KEGG_STEROID_BIOSYNTHESIS Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 EBP 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase [1] -2.68[2] -2.15[3] -1.39[4] -2.18[5] -1.67[6] -1.83[7]
2 DHCR24 Delta(24)-sterol reductase [8] 1.07[9] 0.49[10] 0.79[11] -0.03[12] 0.55[13] 1.10[14]
3 MSMO1 Methylsterol monooxygenase 1 [15] -1.94[16] -0.40[17] -0.09[18] -1.65[19] -1.05[20] 0.08[21]
4 FDFT1 Squalene synthase [22] -0.13[23] 0.35[24] -0.14[25] -1.20[26] -0.35[27] -1.39[28]
5 CYP51A1 Lanosterol 14-alpha demethylase [29] -1.08[30] -0.15[31] -0.26[32] 0.14[33] -0.40[34] 0.37[35]
6 LIPA Lysosomal acid lipase/cholesteryl ester hydrolase [36] 0.94[37] -0.52[38] -1.63[39] 0.66[40] 0.84[41] -0.71[42]
7 SQLE Squalene monooxygenase [43] -0.24[44] 0.88[45] 0.56[46] 0.42[47] -0.36[48] -0.75[49]
8 DHCR7 7-dehydrocholesterol reductase [50] 0.62[51] 0.88[52] 1.08[53] -0.06[54] -0.03[55] 0.69[56]
9 TM7SF2 Delta(14)-sterol reductase [57] 0.22[58] -0.33[59] -0.72[60] 0.02[61] -1.98[62] -0.40[63]
10 NSDHL Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating [64] -0.19[65] -0.69[66] -1.34[67] 0.79[68] 0.03[69] -1.10[70]
11 LSS Lanosterol synthase [71] 0.99[72] 1.62[73] 0.52[74] 1.68[75] 1.07[76] 0.63[77]
12 HSD17B7 3-keto-steroid reductase [78] -1.59[79] -1.21[80] -1.23[81] -0.81[82] -1.38[83] -1.22[84]
13 SOAT1 Sterol O-acyltransferase 1 [85] 2.65[86] 1.73[87] 2.46[88] 5.48[89] 4.89[90] 1.23[91]
14 SOAT2 Sterol O-acyltransferase 2 [92] 2.96[93] 3.97[94] 2.58[95] -3.72[96] -4.47[97] -1.78[98]
15 CEL Bile salt-activated lipase [99] 5.00[100] 4.03[101] 0.65[102] 3.38[103] 3.24[104] -1.86[105]
16 CYP27B1 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial [106] 4.31[107] 4.27[108] 3.62[109] 3.76[110] 4.29[111] 1.24[112]
17 SC5D Lathosterol oxidase [113] [114] [115] [116] [117] [118] [119]
[1]
ref_hepatocyte EBP
Mean 181
Standard deviation 65
Values 1.8e+02 2.8e+02 1.5e+02 1e+02 1.9e+02
[2]
HepG2 EBP
Mean 20.1
Standard deviation 4.7
Values 17 23
[3]
HepG2.C3A EBP
Mean 71.4
Standard deviation 13
Values 80 63
[4]
HuH.7 EBP
Mean 120
Standard deviation 17
Values 1.1e+02 1.1e+02 1.4e+02
[5]
SNU475 EBP
Mean 12.4
Standard deviation 1.5
Values 11 13
[6]
THLE EBP
Mean 22.6
Standard deviation 3.6
Values 20 25
[7]
liver EBP
Mean 97.6
Standard deviation 78
Values 24 1.8e+02 1.5e+02 37
[8]
ref_hepatocyte DHCR24
Mean 160
Standard deviation 83
Values 1.8e+02 1.1e+02 2e+02 44 2.6e+02
[9]
HepG2 DHCR24
Mean 239
Standard deviation 90
Values 1.8e+02 3e+02
[10]
HepG2.C3A DHCR24
Mean 395
Standard deviation 1.3e+02
Values 4.9e+02 3e+02
[11]
HuH.7 DHCR24
Mean 482
Standard deviation 1.1e+02
Values 4.9e+02 5.9e+02 3.7e+02
[12]
SNU475 DHCR24
Mean 48.6
Standard deviation 27
Values 68 29
[13]
THLE DHCR24
Mean 93.2
Standard deviation 28
Values 73 1.1e+02
[14]
liver DHCR24
Mean 661
Standard deviation 1.8e+02
Values 6.7e+02 5.4e+02 9.1e+02 5.3e+02
[15]
ref_hepatocyte MSMO1
Mean 108
Standard deviation 90
Values 88 72 1e+02 21 2.6e+02
[16]
HepG2 MSMO1
Mean 20.1
Standard deviation 11
Values 12 28
[17]
HepG2.C3A MSMO1
Mean 144
Standard deviation 56
Values 1.8e+02 1e+02
[18]
HuH.7 MSMO1
Mean 177
Standard deviation 63
Values 1.3e+02 2.5e+02 1.6e+02
[19]
SNU475 MSMO1
Mean 10.6
Standard deviation 4
Values 13 7.8
[20]
THLE MSMO1
Mean 20.7
Standard deviation 3.4
Values 18 23
[21]
liver MSMO1
Mean 219
Standard deviation 94
Values 1.9e+02 1.6e+02 3.6e+02 1.7e+02
[22]
ref_hepatocyte FDFT1
Mean 87.4
Standard deviation 77
Values 2.2e+02 91 48 41 38
[23]
HepG2 FDFT1
Mean 56.9
Standard deviation 24
Values 40 74
[24]
HepG2.C3A FDFT1
Mean 196
Standard deviation 63
Values 2.4e+02 1.5e+02
[25]
HuH.7 FDFT1
Mean 138
Standard deviation 16
Values 1.3e+02 1.3e+02 1.6e+02
[26]
SNU475 FDFT1
Mean 11.8
Standard deviation 4
Values 15 9
[27]
THLE FDFT1
Mean 27.4
Standard deviation 0.93
Values 27 28
[28]
liver FDFT1
Mean 64.1
Standard deviation 23
Values 45 62 98 52
[29]
ref_hepatocyte CYP51A1
Mean 63
Standard deviation 38
Values 1.2e+02 88 27 38 46
[30]
HepG2 CYP51A1
Mean 21.2
Standard deviation 5.5
Values 17 25
[31]
HepG2.C3A CYP51A1
Mean 99.9
Standard deviation 49
Values 1.3e+02 66
[32]
HuH.7 CYP51A1
Mean 91.5
Standard deviation 23
Values 79 1.2e+02 78
[33]
SNU475 CYP51A1
Mean 21.5
Standard deviation 2.5
Values 23 20
[34]
THLE CYP51A1
Mean 19
Standard deviation 1.2
Values 18 20
[35]
liver CYP51A1
Mean 156
Standard deviation 52
Values 1.8e+02 89 2.1e+02 1.5e+02
[36]
ref_hepatocyte LIPA
Mean 49.8
Standard deviation 49
Values 1.3e+02 52 23 9.5 31
[37]
HepG2 LIPA
Mean 68.3
Standard deviation 18
Values 56 81
[38]
HepG2.C3A LIPA
Mean 61.2
Standard deviation 4.6
Values 64 58
[39]
HuH.7 LIPA
Mean 28.1
Standard deviation 2.4
Values 27 31 27
[40]
SNU475 LIPA
Mean 24.3
Standard deviation 3
Values 26 22
[41]
THLE LIPA
Mean 35.6
Standard deviation 1.9
Values 34 37
[42]
liver LIPA
Mean 58.5
Standard deviation 24
Values 79 43 79 33
[43]
ref_hepatocyte SQLE
Mean 34.4
Standard deviation 33
Values 86 47 12 17 9.9
[44]
HepG2 SQLE
Mean 20.7
Standard deviation 9.1
Values 14 27
[45]
HepG2.C3A SQLE
Mean 111
Standard deviation 44
Values 1.4e+02 80
[46]
HuH.7 SQLE
Mean 88.5
Standard deviation 14
Values 88 1e+02 75
[47]
SNU475 SQLE
Mean 14.3
Standard deviation 3.6
Values 17 12
[48]
THLE SQLE
Mean 10.7
Standard deviation 4.6
Values 7.4 14
[49]
liver SQLE
Mean 39.4
Standard deviation 14
Values 28 27 54 49
[50]
ref_hepatocyte DHCR7
Mean 31.8
Standard deviation 19
Values 21 13 43 23 59
[51]
HepG2 DHCR7
Mean 34.7
Standard deviation 11
Values 27 43
[52]
HepG2.C3A DHCR7
Mean 103
Standard deviation 68
Values 1.5e+02 54
[53]
HuH.7 DHCR7
Mean 117
Standard deviation 29
Values 1.1e+02 1.5e+02 90
[54]
SNU475 DHCR7
Mean 9.4
Standard deviation 1.9
Values 11 8
[55]
THLE DHCR7
Mean 12.4
Standard deviation 3.1
Values 10 15
[56]
liver DHCR7
Mean 98.2
Standard deviation 72
Values 50 69 2.1e+02 68
[57]
ref_hepatocyte TM7SF2
Mean 22.9
Standard deviation 25
Values 24 1.4 26 0.92 62
[58]
HepG2 TM7SF2
Mean 19
Standard deviation 5.7
Values 15 23
[59]
HepG2.C3A TM7SF2
Mean 32
Standard deviation 9.1
Values 38 26
[60]
HuH.7 TM7SF2
Mean 24.2
Standard deviation 0.33
Values 25 24 24
[61]
SNU475 TM7SF2
Mean 7.18
Standard deviation 2.2
Values 8.8 5.6
[62]
THLE TM7SF2
Mean 2.32
Standard deviation 0.45
Values 2.6 2
[63]
liver TM7SF2
Mean 33.4
Standard deviation 23
Values 24 27 67 16
[64]
ref_hepatocyte NSDHL
Mean 19.7
Standard deviation 8
Values 14 17 31 12 24
[65]
HepG2 NSDHL
Mean 12.3
Standard deviation 4.3
Values 9.2 15
[66]
HepG2.C3A NSDHL
Mean 21.5
Standard deviation 0.63
Values 22 21
[67]
HuH.7 NSDHL
Mean 13.6
Standard deviation 1.6
Values 14 12 15
[68]
SNU475 NSDHL
Mean 10.5
Standard deviation 1
Values 11 9.8
[69]
THLE NSDHL
Mean 8.01
Standard deviation 1.5
Values 6.9 9.1
[70]
liver NSDHL
Mean 17.7
Standard deviation 6.5
Values 11 18 26 15
[71]
ref_hepatocyte LSS
Mean 16.9
Standard deviation 8
Values 31 16 12 11 14
[72]
HepG2 LSS
Mean 23.9
Standard deviation 12
Values 15 32
[73]
HepG2.C3A LSS
Mean 91.2
Standard deviation 46
Values 1.2e+02 59
[74]
HuH.7 LSS
Mean 42.1
Standard deviation 4.8
Values 40 48 39
[75]
SNU475 LSS
Mean 16.7
Standard deviation 8.9
Values 23 10
[76]
THLE LSS
Mean 14.1
Standard deviation 4.1
Values 11 17
[77]
liver LSS
Mean 49.9
Standard deviation 22
Values 44 39 34 83
[78]
ref_hepatocyte HSD17B7
Mean 14.9
Standard deviation 12
Values 14 8.9 35 4 12
[79]
HepG2 HSD17B7
Mean 3.52
Standard deviation 0.97
Values 2.8 4.2
[80]
HepG2.C3A HSD17B7
Mean 11.3
Standard deviation 3.5
Values 14 8.9
[81]
HuH.7 HSD17B7
Mean 11.1
Standard deviation 1.6
Values 9.5 13 11
[82]
SNU475 HSD17B7
Mean 2.62
Standard deviation 1.2
Values 3.5 1.7
[83]
THLE HSD17B7
Mean 2.28
Standard deviation 0.47
Values 1.9 2.6
[84]
liver HSD17B7
Mean 12.3
Standard deviation 4.1
Values 6.2 15 13 15
[85]
ref_hepatocyte SOAT1
Mean 4.02
Standard deviation 3.9
Values 11 3.3 2.5 0.73 2.8
[86]
HepG2 SOAT1
Mean 18
Standard deviation 7.3
Values 13 23
[87]
HepG2.C3A SOAT1
Mean 23.4
Standard deviation 4.3
Values 20 26
[88]
HuH.7 SOAT1
Mean 38.5
Standard deviation 5
Values 44 36 36
[89]
SNU475 SOAT1
Mean 55.4
Standard deviation 0.022
Values 55 55
[90]
THLE SOAT1
Mean 47.6
Standard deviation 11
Values 40 56
[91]
liver SOAT1
Mean 18.1
Standard deviation 2.1
Values 21 17 16 18
[92]
ref_hepatocyte SOAT2
Mean 1.25
Standard deviation 1.8
Values 4.4 0 0.34 0.4 1.1
[93]
HepG2 SOAT2
Mean 6.93
Standard deviation 0.014
Values 6.9 6.9
[94]
HepG2.C3A SOAT2
Mean 34.3
Standard deviation 14
Values 44 25
[95]
HuH.7 SOAT2
Mean 13
Standard deviation 2.2
Values 11 15 13
[96]
SNU475 SOAT2
Mean 0.0293
Standard deviation 0.0087
Values 0.023 0.035
[97]
THLE SOAT2
Mean 0.0225
Standard deviation 0.0017
Values 0.024 0.021
[98]
liver SOAT2
Mean 0.7
Standard deviation 0.61
Values 0.29 1.6 0.36 0.56
[99]
ref_hepatocyte CEL
Mean 0.0634
Standard deviation 0.059
Values 0.099 0 0.12 0 0.098
[100]
HepG2 CEL
Mean 1.45
Standard deviation 0.58
Values 1.9 1
[101]
HepG2.C3A CEL
Mean 1.82
Standard deviation 0.098
Values 1.7 1.9
[102]
HuH.7 CEL
Mean 0.173
Standard deviation 0.076
Values 0.16 0.1 0.25
[103]
SNU475 CEL
Mean 0.204
Standard deviation 0.02
Values 0.19 0.22
[104]
THLE CEL
Mean 0.239
Standard deviation 0.097
Values 0.31 0.17
[105]
liver CEL
Mean 0.0336
Standard deviation 0.05
Values 0.029 0 0 0.11
[106]
ref_hepatocyte CYP27B1
Mean 0.0505
Standard deviation 0.082
Values 0 0 0 0.19 0.065
[107]
HepG2 CYP27B1
Mean 0.715
Standard deviation 0.14
Values 0.62 0.81
[108]
HepG2.C3A CYP27B1
Mean 1.72
Standard deviation 0.25
Values 1.9 1.5
[109]
HuH.7 CYP27B1
Mean 1.08
Standard deviation 0.18
Values 1.1 0.89 1.3
[110]
SNU475 CYP27B1
Mean 0.211
Standard deviation 0.1
Values 0.14 0.28
[111]
THLE CYP27B1
Mean 0.395
Standard deviation 0.14
Values 0.5 0.29
[112]
liver CYP27B1
Mean 0.228
Standard deviation 0.17
Values 0.14 0.071 0.46 0.24
[113]
ref_hepatocyte SC5D
Missing
[114]
HepG2 SC5D
Missing
[115]
HepG2.C3A SC5D
Missing
[116]
HuH.7 SC5D
Missing
[117]
SNU475 SC5D
Missing
[118]
THLE SC5D
Missing
[119]
liver SC5D
Missing