KEGG_TGF_BETA_SIGNALING_PATHWAY | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | RHOA | Transforming protein RhoA | [1] | -1.44[2] | -1.68[3] | -1.20[4] | -1.58[5] | -1.21[6] | -1.71[7] |
2 | SKP1 | S-phase kinase-associated protein 1 | [8] | -1.49[9] | -0.83[10] | -1.44[11] | -0.86[12] | -0.72[13] | -1.08[14] |
3 | ID2 | DNA-binding protein inhibitor ID-2 | [15] | -0.13[16] | -0.25[17] | -1.02[18] | -1.77[19] | -2.75[20] | -0.20[21] |
4 | RBX1 | E3 ubiquitin-protein ligase RBX1 | [22] | -2.56[23] | -1.87[24] | -1.73[25] | -3.06[26] | -2.72[27] | -2.48[28] |
5 | MYC | Myc proto-oncogene protein | [29] | -0.08[30] | -0.15[31] | -1.92[32] | -3.14[33] | -0.86[34] | -2.38[35] |
6 | PPP2R1A | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isofor | 0.30[36] | 0.38[37] | 0.56[38] | 0.85[39] | 0.10[40] | -0.24[41] | |
7 | PPP2CA | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform | -0.23[42] | 0.12[43] | -0.25[44] | 0.39[45] | 0.42[46] | -0.49[47] | |
8 | ID1 | DNA-binding protein inhibitor ID-1 | [48] | 1.47[49] | 1.00[50] | 0.86[51] | -0.04[52] | 0.12[53] | -1.58[54] |
9 | PPP2CB | Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform | -0.90[55] | -0.98[56] | -0.64[57] | -0.81[58] | -1.00[59] | -1.37[60] | |
10 | INHBE | Inhibin beta E chain | [61] | -0.73[62] | -0.55[63] | -1.41[64] | -7.54[65] | -5.97[66] | 0.75[67] |
11 | RPS6KB2 | Ribosomal protein S6 kinase beta-2 | [68] | [69] | [70] | [71] | [72] | [73] | [74] |
12 | ID3 | DNA-binding protein inhibitor ID-3 | [75] | 0.96[76] | 0.32[77] | -1.56[78] | 1.62[79] | 0.75[80] | -0.92[81] |
13 | TFDP1 | Transcription factor Dp-1 | [82] | 0.16[83] | -0.25[84] | 0.08[85] | 0.25[86] | 0.74[87] | -1.53[88] |
14 | CUL1 | Cullin-1 | [89] | -0.89[90] | 0.05[91] | -0.14[92] | 0.23[93] | -0.20[94] | 0.36[95] |
15 | PPP2R1B | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform | -0.05[96] | -0.32[97] | 0.36[98] | -0.08[99] | -0.38[100] | 2.55[101] | |
16 | TGFBR2 | TGF-beta receptor type-2 | [102] | 2.31[103] | 2.04[104] | 1.95[105] | 0.71[106] | 2.34[107] | 1.12[108] |
17 | MAPK1 | Mitogen-activated protein kinase 1 | [109] | 1.20[110] | 1.60[111] | 1.69[112] | 1.50[113] | 1.06[114] | 1.39[115] |
18 | E2F4 | Transcription factor E2F4 | [116] | 0.63[117] | 1.00[118] | 0.28[119] | 0.07[120] | -0.02[121] | -0.63[122] |
19 | THBS1 | Thrombospondin-1 | [123] | 2.00[124] | -2.57[125] | -2.31[126] | 2.49[127] | 2.09[128] | 0.73[129] |
20 | INHBC | Inhibin beta C chain | [130] | -2.89[131] | -2.20[132] | -5.41[133] | -9.30[134] | -11.43[135] | 2.07[136] |
21 | ROCK1 | Rho-associated protein kinase 1 | [137] | -1.46[138] | 0.32[139] | 1.36[140] | 1.01[141] | 0.27[142] | 1.20[143] |
22 | RBL2 | Retinoblastoma-like protein 2 | [144] | 0.33[145] | 1.44[146] | 1.75[147] | 0.88[148] | 0.50[149] | 1.76[150] |
23 | CHRD | Chordin | [151] | -1.95[152] | 0.89[153] | -1.26[154] | -5.08[155] | -6.70[156] | 1.23[157] |
24 | SMAD3 | Mothers against decapentaplegic homolog 3 | [158] | 1.43[159] | 1.08[160] | 1.57[161] | 1.44[162] | 2.24[163] | -0.17[164] |
25 | BMP2 | Bone morphogenetic protein 2 | [165] | -5.48[166] | -8.35[167] | 1.00[168] | -2.24[169] | -2.08[170] | -2.57[171] |
26 | SMAD1 | Mothers against decapentaplegic homolog 1 | [172] | -1.55[173] | -1.04[174] | -0.49[175] | -1.08[176] | -0.61[177] | 0.24[178] |
27 | ROCK2 | Rho-associated protein kinase 2 | [179] | 0.97[180] | 2.47[181] | 1.20[182] | 2.28[183] | -0.03[184] | 1.54[185] |
28 | TGFBR1 | TGF-beta receptor type-1 | [186] | -0.18[187] | 0.31[188] | 0.07[189] | -0.01[190] | 1.01[191] | 0.95[192] |
29 | MAPK3 | Mitogen-activated protein kinase 3 | [193] | 1.35[194] | 1.65[195] | 1.95[196] | 0.07[197] | 0.01[198] | -1.42[199] |
30 | SMAD7 | Mothers against decapentaplegic homolog 7 | [200] | 1.35[201] | -0.27[202] | -1.03[203] | 0.23[204] | -0.15[205] | -0.38[206] |
31 | SP1 | Transcription factor Sp1 | [207] | 1.31[208] | 1.82[209] | 3.14[210] | 2.32[211] | 1.92[212] | 1.77[213] |
32 | SMURF1 | E3 ubiquitin-protein ligase SMURF1 | [214] | 0.94[215] | 0.64[216] | 1.81[217] | 0.86[218] | 0.67[219] | 1.00[220] |
33 | ACVR1 | Activin receptor type-1 | [221] | -0.16[222] | -0.18[223] | 0.37[224] | 0.17[225] | 0.24[226] | 0.40[227] |
34 | FST | Follistatin | [228] | -0.54[229] | 1.37[230] | -2.07[231] | -5.10[232] | -3.91[233] | -0.34[234] |
35 | RPS6KB1 | Ribosomal protein S6 kinase beta-1 | [235] | [236] | [237] | [238] | [239] | [240] | [241] |
36 | SMAD4 | Mothers against decapentaplegic homolog 4 | [242] | 0.89[243] | 1.78[244] | 2.00[245] | 1.56[246] | 1.84[247] | 2.41[248] |
37 | TGFB2 | Transforming growth factor beta-2 | [249] | -4.80[250] | -7.07[251] | -1.01[252] | 3.11[253] | 1.62[254] | -3.15[255] |
38 | SMAD5 | Mothers against decapentaplegic homolog 5 | [256] | 1.32[257] | 2.28[258] | 2.32[259] | 2.29[260] | 2.25[261] | 2.57[262] |
39 | BMPR1A | Bone morphogenetic protein receptor type-1A | [263] | 0.80[264] | 1.70[265] | 0.62[266] | 0.90[267] | 1.08[268] | 0.79[269] |
40 | SMAD2 | Mothers against decapentaplegic homolog 2 | [270] | 1.52[271] | 2.03[272] | 1.79[273] | 2.03[274] | 2.14[275] | 2.19[276] |
41 | EP300 | Histone acetyltransferase p300 | [277] | 2.22[278] | 2.07[279] | 3.22[280] | 2.22[281] | 2.19[282] | 2.37[283] |
42 | ZFYVE16 | Zinc finger FYVE domain-containing protein 16 | [284] | 0.23[285] | 2.24[286] | 2.42[287] | 2.25[288] | 1.78[289] | 2.25[290] |
43 | CDKN2B | Cyclin-dependent kinase 4 inhibitor B | [291] | -0.14[292] | -4.35[293] | -0.24[294] | 0.81[295] | 1.02[296] | -2.46[297] |
44 | TGFB1 | Transforming growth factor beta-1 | [298] | 2.97[299] | 2.19[300] | -0.30[301] | 3.48[302] | 2.63[303] | -1.61[304] |
45 | SMURF2 | E3 ubiquitin-protein ligase SMURF2 | [305] | 1.21[306] | 1.50[307] | 0.27[308] | 0.84[309] | 1.20[310] | -0.25[311] |
46 | ZFYVE9 | Zinc finger FYVE domain-containing protein 9 | [312] | 1.14[313] | 1.63[314] | 1.84[315] | 1.25[316] | 1.62[317] | 1.82[318] |
47 | CREBBP | CREB-binding protein | [319] | 2.39[320] | 1.87[321] | 2.74[322] | 2.40[323] | 2.33[324] | 2.85[325] |
48 | LTBP1 | Latent-transforming growth factor beta-binding protein 1 | [326] | -1.26[327] | -7.06[328] | -0.76[329] | 1.91[330] | 2.04[331] | 2.00[332] |
49 | BMP4 | Bone morphogenetic protein 4 | [333] | 3.98[334] | 3.47[335] | 0.66[336] | 1.65[337] | -0.57[338] | -1.57[339] |
50 | SMAD6 | Mothers against decapentaplegic homolog 6 | [340] | 0.91[341] | -0.57[342] | 0.10[343] | 1.10[344] | -0.53[345] | 0.48[346] |
51 | TGFB3 | Transforming growth factor beta-3 | [347] | -2.05[348] | -2.66[349] | -2.64[350] | -0.18[351] | -1.33[352] | 0.07[353] |
52 | INHBB | Inhibin beta B chain | [354] | 2.65[355] | -3.76[356] | -5.46[357] | -2.77[358] | 3.15[359] | -0.09[360] |
53 | INHBA | Inhibin beta A chain | [361] | -8.00[362] | -7.45[363] | -6.74[364] | 2.57[365] | -1.12[366] | 0.22[367] |
54 | BMPR2 | Bone morphogenetic protein receptor type-2 | [368] | 2.68[369] | 1.97[370] | 2.90[371] | 3.78[372] | 3.03[373] | 3.91[374] |
55 | E2F5 | Transcription factor E2F5 | [375] | 1.02[376] | 2.24[377] | 2.90[378] | -0.33[379] | -1.95[380] | -2.07[381] |
56 | ACVR2A | Activin receptor type-2A | [382] | 0.35[383] | 1.62[384] | 1.71[385] | 0.47[386] | 0.89[387] | 2.30[388] |
57 | COMP | Cartilage oligomeric matrix protein | [389] | 2.61[390] | 0.36[391] | -4.38[392] | -4.97[393] | -4.93[394] | -6.99[395] |
58 | RBL1 | Retinoblastoma-like protein 1 | [396] | 1.27[397] | 2.40[398] | 1.29[399] | 2.46[400] | 2.71[401] | 0.30[402] |
59 | DCN | Decorin | [403] | -6.84[404] | -8.32[405] | -5.17[406] | 1.19[407] | 5.26[408] | 5.31[409] |
60 | THBS3 | Thrombospondin-3 | [410] | 0.18[411] | -0.61[412] | 2.07[413] | 1.07[414] | 1.93[415] | 1.23[416] |
61 | ACVR2B | Activin receptor type-2B | [417] | 1.77[418] | 3.43[419] | 4.51[420] | 0.74[421] | 0.46[422] | 2.79[423] |
62 | BMP6 | Bone morphogenetic protein 6 | [424] | -0.35[425] | -2.81[426] | -3.64[427] | -1.13[428] | -2.46[429] | 1.20[430] |
63 | GDF7 | Growth/differentiation factor 7 | [431] | -0.49[432] | 0.16[433] | -0.59[434] | [435] | -7.78[436] | 1.43[437] |
64 | ACVRL1 | Serine/threonine-protein kinase receptor R3 | [438] | -4.60[439] | -4.73[440] | -3.54[441] | -2.56[442] | -2.35[443] | 2.62[444] |
65 | LEFTY1 | Left-right determination factor 1 | [445] | -1.05[446] | -2.26[447] | -0.77[448] | -4.92[449] | -4.95[450] | -1.31[451] |
66 | BMP8B | Bone morphogenetic protein 8B | [452] | -0.42[453] | 0.21[454] | 1.99[455] | -0.61[456] | -1.04[457] | -0.43[458] |
67 | SMAD9 | Mothers against decapentaplegic homolog 9 | [459] | 3.48[460] | 3.43[461] | 2.95[462] | 1.84[463] | 3.27[464] | 2.50[465] |
68 | BMP7 | Bone morphogenetic protein 7 | [466] | -1.99[467] | -0.93[468] | -0.85[469] | -0.99[470] | -1.46[471] | -1.54[472] |
69 | IFNG | Interferon gamma | [473] | [474] | [475] | [476] | -1.05[477] | [478] | -2.68[479] |
70 | ID4 | DNA-binding protein inhibitor ID-4 | [480] | 1.01[481] | 1.55[482] | 2.40[483] | 0.14[484] | 1.58[485] | 1.99[486] |
71 | BMP8A | Bone morphogenetic protein 8A | [487] | -0.81[488] | 0.69[489] | 2.34[490] | -0.52[491] | 1.28[492] | 2.71[493] |
72 | ACVR1C | Activin receptor type-1C | [494] | -1.78[495] | -0.53[496] | 4.95[497] | -1.39[498] | -2.39[499] | 3.40[500] |
73 | TNF | Tumor necrosis factor | [501] | 0.60[502] | -1.28[503] | -5.62[504] | -2.57[505] | -5.88[506] | -2.27[507] |
74 | LEFTY2 | Left-right determination factor 2 | [508] | -0.24[509] | -0.18[510] | 3.07[511] | -0.16[512] | -4.82[513] | -2.40[514] |
75 | AMHR2 | Anti-Muellerian hormone type-2 receptor | [515] | 1.45[516] | 0.18[517] | -1.28[518] | -3.85[519] | -3.14[520] | 1.60[521] |
76 | THBS2 | Thrombospondin-2 | [522] | 3.46[523] | -0.53[524] | -2.46[525] | 3.62[526] | 8.91[527] | 6.87[528] |
77 | THBS4 | Thrombospondin-4 | [529] | 0.82[530] | 1.53[531] | 8.67[532] | 1.47[533] | 1.31[534] | 1.17[535] |
78 | AMH | Muellerian-inhibiting factor | [536] | -1.63[537] | 3.16[538] | 6.18[539] | 1.53[540] | 4.76[541] | 1.13[542] |
79 | BMP5 | Bone morphogenetic protein 5 | [543] | -1.92[544] | [545] | -3.59[546] | 6.69[547] | -3.85[548] | 4.52[549] |
80 | BMPR1B | Bone morphogenetic protein receptor type-1B | [550] | -1.51[551] | -2.09[552] | 3.82[553] | 5.43[554] | 1.98[555] | 6.18[556] |
81 | NODAL | Nodal homolog | [557] | 3.39[558] | -0.06[559] | 5.01[560] | 3.21[561] | 1.84[562] | 4.29[563] |
82 | GDF5 | Growth/differentiation factor 5 | [564] | [565] | [566] | [567] | [568] | [569] | [570] |
83 | PITX2 | Pituitary homeobox 2 | [571] | [572] | [573] | [574] | [575] | [576] | [577] |
84 | SKP1P2 | [578] | [579] | [580] | [581] | [582] | [583] | [584] | |
85 | NOG | Noggin | [585] | [586] | [587] | [588] | [589] | [590] | [591] |
86 | GDF6 | Growth/differentiation factor 6 | [592] | [593] | [594] | [595] | [596] | [597] | [598] |