KEGG_TYPE_II_DIABETES_MELLITUS | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | SLC2A2 | Solute carrier family 2, facilitated glucose transporter member 2 | [1] | -5.16[2] | -4.11[3] | -3.41[4] | -9.10[5] | -13.02[6] | 0.01[7] |
2 | SOCS3 | Suppressor of cytokine signaling 3 | [8] | -6.10[9] | -6.24[10] | -4.47[11] | -3.12[12] | -3.75[13] | -1.70[14] |
3 | MAPK1 | Mitogen-activated protein kinase 1 | [15] | -0.25[16] | 0.16[17] | 0.04[18] | -0.48[19] | -0.38[20] | -0.06[21] |
4 | PRKCZ | Protein kinase C zeta type | [22] | -1.49[23] | -0.83[24] | -2.78[25] | -4.62[26] | -6.38[27] | -3.47[28] |
5 | PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha | [29] | -2.43[30] | -2.04[31] | -0.90[32] | -0.26[33] | -0.31[34] | 1.17[35] |
6 | PKLR | Pyruvate kinase PKLR | [36] | -3.82[37] | -1.68[38] | -3.35[39] | -12.50[40] | -11.95[41] | -0.87[42] |
7 | MAPK8 | Mitogen-activated protein kinase 8 | [43] | -3.40[44] | -1.72[45] | -2.80[46] | -3.23[47] | -2.92[48] | -2.34[49] |
8 | INSR | Insulin receptor | [50] | -1.50[51] | -0.58[52] | 0.91[53] | -5.41[54] | -2.36[55] | 2.17[56] |
9 | PIK3R2 | Phosphatidylinositol 3-kinase regulatory subunit beta | [57] | -0.08[58] | 0.41[59] | 1.07[60] | -1.62[61] | -0.61[62] | -2.12[63] |
10 | MAPK9 | Mitogen-activated protein kinase 9 | [64] | -0.73[65] | -0.23[66] | -0.12[67] | -0.61[68] | -0.71[69] | -1.32[70] |
11 | MAPK3 | Mitogen-activated protein kinase 3 | [71] | -0.11[72] | 0.21[73] | 0.30[74] | -1.90[75] | -1.43[76] | -2.87[77] |
12 | SOCS2 | Suppressor of cytokine signaling 2 | [78] | -2.76[79] | -5.03[80] | -6.74[81] | -1.67[82] | -6.95[83] | -0.18[84] |
13 | PRKCD | Protein kinase C delta type | [85] | -0.86[86] | -0.34[87] | -0.81[88] | -2.83[89] | -1.22[90] | -2.90[91] |
14 | IKBKB | Inhibitor of nuclear factor kappa-B kinase subunit beta | [92] | -1.44[93] | -1.11[94] | -0.95[95] | -2.07[96] | -1.53[97] | -0.65[98] |
15 | MTOR | Serine/threonine-protein kinase mTOR | [99] | 0.58[100] | 1.86[101] | 1.48[102] | 0.36[103] | 0.88[104] | 1.62[105] |
16 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.75[106] | 0.03[107] | 0.24[108] | -1.27[109] | -0.67[110] | -0.67[111] | |
17 | IRS1 | Insulin receptor substrate 1 | [112] | 0.13[113] | -0.15[114] | 1.33[115] | -0.62[116] | -0.59[117] | 0.28[118] |
18 | SOCS4 | Suppressor of cytokine signaling 4 | [119] | -1.32[120] | -0.25[121] | 0.30[122] | -0.54[123] | 0.52[124] | -0.06[125] |
19 | IRS2 | Insulin receptor substrate 2 | [126] | -7.61[127] | [128] | -4.43[129] | -2.99[130] | 1.28[131] | 0.55[132] |
20 | SOCS1 | Suppressor of cytokine signaling 1 | [133] | -3.41[134] | -2.27[135] | -1.95[136] | -4.12[137] | -5.05[138] | -3.30[139] |
21 | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | -2.34[140] | -0.43[141] | -0.19[142] | -1.20[143] | -0.55[144] | 0.08[145] | |
22 | HK1 | Hexokinase-1 | [146] | -1.04[147] | -5.66[148] | -6.88[149] | 2.21[150] | 2.70[151] | -0.92[152] |
23 | PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | -0.07[153] | 1.29[154] | -2.47[155] | -2.05[156] | -0.83[157] | -1.53[158] | |
24 | PRKCE | Protein kinase C epsilon type | [159] | -1.32[160] | -2.56[161] | -0.01[162] | -1.34[163] | -0.53[164] | 1.73[165] |
25 | HK2 | Hexokinase-2 | [166] | 3.93[167] | 4.55[168] | 3.66[169] | 1.54[170] | 2.76[171] | -1.29[172] |
26 | GCK | Glucokinase | [173] | -9.91[174] | -7.64[175] | -10.78[176] | -9.25[177] | -6.85[178] | 0.10[179] |
27 | HK3 | Hexokinase-3 | [180] | -9.80[181] | -9.46[182] | -10.32[183] | -7.83[184] | -10.57[185] | 1.14[186] |
28 | SLC2A4 | Solute carrier family 2, facilitated glucose transporter member 4 | [187] | -0.13[188] | 0.38[189] | 1.05[190] | -4.46[191] | -4.74[192] | -0.39[193] |
29 | KCNJ11 | ATP-sensitive inward rectifier potassium channel 11 | [194] | -1.65[195] | -1.89[196] | -2.40[197] | -3.53[198] | -3.82[199] | -2.28[200] |
30 | PIK3R3 | Phosphatidylinositol 3-kinase regulatory subunit gamma | [201] | -0.24[202] | 0.04[203] | 0.94[204] | 0.84[205] | 0.31[206] | 0.85[207] |
31 | PIK3R5 | Phosphoinositide 3-kinase regulatory subunit 5 | [208] | -9.13[209] | [210] | -4.17[211] | -6.25[212] | -5.46[213] | 0.51[214] |
32 | CACNA1D | Voltage-dependent L-type calcium channel subunit alpha-1D | [215] | -5.68[216] | -2.39[217] | -0.04[218] | -3.79[219] | -5.99[220] | 2.68[221] |
33 | TNF | Tumor necrosis factor | [222] | -0.86[223] | -2.72[224] | -7.27[225] | -4.55[226] | -7.32[227] | -3.72[228] |
34 | MAFA | Transcription factor MafA | [229] | -1.54[230] | -2.92[231] | -2.14[232] | -5.76[233] | -3.30[234] | [235] |
35 | ADIPOQ | Adiponectin | [236] | -3.47[237] | -3.00[238] | -3.18[239] | -3.19[240] | -3.75[241] | -2.58[242] |
36 | PIK3CG | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | [243] | [244] | [245] | -0.98[246] | -5.42[247] | 2.27[248] | |
37 | PDX1 | Pancreas/duodenum homeobox protein 1 | [249] | -1.56[250] | -3.97[251] | 3.99[252] | -4.59[253] | [254] | 0.61[255] |
38 | ABCC8 | ATP-binding cassette sub-family C member 8 | [256] | -2.85[257] | [258] | -3.46[259] | [260] | [261] | -0.34[262] |
39 | CACNA1A | Voltage-dependent P/Q-type calcium channel subunit alpha-1A | [263] | -4.06[264] | -2.44[265] | 0.50[266] | 2.61[267] | 1.12[268] | 2.45[269] |
40 | IRS4 | Insulin receptor substrate 4 | [270] | [271] | [272] | [273] | -3.88[274] | -4.53[275] | [276] |
41 | MAPK10 | Mitogen-activated protein kinase 10 | [277] | -3.44[278] | [279] | [280] | 6.58[281] | 2.77[282] | 5.42[283] |
42 | CACNA1C | Voltage-dependent L-type calcium channel subunit alpha-1C | [284] | 2.77[285] | 0.53[286] | 3.44[287] | 3.40[288] | 6.07[289] | 6.48[290] |
43 | CACNA1G | Voltage-dependent T-type calcium channel subunit alpha-1G | [291] | [292] | [293] | [294] | [295] | [296] | [297] |
44 | CACNA1B | Voltage-dependent N-type calcium channel subunit alpha-1B | [298] | [299] | [300] | [301] | [302] | [303] | [304] |
45 | CACNA1E | Voltage-dependent R-type calcium channel subunit alpha-1E | [305] | [306] | [307] | [308] | [309] | [310] | [311] |
46 | PKM | Pyruvate kinase PKM | [312] | [313] | [314] | [315] | [316] | [317] | [318] |
47 | INS | Insulin | [319] | [320] | [321] | [322] | [323] | [324] | [325] |