KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 HMGCS2 Hydroxymethylglutaryl-CoA synthase, mitochondrial [1] -10.62[2] -10.21[3] -3.49[4] -7.73[5] -11.66[6] 0.66[7]
2 FDPS Farnesyl pyrophosphate synthase [8] -0.16[9] -0.47[10] -0.38[11] -0.09[12] 0.28[13] -1.77[14]
3 ACAT1 Acetyl-CoA acetyltransferase, mitochondrial [15] 0.33[16] -1.73[17] -3.10[18] -0.04[19] -0.66[20] 0.41[21]
4 HMGCS1 Hydroxymethylglutaryl-CoA synthase, cytoplasmic [22] -0.99[23] 0.31[24] 1.49[25] -1.43[26] -1.19[27] -0.42[28]
5 ACAT2 Acetyl-CoA acetyltransferase, cytosolic [29] 0.66[30] 0.75[31] 0.06[32] -0.75[33] 0.26[34] -0.91[35]
6 IDI1 Isopentenyl-diphosphate Delta-isomerase 1 [36] -0.04[37] 1.51[38] -0.10[39] 1.29[40] 0.56[41] 0.14[42]
7 PMVK Phosphomevalonate kinase [43] 0.27[44] -1.59[45] -0.56[46] 0.80[47] 1.04[48] -2.35[49]
8 MVD Diphosphomevalonate decarboxylase [50] 1.56[51] 2.11[52] 1.09[53] 0.45[54] 0.97[55] -0.61[56]
9 HMGCR 3-hydroxy-3-methylglutaryl-coenzyme A reductase [57] 2.25[58] 3.07[59] 3.14[60] 2.55[61] 2.72[62] 1.20[63]
10 MVK Mevalonate kinase [64] 0.50[65] 0.93[66] 0.17[67] -0.37[68] -0.09[69] 0.07[70]
11 DHDDS Dehydrodolichyl diphosphate synthase complex subunit DHDDS [71] 2.69[72] 1.49[73] 0.53[74] 3.23[75] 3.24[76] -0.71[77]
12 PDSS2 Decaprenyl-diphosphate synthase subunit 2 [78] 2.75[79] 1.05[80] 0.85[81] 1.29[82] 2.86[83] 0.91[84]
13 GGPS1 Geranylgeranyl pyrophosphate synthase [85] 3.03[86] 2.34[87] 2.10[88] 4.46[89] 3.32[90] 0.17[91]
14 PDSS1 Decaprenyl-diphosphate synthase subunit 1 [92] 2.86[93] 1.79[94] 1.09[95] 3.12[96] 3.23[97] -0.29[98]
15 IDI2 Isopentenyl-diphosphate delta-isomerase 2 [99] 3.57[100] 2.51[101] 2.28[102] 5.63[103] 4.65[104] 0.33[105]
[1]
ref_hepatocyte HMGCS2
Mean 222
Standard deviation 3.3e+02
Values 1.4 0.38 3.8e+02 3.3 7.2e+02
[2]
HepG2 HMGCS2
Mean 0.0443
Standard deviation 0.046
Values 0.011 0.077
[3]
HepG2.C3A HMGCS2
Mean 0.2
Standard deviation 0.1
Values 0.27 0.13
[4]
HuH.7 HMGCS2
Mean 23.3
Standard deviation 9.9
Values 18 35 17
[5]
SNU475 HMGCS2
Mean 0.265
Standard deviation 0.27
Values 0.46 0.071
[6]
THLE HMGCS2
Mean 0.0139
Standard deviation 0.0029
Values 0.012 0.016
[7]
liver HMGCS2
Mean 562
Standard deviation 3.1e+02
Values 2.7e+02 9.5e+02 6.9e+02 3.5e+02
[8]
ref_hepatocyte FDPS
Mean 168
Standard deviation 1.2e+02
Values 1.8e+02 3.6e+02 1e+02 65 1.3e+02
[9]
HepG2 FDPS
Mean 47.3
Standard deviation 9.8
Values 40 54
[10]
HepG2.C3A FDPS
Mean 130
Standard deviation 36
Values 1.5e+02 1e+02
[11]
HuH.7 FDPS
Mean 153
Standard deviation 26
Values 1.4e+02 1.3e+02 1.8e+02
[12]
SNU475 FDPS
Mean 40
Standard deviation 13
Values 49 31
[13]
THLE FDPS
Mean 41.3
Standard deviation 7.5
Values 36 47
[14]
liver FDPS
Mean 78.7
Standard deviation 39
Values 54 76 1.3e+02 50
[15]
ref_hepatocyte ACAT1
Mean 166
Standard deviation 1.7e+02
Values 49 47 3.2e+02 23 3.9e+02
[16]
HepG2 ACAT1
Mean 65.7
Standard deviation 6.9
Values 61 71
[17]
HepG2.C3A ACAT1
Mean 53.7
Standard deviation 16
Values 43 65
[18]
HuH.7 ACAT1
Mean 22.9
Standard deviation 6
Values 22 17 29
[19]
SNU475 ACAT1
Mean 40.9
Standard deviation 14
Values 51 31
[20]
THLE ACAT1
Mean 21.3
Standard deviation 4.8
Values 18 25
[21]
liver ACAT1
Mean 353
Standard deviation 1.8e+02
Values 2.4e+02 4.7e+02 5.4e+02 1.6e+02
[22]
ref_hepatocyte HMGCS1
Mean 128
Standard deviation 1e+02
Values 2.5e+02 2.3e+02 32 58 72
[23]
HepG2 HMGCS1
Mean 20.3
Standard deviation 12
Values 12 28
[24]
HepG2.C3A HMGCS1
Mean 170
Standard deviation 81
Values 2.3e+02 1.1e+02
[25]
HuH.7 HMGCS1
Mean 427
Standard deviation 1.7e+02
Values 3.3e+02 6.2e+02 3.3e+02
[26]
SNU475 HMGCS1
Mean 12.1
Standard deviation 4.1
Values 15 9.2
[27]
THLE HMGCS1
Mean 11.4
Standard deviation 0.78
Values 11 12
[28]
liver HMGCS1
Mean 154
Standard deviation 63
Values 1.9e+02 79 1.3e+02 2.2e+02
[29]
ref_hepatocyte ACAT2
Mean 68.2
Standard deviation 50
Values 1.5e+02 51 49 17 76
[30]
HepG2 ACAT2
Mean 33.9
Standard deviation 23
Values 18 50
[31]
HepG2.C3A ACAT2
Mean 123
Standard deviation 6.4
Values 1.3e+02 1.2e+02
[32]
HuH.7 ACAT2
Mean 84.1
Standard deviation 10
Values 82 76 95
[33]
SNU475 ACAT2
Mean 10.3
Standard deviation 0.34
Values 11 10
[34]
THLE ACAT2
Mean 16.6
Standard deviation 3.1
Values 14 19
[35]
liver ACAT2
Mean 58.5
Standard deviation 28
Values 47 48 1e+02 39
[36]
ref_hepatocyte IDI1
Mean 49.3
Standard deviation 26
Values 79 59 33 14 62
[37]
HepG2 IDI1
Mean 15.1
Standard deviation 12
Values 6.9 23
[38]
HepG2.C3A IDI1
Mean 151
Standard deviation 3.5
Values 1.5e+02 1.5e+02
[39]
HuH.7 IDI1
Mean 54.3
Standard deviation 7.2
Values 46 58 59
[40]
SNU475 IDI1
Mean 30.7
Standard deviation 8.7
Values 37 24
[41]
THLE IDI1
Mean 14.8
Standard deviation 3.6
Values 12 17
[42]
liver IDI1
Mean 87.2
Standard deviation 46
Values 57 84 1.5e+02 55
[43]
ref_hepatocyte PMVK
Mean 22.4
Standard deviation 12
Values 3.4 22 33 20 34
[44]
HepG2 PMVK
Mean 8.49
Standard deviation 1
Values 9.2 7.8
[45]
HepG2.C3A PMVK
Mean 7.97
Standard deviation 0.74
Values 8.5 7.4
[46]
HuH.7 PMVK
Mean 17.9
Standard deviation 3.9
Values 18 14 22
[47]
SNU475 PMVK
Mean 9.92
Standard deviation 2.1
Values 11 8.5
[48]
THLE PMVK
Mean 9.34
Standard deviation 1.8
Values 8 11
[49]
liver PMVK
Mean 7.06
Standard deviation 5.2
Values 2.4 13 9 3.4
[50]
ref_hepatocyte MVD
Mean 20.1
Standard deviation 9.1
Values 34 10 17 15 24
[51]
HepG2 MVD
Mean 18.7
Standard deviation 5.5
Values 15 23
[52]
HepG2.C3A MVD
Mean 92.8
Standard deviation 59
Values 1.3e+02 51
[53]
HuH.7 MVD
Mean 50.8
Standard deviation 5.1
Values 51 45 56
[54]
SNU475 MVD
Mean 7
Standard deviation 2.5
Values 8.8 5.2
[55]
THLE MVD
Mean 7.96
Standard deviation 0.012
Values 8 8
[56]
liver MVD
Mean 21.1
Standard deviation 12
Values 14 12 39 19
[57]
ref_hepatocyte HMGCR
Mean 14.8
Standard deviation 13
Values 37 12 5.9 9.1 9.8
[58]
HepG2 HMGCR
Mean 22.2
Standard deviation 14
Values 12 32
[59]
HepG2.C3A HMGCR
Mean 133
Standard deviation 31
Values 1.5e+02 1.1e+02
[60]
HuH.7 HMGCR
Mean 154
Standard deviation 61
Values 1.3e+02 2.2e+02 1.1e+02
[61]
SNU475 HMGCR
Mean 22
Standard deviation 2.5
Values 24 20
[62]
THLE HMGCR
Mean 19.8
Standard deviation 3.5
Values 17 22
[63]
liver HMGCR
Mean 54.5
Standard deviation 28
Values 71 20 46 81
[64]
ref_hepatocyte MVK
Mean 14.5
Standard deviation 7.2
Values 12 8.7 20 7.9 24
[65]
HepG2 MVK
Mean 6.45
Standard deviation 1.7
Values 5.3 7.6
[66]
HepG2.C3A MVK
Mean 29.6
Standard deviation 8.4
Values 36 24
[67]
HuH.7 MVK
Mean 19.4
Standard deviation 2
Values 19 18 22
[68]
SNU475 MVK
Mean 2.86
Standard deviation 0.47
Values 3.2 2.5
[69]
THLE MVK
Mean 2.76
Standard deviation 0.64
Values 2.3 3.2
[70]
liver MVK
Mean 24.4
Standard deviation 13
Values 11 36 35 16
[71]
ref_hepatocyte DHDDS
Mean 7.73
Standard deviation 4.3
Values 5.5 14 5.2 11 3.5
[72]
HepG2 DHDDS
Mean 15.7
Standard deviation 1.1
Values 15 16
[73]
HepG2.C3A DHDDS
Mean 23.3
Standard deviation 2.3
Values 22 25
[74]
HuH.7 DHDDS
Mean 13.2
Standard deviation 2.5
Values 15 10 14
[75]
SNU475 DHDDS
Mean 18.5
Standard deviation 0.043
Values 18 18
[76]
THLE DHDDS
Mean 14.8
Standard deviation 0.9
Values 14 15
[77]
liver DHDDS
Mean 7.61
Standard deviation 3.2
Values 6.3 7.9 12 4.3
[78]
ref_hepatocyte PDSS2
Mean 5.1
Standard deviation 2
Values 3.9 4.6 6.8 2.7 7.5
[79]
HepG2 PDSS2
Mean 10.8
Standard deviation 2.8
Values 8.8 13
[80]
HepG2.C3A PDSS2
Mean 11.3
Standard deviation 1.6
Values 10 12
[81]
HuH.7 PDSS2
Mean 10.9
Standard deviation 0.57
Values 11 10 11
[82]
SNU475 PDSS2
Mean 3.17
Standard deviation 0.19
Values 3.3 3
[83]
THLE PDSS2
Mean 7.52
Standard deviation 0.72
Values 7 8
[84]
liver PDSS2
Mean 15.4
Standard deviation 2
Values 14 16 18 13
[85]
ref_hepatocyte GGPS1
Mean 3.62
Standard deviation 1.6
Values 6.4 2.5 3.1 2.9 3.2
[86]
HepG2 GGPS1
Mean 9.28
Standard deviation 2.3
Values 7.6 11
[87]
HepG2.C3A GGPS1
Mean 19.7
Standard deviation 0.38
Values 20 19
[88]
HuH.7 GGPS1
Mean 18.5
Standard deviation 0.7
Values 18 18 19
[89]
SNU475 GGPS1
Mean 20.3
Standard deviation 4.3
Values 23 17
[90]
THLE GGPS1
Mean 7.32
Standard deviation 0.42
Values 7.6 7
[91]
liver GGPS1
Mean 6.56
Standard deviation 3.2
Values 4.6 10 8.2 3.3
[92]
ref_hepatocyte PDSS1
Mean 2.39
Standard deviation 0.94
Values 1.8 3.6 1.9 3.2 1.5
[93]
HepG2 PDSS1
Mean 5.47
Standard deviation 0.88
Values 4.8 6.1
[94]
HepG2.C3A PDSS1
Mean 8.85
Standard deviation 4.4
Values 5.8 12
[95]
HuH.7 PDSS1
Mean 6.03
Standard deviation 3.1
Values 6.3 2.8 8.9
[96]
SNU475 PDSS1
Mean 5.28
Standard deviation 1.6
Values 4.2 6.4
[97]
THLE PDSS1
Mean 4.54
Standard deviation 1.2
Values 3.7 5.4
[98]
liver PDSS1
Mean 3.14
Standard deviation 1
Values 2.8 3.6 4.2 1.9
[99]
ref_hepatocyte IDI2
Mean 0.262
Standard deviation 0.32
Values 0 0 0.63 0.079 0.6
[100]
HepG2 IDI2
Mean 0.98
Standard deviation 0.15
Values 1.1 0.87
[101]
HepG2.C3A IDI2
Mean 1.6
Standard deviation 0.39
Values 1.9 1.3
[102]
HuH.7 IDI2
Mean 1.5
Standard deviation 0.45
Values 1.5 1 1.9
[103]
SNU475 IDI2
Mean 3.28
Standard deviation 1.1
Values 2.5 4.1
[104]
THLE IDI2
Mean 1.33
Standard deviation 0.055
Values 1.3 1.4
[105]
liver IDI2
Mean 0.531
Standard deviation 0.12
Values 0.41 0.71 0.51 0.49