KEGG_PROSTATE_CANCER | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | HSP90AB1 | Heat shock protein HSP 90-beta | [1] | 0.23[2] | 0.01[3] | -0.55[4] | -0.52[5] | -0.87[6] | -1.82[7] |
2 | HSP90B1 | Endoplasmin | [8] | -1.29[9] | 0.04[10] | -0.77[11] | -0.85[12] | -0.65[13] | 0.25[14] |
3 | HSP90AA1 | Heat shock protein HSP 90-alpha | [15] | -0.64[16] | 0.01[17] | -0.52[18] | 0.11[19] | 0.07[20] | -0.98[21] |
4 | ATF4 | Cyclic AMP-dependent transcription factor ATF-4 | [22] | -1.17[23] | -0.39[24] | -0.24[25] | -3.01[26] | -1.29[27] | -1.94[28] |
5 | CREB3L3 | Cyclic AMP-responsive element-binding protein 3-like protein 3 | [29] | -5.17[30] | -3.58[31] | -1.83[32] | -9.86[33] | -8.30[34] | 0.16[35] |
6 | NFKBIA | NF-kappa-B inhibitor alpha | [36] | -1.05[37] | -3.16[38] | -3.30[39] | -3.50[40] | -1.34[41] | -0.86[42] |
7 | CDKN1A | Cyclin-dependent kinase inhibitor 1 | [43] | 0.84[44] | -0.87[45] | -3.31[46] | -1.97[47] | 0.86[48] | -1.56[49] |
8 | AKT1 | RAC-alpha serine/threonine-protein kinase | [50] | 0.08[51] | -0.47[52] | -1.30[53] | -0.03[54] | 0.26[55] | 0.03[56] |
9 | CTNNB1 | Catenin beta-1 | [57] | 1.62[58] | 0.80[59] | 1.93[60] | 0.78[61] | 1.28[62] | 1.39[63] |
10 | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1 | [64] | -0.93[65] | -1.57[66] | -0.75[67] | -0.52[68] | 0.26[69] | -0.91[70] |
11 | MAP2K2 | Dual specificity mitogen-activated protein kinase kinase 2 | [71] | 0.06[72] | -0.58[73] | 0.53[74] | -0.82[75] | -0.06[76] | -1.42[77] |
12 | CCND1 | G1/S-specific cyclin-D1 | [78] | 3.05[79] | 0.23[80] | 1.31[81] | 1.90[82] | 0.70[83] | 1.33[84] |
13 | IKBKG | NF-kappa-B essential modulator | [85] | -0.89[86] | -1.06[87] | -3.06[88] | -0.83[89] | -1.77[90] | -0.32[91] |
14 | GRB2 | Growth factor receptor-bound protein 2 | [92] | 1.20[93] | 0.72[94] | 1.08[95] | 0.57[96] | 0.76[97] | 0.58[98] |
15 | IGF1 | Insulin-like growth factor I | [99] | -8.42[100] | -9.67[101] | -7.64[102] | -1.52[103] | -9.08[104] | 1.20[105] |
16 | CREB3 | Cyclic AMP-responsive element-binding protein 3 | [106] | -0.63[107] | -1.05[108] | -1.31[109] | -1.15[110] | -0.39[111] | -0.83[112] |
17 | BAD | Bcl2-associated agonist of cell death | [113] | -1.67[114] | -1.86[115] | -2.56[116] | -1.04[117] | -0.37[118] | -1.14[119] |
18 | RELA | Transcription factor p65 | [120] | 0.14[121] | -0.69[122] | -0.31[123] | -0.03[124] | 0.14[125] | -0.60[126] |
19 | RAF1 | RAF proto-oncogene serine/threonine-protein kinase | [127] | -0.06[128] | 0.03[129] | 1.54[130] | -0.16[131] | 0.97[132] | 1.38[133] |
20 | NRAS | GTPase NRas | [134] | 0.63[135] | 0.75[136] | 1.40[137] | 1.02[138] | 0.86[139] | 0.03[140] |
21 | CDKN1B | Cyclin-dependent kinase inhibitor 1B | [141] | -0.08[142] | 0.04[143] | 0.48[144] | -1.09[145] | -0.35[146] | -0.63[147] |
22 | ARAF | Serine/threonine-protein kinase A-Raf | [148] | -0.45[149] | -1.08[150] | -0.56[151] | -0.07[152] | 0.23[153] | 1.15[154] |
23 | CDK2 | Cyclin-dependent kinase 2 | [155] | -0.41[156] | -0.56[157] | 0.06[158] | 0.00[159] | 0.86[160] | -1.91[161] |
24 | HRAS | GTPase HRas | [162] | -1.01[163] | -2.03[164] | -2.58[165] | -0.93[166] | -0.87[167] | -2.38[168] |
25 | MAPK1 | Mitogen-activated protein kinase 1 | [169] | 1.71[170] | 1.53[171] | 1.60[172] | 1.87[173] | 1.79[174] | 2.05[175] |
26 | AKT2 | RAC-beta serine/threonine-protein kinase | [176] | 0.96[177] | 0.92[178] | 1.29[179] | 0.88[180] | 0.94[181] | 1.41[182] |
27 | KRAS | GTPase KRas | [183] | -0.51[184] | -0.85[185] | 0.99[186] | 0.82[187] | 0.75[188] | 0.95[189] |
28 | PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha | [190] | -0.47[191] | -0.67[192] | 0.67[193] | 2.09[194] | 1.86[195] | 3.28[196] |
29 | SOS1 | Son of sevenless homolog 1 | [197] | -0.10[198] | 1.11[199] | 0.87[200] | 0.87[201] | 0.37[202] | 0.82[203] |
30 | PTEN | Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protei | -0.54[204] | 0.54[205] | 0.98[206] | -0.54[207] | 0.98[208] | 2.76[209] | |
31 | SRD5A2 | 3-oxo-5-alpha-steroid 4-dehydrogenase 2 | [210] | -8.69[211] | -8.19[212] | -8.02[213] | -12.32[214] | -12.02[215] | 0.01[216] |
32 | ERBB2 | Receptor tyrosine-protein kinase erbB-2 | [217] | 2.37[218] | 0.88[219] | 2.29[220] | 1.28[221] | 1.15[222] | 0.43[223] |
33 | MDM2 | E3 ubiquitin-protein ligase Mdm2 | [224] | 2.11[225] | 3.21[226] | 0.69[227] | 0.53[228] | 1.68[229] | 2.44[230] |
34 | NFKB1 | Nuclear factor NF-kappa-B p105 subunit | [231] | 0.67[232] | 0.03[233] | 0.06[234] | -0.23[235] | 0.96[236] | 0.73[237] |
35 | GSTP1 | Glutathione S-transferase P | [238] | -3.96[239] | -3.40[240] | 4.53[241] | 5.73[242] | 3.76[243] | 0.22[244] |
36 | EGFR | Epidermal growth factor receptor | [245] | -0.70[246] | -1.39[247] | 1.74[248] | 0.46[249] | 1.34[250] | 2.93[251] |
37 | TP53 | Cellular tumor antigen p53 | [252] | 1.64[253] | 0.88[254] | 1.89[255] | 1.31[256] | 1.25[257] | 0.24[258] |
38 | PIK3R2 | Phosphatidylinositol 3-kinase regulatory subunit beta | [259] | 1.88[260] | 1.78[261] | 2.63[262] | 0.73[263] | 1.56[264] | -0.01[265] |
39 | PDGFC | Platelet-derived growth factor C | [266] | -1.27[267] | -0.65[268] | -0.47[269] | 0.92[270] | 1.43[271] | 0.48[272] |
40 | AR | Androgen receptor | [273] | -10.45[274] | -10.09[275] | -11.69[276] | -1.72[277] | -4.49[278] | 3.93[279] |
41 | MAPK3 | Mitogen-activated protein kinase 3 | [280] | 1.85[281] | 1.58[282] | 1.86[283] | 0.44[284] | 0.74[285] | -0.76[286] |
42 | GSK3B | Glycogen synthase kinase-3 beta | [287] | 1.27[288] | 0.59[289] | 1.40[290] | 1.84[291] | 1.94[292] | 1.44[293] |
43 | CHUK | Inhibitor of nuclear factor kappa-B kinase subunit alpha | [294] | 0.90[295] | 1.81[296] | 2.01[297] | 0.67[298] | 1.76[299] | 1.79[300] |
44 | CREB3L2 | Cyclic AMP-responsive element-binding protein 3-like protein 2 | [301] | 2.40[302] | 2.44[303] | 2.73[304] | 1.93[305] | 1.83[306] | 1.98[307] |
45 | PDPK1 | 3-phosphoinositide-dependent protein kinase 1 | [308] | 2.33[309] | 3.21[310] | 2.16[311] | 1.46[312] | 2.12[313] | 2.78[314] |
46 | IKBKB | Inhibitor of nuclear factor kappa-B kinase subunit beta | [315] | 0.52[316] | 0.26[317] | 0.61[318] | 0.28[319] | 0.64[320] | 1.46[321] |
47 | CCNE1 | G1/S-specific cyclin-E1 | [322] | 1.24[323] | 1.03[324] | -0.54[325] | -0.38[326] | 0.49[327] | -4.35[328] |
48 | MTOR | Serine/threonine-protein kinase mTOR | [329] | 2.54[330] | 3.23[331] | 3.04[332] | 2.70[333] | 3.06[334] | 3.73[335] |
49 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 1.21[336] | 1.40[337] | 1.81[338] | 1.07[339] | 1.50[340] | 1.43[341] | |
50 | RB1 | Retinoblastoma-associated protein | [342] | 1.22[343] | 1.40[344] | 2.21[345] | 2.30[346] | 2.89[347] | 1.75[348] |
51 | CASP9 | Caspase-9 | [349] | 0.16[350] | 0.80[351] | 0.16[352] | 0.27[353] | -0.15[354] | -0.26[355] |
52 | SOS2 | Son of sevenless homolog 2 | [356] | -0.02[357] | 0.78[358] | 0.26[359] | 1.71[360] | 1.85[361] | 2.12[362] |
53 | CREB3L4 | Cyclic AMP-responsive element-binding protein 3-like protein 4 | [363] | -0.58[364] | 0.06[365] | 1.52[366] | 0.40[367] | -0.16[368] | -0.40[369] |
54 | E2F1 | Transcription factor E2F1 | [370] | 1.95[371] | 1.49[372] | 1.86[373] | 1.89[374] | 2.60[375] | -3.34[376] |
55 | EP300 | Histone acetyltransferase p300 | [377] | 2.73[378] | 2.00[379] | 3.14[380] | 2.59[381] | 2.92[382] | 3.03[383] |
56 | TCF7L2 | Transcription factor 7-like 2 | [384] | 0.87[385] | 1.32[386] | 1.76[387] | 0.72[388] | 0.97[389] | 2.00[390] |
57 | E2F3 | Transcription factor E2F3 | [391] | 1.72[392] | 1.23[393] | 0.73[394] | 2.65[395] | 2.37[396] | 0.11[397] |
58 | TGFA | Protransforming growth factor alpha | [398] | 1.79[399] | 2.54[400] | -8.27[401] | -0.94[402] | -1.89[403] | -0.12[404] |
59 | NKX3-1 | Homeobox protein Nkx-3.1 | [405] | -0.29[406] | -1.57[407] | -3.97[408] | -2.31[409] | 0.55[410] | 0.04[411] |
60 | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | -0.38[412] | 0.94[413] | 1.37[414] | 1.15[415] | 1.63[416] | 2.19[417] | |
61 | PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | 1.89[418] | 2.66[419] | -0.91[420] | 0.30[421] | 1.34[422] | 0.58[423] | |
62 | CREB1 | Cyclic AMP-responsive element-binding protein 1 | [424] | 1.72[425] | 2.56[426] | 3.30[427] | 2.56[428] | 2.78[429] | 2.62[430] |
63 | TCF7L1 | Transcription factor 7-like 1 | [431] | -3.05[432] | -1.56[433] | 0.88[434] | -1.80[435] | -1.40[436] | 0.57[437] |
64 | CREBBP | CREB-binding protein | [438] | 2.90[439] | 1.80[440] | 2.65[441] | 2.78[442] | 3.06[443] | 3.51[444] |
65 | FOXO1 | Forkhead box protein O1 | [445] | 1.69[446] | 1.04[447] | 1.42[448] | 1.20[449] | 3.49[450] | 3.37[451] |
66 | TCF7 | Transcription factor 7 | [452] | 2.44[453] | 0.78[454] | 0.08[455] | 0.18[456] | 0.15[457] | -0.09[458] |
67 | PDGFA | Platelet-derived growth factor subunit A | [459] | -1.00[460] | -1.11[461] | 1.22[462] | -0.32[463] | -0.96[464] | -0.47[465] |
68 | FGFR2 | Fibroblast growth factor receptor 2 | [466] | -2.51[467] | -1.62[468] | 2.57[469] | 1.48[470] | -3.09[471] | 3.70[472] |
69 | BRAF | Serine/threonine-protein kinase B-raf | [473] | 0.25[474] | -0.34[475] | 1.94[476] | 0.76[477] | 0.73[478] | 2.13[479] |
70 | CCNE2 | G1/S-specific cyclin-E2 | [480] | 0.42[481] | 0.50[482] | 0.28[483] | 3.06[484] | 3.23[485] | -0.08[486] |
71 | FGFR1 | Fibroblast growth factor receptor 1 | [487] | 4.58[488] | 2.58[489] | 4.47[490] | 5.08[491] | 4.62[492] | 1.94[493] |
72 | IGF1R | Insulin-like growth factor 1 receptor | [494] | 4.74[495] | 3.74[496] | 2.65[497] | 4.49[498] | 4.31[499] | 2.37[500] |
73 | PDGFB | Platelet-derived growth factor subunit B | [501] | 3.06[502] | 2.60[503] | 0.03[504] | 0.09[505] | -0.07[506] | 0.65[507] |
74 | PDGFRA | Platelet-derived growth factor receptor alpha | [508] | -3.62[509] | -4.92[510] | 2.96[511] | 0.55[512] | 5.49[513] | 5.60[514] |
75 | PDGFRB | Platelet-derived growth factor receptor beta | [515] | 1.30[516] | 1.38[517] | -0.83[518] | 1.88[519] | 2.71[520] | 3.69[521] |
76 | PIK3R3 | Phosphatidylinositol 3-kinase regulatory subunit gamma | [522] | 1.72[523] | 1.41[524] | 2.51[525] | 3.19[526] | 2.48[527] | 2.95[528] |
77 | AKT3 | RAC-gamma serine/threonine-protein kinase | [529] | -1.84[530] | -4.72[531] | -3.78[532] | 5.86[533] | 5.09[534] | 3.89[535] |
78 | PIK3R5 | Phosphoinositide 3-kinase regulatory subunit 5 | [536] | -7.17[537] | [538] | -2.60[539] | -3.90[540] | -3.29[541] | 2.62[542] |
79 | CREB5 | Cyclic AMP-responsive element-binding protein 5 | [543] | 0.93[544] | -2.88[545] | 1.04[546] | 1.48[547] | 2.30[548] | 0.77[549] |
80 | E2F2 | Transcription factor E2F2 | [550] | 4.25[551] | 4.82[552] | 4.58[553] | 4.07[554] | 4.67[555] | 1.70[556] |
81 | CREB3L1 | Cyclic AMP-responsive element-binding protein 3-like protein 1 | [557] | 0.00[558] | -3.25[559] | 6.67[560] | 5.33[561] | 5.89[562] | 0.04[563] |
82 | BCL2 | Apoptosis regulator Bcl-2 | [564] | -2.85[565] | 2.23[566] | -4.93[567] | 1.79[568] | 1.78[569] | 3.51[570] |
83 | PIK3CG | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | [571] | [572] | [573] | 1.36[574] | -3.25[575] | 4.38[576] | |
84 | LEF1 | Lymphoid enhancer-binding factor 1 | [577] | 2.65[578] | -4.59[579] | 3.57[580] | 1.10[581] | -0.33[582] | 1.36[583] |
85 | PDGFD | Platelet-derived growth factor D | [584] | 2.37[585] | -2.75[586] | -4.70[587] | 2.85[588] | 4.68[589] | 6.35[590] |
86 | EGF | Pro-epidermal growth factor | [591] | 1.97[592] | 3.44[593] | 7.30[594] | 9.05[595] | 6.74[596] | 1.86[597] |
87 | INS | Insulin | [598] | [599] | [600] | [601] | [602] | [603] | [604] |
88 | KLK3 | Prostate-specific antigen | [605] | [606] | [607] | [608] | [609] | [610] | [611] |
89 | INSRR | Insulin receptor-related protein | [612] | [613] | [614] | [615] | [616] | [617] | [618] |