KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 PCK1 Phosphoenolpyruvate carboxykinase, cytosolic [GTP] [1] -8.84[2] -4.59[3] -11.96[4] [5] -15.21[6] 0.61[7]
2 GLUD1 Glutamate dehydrogenase 1, mitochondrial [8] -0.64[9] 0.78[10] -0.15[11] -2.03[12] -1.02[13] 0.60[14]
3 PCK2 Phosphoenolpyruvate carboxykinase [GTP], mitochondrial [15] -0.36[16] -1.78[17] -0.78[18] -4.01[19] -1.83[20] -0.72[21]
4 MDH1 Malate dehydrogenase, cytoplasmic [22] -0.42[23] 0.18[24] -0.08[25] 0.87[26] 0.65[27] -1.03[28]
5 ATP1A1 Sodium/potassium-transporting ATPase subunit alpha-1 [29] 2.58[30] 1.66[31] 2.18[32] 1.63[33] 2.20[34] -0.39[35]
6 SLC38A3 Sodium-coupled neutral amino acid transporter 3 [36] -2.96[37] -0.83[38] -0.64[39] -5.28[40] -5.36[41] -0.12[42]
7 ATP1B1 Sodium/potassium-transporting ATPase subunit beta-1 [43] -0.10[44] 0.32[45] 0.65[46] 0.71[47] -0.42[48] -1.21[49]
8 CA2 Carbonic anhydrase 2 [50] -7.96[51] -8.60[52] -0.61[53] -8.12[54] -6.21[55] -0.56[56]
9 SLC25A10 Mitochondrial dicarboxylate carrier [57] 0.82[58] 0.62[59] -0.77[60] -0.59[61] -0.02[62] -0.94[63]
10 GLS2 Glutaminase liver isoform, mitochondrial [64] -2.28[65] -1.70[66] -5.72[67] -5.71[68] -5.04[69] 0.04[70]
11 ATP1B3 Sodium/potassium-transporting ATPase subunit beta-3 [71] 1.17[72] 0.43[73] 0.91[74] 2.19[75] 3.02[76] -2.46[77]
12 GLS Glutaminase kidney isoform, mitochondrial [78] 1.50[79] 2.33[80] 1.56[81] 4.35[82] 2.90[83] -1.00[84]
13 GLUD2 Glutamate dehydrogenase 2, mitochondrial [85] -7.82[86] -6.22[87] 0.93[88] -6.43[89] -3.82[90] -0.34[91]
14 SLC4A4 Electrogenic sodium bicarbonate cotransporter 1 [92] -5.85[93] -5.87[94] 1.84[95] 3.21[96] 0.73[97] 3.62[98]
15 FXYD2 Sodium/potassium-transporting ATPase subunit gamma [99] -0.36[100] -2.28[101] [102] [103] [104] -0.61[105]
16 AQP1 Aquaporin-1 [106] -4.54[107] [108] -1.31[109] 3.98[110] -0.29[111] 3.95[112]
17 ATP1B2 Sodium/potassium-transporting ATPase subunit beta-2 [113] -2.13[114] -1.40[115] 0.13[116] 0.70[117] 0.00[118] 1.37[119]
18 ATP1A3 Sodium/potassium-transporting ATPase subunit alpha-3 [120] 1.06[121] [122] -3.69[123] 0.62[124] 0.61[125] -1.66[126]
19 ATP1B4 Protein ATP1B4 [127] -0.05[128] 1.27[129] 0.94[130] 1.53[131] 2.05[132] -1.68[133]
20 SLC9A3 Sodium/hydrogen exchanger 3 [134] 0.05[135] -0.57[136] 0.80[137] 1.91[138] 3.83[139] -0.88[140]
21 ATP1A2 Sodium/potassium-transporting ATPase subunit alpha-2 [141] 2.71[142] 1.18[143] 0.66[144] 3.80[145] 1.77[146] 2.04[147]
22 ATP1A4 Sodium/potassium-transporting ATPase subunit alpha-4 [148] [149] [150] [151] [152] [153] [154]
23 CA4 Carbonic anhydrase 4 [155] [156] [157] [158] [159] [160] [161]
[1]
ref_hepatocyte PCK1
Mean 142
Standard deviation 1.9e+02
Values 30 0.041 4.4e+02 5.3 2.4e+02
[2]
HepG2 PCK1
Mean 0.593
Standard deviation 0.35
Values 0.84 0.34
[3]
HepG2.C3A PCK1
Mean 10.1
Standard deviation 5.7
Values 14 6
[4]
HuH.7 PCK1
Mean 0.0471
Standard deviation 0.082
Values 0 0.14 0
[5]
SNU475 PCK1
Mean 0
Standard deviation 0
Values 0 0
[6]
THLE PCK1
Mean 0.00266
Standard deviation 0.0038
Values 0 0.0053
[7]
liver PCK1
Mean 420
Standard deviation 94
Values 4.8e+02 3.7e+02 5.2e+02 3.2e+02
[8]
ref_hepatocyte GLUD1
Mean 132
Standard deviation 1.1e+02
Values 2.2e+02 24 1.4e+02 15 2.7e+02
[9]
HepG2 GLUD1
Mean 161
Standard deviation 65
Values 1.2e+02 2.1e+02
[10]
HepG2.C3A GLUD1
Mean 386
Standard deviation 27
Values 4.1e+02 3.7e+02
[11]
HuH.7 GLUD1
Mean 157
Standard deviation 18
Values 1.5e+02 1.8e+02 1.5e+02
[12]
SNU475 GLUD1
Mean 22.7
Standard deviation 0.64
Values 23 22
[13]
THLE GLUD1
Mean 46.4
Standard deviation 7.4
Values 41 52
[14]
liver GLUD1
Mean 386
Standard deviation 1.2e+02
Values 4.1e+02 5.5e+02 2.7e+02 3.1e+02
[15]
ref_hepatocyte PCK2
Mean 119
Standard deviation 1.4e+02
Values 56 13 1.7e+02 18 3.4e+02
[16]
HepG2 PCK2
Mean 177
Standard deviation 94
Values 2.4e+02 1.1e+02
[17]
HepG2.C3A PCK2
Mean 59.6
Standard deviation 38
Values 86 33
[18]
HuH.7 PCK2
Mean 91.6
Standard deviation 15
Values 95 76 1e+02
[19]
SNU475 PCK2
Mean 5.25
Standard deviation 0.37
Values 5 5.5
[20]
THLE PCK2
Mean 24
Standard deviation 0.56
Values 24 24
[21]
liver PCK2
Mean 140
Standard deviation 82
Values 61 2.3e+02 1.8e+02 82
[22]
ref_hepatocyte MDH1
Mean 74.5
Standard deviation 43
Values 99 52 1e+02 9.2 1.1e+02
[23]
HepG2 MDH1
Mean 106
Standard deviation 36
Values 80 1.3e+02
[24]
HepG2.C3A MDH1
Mean 144
Standard deviation 49
Values 1.1e+02 1.8e+02
[25]
HuH.7 MDH1
Mean 93.1
Standard deviation 25
Values 96 67 1.2e+02
[26]
SNU475 MDH1
Mean 95.9
Standard deviation 44
Values 1.3e+02 65
[27]
THLE MDH1
Mean 83.2
Standard deviation 9.4
Values 77 90
[28]
liver MDH1
Mean 70.6
Standard deviation 50
Values 34 1.2e+02 1.1e+02 22
[29]
ref_hepatocyte ATP1A1
Mean 57.3
Standard deviation 24
Values 89 46 76 43 32
[30]
HepG2 ATP1A1
Mean 651
Standard deviation 1.9e+02
Values 7.9e+02 5.1e+02
[31]
HepG2.C3A ATP1A1
Mean 309
Standard deviation 82
Values 3.7e+02 2.5e+02
[32]
HuH.7 ATP1A1
Mean 343
Standard deviation 53
Values 3.4e+02 3.9e+02 2.9e+02
[33]
SNU475 ATP1A1
Mean 125
Standard deviation 9.8
Values 1.2e+02 1.3e+02
[34]
THLE ATP1A1
Mean 187
Standard deviation 35
Values 1.6e+02 2.1e+02
[35]
liver ATP1A1
Mean 84.2
Standard deviation 8.3
Values 80 96 82 78
[36]
ref_hepatocyte SLC38A3
Mean 55.2
Standard deviation 73
Values 13 0.33 93 3.5 1.7e+02
[37]
HepG2 SLC38A3
Mean 13.5
Standard deviation 4.1
Values 11 16
[38]
HepG2.C3A SLC38A3
Mean 53.1
Standard deviation 28
Values 73 33
[39]
HuH.7 SLC38A3
Mean 46.7
Standard deviation 12
Values 43 60 37
[40]
SNU475 SLC38A3
Mean 1
Standard deviation 0.019
Values 1 0.99
[41]
THLE SLC38A3
Mean 0.955
Standard deviation 0.08
Values 1 0.9
[42]
liver SLC38A3
Mean 98.1
Standard deviation 81
Values 24 1.9e+02 1.4e+02 36
[43]
ref_hepatocyte ATP1B1
Mean 43.8
Standard deviation 19
Values 61 66 23 29 39
[44]
HepG2 ATP1B1
Mean 77.7
Standard deviation 7.7
Values 72 83
[45]
HepG2.C3A ATP1B1
Mean 93.2
Standard deviation 15
Values 1e+02 83
[46]
HuH.7 ATP1B1
Mean 90.4
Standard deviation 15
Values 81 1.1e+02 82
[47]
SNU475 ATP1B1
Mean 50.5
Standard deviation 8.1
Values 56 45
[48]
THLE ATP1B1
Mean 23.2
Standard deviation 4.8
Values 20 27
[49]
liver ATP1B1
Mean 36.5
Standard deviation 10
Values 41 44 39 22
[50]
ref_hepatocyte CA2
Mean 32.4
Standard deviation 31
Values 0.071 23 53 11 74
[51]
HepG2 CA2
Mean 0.248
Standard deviation 0.071
Values 0.3 0.2
[52]
HepG2.C3A CA2
Mean 0.143
Standard deviation 0.0045
Values 0.15 0.14
[53]
HuH.7 CA2
Mean 28
Standard deviation 3.5
Values 25 27 32
[54]
SNU475 CA2
Mean 0.0819
Standard deviation 0.063
Values 0.037 0.13
[55]
THLE CA2
Mean 0.312
Standard deviation 0.095
Values 0.38 0.24
[56]
liver CA2
Mean 42.6
Standard deviation 37
Values 12 91 53 15
[57]
ref_hepatocyte SLC25A10
Mean 20.2
Standard deviation 13
Values 17 12 32 5.7 35
[58]
HepG2 SLC25A10
Mean 68
Standard deviation 10
Values 61 75
[59]
HepG2.C3A SLC25A10
Mean 52.9
Standard deviation 15
Values 43 63
[60]
HuH.7 SLC25A10
Mean 15.6
Standard deviation 8.3
Values 21 6 20
[61]
SNU475 SLC25A10
Mean 9.47
Standard deviation 0.77
Values 8.9 10
[62]
THLE SLC25A10
Mean 14.1
Standard deviation 3.4
Values 12 17
[63]
liver SLC25A10
Mean 20.3
Standard deviation 8.1
Values 11 31 21 19
[64]
ref_hepatocyte GLS2
Mean 17.1
Standard deviation 20
Values 1.3 3.2 36 2.5 43
[65]
HepG2 GLS2
Mean 6.74
Standard deviation 0.93
Values 6.1 7.4
[66]
HepG2.C3A GLS2
Mean 9.03
Standard deviation 1.6
Values 7.9 10
[67]
HuH.7 GLS2
Mean 0.429
Standard deviation 0.081
Values 0.4 0.52 0.37
[68]
SNU475 GLS2
Mean 0.231
Standard deviation 0.061
Values 0.27 0.19
[69]
THLE GLS2
Mean 0.37
Standard deviation 0.071
Values 0.42 0.32
[70]
liver GLS2
Mean 33.9
Standard deviation 12
Values 35 31 50 20
[71]
ref_hepatocyte ATP1B3
Mean 13.6
Standard deviation 14
Values 35 20 3.4 7.2 2.2
[72]
HepG2 ATP1B3
Mean 58.1
Standard deviation 2.3
Values 60 56
[73]
HepG2.C3A ATP1B3
Mean 31.3
Standard deviation 11
Values 24 39
[74]
HuH.7 ATP1B3
Mean 33.6
Standard deviation 11
Values 36 22 43
[75]
SNU475 ATP1B3
Mean 43.5
Standard deviation 9.4
Values 37 50
[76]
THLE ATP1B3
Mean 78.4
Standard deviation 10
Values 71 86
[77]
liver ATP1B3
Mean 4.76
Standard deviation 3.8
Values 1.5 9 7 1.5
[78]
ref_hepatocyte GLS
Mean 9.86
Standard deviation 9.8
Values 16 23 1 6.9 1.5
[79]
HepG2 GLS
Mean 53
Standard deviation 14
Values 43 63
[80]
HepG2.C3A GLS
Mean 84.4
Standard deviation 0.68
Values 85 84
[81]
HuH.7 GLS
Mean 38.2
Standard deviation 5.2
Values 42 32 40
[82]
SNU475 GLS
Mean 142
Standard deviation 34
Values 1.7e+02 1.2e+02
[83]
THLE GLS
Mean 52.3
Standard deviation 7.1
Values 47 57
[84]
liver GLS
Mean 9.55
Standard deviation 3
Values 12 8.7 5.7 11
[85]
ref_hepatocyte GLUD2
Mean 1.78
Standard deviation 0.84
Values 0.68 1.7 1.4 2.9 2.2
[86]
HepG2 GLUD2
Mean 0.015
Standard deviation 0.021
Values 0 0.03
[87]
HepG2.C3A GLUD2
Mean 0.0409
Standard deviation 0.0028
Values 0.039 0.043
[88]
HuH.7 GLUD2
Mean 4.46
Standard deviation 1.7
Values 3.2 6.4 3.7
[89]
SNU475 GLUD2
Mean 0.0146
Standard deviation 0.00091
Values 0.014 0.015
[90]
THLE GLUD2
Mean 0.0896
Standard deviation 0.0012
Values 0.089 0.09
[91]
liver GLUD2
Mean 2.71
Standard deviation 0.95
Values 3.6 2.3 1.6 3.4
[92]
ref_hepatocyte SLC4A4
Mean 1.37
Standard deviation 1.1
Values 0 2.3 1.5 0.49 2.5
[93]
HepG2 SLC4A4
Mean 0.0451
Standard deviation 0.015
Values 0.034 0.056
[94]
HepG2.C3A SLC4A4
Mean 0.0399
Standard deviation 0.026
Values 0.058 0.021
[95]
HuH.7 SLC4A4
Mean 6.45
Standard deviation 0.98
Values 7.2 6.8 5.4
[96]
SNU475 SLC4A4
Mean 8.92
Standard deviation 3.7
Values 12 6.3
[97]
THLE SLC4A4
Mean 1.62
Standard deviation 0.094
Values 1.7 1.6
[98]
liver SLC4A4
Mean 32.5
Standard deviation 15
Values 38 25 16 51
[99]
ref_hepatocyte FXYD2
Mean 0.931
Standard deviation 1.2
Values 2.6 0 1.8 0 0.3
[100]
HepG2 FXYD2
Mean 1.38
Standard deviation 0.014
Values 1.4 1.4
[101]
HepG2.C3A FXYD2
Mean 0.328
Standard deviation 0.19
Values 0.19 0.46
[102]
HuH.7 FXYD2
Mean 0
Standard deviation 0
Values 0 0 0
[103]
SNU475 FXYD2
Mean 0
Standard deviation 0
Values 0 0
[104]
THLE FXYD2
Mean 0
Standard deviation 0
Values 0 0
[105]
liver FXYD2
Mean 1.17
Standard deviation 1.8
Values 0 3.9 0.82 0
[106]
ref_hepatocyte AQP1
Mean 0.349
Standard deviation 0.51
Values 0 0 1.2 0.022 0.57
[107]
HepG2 AQP1
Mean 0.0287
Standard deviation 0.041
Values 0.057 0
[108]
HepG2.C3A AQP1
Mean 0
Standard deviation 0
Values 0 0
[109]
HuH.7 AQP1
Mean 0.186
Standard deviation 0.062
Values 0.25 0.13 0.17
[110]
SNU475 AQP1
Mean 3.9
Standard deviation 1.9
Values 2.6 5.2
[111]
THLE AQP1
Mean 0.203
Standard deviation 0.11
Values 0.28 0.13
[112]
liver AQP1
Mean 10.4
Standard deviation 3.8
Values 9.2 11 6.2 15
[113]
ref_hepatocyte ATP1B2
Mean 0.326
Standard deviation 0.32
Values 0.84 0.42 0.14 0.19 0.033
[114]
HepG2 ATP1B2
Mean 0.142
Standard deviation 0.043
Values 0.17 0.11
[115]
HepG2.C3A ATP1B2
Mean 0.211
Standard deviation 0.1
Values 0.28 0.14
[116]
HuH.7 ATP1B2
Mean 0.469
Standard deviation 0.13
Values 0.37 0.62 0.42
[117]
SNU475 ATP1B2
Mean 0.373
Standard deviation 0.068
Values 0.32 0.42
[118]
THLE ATP1B2
Mean 0.232
Standard deviation 0.065
Values 0.28 0.19
[119]
liver ATP1B2
Mean 1.62
Standard deviation 2.2
Values 0.23 5 0.9 0.4
[120]
ref_hepatocyte ATP1A3
Mean 0.0881
Standard deviation 0.16
Values 0.068 0 0 0.37 0
[121]
HepG2 ATP1A3
Mean 0.349
Standard deviation 0.14
Values 0.25 0.45
[122]
HepG2.C3A ATP1A3
Mean 0
Standard deviation 0
Values 0 0
[123]
HuH.7 ATP1A3
Mean 0.00898
Standard deviation 0.0094
Values 0.0082 0 0.019
[124]
SNU475 ATP1A3
Mean 0.0958
Standard deviation 0.044
Values 0.065 0.13
[125]
THLE ATP1A3
Mean 0.0958
Standard deviation 0.015
Values 0.11 0.085
[126]
liver ATP1A3
Mean 0.0539
Standard deviation 0.039
Values 0.086 0 0.077 0.053
[127]
ref_hepatocyte ATP1B4
Mean 0.081
Standard deviation 0.086
Values 0 0.028 0.14 0.035 0.2
[128]
HepG2 ATP1B4
Mean 0.15
Standard deviation 0.00081
Values 0.15 0.15
[129]
HepG2.C3A ATP1B4
Mean 0.333
Standard deviation 0.059
Values 0.29 0.38
[130]
HuH.7 ATP1B4
Mean 0.205
Standard deviation 0.04
Values 0.24 0.16 0.22
[131]
SNU475 ATP1B4
Mean 0.165
Standard deviation 0.024
Values 0.15 0.18
[132]
THLE ATP1B4
Mean 0.239
Standard deviation 0.045
Values 0.21 0.27
[133]
liver ATP1B4
Mean 0.0487
Standard deviation 0.062
Values 0.13 0 0 0.066
[134]
ref_hepatocyte SLC9A3
Mean 0.0804
Standard deviation 0.11
Values 0 0 0.052 0.26 0.089
[135]
HepG2 SLC9A3
Mean 0.158
Standard deviation 0.13
Values 0.25 0.064
[136]
HepG2.C3A SLC9A3
Mean 0.0925
Standard deviation 0.021
Values 0.078 0.11
[137]
HuH.7 SLC9A3
Mean 0.184
Standard deviation 0.11
Values 0.082 0.3 0.17
[138]
SNU475 SLC9A3
Mean 0.213
Standard deviation 0.065
Values 0.17 0.26
[139]
THLE SLC9A3
Mean 0.813
Standard deviation 0.16
Values 0.93 0.7
[140]
liver SLC9A3
Mean 0.0841
Standard deviation 0.1
Values 0.086 0 0.026 0.23
[141]
ref_hepatocyte ATP1A2
Mean 0.0637
Standard deviation 0.067
Values 0.054 0.093 0.0086 0 0.16
[142]
HepG2 ATP1A2
Mean 0.793
Standard deviation 0.85
Values 1.4 0.19
[143]
HepG2.C3A ATP1A2
Mean 0.247
Standard deviation 0.06
Values 0.2 0.29
[144]
HuH.7 ATP1A2
Mean 0.133
Standard deviation 0.041
Values 0.11 0.18 0.1
[145]
SNU475 ATP1A2
Mean 0.627
Standard deviation 0.077
Values 0.68 0.57
[146]
THLE ATP1A2
Mean 0.155
Standard deviation 0.016
Values 0.17 0.14
[147]
liver ATP1A2
Mean 0.506
Standard deviation 0.4
Values 0.34 0.35 0.23 1.1
[148]
ref_hepatocyte ATP1A4
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[149]
HepG2 ATP1A4
Mean 0
Standard deviation 0
Values 0 0
[150]
HepG2.C3A ATP1A4
Mean 0
Standard deviation 0
Values 0 0
[151]
HuH.7 ATP1A4
Mean 0
Standard deviation 0
Values 0 0 0
[152]
SNU475 ATP1A4
Mean 0.00253
Standard deviation 0.0036
Values 0 0.0051
[153]
THLE ATP1A4
Mean 0
Standard deviation 0
Values 0 0
[154]
liver ATP1A4
Mean 0.00331
Standard deviation 0.0066
Values 0 0 0 0.013
[155]
ref_hepatocyte CA4
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[156]
HepG2 CA4
Mean 0.155
Standard deviation 0.0073
Values 0.16 0.15
[157]
HepG2.C3A CA4
Mean 0.0204
Standard deviation 0.0014
Values 0.019 0.021
[158]
HuH.7 CA4
Mean 2.44
Standard deviation 1.5
Values 2.5 0.94 3.9
[159]
SNU475 CA4
Mean 0.146
Standard deviation 0.13
Values 0.24 0.056
[160]
THLE CA4
Mean 0
Standard deviation 0
Values 0 0
[161]
liver CA4
Mean 0.0866
Standard deviation 0.037
Values 0.043 0.094 0.077 0.13