KEGG_P53_SIGNALING_PATHWAY | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | SERPINE1 | Plasminogen activator inhibitor 1 | [1] | 0.53[2] | 0.87[3] | -5.20[4] | -3.58[5] | 1.91[6] | -3.84[7] |
2 | GADD45B | Growth arrest and DNA damage-inducible protein GADD45 beta | [8] | -4.78[9] | -5.42[10] | -3.54[11] | -3.80[12] | -3.99[13] | -2.13[14] |
3 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | [15] | -3.07[16] | -4.04[17] | -3.18[18] | -3.77[19] | -3.21[20] | -2.97[21] |
4 | EI24 | Etoposide-induced protein 2.4 homolog | [22] | -0.64[23] | -1.57[24] | -1.92[25] | -0.60[26] | -1.95[27] | 0.65[28] |
5 | SFN | 14-3-3 protein sigma | [29] | -2.96[30] | -3.21[31] | -2.15[32] | -7.61[33] | -9.72[34] | -10.05[35] |
6 | GADD45G | Growth arrest and DNA damage-inducible protein GADD45 gamma | [36] | -10.52[37] | [38] | -8.21[39] | -7.61[40] | -8.73[41] | -1.68[42] |
7 | CDKN1A | Cyclin-dependent kinase inhibitor 1 | [43] | 0.24[44] | -1.04[45] | -3.06[46] | -1.77[47] | -0.39[48] | -1.79[49] |
8 | PERP | p53 apoptosis effector related to PMP-22 | [50] | -0.04[51] | 0.07[52] | 0.16[53] | -0.21[54] | -1.33[55] | 0.25[56] |
9 | SHISA5 | Protein shisa-5 | [57] | -0.36[58] | -0.98[59] | 0.92[60] | 0.17[61] | -1.43[62] | 0.15[63] |
10 | STEAP3 | Metalloreductase STEAP3 | [64] | -2.07[65] | -2.68[66] | -4.20[67] | -1.17[68] | -3.25[69] | 1.75[70] |
11 | BAX | Apoptosis regulator BAX | [71] | -0.27[72] | -0.95[73] | -0.75[74] | -1.38[75] | -2.18[76] | -3.91[77] |
12 | CCND1 | G1/S-specific cyclin-D1 | [78] | 2.45[79] | 0.06[80] | 1.56[81] | 2.10[82] | -0.56[83] | 1.10[84] |
13 | CDK4 | Cyclin-dependent kinase 4 | [85] | 0.73[86] | 1.43[87] | 1.72[88] | 0.40[89] | -0.13[90] | -0.79[91] |
14 | CCNG1 | Cyclin-G1 | [92] | 0.20[93] | 1.58[94] | 2.31[95] | -0.03[96] | -0.83[97] | 0.55[98] |
15 | IGF1 | Insulin-like growth factor I | [99] | -9.02[100] | -9.85[101] | -7.39[102] | -1.32[103] | -10.33[104] | 0.96[105] |
16 | TNFRSF10 | Tumor necrosis factor receptor superfamily member 10B | [106] | 1.39[107] | 1.37[108] | 1.84[109] | -0.11[110] | 0.32[111] | 0.08[112] |
17 | CYCS | Cytochrome c | [113] | 0.73[114] | 1.04[115] | 1.78[116] | 1.55[117] | 0.78[118] | 1.36[119] |
18 | CASP3 | Caspase-3 | [120] | -0.47[121] | 0.32[122] | -1.56[123] | -0.68[124] | -0.86[125] | -0.76[126] |
19 | BID | BH3-interacting domain death agonist | [127] | -0.87[128] | -0.65[129] | -0.37[130] | -0.07[131] | -1.78[132] | 0.22[133] |
20 | CDK2 | Cyclin-dependent kinase 2 | [134] | -1.02[135] | -0.74[136] | 0.31[137] | 0.20[138] | -0.39[139] | -2.14[140] |
21 | RRM2 | Ribonucleoside-diphosphate reductase subunit M2 | [141] | 0.98[142] | 1.23[143] | 1.38[144] | 2.33[145] | 1.19[146] | -0.80[147] |
22 | FAS | Tumor necrosis factor receptor superfamily member 6 | [148] | -2.20[149] | -1.31[150] | -8.65[151] | -1.52[152] | -2.18[153] | -1.68[154] |
23 | THBS1 | Thrombospondin-1 | [155] | 1.90[156] | -2.82[157] | -2.15[158] | 3.06[159] | 1.57[160] | 1.16[161] |
24 | TP53I3 | Quinone oxidoreductase PIG3 | [162] | -0.20[163] | -0.80[164] | -1.99[165] | 0.55[166] | -1.73[167] | -1.73[168] |
25 | CASP8 | Caspase-8 | [169] | -0.58[170] | 0.10[171] | -0.06[172] | 0.14[173] | -1.78[174] | -1.38[175] |
26 | CD82 | CD82 antigen | [176] | -6.65[177] | -7.25[178] | -4.56[179] | -2.55[180] | -1.35[181] | 0.75[182] |
27 | CCNB1 | G2/mitotic-specific cyclin-B1 | [183] | 1.24[184] | 1.59[185] | 2.44[186] | 1.83[187] | 1.63[188] | -2.30[189] |
28 | SESN2 | Sestrin-2 | [190] | 0.19[191] | -0.34[192] | 0.93[193] | -0.80[194] | -1.19[195] | 0.29[196] |
29 | SIAH1 | E3 ubiquitin-protein ligase SIAH1 | [197] | -2.41[198] | -1.83[199] | -1.15[200] | -1.88[201] | -2.99[202] | -0.96[203] |
30 | PTEN | Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protei | -1.14[204] | 0.37[205] | 1.23[206] | -0.34[207] | -0.27[208] | 2.52[209] | |
31 | DDB2 | DNA damage-binding protein 2 | [210] | 0.48[211] | 0.11[212] | -0.53[213] | -1.39[214] | -1.98[215] | -1.48[216] |
32 | MDM2 | E3 ubiquitin-protein ligase Mdm2 | [217] | 1.51[218] | 3.04[219] | 0.94[220] | 0.73[221] | 0.43[222] | 2.21[223] |
33 | CDK1 | Cyclin-dependent kinase 1 | [224] | 0.65[225] | 2.83[226] | 2.23[227] | 2.49[228] | 2.13[229] | -2.43[230] |
34 | CHEK2 | Serine/threonine-protein kinase Chk2 | [231] | -0.50[232] | 0.05[233] | 1.12[234] | -0.03[235] | -1.58[236] | -3.24[237] |
35 | TP53 | Cellular tumor antigen p53 | [238] | 1.03[239] | 0.71[240] | 2.14[241] | 1.51[242] | 0.00[243] | 0.00[244] |
36 | RRM2B | Ribonucleoside-diphosphate reductase subunit M2 B | [245] | 0.63[246] | 0.92[247] | 0.41[248] | 1.23[249] | -0.15[250] | 0.49[251] |
37 | BBC3 | Bcl-2-binding component 3 | [252] | 0.14[253] | 0.14[254] | 0.30[255] | -2.58[256] | -3.00[257] | -4.29[258] |
38 | CDK6 | Cyclin-dependent kinase 6 | [259] | 1.44[260] | 2.26[261] | 1.33[262] | 1.14[263] | 0.76[264] | 2.11[265] |
39 | IGFBP3 | Insulin-like growth factor-binding protein 3 | [266] | 2.44[267] | -2.33[268] | -2.20[269] | 0.67[270] | -1.49[271] | 4.27[272] |
40 | CCND3 | G1/S-specific cyclin-D3 | [273] | 0.35[274] | -0.60[275] | -1.56[276] | 3.88[277] | 1.88[278] | 0.70[279] |
41 | CCNE1 | G1/S-specific cyclin-E1 | [280] | 0.63[281] | 0.86[282] | -0.29[283] | -0.18[284] | -0.76[285] | -4.59[286] |
42 | TSC2 | Tuberin | [287] | 1.21[288] | 0.85[289] | 2.21[290] | 1.42[291] | 0.77[292] | 2.12[293] |
43 | SESN1 | Sestrin-1 | [294] | 0.68[295] | 1.13[296] | -0.72[297] | -0.66[298] | -0.62[299] | 0.74[300] |
44 | PPM1D | Protein phosphatase 1D | [301] | 0.65[302] | 1.00[303] | 0.88[304] | -0.27[305] | -0.38[306] | 0.15[307] |
45 | CASP9 | Caspase-9 | [308] | -0.45[309] | 0.63[310] | 0.41[311] | 0.47[312] | -1.40[313] | -0.49[314] |
46 | RCHY1 | RING finger and CHY zinc finger domain-containing protein 1 | [315] | 0.09[316] | 0.76[317] | 0.83[318] | 0.46[319] | 0.01[320] | 1.69[321] |
47 | CHEK1 | Serine/threonine-protein kinase Chk1 | [322] | 0.93[323] | 1.41[324] | 1.64[325] | 2.37[326] | 1.42[327] | -1.99[328] |
48 | PMAIP1 | Phorbol-12-myristate-13-acetate-induced protein 1 | [329] | -0.55[330] | -3.80[331] | 0.41[332] | 2.50[333] | 0.55[334] | -4.25[335] |
49 | CCNB2 | G2/mitotic-specific cyclin-B2 | [336] | 1.49[337] | 2.36[338] | 3.41[339] | 2.74[340] | 2.55[341] | -1.56[342] |
50 | ZMAT3 | Zinc finger matrin-type protein 3 | [343] | 2.17[344] | 2.19[345] | 0.73[346] | 1.83[347] | 1.68[348] | 2.29[349] |
51 | CCNG2 | Cyclin-G2 | [350] | 0.28[351] | 1.06[352] | 2.65[353] | 0.54[354] | 0.84[355] | 0.16[356] |
52 | ATR | Serine/threonine-protein kinase ATR | [357] | 0.49[358] | 1.60[359] | 2.35[360] | 2.75[361] | 1.53[362] | 3.59[363] |
53 | APAF1 | Apoptotic protease-activating factor 1 | [364] | 1.06[365] | 1.60[366] | 2.51[367] | 2.85[368] | 0.77[369] | 1.53[370] |
54 | ATM | Serine-protein kinase ATM | [371] | 2.43[372] | 4.15[373] | 4.54[374] | 4.38[375] | 2.68[376] | 5.03[377] |
55 | MDM4 | Protein Mdm4 | [378] | 1.04[379] | 2.16[380] | 3.26[381] | 2.51[382] | 1.22[383] | 4.60[384] |
56 | CCNE2 | G1/S-specific cyclin-E2 | [385] | -0.18[386] | 0.33[387] | 0.53[388] | 3.26[389] | 1.98[390] | -0.31[391] |
57 | GTSE1 | G2 and S phase-expressed protein 1 | [392] | 2.25[393] | 2.61[394] | 3.33[395] | 2.99[396] | 2.83[397] | -0.98[398] |
58 | CCND2 | G1/S-specific cyclin-D2 | [399] | 2.54[400] | 1.24[401] | -4.30[402] | -4.23[403] | -2.50[404] | 1.90[405] |
59 | SESN3 | Sestrin-3 | [406] | 0.82[407] | -2.61[408] | 5.20[409] | 2.70[410] | 1.40[411] | 3.39[412] |
60 | CDKN2A | Cyclin-dependent kinase inhibitor 2A | [413] | 3.48[414] | 1.36[415] | 5.43[416] | 5.43[417] | 6.03[418] | -2.11[419] |
61 | TP73 | Tumor protein p73 | [420] | 0.12[421] | 2.79[422] | 2.38[423] | 0.90[424] | 0.85[425] | 0.69[426] |
62 | CCNB3 | G2/mitotic-specific cyclin-B3 | [427] | -2.27[428] | -2.89[429] | -2.49[430] | -1.68[431] | -0.01[432] | 1.88[433] |
63 | RPRM | Protein reprimo | [434] | -5.79[435] | [436] | -4.78[437] | 5.35[438] | -4.65[439] | [440] |
64 | TP53AIP1 | p53-regulated apoptosis-inducing protein 1 | [441] | -0.68[442] | -0.44[443] | -0.51[444] | -0.31[445] | -1.83[446] | 0.38[447] |
65 | COP1 | [448] | [449] | [450] | [451] | [452] | [453] | [454] | |
66 | ADGRB1 | Adhesion G protein-coupled receptor B1 | [455] | [456] | [457] | [458] | [459] | [460] | [461] |
67 | SERPINB5 | Serpin B5 | [462] | [463] | [464] | [465] | [466] | [467] | [468] |
68 | PIDD1 | p53-induced death domain-containing protein 1 | [469] | [470] | [471] | [472] | [473] | [474] | [475] |