KEGG_ONE_CARBON_POOL_BY_FOLATE Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 SHMT1 Serine hydroxymethyltransferase, cytosolic [1] -2.51[2] -3.03[3] -2.19[4] -1.33[5] -2.21[6] 0.87[7]
2 FTCD Formimidoyltransferase-cyclodeaminase [8] -2.04[9] -1.20[10] -7.43[11] -8.33[12] -11.14[13] -0.82[14]
3 SHMT2 Serine hydroxymethyltransferase, mitochondrial [15] 0.36[16] 1.00[17] 0.89[18] -0.15[19] 0.52[20] -0.43[21]
4 ALDH1L1 Cytosolic 10-formyltetrahydrofolate dehydrogenase [22] -3.64[23] -12.69[24] -13.30[25] -6.53[26] -6.95[27] 0.68[28]
5 MTHFD1 C-1-tetrahydrofolate synthase, cytoplasmic [29] 0.14[30] -0.86[31] -0.60[32] 0.61[33] 0.68[34] 0.66[35]
6 MTHFS 5-formyltetrahydrofolate cyclo-ligase [36] -4.08[37] -3.79[38] -4.10[39] -4.16[40] -4.14[41] -2.82[42]
7 ATIC Bifunctional purine biosynthesis protein PURH [43] 1.62[44] 1.03[45] 1.35[46] 1.14[47] 0.86[48] -1.57[49]
8 TYMS Thymidylate synthase [50] -0.79[51] -0.82[52] -0.62[53] 0.21[54] -0.34[55] -6.23[56]
9 GART Trifunctional purine biosynthetic protein adenosine-3 [57] 1.29[58] 0.63[59] 0.41[60] 1.68[61] 1.39[62] -0.81[63]
10 AMT Aminomethyltransferase, mitochondrial [64] -0.03[65] -0.03[66] 1.27[67] -4.16[68] -3.84[69] -0.69[70]
11 DHFR Dihydrofolate reductase [71] 2.02[72] 2.29[73] 2.99[74] 2.76[75] 3.02[76] -0.18[77]
12 MTHFD1L Monofunctional C1-tetrahydrofolate synthase, mitochondrial [78] 2.45[79] 1.64[80] 1.72[81] 2.19[82] 1.51[83] -2.18[84]
13 MTHFD2 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial 3.38[85] 3.76[86] 2.80[87] 1.25[88] 3.37[89] -2.65[90]
14 MTFMT Methionyl-tRNA formyltransferase, mitochondrial [91] 0.48[92] 0.08[93] 0.52[94] 1.05[95] 0.96[96] 0.27[97]
15 MTR Methionine synthase [98] 2.75[99] 2.99[100] 3.50[101] 4.66[102] 3.39[103] 3.05[104]
16 MTHFD2L Probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2 -0.96[105] 0.57[106] -0.84[107] 0.64[108] 0.60[109] 1.86[110]
17 MTHFR Methylenetetrahydrofolate reductase [111] 1.81[112] 2.73[113] 3.34[114] 4.21[115] 2.38[116] 3.50[117]
[1]
ref_hepatocyte SHMT1
Mean 76.7
Standard deviation 82
Values 15 16 1.7e+02 18 1.6e+02
[2]
HepG2 SHMT1
Mean 21.2
Standard deviation 4.7
Values 18 25
[3]
HepG2.C3A SHMT1
Mean 18
Standard deviation 5.4
Values 14 22
[4]
HuH.7 SHMT1
Mean 24
Standard deviation 7.5
Values 25 16 31
[5]
SNU475 SHMT1
Mean 19.7
Standard deviation 0.95
Values 20 19
[6]
THLE SHMT1
Mean 18.2
Standard deviation 3.2
Values 16 21
[7]
liver SHMT1
Mean 246
Standard deviation 1.2e+02
Values 1.6e+02 3.3e+02 3.7e+02 1.3e+02
[8]
ref_hepatocyte FTCD
Mean 68.2
Standard deviation 89
Values 16 4.8 1e+02 7.2 2.1e+02
[9]
HepG2 FTCD
Mean 26.2
Standard deviation 1.2
Values 27 25
[10]
HepG2.C3A FTCD
Mean 57.1
Standard deviation 32
Values 80 34
[11]
HuH.7 FTCD
Mean 0.564
Standard deviation 0.18
Values 0.36 0.69 0.64
[12]
SNU475 FTCD
Mean 0.136
Standard deviation 0.057
Values 0.18 0.096
[13]
THLE FTCD
Mean 0.0331
Standard deviation 0.013
Values 0.024 0.043
[14]
liver FTCD
Mean 67.7
Standard deviation 27
Values 43 1.1e+02 64 58
[15]
ref_hepatocyte SHMT2
Mean 66.5
Standard deviation 44
Values 27 32 1.4e+02 61 78
[16]
HepG2 SHMT2
Mean 135
Standard deviation 40
Values 1.6e+02 1.1e+02
[17]
HepG2.C3A SHMT2
Mean 256
Standard deviation 1e+02
Values 3.3e+02 1.8e+02
[18]
HuH.7 SHMT2
Mean 175
Standard deviation 6.4
Values 1.7e+02 1.8e+02 1.8e+02
[19]
SNU475 SHMT2
Mean 38.7
Standard deviation 3
Values 37 41
[20]
THLE SHMT2
Mean 105
Standard deviation 2.1
Values 1.1e+02 1e+02
[21]
liver SHMT2
Mean 86.4
Standard deviation 29
Values 67 1e+02 1.2e+02 59
[22]
ref_hepatocyte ALDH1L1
Mean 53.8
Standard deviation 57
Values 22 12 1.1e+02 4.3 1.3e+02
[23]
HepG2 ALDH1L1
Mean 6.81
Standard deviation 2.3
Values 8.4 5.2
[24]
HepG2.C3A ALDH1L1
Mean 0.0156
Standard deviation 0.0083
Values 0.0097 0.021
[25]
HuH.7 ALDH1L1
Mean 0.00761
Standard deviation 0.0083
Values 0.016 0.0064 0
[26]
SNU475 ALDH1L1
Mean 0.375
Standard deviation 0.16
Values 0.26 0.49
[27]
THLE ALDH1L1
Mean 0.478
Standard deviation 0.039
Values 0.45 0.51
[28]
liver ALDH1L1
Mean 151
Standard deviation 64
Values 1.5e+02 1.2e+02 2.4e+02 90
[29]
ref_hepatocyte MTHFD1
Mean 38.3
Standard deviation 33
Values 17 24 54 7.6 88
[30]
HepG2 MTHFD1
Mean 66.6
Standard deviation 5.5
Values 63 70
[31]
HepG2.C3A MTHFD1
Mean 40.6
Standard deviation 9.4
Values 34 47
[32]
HuH.7 MTHFD1
Mean 36.1
Standard deviation 17
Values 50 17 42
[33]
SNU475 MTHFD1
Mean 37.7
Standard deviation 1.4
Values 39 37
[34]
THLE MTHFD1
Mean 67.1
Standard deviation 15
Values 56 78
[35]
liver MTHFD1
Mean 106
Standard deviation 16
Values 99 90 1.3e+02 1.1e+02
[36]
ref_hepatocyte MTHFS
Mean 33.8
Standard deviation 36
Values 4.8 6.2 75 12 71
[37]
HepG2 MTHFS
Mean 3.16
Standard deviation 0.23
Values 3 3.3
[38]
HepG2.C3A MTHFS
Mean 4.68
Standard deviation 1.1
Values 3.9 5.5
[39]
HuH.7 MTHFS
Mean 2.82
Standard deviation 0.4
Values 2.4 3.2 2.8
[40]
SNU475 MTHFS
Mean 1.22
Standard deviation 0.081
Values 1.3 1.2
[41]
THLE MTHFS
Mean 2.1
Standard deviation 0.12
Values 2 2.2
[42]
liver MTHFS
Mean 8.42
Standard deviation 9.4
Values 0.66 19 13 0.46
[43]
ref_hepatocyte ATIC
Mean 24.9
Standard deviation 8.1
Values 32 32 19 28 14
[44]
HepG2 ATIC
Mean 121
Standard deviation 12
Values 1.3e+02 1.1e+02
[45]
HepG2.C3A ATIC
Mean 97.3
Standard deviation 10
Values 1e+02 90
[46]
HuH.7 ATIC
Mean 90.3
Standard deviation 22
Values 1e+02 65 1.1e+02
[47]
SNU475 ATIC
Mean 35.2
Standard deviation 3.4
Values 33 38
[48]
THLE ATIC
Mean 49.5
Standard deviation 10
Values 42 57
[49]
liver ATIC
Mean 14.7
Standard deviation 12
Values 5.3 21 29 4.1
[50]
ref_hepatocyte TYMS
Mean 24.8
Standard deviation 32
Values 69 49 3.3 2.5 0.91
[51]
HepG2 TYMS
Mean 22.7
Standard deviation 7.9
Values 17 28
[52]
HepG2.C3A TYMS
Mean 26.9
Standard deviation 18
Values 14 40
[53]
HuH.7 TYMS
Mean 23
Standard deviation 12
Values 28 9.1 32
[54]
SNU475 TYMS
Mean 18.5
Standard deviation 1.2
Values 18 19
[55]
THLE TYMS
Mean 21.5
Standard deviation 4.9
Values 18 25
[56]
liver TYMS
Mean 0.58
Standard deviation 0.68
Values 0.4 0.35 1.6 0
[57]
ref_hepatocyte GART
Mean 21.4
Standard deviation 16
Values 17 43 8 33 7.1
[58]
HepG2 GART
Mean 83.2
Standard deviation 13
Values 92 74
[59]
HepG2.C3A GART
Mean 63.6
Standard deviation 1.3
Values 63 65
[60]
HuH.7 GART
Mean 40.7
Standard deviation 14
Values 48 25 50
[61]
SNU475 GART
Mean 44.2
Standard deviation 5.5
Values 40 48
[62]
THLE GART
Mean 61.8
Standard deviation 11
Values 54 69
[63]
liver GART
Mean 21.4
Standard deviation 7.5
Values 26 12 29 20
[64]
ref_hepatocyte AMT
Mean 14.4
Standard deviation 9.4
Values 18 5.5 15 5.5 28
[65]
HepG2 AMT
Mean 22.4
Standard deviation 2
Values 21 24
[66]
HepG2.C3A AMT
Mean 27.1
Standard deviation 1.4
Values 26 28
[67]
HuH.7 AMT
Mean 49.9
Standard deviation 15
Values 52 34 64
[68]
SNU475 AMT
Mean 0.521
Standard deviation 0.31
Values 0.74 0.3
[69]
THLE AMT
Mean 1.11
Standard deviation 0.68
Values 1.6 0.63
[70]
liver AMT
Mean 15.7
Standard deviation 10
Values 8.5 20 28 6.2
[71]
ref_hepatocyte DHFR
Mean 6.89
Standard deviation 3.8
Values 10 7.9 6.3 0.65 9.3
[72]
HepG2 DHFR
Mean 44.3
Standard deviation 17
Values 32 56
[73]
HepG2.C3A DHFR
Mean 64.7
Standard deviation 42
Values 35 95
[74]
HuH.7 DHFR
Mean 78.4
Standard deviation 42
Values 1.1e+02 31 96
[75]
SNU475 DHFR
Mean 30.2
Standard deviation 0.92
Values 31 30
[76]
THLE DHFR
Mean 61.5
Standard deviation 17
Values 50 73
[77]
liver DHFR
Mean 10.7
Standard deviation 3.8
Values 9.2 15 6.4 12
[78]
ref_hepatocyte MTHFD1L
Mean 5.11
Standard deviation 3.9
Values 4.8 6.5 3.2 11 0.36
[79]
HepG2 MTHFD1L
Mean 44.3
Standard deviation 12
Values 53 36
[80]
HepG2.C3A MTHFD1L
Mean 30.6
Standard deviation 12
Values 39 22
[81]
HuH.7 MTHFD1L
Mean 23.9
Standard deviation 6.6
Values 30 17 26
[82]
SNU475 MTHFD1L
Mean 15
Standard deviation 1.1
Values 14 16
[83]
THLE MTHFD1L
Mean 16
Standard deviation 2
Values 15 17
[84]
liver MTHFD1L
Mean 1.99
Standard deviation 0.21
Values 2 2.2 1.7 2.1
[85]
ref_hepatocyte MTHFD2
Mean 4.93
Standard deviation 5.2
Values 14 1.1 3.3 5.2 1.3
[86]
HepG2 MTHFD2
Mean 81.4
Standard deviation 25
Values 99 64
[87]
HepG2.C3A MTHFD2
Mean 129
Standard deviation 63
Values 1.7e+02 84
[88]
HuH.7 MTHFD2
Mean 49.2
Standard deviation 11
Values 55 37 55
[89]
SNU475 MTHFD2
Mean 7.54
Standard deviation 0.064
Values 7.6 7.5
[90]
THLE MTHFD2
Mean 56.2
Standard deviation 0.51
Values 56 57
[91]
liver MTHFD2
Mean 1.38
Standard deviation 0.47
Values 1.2 2.1 1 1.2
[92]
ref_hepatocyte MTFMT
Mean 2.98
Standard deviation 0.67
Values 3.8 3.5 2.8 2.5 2.2
[93]
HepG2 MTFMT
Mean 6.6
Standard deviation 0.43
Values 6.9 6.3
[94]
HepG2.C3A MTFMT
Mean 6.04
Standard deviation 0.61
Values 5.6 6.5
[95]
HuH.7 MTFMT
Mean 6.11
Standard deviation 1.8
Values 6.3 4.2 7.8
[96]
SNU475 MTFMT
Mean 3.99
Standard deviation 0.62
Values 4.4 3.6
[97]
THLE MTFMT
Mean 6.38
Standard deviation 0.37
Values 6.1 6.6
[98]
liver MTFMT
Mean 6.33
Standard deviation 1.3
Values 6.2 6.7 7.8 4.6
[99]
ref_hepatocyte MTR
Mean 1.43
Standard deviation 1
Values 2.9 2.1 0.53 1.2 0.48
[100]
HepG2 MTR
Mean 15.2
Standard deviation 4.2
Values 12 18
[101]
HepG2.C3A MTR
Mean 21.8
Standard deviation 0.68
Values 22 21
[102]
HuH.7 MTR
Mean 23.2
Standard deviation 4.8
Values 29 21 20
[103]
SNU475 MTR
Mean 23.4
Standard deviation 7.7
Values 29 18
[104]
THLE MTR
Mean 16.5
Standard deviation 1
Values 17 16
[105]
liver MTR
Mean 20.9
Standard deviation 9.9
Values 34 12 14 24
[106]
ref_hepatocyte MTHFD2L
Mean 0.936
Standard deviation 0.65
Values 0.6 0.5 0.55 0.99 2
[107]
HepG2 MTHFD2L
Mean 0.759
Standard deviation 0.11
Values 0.68 0.84
[108]
HepG2.C3A MTHFD2L
Mean 2.66
Standard deviation 0.36
Values 2.4 2.9
[109]
HuH.7 MTHFD2L
Mean 0.745
Standard deviation 0.26
Values 0.55 1 0.65
[110]
SNU475 MTHFD2L
Mean 0.939
Standard deviation 0.43
Values 0.64 1.2
[111]
THLE MTHFD2L
Mean 1.55
Standard deviation 0.053
Values 1.6 1.5
[112]
liver MTHFD2L
Mean 5.97
Standard deviation 3.1
Values 10 6.3 2.6 5
[113]
ref_hepatocyte MTHFR
Mean 0.857
Standard deviation 0.14
Values 0.9 0.92 0.95 0.91 0.6
[114]
HepG2 MTHFR
Mean 4.76
Standard deviation 0.36
Values 4.5 5
[115]
HepG2.C3A MTHFR
Mean 10.9
Standard deviation 2
Values 12 9.5
[116]
HuH.7 MTHFR
Mean 12.4
Standard deviation 3.7
Values 11 17 9.7
[117]
SNU475 MTHFR
Mean 10.2
Standard deviation 3.7
Values 13 7.6
[118]
THLE MTHFR
Mean 4.9
Standard deviation 0.19
Values 5 4.8
[119]
liver MTHFR
Mean 17.1
Standard deviation 4.4
Values 21 17 11 19