KEGG_PPAR_SIGNALING_PATHWAY |
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Order |
Gene |
Description |
ref_hepatocyte |
HepG2 |
HepG2.C3A |
HuH.7 |
SNU475 |
THLE |
liver |
1 |
APOA2 |
Apolipoprotein A-II |
[1] |
-0.33[2] |
-0.42[3] |
-1.04[4] |
-8.10[5] |
-7.83[6] |
-1.01[7] |
2 |
APOA1 |
Apolipoprotein A-I |
[8] |
-0.32[9] |
-0.17[10] |
-2.40[11] |
-8.61[12] |
-8.73[13] |
-0.04[14] |
3 |
APOC3 |
Apolipoprotein C-III |
[15] |
-4.18[16] |
-2.64[17] |
-3.84[18] |
-11.23[19] |
-11.81[20] |
-0.53[21] |
4 |
FABP1 |
Fatty acid-binding protein, liver |
[22] |
-5.72[23] |
-0.70[24] |
-0.11[25] |
-7.95[26] |
-7.85[27] |
-1.13[28] |
5 |
DBI |
Acyl-CoA-binding protein |
[29] |
-1.16[30] |
-0.38[31] |
-0.53[32] |
-0.05[33] |
-0.27[34] |
-2.29[35] |
6 |
UBC |
Polyubiquitin-C |
[36] |
2.17[37] |
1.14[38] |
1.30[39] |
3.52[40] |
3.55[41] |
-0.31[42] |
7 |
SCP2 |
Non-specific lipid-transfer protein |
[43] |
0.08[44] |
0.08[45] |
0.74[46] |
2.02[47] |
1.91[48] |
1.45[49] |
8 |
HMGCS2 |
Hydroxymethylglutaryl-CoA synthase, mitochondrial |
[50] |
-9.51[51] |
-8.30[52] |
-0.98[53] |
-5.14[54] |
-9.51[55] |
1.94[56] |
9 |
SCD |
Acyl-CoA desaturase |
[57] |
3.30[58] |
3.99[59] |
5.16[60] |
2.47[61] |
1.59[62] |
1.61[63] |
10 |
ACSL1 |
Long-chain-fatty-acid--CoA ligase 1 |
[64] |
1.89[65] |
-1.71[66] |
-0.68[67] |
0.50[68] |
3.70[69] |
3.37[70] |
11 |
PCK1 |
Phosphoenolpyruvate carboxykinase, cytosolic [GTP] |
[71] |
-5.13[72] |
-2.01[73] |
-9.29[74] |
[75] |
-11.26[76] |
2.17[77] |
12 |
CYP27A1 |
Sterol 26-hydroxylase, mitochondrial |
[78] |
1.84[79] |
1.49[80] |
-1.20[81] |
0.89[82] |
-0.62[83] |
1.20[84] |
13 |
PCK2 |
Phosphoenolpyruvate carboxykinase [GTP], mitochondrial |
[85] |
3.35[86] |
0.81[87] |
1.89[88] |
0.06[89] |
2.13[90] |
0.83[91] |
14 |
ACAA1 |
3-ketoacyl-CoA thiolase, peroxisomal |
[92] |
1.46[93] |
1.82[94] |
0.35[95] |
1.11[96] |
1.45[97] |
1.25[98] |
15 |
CYP4A11 |
Cytochrome P450 4A11 |
[99] |
-10.74[100] |
-9.25[101] |
-10.72[102] |
-6.88[103] |
-7.86[104] |
1.99[105] |
16 |
SLC27A5 |
Bile acyl-CoA synthetase |
[106] |
-1.52[107] |
-1.41[108] |
-2.61[109] |
-2.04[110] |
-4.50[111] |
1.74[112] |
17 |
SLC27A2 |
Very long-chain acyl-CoA synthetase |
[113] |
0.39[114] |
-0.59[115] |
-0.45[116] |
1.38[117] |
-2.50[118] |
2.27[119] |
18 |
APOA5 |
Apolipoprotein A-V |
[120] |
1.28[121] |
1.84[122] |
0.10[123] |
-6.81[124] |
-5.49[125] |
3.29[126] |
19 |
ACADM |
Medium-chain specific acyl-CoA dehydrogenase, mitochondrial |
[127] |
1.95[128] |
2.24[129] |
1.92[130] |
4.07[131] |
3.19[132] |
1.94[133] |
20 |
ILK |
Integrin-linked protein kinase |
[134] |
3.12[135] |
1.92[136] |
2.25[137] |
5.00[138] |
4.15[139] |
-0.34[140] |
21 |
CYP8B1 |
7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase |
[141] |
-4.30[142] |
-2.89[143] |
-6.42[144] |
-4.53[145] |
-6.32[146] |
3.56[147] |
22 |
EHHADH |
Peroxisomal bifunctional enzyme |
[148] |
1.04[149] |
0.68[150] |
1.67[151] |
2.22[152] |
1.56[153] |
2.75[154] |
23 |
ACSL5 |
Long-chain-fatty-acid--CoA ligase 5 |
[155] |
4.17[156] |
2.94[157] |
-0.09[158] |
2.05[159] |
-0.46[160] |
2.21[161] |
24 |
ANGPTL4 |
Angiopoietin-related protein 4 |
[162] |
2.21[163] |
0.10[164] |
0.96[165] |
2.49[166] |
6.50[167] |
1.59[168] |
25 |
FADS2 |
Fatty acid desaturase 2 |
[169] |
2.41[170] |
2.73[171] |
5.38[172] |
5.78[173] |
3.33[174] |
0.71[175] |
26 |
ACOX2 |
Peroxisomal acyl-coenzyme A oxidase 2 |
[176] |
1.51[177] |
1.69[178] |
1.84[179] |
-2.42[180] |
-0.06[181] |
2.23[182] |
27 |
ACSL3 |
Long-chain-fatty-acid--CoA ligase 3 |
[183] |
4.02[184] |
5.03[185] |
4.61[186] |
5.66[187] |
5.20[188] |
1.83[189] |
28 |
NR1H3 |
Oxysterols receptor LXR-alpha |
[190] |
2.25[191] |
2.14[192] |
3.47[193] |
2.71[194] |
1.41[195] |
0.80[196] |
29 |
RXRA |
Retinoic acid receptor RXR-alpha |
[197] |
3.87[198] |
2.53[199] |
3.77[200] |
5.46[201] |
5.17[202] |
3.26[203] |
30 |
FABP5 |
Fatty acid-binding protein, epidermal |
[204] |
4.16[205] |
2.45[206] |
3.64[207] |
3.28[208] |
3.78[209] |
-3.30[210] |
31 |
CPT2 |
Carnitine O-palmitoyltransferase 2, mitochondrial |
[211] |
2.41[212] |
2.14[213] |
3.13[214] |
4.00[215] |
4.30[216] |
3.00[217] |
32 |
ACOX1 |
Peroxisomal acyl-coenzyme A oxidase 1 |
[218] |
4.85[219] |
4.14[220] |
4.04[221] |
5.02[222] |
4.71[223] |
4.19[224] |
33 |
CPT1A |
Carnitine O-palmitoyltransferase 1, liver isoform |
[225] |
5.38[226] |
2.68[227] |
3.85[228] |
7.68[229] |
6.42[230] |
4.04[231] |
34 |
MMP1 |
Interstitial collagenase |
[232] |
-1.24[233] |
-6.15[234] |
[235] |
3.70[236] |
3.29[237] |
-11.02[238] |
35 |
PPARD |
Peroxisome proliferator-activated receptor delta |
[239] |
3.56[240] |
1.87[241] |
2.01[242] |
5.53[243] |
5.98[244] |
-0.51[245] |
36 |
GK |
Glycerol kinase |
[246] |
4.35[247] |
5.34[248] |
4.58[249] |
1.94[250] |
4.15[251] |
3.11[252] |
37 |
ACSL4 |
Long-chain-fatty-acid--CoA ligase 4 |
[253] |
6.64[254] |
7.23[255] |
7.93[256] |
7.00[257] |
7.87[258] |
2.07[259] |
38 |
SLC27A4 |
Long-chain fatty acid transport protein 4 |
[260] |
3.90[261] |
2.92[262] |
1.97[263] |
4.67[264] |
5.47[265] |
1.55[266] |
39 |
ACOX3 |
Peroxisomal acyl-coenzyme A oxidase 3 |
[267] |
3.81[268] |
2.27[269] |
2.80[270] |
4.60[271] |
4.05[272] |
1.41[273] |
40 |
AQP7 |
Aquaporin-7 |
[274] |
-0.37[275] |
-0.40[276] |
-0.64[277] |
-3.23[278] |
-5.57[279] |
0.19[280] |
41 |
SORBS1 |
Sorbin and SH3 domain-containing protein 1 |
[281] |
2.91[282] |
4.65[283] |
5.75[284] |
1.70[285] |
2.17[286] |
4.06[287] |
42 |
RXRB |
Retinoic acid receptor RXR-beta |
[288] |
4.94[289] |
4.12[290] |
3.45[291] |
7.03[292] |
5.95[293] |
1.22[294] |
43 |
ACADL |
Long-chain specific acyl-CoA dehydrogenase, mitochondrial |
[295] |
-6.13[296] |
-7.90[297] |
-6.76[298] |
-4.63[299] |
-0.80[300] |
1.88[301] |
44 |
ME1 |
NADP-dependent malic enzyme |
[302] |
-2.42[303] |
-2.93[304] |
5.61[305] |
8.34[306] |
6.87[307] |
1.63[308] |
45 |
CYP7A1 |
Cholesterol 7-alpha-monooxygenase |
[309] |
-0.42[310] |
-3.89[311] |
-7.02[312] |
-4.52[313] |
[314] |
-1.85[315] |
46 |
PPARA |
Peroxisome proliferator-activated receptor alpha |
[316] |
4.59[317] |
4.44[318] |
5.69[319] |
5.48[320] |
4.69[321] |
5.26[322] |
47 |
PLTP |
Phospholipid transfer protein |
[323] |
5.43[324] |
4.13[325] |
5.92[326] |
2.03[327] |
6.85[328] |
2.73[329] |
48 |
PPARG |
Peroxisome proliferator-activated receptor gamma |
[330] |
3.83[331] |
4.31[332] |
5.22[333] |
6.29[334] |
6.30[335] |
0.73[336] |
49 |
PDPK1 |
3-phosphoinositide-dependent protein kinase 1 |
[337] |
6.25[338] |
6.31[339] |
5.42[340] |
6.88[341] |
7.32[342] |
3.61[343] |
50 |
CYP4A22 |
Cytochrome P450 4A22 |
[344] |
[345] |
[346] |
[347] |
[348] |
[349] |
3.38[350] |
51 |
PLIN1 |
Perilipin-1 |
[351] |
0.06[352] |
-0.69[353] |
-1.23[354] |
1.21[355] |
0.56[356] |
3.12[357] |
52 |
CD36 |
Platelet glycoprotein 4 |
[358] |
5.26[359] |
3.44[360] |
-1.24[361] |
8.63[362] |
-0.33[363] |
4.20[364] |
53 |
SLC27A1 |
Long-chain fatty acid transport protein 1 |
[365] |
4.66[366] |
4.27[367] |
4.06[368] |
6.00[369] |
5.64[370] |
2.18[371] |
54 |
CPT1B |
Carnitine O-palmitoyltransferase 1, muscle isoform |
[372] |
0.20[373] |
0.79[374] |
1.61[375] |
1.08[376] |
1.50[377] |
-0.98[378] |
55 |
SCD5 |
Stearoyl-CoA desaturase 5 |
[379] |
0.30[380] |
0.56[381] |
4.10[382] |
6.58[383] |
8.16[384] |
0.51[385] |
56 |
FABP3 |
Fatty acid-binding protein, heart |
[386] |
1.54[387] |
1.25[388] |
0.69[389] |
3.76[390] |
3.57[391] |
0.84[392] |
57 |
ACSL6 |
Long-chain-fatty-acid--CoA ligase 6 |
[393] |
3.86[394] |
5.09[395] |
2.88[396] |
4.18[397] |
3.66[398] |
4.13[399] |
58 |
LPL |
Lipoprotein lipase |
[400] |
[401] |
[402] |
-4.22[403] |
6.02[404] |
2.42[405] |
0.87[406] |
59 |
FABP2 |
Fatty acid-binding protein, intestinal |
[407] |
2.49[408] |
5.08[409] |
0.03[410] |
[411] |
0.55[412] |
-0.43[413] |
60 |
CPT1C |
Carnitine O-palmitoyltransferase 1, brain isoform |
[414] |
3.65[415] |
1.46[416] |
1.99[417] |
6.99[418] |
11.55[419] |
2.71[420] |
61 |
ADIPOQ |
Adiponectin |
[421] |
2.41[422] |
1.47[423] |
1.64[424] |
4.58[425] |
3.62[426] |
0.36[427] |
62 |
OLR1 |
Oxidized low-density lipoprotein receptor 1 |
[428] |
1.59[429] |
[430] |
3.40[431] |
12.22[432] |
8.90[433] |
0.04[434] |
63 |
FABP4 |
Fatty acid-binding protein, adipocyte |
[435] |
[436] |
[437] |
[438] |
[439] |
0.46[440] |
4.27[441] |
64 |
RXRG |
Retinoic acid receptor RXR-gamma |
[442] |
0.19[443] |
[444] |
[445] |
3.39[446] |
[447] |
3.62[448] |
65 |
SLC27A6 |
Long-chain fatty acid transport protein 6 |
[449] |
[450] |
[451] |
[452] |
3.75[453] |
6.77[454] |
-0.83[455] |
66 |
GK2 |
Glycerol kinase 2 |
[456] |
[457] |
[458] |
[459] |
[460] |
[461] |
[462] |
67 |
UCP1 |
Mitochondrial brown fat uncoupling protein 1 |
[463] |
[464] |
[465] |
[466] |
[467] |
[468] |
[469] |
68 |
FABP6 |
Gastrotropin |
[470] |
[471] |
[472] |
[473] |
[474] |
[475] |
[476] |
69 |
FABP7 |
Fatty acid-binding protein, brain |
[477] |
[478] |
[479] |
[480] |
[481] |
[482] |
[483] |
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