2.82[675] | 8.59[676] | 5.20[677] |
99 | CD8B | T-cell surface glycoprotein CD8 beta chain | [678] | 0.90[679] | -0.85[680] | 7.83[681] | [682] | -2.00[683] | 3.10[684] |
100 | PDCD1 | Programmed cell death protein 1 | [685] | 4.73[686] | 1.31[687] | [688] | -0.16[689] | [690] | 2.59[691] |
101 | RASGRP1 | RAS guanyl-releasing protein 1 | [692] | 1.14[693] | 1.72[694] | 2.45[695] | 4.22[696] | 5.24[697] | 6.78[698] |
102 | CHP1 | Calcineurin B homologous protein 1 | [699] | [700] | [701] | [702] | [703] | [704] | [705] |
103 | IL2 | Interleukin-2 | [706] | [707] | [708] | [709] | [710] | [711] | [712] |
104 | IL4 | Interleukin-4 | [713] | [714] | [715] | [716] | [717] | [718] | [719] |
105 | PPP3R2 | Calcineurin subunit B type 2 | [720] | [721] | [722] | [723] | [724] | [725] | [726] |
106 | PAK5 | Serine/threonine-protein kinase PAK 5 | [727] | [728] | [729] | [730] | [731] | [732] | [733] |
107 | IL5 | Interleukin-5 | [734] | [735] | [736] | [737] | [738] | [739] | [740] |
108 | CTLA4 | Cytotoxic T-lymphocyte protein 4 | [741] | [742] | [743] | [744] | [745] | [746] | [747] |