KEGG_SPHINGOLIPID_METABOLISM | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | NEU1 | Sialidase-1 | [1] | 0.39[2] | -0.25[3] | -1.10[4] | -1.55[5] | -1.78[6] | -1.76[7] |
2 | ASAH1 | Acid ceramidase | [8] | -0.42[9] | -0.62[10] | 0.13[11] | -0.85[12] | -1.08[13] | -0.57[14] |
3 | SMPD1 | Sphingomyelin phosphodiesterase | [15] | -2.64[16] | -3.31[17] | -3.01[18] | -1.56[19] | -1.19[20] | 0.32[21] |
4 | DEGS1 | Sphingolipid delta(4)-desaturase DES1 | [22] | -1.21[23] | -1.76[24] | -1.15[25] | 1.16[26] | 0.45[27] | -0.63[28] |
5 | GLB1 | Beta-galactosidase | [29] | 0.13[30] | -0.27[31] | 1.26[32] | -0.61[33] | 0.06[34] | -0.04[35] |
6 | SPTLC1 | Serine palmitoyltransferase 1 | [36] | -0.36[37] | 0.28[38] | 0.09[39] | 0.25[40] | 0.77[41] | -0.99[42] |
7 | SPHK1 | Sphingosine kinase 1 | [43] | 1.05[44] | 1.71[45] | -0.29[46] | -2.30[47] | -0.15[48] | -5.16[49] |
8 | SMPD4 | Sphingomyelin phosphodiesterase 4 | [50] | 0.76[51] | 0.57[52] | 0.55[53] | 0.47[54] | 0.52[55] | -0.71[56] |
9 | NEU4 | Sialidase-4 | [57] | 0.28[58] | 1.18[59] | -7.96[60] | -5.75[61] | -8.65[62] | -0.32[63] |
10 | GLA | Alpha-galactosidase A | [64] | -0.60[65] | -1.28[66] | 0.37[67] | 0.11[68] | -0.21[69] | -1.71[70] |
11 | GBA | Glucosylceramidase | [71] | -0.43[72] | -1.98[73] | 0.31[74] | 0.74[75] | 0.77[76] | -1.07[77] |
12 | SGPP1 | Sphingosine-1-phosphate phosphatase 1 | [78] | -1.41[79] | -1.30[80] | -1.89[81] | -0.59[82] | -0.51[83] | 0.55[84] |
13 | KDSR | 3-ketodihydrosphingosine reductase | [85] | -1.09[86] | -0.81[87] | -0.90[88] | -0.30[89] | 0.52[90] | 1.40[91] |
14 | UGCG | Ceramide glucosyltransferase | [92] | -2.98[93] | -1.93[94] | -0.78[95] | -0.40[96] | 0.92[97] | -0.71[98] |
15 | SGPL1 | Sphingosine-1-phosphate lyase 1 | [99] | 1.51[100] | 0.91[101] | 0.64[102] | 1.52[103] | 0.83[104] | 2.10[105] |
16 | CERK | Ceramide kinase | [106] | 1.59[107] | 2.17[108] | 2.05[109] | 1.37[110] | 1.28[111] | 1.02[112] |
17 | ARSA | Arylsulfatase A | [113] | 0.33[114] | -0.28[115] | 0.61[116] | 0.03[117] | -0.56[118] | 0.56[119] |
18 | SGMS1 | Phosphatidylcholine:ceramide cholinephosphotransferase 1 | [120] | -1.09[121] | -0.14[122] | -0.68[123] | 0.94[124] | 0.75[125] | 0.93[126] |
19 | SPHK2 | Sphingosine kinase 2 | [127] | -0.69[128] | -0.53[129] | -0.33[130] | 0.07[131] | -0.63[132] | 0.25[133] |
20 | SGMS2 | Phosphatidylcholine:ceramide cholinephosphotransferase 2 | [134] | -2.56[135] | -2.23[136] | -5.80[137] | 0.81[138] | 1.94[139] | 1.66[140] |
21 | SMPD2 | Sphingomyelin phosphodiesterase 2 | [141] | -1.48[142] | -1.18[143] | -1.29[144] | -1.87[145] | -0.87[146] | -1.77[147] |
22 | ENPP7 | Ectonucleotide pyrophosphatase/phosphodiesterase family member 7 | -3.09[148] | 0.52[149] | -3.50[150] | -10.43[151] | [152] | -0.08[153] | |
23 | SPTLC2 | Serine palmitoyltransferase 2 | [154] | 2.07[155] | 1.88[156] | 1.46[157] | 2.67[158] | 2.22[159] | 2.68[160] |
24 | GALC | Galactocerebrosidase | [161] | -6.59[162] | -6.05[163] | 3.07[164] | 2.51[165] | 1.64[166] | 2.44[167] |
25 | ACER3 | Alkaline ceramidase 3 | [168] | 0.54[169] | -0.09[170] | 0.26[171] | 2.08[172] | 1.88[173] | 1.42[174] |
26 | GAL3ST1 | Galactosylceramide sulfotransferase | [175] | 0.31[176] | 1.30[177] | 0.71[178] | -0.10[179] | -4.24[180] | -2.20[181] |
27 | UGT8 | 2-hydroxyacylsphingosine 1-beta-galactosyltransferase | [182] | -2.09[183] | -0.48[184] | 2.04[185] | 1.00[186] | 1.00[187] | 2.85[188] |
28 | SMPD3 | Sphingomyelin phosphodiesterase 3 | [189] | -0.41[190] | 0.04[191] | -0.21[192] | 0.24[193] | -0.82[194] | 2.77[195] |
29 | NEU3 | Sialidase-3 | [196] | 2.42[197] | 1.70[198] | 1.76[199] | 1.92[200] | 1.92[201] | 2.33[202] |
30 | B4GALT6 | Beta-1,4-galactosyltransferase 6 | [203] | -0.10[204] | 0.91[205] | 1.95[206] | 3.64[207] | 2.56[208] | 0.75[209] |
31 | ASAH2 | Neutral ceramidase | [210] | 0.53[211] | 2.04[212] | -0.45[213] | -1.30[214] | -1.06[215] | 0.25[216] |
32 | ACER2 | Alkaline ceramidase 2 | [217] | 2.26[218] | 1.29[219] | 0.69[220] | -0.75[221] | 1.70[222] | 2.81[223] |
33 | DEGS2 | Sphingolipid delta(4)-desaturase/C4-monooxygenase DES2 | [224] | 4.25[225] | -1.71[226] | 0.66[227] | 1.06[228] | -1.56[229] | 2.86[230] |
34 | NEU2 | Sialidase-2 | [231] | [232] | [233] | [234] | [235] | [236] | [237] |
35 | SGPP2 | Sphingosine-1-phosphate phosphatase 2 | [238] | [239] | [240] | [241] | [242] | [243] | [244] |
36 | PLPP3 | Phospholipid phosphatase 3 | [245] | [246] | [247] | [248] | [249] | [250] | [251] |
37 | ACER1 | Alkaline ceramidase 1 | [252] | [253] | [254] | [255] | [256] | [257] | [258] |
38 | PLPP2 | Phospholipid phosphatase 2 | [259] | [260] | [261] | [262] | [263] | [264] | [265] |
39 | PLPP1 | Phospholipid phosphatase 1 | [266] | [267] | [268] | [269] | [270] | [271] | [272] |