KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | LBP | Lipopolysaccharide-binding protein | [1] | -11.17[2] | -13.91[3] | -6.05[4] | -12.55[5] | -17.40[6] | 0.10[7] |
2 | CD14 | Monocyte differentiation antigen CD14 | [8] | -7.85[9] | -7.64[10] | -4.55[11] | -4.22[12] | -5.07[13] | -0.48[14] |
3 | NFKBIA | NF-kappa-B inhibitor alpha | [15] | -0.57[16] | -2.07[17] | -2.18[18] | -2.94[19] | -0.71[20] | -1.11[21] |
4 | RAC1 | Ras-related C3 botulinum toxin substrate 1 | [22] | 0.09[23] | 0.05[24] | 1.03[25] | 0.59[26] | 0.92[27] | -0.94[28] |
5 | JUN | Transcription factor AP-1 | [29] | 0.00[30] | -1.26[31] | -0.72[32] | -1.12[33] | -0.21[34] | -1.78[35] |
6 | FOS | Proto-oncogene c-Fos | [36] | -5.52[37] | -3.98[38] | -4.37[39] | -5.59[40] | -4.18[41] | -1.27[42] |
7 | AKT1 | RAC-alpha serine/threonine-protein kinase | [43] | 0.57[44] | 0.62[45] | -0.19[46] | 0.53[47] | 0.89[48] | -0.21[49] |
8 | MAP2K3 | Dual specificity mitogen-activated protein kinase kinase 3 | [50] | -0.73[51] | -0.15[52] | -0.98[53] | -1.25[54] | -1.04[55] | -1.41[56] |
9 | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1 | [57] | -0.44[58] | -0.48[59] | 0.37[60] | 0.04[61] | 0.89[62] | -1.16[63] |
10 | MAP2K2 | Dual specificity mitogen-activated protein kinase kinase 2 | [64] | 0.54[65] | 0.50[66] | 1.65[67] | -0.26[68] | 0.57[69] | -1.67[70] |
11 | SPP1 | Osteopontin | [71] | 3.66[72] | 2.72[73] | -5.51[74] | 2.48[75] | -5.24[76] | -1.05[77] |
12 | IKBKG | NF-kappa-B essential modulator | [78] | -0.40[79] | 0.03[80] | -1.94[81] | -0.27[82] | -1.14[83] | -0.57[84] |
13 | IRAK1 | Interleukin-1 receptor-associated kinase 1 | [85] | 1.90[86] | 1.58[87] | 0.84[88] | 1.38[89] | 2.09[90] | -0.66[91] |
14 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | [92] | 0.41[93] | -0.22[94] | 1.16[95] | 3.11[96] | 1.19[97] | 0.98[98] |
15 | TOLLIP | Toll-interacting protein | [99] | 0.22[100] | 0.39[101] | 0.67[102] | -0.45[103] | -0.95[104] | 1.17[105] |
16 | RELA | Transcription factor p65 | [106] | 0.62[107] | 0.40[108] | 0.81[109] | 0.52[110] | 0.78[111] | -0.85[112] |
17 | IFNAR2 | Interferon alpha/beta receptor 2 | [113] | -0.72[114] | -0.78[115] | 0.17[116] | -0.81[117] | -0.48[118] | -0.75[119] |
18 | MYD88 | Myeloid differentiation primary response protein MyD88 | [120] | 0.30[121] | 0.64[122] | 0.35[123] | -0.46[124] | 0.18[125] | 0.83[126] |
19 | IRF7 | Interferon regulatory factor 7 | [127] | -8.75[128] | -7.46[129] | -6.09[130] | -2.57[131] | -2.48[132] | -0.04[133] |
20 | MAPK1 | Mitogen-activated protein kinase 1 | [134] | 2.20[135] | 2.62[136] | 2.72[137] | 2.43[138] | 2.42[139] | 1.81[140] |
21 | AKT2 | RAC-beta serine/threonine-protein kinase | [141] | 1.45[142] | 2.01[143] | 2.41[144] | 1.44[145] | 1.57[146] | 1.16[147] |
22 | IRF3 | Interferon regulatory factor 3 | [148] | 0.79[149] | 1.24[150] | 2.24[151] | 0.93[152] | 0.87[153] | -1.15[154] |
23 | TAB2 | TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 | [155] | 0.85[156] | 1.30[157] | 1.84[158] | 2.28[159] | 2.08[160] | 0.27[161] |
24 | FADD | FAS-associated death domain protein | [162] | 0.53[163] | 0.10[164] | 1.10[165] | 2.51[166] | 0.67[167] | -1.74[168] |
25 | CASP8 | Caspase-8 | [169] | 0.51[170] | 1.36[171] | 0.81[172] | 0.50[173] | 0.10[174] | -1.39[175] |
26 | MAPK14 | Mitogen-activated protein kinase 14 | [176] | 1.96[177] | 2.32[178] | 2.16[179] | 2.26[180] | 2.08[181] | 1.31[182] |
27 | MAP3K7 | Mitogen-activated protein kinase kinase kinase 7 | [183] | 0.39[184] | 1.74[185] | 1.89[186] | 1.07[187] | 1.59[188] | 0.28[189] |
28 | IFNAR1 | Interferon alpha/beta receptor 1 | [190] | 0.55[191] | 1.31[192] | 1.28[193] | 1.57[194] | 1.90[195] | 2.46[196] |
29 | PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha | [197] | 0.02[198] | 0.42[199] | 1.78[200] | 2.65[201] | 2.49[202] | 3.03[203] |
30 | MAPK8 | Mitogen-activated protein kinase 8 | [204] | -0.96[205] | 0.74[206] | -0.12[207] | -0.32[208] | -0.12[209] | -0.48[210] |
31 | TBK1 | Serine/threonine-protein kinase TBK1 | [211] | -0.15[212] | 1.82[213] | 1.23[214] | 1.07[215] | 1.50[216] | 0.50[217] |
32 | NFKB1 | Nuclear factor NF-kappa-B p105 subunit | [218] | 1.16[219] | 1.12[220] | 1.18[221] | 0.33[222] | 1.59[223] | 0.48[224] |
33 | CCL3 | C-C motif chemokine 3 | [225] | [226] | [227] | [228] | -7.61[229] | [230] | -4.39[231] |
34 | CCL4 | C-C motif chemokine 4 | [232] | [233] | [234] | [235] | [236] | [237] | -3.38[238] |
35 | MAPK13 | Mitogen-activated protein kinase 13 | [239] | 2.83[240] | 3.52[241] | 1.11[242] | -1.31[243] | 0.56[244] | -1.69[245] |
36 | PIK3R2 | Phosphatidylinositol 3-kinase regulatory subunit beta | [246] | 2.36[247] | 2.87[248] | 3.75[249] | 1.29[250] | 2.19[251] | -0.26[252] |
37 | MAP2K4 | Dual specificity mitogen-activated protein kinase kinase 4 | [253] | 1.19[254] | 2.11[255] | 1.58[256] | 1.78[257] | 1.53[258] | 1.09[259] |
38 | CD40 | Tumor necrosis factor receptor superfamily member 5 | [260] | -0.31[261] | -1.22[262] | -9.20[263] | -2.24[264] | -0.57[265] | -0.90[266] |
39 | TICAM1 | TIR domain-containing adapter molecule 1 | [267] | -0.22[268] | -1.04[269] | 0.16[270] | -0.64[271] | 0.75[272] | -0.47[273] |
40 | MAPK9 | Mitogen-activated protein kinase 9 | [274] | 1.71[275] | 2.23[276] | 2.56[277] | 2.29[278] | 2.09[279] | 0.54[280] |
41 | RIPK1 | Receptor-interacting serine/threonine-protein kinase 1 | [281] | 0.78[282] | 1.22[283] | 1.18[284] | 1.66[285] | 1.53[286] | 1.51[287] |
42 | CCL5 | C-C motif chemokine 5 | [288] | -4.27[289] | -3.45[290] | -3.01[291] | -3.13[292] | -3.97[293] | 0.76[294] |
43 | MAPK3 | Mitogen-activated protein kinase 3 | [295] | 2.34[296] | 2.67[297] | 2.98[298] | 1.00[299] | 1.37[300] | -1.01[301] |
44 | CHUK | Inhibitor of nuclear factor kappa-B kinase subunit alpha | [302] | 1.39[303] | 2.90[304] | 3.13[305] | 1.23[306] | 2.39[307] | 1.55[308] |
45 | MAP2K7 | Dual specificity mitogen-activated protein kinase kinase 7 | [309] | 1.45[310] | 1.89[311] | 2.73[312] | 0.86[313] | 1.76[314] | -0.73[315] |
46 | TAB1 | TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 | [316] | 1.13[317] | 2.07[318] | 2.42[319] | 0.59[320] | 1.27[321] | 0.25[322] |
47 | IKBKB | Inhibitor of nuclear factor kappa-B kinase subunit beta | [323] | 1.01[324] | 1.35[325] | 1.73[326] | 0.84[327] | 1.27[328] | 1.21[329] |
48 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 1.70[330] | 2.49[331] | 2.92[332] | 1.63[333] | 2.13[334] | 1.19[335] | |
49 | IL1B | Interleukin-1 beta | [336] | -8.21[337] | -7.79[338] | -3.20[339] | -3.01[340] | 2.92[341] | -5.17[342] |
50 | LY96 | Lymphocyte antigen 96 | [343] | -2.16[344] | -2.27[345] | -8.41[346] | -0.78[347] | -4.06[348] | -1.33[349] |
51 | TIRAP | Toll/interleukin-1 receptor domain-containing adapter protein | [350] | 0.35[351] | 0.60[352] | 0.98[353] | 0.86[354] | 0.03[355] | 0.30[356] |
52 | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | 0.11[357] | 2.03[358] | 2.49[359] | 1.71[360] | 2.26[361] | 1.94[362] | |
53 | PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | 2.37[363] | 3.75[364] | 0.21[365] | 0.86[366] | 1.97[367] | 0.33[368] | |
54 | MAP3K8 | Mitogen-activated protein kinase kinase kinase 8 | [369] | 2.23[370] | 2.53[371] | 1.98[372] | 0.68[373] | 2.35[374] | 0.52[375] |
55 | MAP2K6 | Dual specificity mitogen-activated protein kinase kinase 6 | [376] | 0.78[377] | -2.15[378] | 2.98[379] | 1.59[380] | -2.10[381] | -1.59[382] |
56 | TLR2 | Toll-like receptor 2 | [383] | -3.06[384] | -1.35[385] | -8.08[386] | -4.39[387] | 2.71[388] | 1.27[389] |
57 | CXCL10 | C-X-C motif chemokine 10 | [390] | -8.66[391] | -6.06[392] | -0.67[393] | -0.98[394] | -8.23[395] | -2.35[396] |
58 | IRAK4 | Interleukin-1 receptor-associated kinase 4 | [397] | 0.74[398] | 2.39[399] | 2.94[400] | 2.00[401] | 2.10[402] | 1.81[403] |
59 | IL6 | Interleukin-6 | [404] | -7.95[405] | [406] | -3.79[407] | -0.28[408] | 2.58[409] | [410] |
60 | TRAF3 | TNF receptor-associated factor 3 | [411] | 3.38[412] | 3.08[413] | 2.96[414] | 3.41[415] | 4.17[416] | 1.96[417] |
61 | TLR3 | Toll-like receptor 3 | [418] | -3.35[419] | -3.53[420] | -3.58[421] | 0.21[422] | 1.64[423] | 1.08[424] |
62 | IRF5 | Interferon regulatory factor 5 | [425] | 0.79[426] | 0.86[427] | -0.04[428] | 0.93[429] | -0.99[430] | 1.01[431] |
63 | TRAF6 | TNF receptor-associated factor 6 | [432] | 1.58[433] | 1.75[434] | 2.59[435] | 2.24[436] | 2.04[437] | 2.94[438] |
64 | IKBKE | Inhibitor of nuclear factor kappa-B kinase subunit epsilon | [439] | 2.21[440] | 2.36[441] | 1.53[442] | 3.14[443] | 3.04[444] | -0.20[445] |
65 | MAPK12 | Mitogen-activated protein kinase 12 | [446] | 3.31[447] | 3.26[448] | 4.64[449] | 2.06[450] | 3.66[451] | -0.88[452] |
66 | TLR4 | Toll-like receptor 4 | [453] | 0.76[454] | -4.11[455] | -4.73[456] | -4.52[457] | 6.25[458] | 4.50[459] |
67 | TLR1 | Toll-like receptor 1 | [460] | -2.88[461] | [462] | -5.97[463] | 0.18[464] | 1.71[465] | 2.10[466] |
68 | TICAM2 | TIR domain-containing adapter molecule 2 | [467] | -7.39[468] | [469] | -6.25[470] | -0.91[471] | -0.23[472] | -1.95[473] |
69 | PIK3R3 | Phosphatidylinositol 3-kinase regulatory subunit gamma | [474] | 2.21[475] | 2.50[476] | 3.62[477] | 3.75[478] | 3.11[479] | 2.71[480] |
70 | CXCL11 | C-X-C motif chemokine 11 | [481] | -7.79[482] | -4.90[483] | -4.46[484] | -1.96[485] | -4.42[486] | -2.82[487] |
71 | CD86 | T-lymphocyte activation antigen CD86 | [488] | [489] | [490] | -3.66[491] | -3.52[492] | -5.19[493] | 1.38[494] |
72 | AKT3 | RAC-gamma serine/threonine-protein kinase | [495] | -1.35[496] | -3.63[497] | -2.67[498] | 6.42[499] | 5.72[500] | 3.64[501] |
73 | MAPK11 | Mitogen-activated protein kinase 11 | [502] | 0.32[503] | 0.50[504] | -0.12[505] | 0.93[506] | 3.27[507] | 0.19[508] |
74 | PIK3R5 | Phosphoinositide 3-kinase regulatory subunit 5 | [509] | -6.68[510] | [511] | -1.49[512] | -3.34[513] | -2.66[514] | 2.37[515] |
75 | CXCL9 | C-X-C motif chemokine 9 | [516] | -7.20[517] | [518] | -3.24[519] | -1.39[520] | [521] | 0.42[522] |
76 | TLR6 | Toll-like receptor 6 | [523] | 1.27[524] | 1.67[525] | 1.17[526] | 2.88[527] | 3.31[528] | 2.77[529] |
77 | IL12A | Interleukin-12 subunit alpha | [530] | -0.92[531] | [532] | 1.13[533] | -0.96[534] | 1.18[535] | -3.15[536] |
78 | CTSK | Cathepsin K | [537] | 1.46[538] | 3.74[539] | 3.56[540] | 3.66[541] | 3.87[542] | 3.15[543] |
79 | TNF | Tumor necrosis factor | [544] | 1.59[545] | -0.26[546] | -4.59[547] | -1.64[548] | -4.52[549] | -1.86[550] |
80 | TLR5 | Toll-like receptor 5 | [551] | -2.79[552] | -4.57[553] | 1.18[554] | -1.41[555] | -0.92[556] | 2.95[557] |
81 | TLR7 | Toll-like receptor 7 | [558] | -0.35[559] | 0.73[560] | 1.31[561] | 0.00[562] | -0.09[563] | 1.30[564] |
82 | TLR8 | Toll-like receptor 8 | [565] | [566] | [567] | [568] | [569] | -5.10[570] | 3.69[571] |
83 | PIK3CG | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | [572] | [573] | [574] | 1.92[575] | -2.62[576] | 4.13[577] | |
84 | CD80 | T-lymphocyte activation antigen CD80 | [578] | [579] | [580] | -4.21[581] | -0.57[582] | -1.29[583] | 2.65[584] |
85 | MAPK10 | Mitogen-activated protein kinase 10 | [585] | -1.00[586] | [587] | [588] | 9.49[589] | 5.57[590] | 7.28[591] |
86 | IFNA13 | [592] | [593] | [594] | [595] | [596] | [597] | [598] | |
87 | IFNA1 | Interferon alpha-1/13 | [599] | [600] | [601] | [602] | [603] | [604] | [605] |
88 | IFNA2 | Interferon alpha-2 | [606] | [607] | [608] | [609] | [610] | [611] | [612] |
89 | IFNA8 | Interferon alpha-8 | [613] | [614] | [615] | [616] | [617] | [618] | [619] |
90 | IFNA17 | Interferon alpha-17 | [620] | [621] | [622] | [623] | [624] | [625] | [626] |
91 | IFNB1 | Interferon beta | [627] | [628] | [629] | [630] | [631] | [632] | [633] |
92 | IFNA16 | Interferon alpha-16 | [634] | [635] | [636] | [637] | [638] | [639] | [640] |
93 | IFNA5 | Interferon alpha-5 | [641] | [642] | [643] | [644] | [645] | [646] | [647] |
94 | IFNA6 | Interferon alpha-6 | [648] | [649] | [650] | [651] | [652] | [653] | [654] |
95 | IFNA21 | Interferon alpha-21 | [655] | [656] | [657] | [658] | [659] | [660] | [661] |
96 | IL12B | Interleukin-12 subunit beta | [662] | [663] | [664] | [665] | [666] | [667] | [668] |
97 | IFNA4 | Interferon alpha-4 | [669] | [670] | [671] | [672] | [673] | [674] | [675] |
98 | IFNA7 | Interferon alpha-7 | [676] | [677] | [678] | [679] | [680] | [681] | [682] |
99 | CXCL8 | Interleukin-8 | [683] | [684] | [685] | [686] | [687] | [688] | [689] |
100 | IFNA10 | Interferon alpha-10 | [690] | [691] | [692] | [693] | [694] | [695] | [696] |
101 | IFNA14 | Interferon alpha-14 | [697] | [698] | [699] | [700] | [701] | [702] | [703] |
102 | TLR9 | Toll-like receptor 9 | [704] | [705] | [706] | [707] | [708] | [709] | [710] |