KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 SCP2 Non-specific lipid-transfer protein [1] -0.86[2] -0.52[3] 0.54[4] 0.44[5] 0.21[6] -0.26[7]
2 CYP27A1 Sterol 26-hydroxylase, mitochondrial [8] 0.90[9] 0.89[10] -1.39[11] -0.68[12] -2.32[13] -0.51[14]
3 AKR1C4 Aldo-keto reductase family 1 member C4 [15] -6.08[16] -4.52[17] -4.30[18] -6.80[19] -12.36[20] -1.48[21]
4 HSD17B4 Peroxisomal multifunctional enzyme type 2 [22] 1.55[23] 1.11[24] 1.66[25] 1.88[26] 2.47[27] 0.17[28]
5 SLC27A5 Bile acyl-CoA synthetase [29] -2.46[30] -2.01[31] -2.80[32] -3.61[33] -6.19[34] 0.03[35]
6 BAAT Bile acid-CoA:amino acid N-acyltransferase [36] -2.53[37] -2.71[38] -4.26[39] -4.38[40] -5.77[41] 1.15[42]
7 CYP8B1 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase [43] -5.24[44] -3.49[45] -6.61[46] -6.10[47] -8.02[48] 1.85[49]
8 HSD3B7 3 beta-hydroxysteroid dehydrogenase type 7 [50] 1.75[51] 1.81[52] -0.51[53] 0.41[54] -0.07[55] -0.26[56]
9 AKR1D1 3-oxo-5-beta-steroid 4-dehydrogenase [57] -0.10[58] 0.47[59] -1.42[60] -6.24[61] -6.54[62] -0.87[63]
10 ACOX2 Peroxisomal acyl-coenzyme A oxidase 2 [64] 0.57[65] 1.09[66] 1.64[67] -4.00[68] -1.76[69] 0.52[70]
11 AMACR Alpha-methylacyl-CoA racemase [71] -0.88[72] -1.66[73] 0.60[74] -0.71[75] -1.21[76] -2.43[77]
12 CYP39A1 24-hydroxycholesterol 7-alpha-hydroxylase [78] -2.08[79] -3.06[80] 2.39[81] -1.06[82] 0.81[83] -0.13[84]
13 CYP7A1 Cholesterol 7-alpha-monooxygenase [85] -1.36[86] -4.49[87] -7.22[88] -6.10[89] [90] -3.56[91]
14 CYP7B1 25-hydroxycholesterol 7-alpha-hydroxylase [92] -5.05[93] -4.56[94] [95] -5.16[96] -1.51[97] 1.67[98]
15 CYP46A1 Cholesterol 24-hydroxylase [99] -0.80[100] -0.26[101] -0.48[102] 1.31[103] 2.43[104] 1.65[105]
16 CH25H Cholesterol 25-hydroxylase [106] -0.15[107] [108] 0.21[109] 12.09[110] 5.50[111] 2.50[112]
[1]
ref_hepatocyte SCP2
Mean 227
Standard deviation 2.8e+02
Values 1.4e+02 77 2e+02 9.1 7.1e+02
[2]
HepG2 SCP2
Mean 35
Standard deviation 12
Values 27 43
[3]
HepG2.C3A SCP2
Mean 68.2
Standard deviation 19
Values 55 82
[4]
HuH.7 SCP2
Mean 78.3
Standard deviation 13
Values 83 63 89
[5]
SNU475 SCP2
Mean 38.6
Standard deviation 10
Values 46 32
[6]
THLE SCP2
Mean 38.9
Standard deviation 1.4
Values 40 38
[7]
liver SCP2
Mean 407
Standard deviation 2e+02
Values 2.1e+02 6.5e+02 4.9e+02 2.8e+02
[8]
ref_hepatocyte CYP27A1
Mean 135
Standard deviation 1.6e+02
Values 62 8 2.1e+02 18 3.7e+02
[9]
HepG2 CYP27A1
Mean 70.5
Standard deviation 16
Values 59 82
[10]
HepG2.C3A CYP27A1
Mean 108
Standard deviation 25
Values 1.3e+02 90
[11]
HuH.7 CYP27A1
Mean 12.2
Standard deviation 7.3
Values 7.2 21 8.9
[12]
SNU475 CYP27A1
Mean 10.5
Standard deviation 1.6
Values 12 9.4
[13]
THLE CYP27A1
Mean 4.01
Standard deviation 0.91
Values 4.7 3.4
[14]
liver CYP27A1
Mean 204
Standard deviation 1e+02
Values 1.2e+02 3.3e+02 2.5e+02 1.1e+02
[15]
ref_hepatocyte AKR1C4
Mean 105
Standard deviation 1.4e+02
Values 0 3.6 2.3e+02 1.7 2.8e+02
[16]
HepG2 AKR1C4
Mean 0.432
Standard deviation 0.36
Values 0.69 0.18
[17]
HepG2.C3A AKR1C4
Mean 1.97
Standard deviation 0.48
Values 1.6 2.3
[18]
HuH.7 AKR1C4
Mean 1.26
Standard deviation 0.56
Values 0.75 1.9 1.2
[19]
SNU475 AKR1C4
Mean 0.118
Standard deviation 0.055
Values 0.079 0.16
[20]
THLE AKR1C4
Mean 0.00296
Standard deviation 0.0042
Values 0.0059 0
[21]
liver AKR1C4
Mean 80.8
Standard deviation 62
Values 66 56 1.7e+02 30
[22]
ref_hepatocyte HSD17B4
Mean 85.8
Standard deviation 51
Values 1.2e+02 57 1.1e+02 11 1.3e+02
[23]
HepG2 HSD17B4
Mean 70.1
Standard deviation 24
Values 53 87
[24]
HepG2.C3A HSD17B4
Mean 80.1
Standard deviation 0.22
Values 80 80
[25]
HuH.7 HSD17B4
Mean 64.3
Standard deviation 5.5
Values 68 58 67
[26]
SNU475 HSD17B4
Mean 39.5
Standard deviation 6.9
Values 44 35
[27]
THLE HSD17B4
Mean 70.3
Standard deviation 2.4
Values 69 72
[28]
liver HSD17B4
Mean 208
Standard deviation 20
Values 2.2e+02 1.9e+02 2.3e+02 1.9e+02
[29]
ref_hepatocyte SLC27A5
Mean 83.6
Standard deviation 1.2e+02
Values 0.8 1.2 1.4e+02 6 2.7e+02
[30]
HepG2 SLC27A5
Mean 4.25
Standard deviation 0.62
Values 4.7 3.8
[31]
HepG2.C3A SLC27A5
Mean 8.96
Standard deviation 1.1
Values 9.7 8.2
[32]
HuH.7 SLC27A5
Mean 2.84
Standard deviation 0.59
Values 2.3 2.7 3.5
[33]
SNU475 SLC27A5
Mean 0.856
Standard deviation 0.043
Values 0.83 0.89
[34]
THLE SLC27A5
Mean 0.169
Standard deviation 0.036
Values 0.2 0.14
[35]
liver SLC27A5
Mean 184
Standard deviation 60
Values 1.1e+02 2.2e+02 2.5e+02 1.6e+02
[36]
ref_hepatocyte BAAT
Mean 50.1
Standard deviation 39
Values 1.6 59 89 17 84
[37]
HepG2 BAAT
Mean 2.42
Standard deviation 0.81
Values 1.9 3
[38]
HepG2.C3A BAAT
Mean 3.29
Standard deviation 0.29
Values 3.5 3.1
[39]
HuH.7 BAAT
Mean 0.621
Standard deviation 0.84
Values 0.098 1.6 0.18
[40]
SNU475 BAAT
Mean 0.302
Standard deviation 0.27
Values 0.49 0.11
[41]
THLE BAAT
Mean 0.136
Standard deviation 0.042
Values 0.17 0.11
[42]
liver BAAT
Mean 239
Standard deviation 1.3e+02
Values 1.7e+02 4.1e+02 2.7e+02 1.1e+02
[43]
ref_hepatocyte CYP8B1
Mean 34.6
Standard deviation 44
Values 1.2 0.33 79 6.4 86
[44]
HepG2 CYP8B1
Mean 0.257
Standard deviation 0.2
Values 0.11 0.4
[45]
HepG2.C3A CYP8B1
Mean 1.33
Standard deviation 0.5
Values 1.7 0.98
[46]
HuH.7 CYP8B1
Mean 0.084
Standard deviation 0.016
Values 0.09 0.096 0.066
[47]
SNU475 CYP8B1
Mean 0.0631
Standard deviation 0.004
Values 0.06 0.066
[48]
THLE CYP8B1
Mean 0.0198
Standard deviation 0.0054
Values 0.024 0.016
[49]
liver CYP8B1
Mean 269
Standard deviation 1.3e+02
Values 1.3e+02 4.2e+02 3e+02 2.2e+02
[50]
ref_hepatocyte HSD3B7
Mean 30.9
Standard deviation 9.6
Values 18 42 31 26 38
[51]
HepG2 HSD3B7
Mean 29.1
Standard deviation 6.4
Values 25 34
[52]
HepG2.C3A HSD3B7
Mean 46.7
Standard deviation 4.6
Values 43 50
[53]
HuH.7 HSD3B7
Mean 5.15
Standard deviation 1.4
Values 4.5 6.7 4.2
[54]
SNU475 HSD3B7
Mean 5.15
Standard deviation 1.7
Values 6.4 3.9
[55]
THLE HSD3B7
Mean 4.37
Standard deviation 0.17
Values 4.2 4.5
[56]
liver HSD3B7
Mean 55.4
Standard deviation 32
Values 26 95 66 35
[57]
ref_hepatocyte AKR1D1
Mean 25.3
Standard deviation 42
Values 4.5 0.35 23 0.37 99
[58]
HepG2 AKR1D1
Mean 6.61
Standard deviation 3
Values 4.5 8.7
[59]
HepG2.C3A AKR1D1
Mean 15.2
Standard deviation 0.35
Values 15 15
[60]
HuH.7 AKR1D1
Mean 2.24
Standard deviation 3.1
Values 0.38 5.8 0.5
[61]
SNU475 AKR1D1
Mean 0.042
Standard deviation 0.027
Values 0.023 0.061
[62]
THLE AKR1D1
Mean 0.0402
Standard deviation 0.027
Values 0.059 0.021
[63]
liver AKR1D1
Mean 29.7
Standard deviation 5.8
Values 35 23 26 34
[64]
ref_hepatocyte ACOX2
Mean 19.6
Standard deviation 24
Values 4.4 1.3 39 1.6 52
[65]
HepG2 ACOX2
Mean 8.11
Standard deviation 2.8
Values 6.1 10
[66]
HepG2.C3A ACOX2
Mean 18
Standard deviation 1.3
Values 17 19
[67]
HuH.7 ACOX2
Mean 14.5
Standard deviation 1.3
Values 13 15 15
[68]
SNU475 ACOX2
Mean 0.154
Standard deviation 0.11
Values 0.074 0.23
[69]
THLE ACOX2
Mean 0.86
Standard deviation 0.15
Values 0.96 0.76
[70]
liver ACOX2
Mean 60.6
Standard deviation 24
Values 37 91 69 45
[71]
ref_hepatocyte AMACR
Mean 11.6
Standard deviation 11
Values 5.6 4.7 17 2.4 28
[72]
HepG2 AMACR
Mean 1.76
Standard deviation 1
Values 1 2.5
[73]
HepG2.C3A AMACR
Mean 1.58
Standard deviation 0.45
Values 1.3 1.9
[74]
HuH.7 AMACR
Mean 4.17
Standard deviation 1.7
Values 3.7 6.1 2.7
[75]
SNU475 AMACR
Mean 0.891
Standard deviation 0.32
Values 1.1 0.66
[76]
THLE AMACR
Mean 0.744
Standard deviation 0.26
Values 0.56 0.93
[77]
liver AMACR
Mean 4.64
Standard deviation 1.1
Values 3.1 5.7 5.1 4.7
[78]
ref_hepatocyte CYP39A1
Mean 7.02
Standard deviation 11
Values 0.052 1.3 8.1 0.69 25
[79]
HepG2 CYP39A1
Mean 0.464
Standard deviation 0.049
Values 0.5 0.43
[80]
HepG2.C3A CYP39A1
Mean 0.363
Standard deviation 0.032
Values 0.34 0.39
[81]
HuH.7 CYP39A1
Mean 8.71
Standard deviation 0.36
Values 8.7 9.1 8.4
[82]
SNU475 CYP39A1
Mean 0.422
Standard deviation 0.11
Values 0.35 0.5
[83]
THLE CYP39A1
Mean 1.83
Standard deviation 0.14
Values 1.9 1.7
[84]
liver CYP39A1
Mean 13.9
Standard deviation 9.4
Values 8.3 28 13 7.1
[85]
ref_hepatocyte CYP7A1
Mean 4.03
Standard deviation 5.2
Values 9.8 0 0.69 0 9.7
[86]
HepG2 CYP7A1
Mean 0.438
Standard deviation 0.47
Values 0.11 0.77
[87]
HepG2.C3A CYP7A1
Mean 0.0774
Standard deviation 0.027
Values 0.058 0.097
[88]
HuH.7 CYP7A1
Mean 0.00642
Standard deviation 0.011
Values 0 0.019 0
[89]
SNU475 CYP7A1
Mean 0.00739
Standard deviation 0.0039
Values 0.0046 0.01
[90]
THLE CYP7A1
Mean 0
Standard deviation 0
Values 0 0
[91]
liver CYP7A1
Mean 0.737
Standard deviation 0.45
Values 0.94 1.1 0.82 0.079
[92]
ref_hepatocyte CYP7B1
Mean 1.44
Standard deviation 1
Values 0 2.2 1.2 1.1 2.7
[93]
HepG2 CYP7B1
Mean 0.0122
Standard deviation 0.001
Values 0.011 0.013
[94]
HepG2.C3A CYP7B1
Mean 0.0263
Standard deviation 0.023
Values 0.0097 0.043
[95]
HuH.7 CYP7B1
Mean 0
Standard deviation 0
Values 0 0 0
[96]
SNU475 CYP7B1
Mean 0.00507
Standard deviation 0.0072
Values 0 0.01
[97]
THLE CYP7B1
Mean 0.0751
Standard deviation 0.014
Values 0.065 0.085
[98]
liver CYP7B1
Mean 9.87
Standard deviation 5.4
Values 17 6.3 4.8 12
[99]
ref_hepatocyte CYP46A1
Mean 0.0447
Standard deviation 0.068
Values 0 0 0.069 0 0.15
[100]
HepG2 CYP46A1
Mean 0.00716
Standard deviation 0.002
Values 0.0057 0.0086
[101]
HepG2.C3A CYP46A1
Mean 0.0161
Standard deviation 0.023
Values 0 0.032
[102]
HuH.7 CYP46A1
Mean 0.00761
Standard deviation 0.0083
Values 0.016 0.0064 0
[103]
SNU475 CYP46A1
Mean 0.0139
Standard deviation 0.02
Values 0.028 0
[104]
THLE CYP46A1
Mean 0.0358
Standard deviation 0.017
Values 0.024 0.048
[105]
liver CYP46A1
Mean 0.303
Standard deviation 0.093
Values 0.17 0.38 0.36 0.3
[106]
ref_hepatocyte CH25H
Mean 0.0114
Standard deviation 0.025
Values 0 0 0 0 0.057
[107]
HepG2 CH25H
Mean 0.00287
Standard deviation 0.0041
Values 0.0057 0
[108]
HepG2.C3A CH25H
Mean 0
Standard deviation 0
Values 0 0
[109]
HuH.7 CH25H
Mean 0.00312
Standard deviation 0.0054
Values 0 0 0.0094
[110]
SNU475 CH25H
Mean 6.24
Standard deviation 0.89
Values 5.6 6.9
[111]
THLE CH25H
Mean 0.0766
Standard deviation 0.05
Values 0.041 0.11
[112]
liver CH25H
Mean 0.138
Standard deviation 0.14
Values 0.014 0.28 0.23 0.026