KEGG_NON_SMALL_CELL_LUNG_CANCER | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | AKT1 | RAC-alpha serine/threonine-protein kinase | [1] | -1.01[2] | -1.05[3] | -2.27[4] | -0.87[5] | -0.78[6] | -0.98[7] |
2 | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1 | [8] | -2.02[9] | -2.16[10] | -1.72[11] | -1.36[12] | -0.78[13] | -1.93[14] |
3 | MAP2K2 | Dual specificity mitogen-activated protein kinase kinase 2 | [15] | -1.03[16] | -1.17[17] | -0.44[18] | -1.66[19] | -1.11[20] | -2.44[21] |
4 | CCND1 | G1/S-specific cyclin-D1 | [22] | 1.96[23] | -0.36[24] | 0.34[25] | 1.06[26] | -0.35[27] | 0.31[28] |
5 | GRB2 | Growth factor receptor-bound protein 2 | [29] | 0.11[30] | 0.13[31] | 0.12[32] | -0.27[33] | -0.28[34] | -0.44[35] |
6 | CDK4 | Cyclin-dependent kinase 4 | [36] | 0.24[37] | 1.01[38] | 0.51[39] | -0.64[40] | 0.08[41] | -1.58[42] |
7 | BAD | Bcl2-associated agonist of cell death | [43] | -2.76[44] | -2.44[45] | -3.53[46] | -1.89[47] | -1.41[48] | -2.16[49] |
8 | RAF1 | RAF proto-oncogene serine/threonine-protein kinase | [50] | -1.15[51] | -0.56[52] | 0.57[53] | -1.01[54] | -0.07[55] | 0.36[56] |
9 | RXRA | Retinoic acid receptor RXR-alpha | [57] | -1.14[58] | -1.16[59] | -0.45[60] | -0.81[61] | -1.07[62] | 1.41[63] |
10 | NRAS | GTPase NRas | [64] | -0.46[65] | 0.16[66] | 0.43[67] | 0.18[68] | -0.18[69] | -0.99[70] |
11 | ARAF | Serine/threonine-protein kinase A-Raf | [71] | -1.54[72] | -1.66[73] | -1.53[74] | -0.92[75] | -0.81[76] | 0.14[77] |
12 | HRAS | GTPase HRas | [78] | -2.10[79] | -2.62[80] | -3.54[81] | -1.77[82] | -1.91[83] | -3.40[84] |
13 | RASSF1 | Ras association domain-containing protein 1 | [85] | -2.14[86] | -1.81[87] | -2.33[88] | -2.31[89] | -0.82[90] | -2.64[91] |
14 | MAPK1 | Mitogen-activated protein kinase 1 | [92] | 0.62[93] | 0.94[94] | 0.64[95] | 1.03[96] | 0.75[97] | 1.04[98] |
15 | AKT2 | RAC-beta serine/threonine-protein kinase | [99] | -0.13[100] | 0.33[101] | 0.33[102] | 0.04[103] | -0.10[104] | 0.39[105] |
16 | KRAS | GTPase KRas | [106] | -1.60[107] | -1.44[108] | 0.03[109] | -0.02[110] | -0.29[111] | -0.06[112] |
17 | PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha | [113] | -1.56[114] | -1.26[115] | -0.30[116] | 1.25[117] | 0.82[118] | 2.26[119] |
18 | SOS1 | Son of sevenless homolog 1 | [120] | -1.19[121] | 0.53[122] | -0.10[123] | 0.02[124] | -0.67[125] | -0.20[126] |
19 | ERBB2 | Receptor tyrosine-protein kinase erbB-2 | [127] | 1.28[128] | 0.29[129] | 1.32[130] | 0.43[131] | 0.11[132] | -0.59[133] |
20 | EGFR | Epidermal growth factor receptor | [134] | -1.78[135] | -1.97[136] | 0.77[137] | -0.39[138] | 0.30[139] | 1.91[140] |
21 | TP53 | Cellular tumor antigen p53 | [141] | 0.55[142] | 0.30[143] | 0.92[144] | 0.47[145] | 0.21[146] | -0.78[147] |
22 | PIK3R2 | Phosphatidylinositol 3-kinase regulatory subunit beta | [148] | 0.79[149] | 1.19[150] | 1.67[151] | -0.11[152] | 0.52[153] | -1.03[154] |
23 | RXRB | Retinoic acid receptor RXR-beta | [155] | -0.07[156] | 0.44[157] | -0.77[158] | 0.76[159] | -0.29[160] | -0.63[161] |
24 | MAPK3 | Mitogen-activated protein kinase 3 | [162] | 0.76[163] | 0.99[164] | 0.90[165] | -0.40[166] | -0.31[167] | -1.78[168] |
25 | CDK6 | Cyclin-dependent kinase 6 | [169] | 0.96[170] | 1.84[171] | 0.11[172] | 0.09[173] | 0.97[174] | 1.33[175] |
26 | PDPK1 | 3-phosphoinositide-dependent protein kinase 1 | [176] | 1.24[177] | 2.62[178] | 1.19[179] | 0.62[180] | 1.08[181] | 1.76[182] |
27 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 2.40[183] | 2.21[184] | 1.40[185] | 2.00[186] | 1.57[187] | -0.40[188] | |
28 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 0.12[189] | 0.82[190] | 0.84[191] | 0.23[192] | 0.46[193] | 0.42[194] | |
29 | RB1 | Retinoblastoma-associated protein | [195] | 0.13[196] | 0.82[197] | 1.24[198] | 1.45[199] | 1.85[200] | 0.74[201] |
30 | FOXO3 | Forkhead box protein O3 | [202] | -0.63[203] | -0.36[204] | 0.14[205] | -0.42[206] | 0.89[207] | 1.59[208] |
31 | CASP9 | Caspase-9 | [209] | -0.93[210] | 0.21[211] | -0.80[212] | -0.58[213] | -1.19[214] | -1.28[215] |
32 | SOS2 | Son of sevenless homolog 2 | [216] | -1.11[217] | 0.20[218] | -0.71[219] | 0.87[220] | 0.80[221] | 1.10[222] |
33 | STK4 | Serine/threonine-protein kinase 4 | [223] | 1.91[224] | 1.98[225] | 1.78[226] | 1.70[227] | 1.83[228] | 1.18[229] |
34 | E2F1 | Transcription factor E2F1 | [230] | 0.86[231] | 0.90[232] | 0.89[233] | 1.04[234] | 1.56[235] | -4.36[236] |
35 | PRKCA | Protein kinase C alpha type | [237] | 1.75[238] | 1.98[239] | 2.20[240] | 1.33[241] | 1.76[242] | 1.18[243] |
36 | E2F3 | Transcription factor E2F3 | [244] | 0.63[245] | 0.64[246] | -0.24[247] | 1.81[248] | 1.33[249] | -0.91[250] |
37 | TGFA | Protransforming growth factor alpha | [251] | 0.70[252] | 1.95[253] | -9.23[254] | -1.78[255] | -2.94[256] | -1.13[257] |
38 | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | -1.47[258] | 0.36[259] | 0.41[260] | 0.31[261] | 0.58[262] | 1.17[263] | |
39 | PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | 0.80[264] | 2.07[265] | -1.88[266] | -0.54[267] | 0.30[268] | -0.44[269] | |
40 | RASSF5 | Ras association domain-containing protein 5 | [270] | -0.37[271] | -4.84[272] | -0.35[273] | 0.53[274] | -0.28[275] | 0.54[276] |
41 | FHIT | Bis(5'-adenosyl)-triphosphatase | [277] | -2.19[278] | -1.84[279] | -2.82[280] | -7.39[281] | -3.17[282] | -0.72[283] |
42 | BRAF | Serine/threonine-protein kinase B-raf | [284] | -0.84[285] | -0.93[286] | 0.97[287] | -0.08[288] | -0.31[289] | 1.11[290] |
43 | PLCG2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 | -2.37[291] | -7.93[292] | -0.62[293] | -3.56[294] | -2.33[295] | 1.98[296] | |
44 | PIK3R3 | Phosphatidylinositol 3-kinase regulatory subunit gamma | [297] | 0.63[298] | 0.83[299] | 1.54[300] | 2.35[301] | 1.44[302] | 1.94[303] |
45 | AKT3 | RAC-gamma serine/threonine-protein kinase | [304] | -2.93[305] | -5.30[306] | -4.75[307] | 5.02[308] | 4.05[309] | 2.87[310] |
46 | PIK3R5 | Phosphoinositide 3-kinase regulatory subunit 5 | [311] | -8.26[312] | [313] | -3.57[314] | -4.74[315] | -4.33[316] | 1.60[317] |
47 | CDKN2A | Cyclin-dependent kinase inhibitor 2A | [318] | 3.00[319] | 0.95[320] | 4.22[321] | 4.39[322] | 6.24[323] | -2.89[324] |
48 | PRKCB | Protein kinase C beta type | [325] | -7.90[326] | -6.52[327] | [328] | 1.66[329] | -3.57[330] | 2.80[331] |
49 | E2F2 | Transcription factor E2F2 | [332] | 3.16[333] | 4.24[334] | 3.61[335] | 3.23[336] | 3.63[337] | 0.68[338] |
50 | RARB | Retinoic acid receptor beta | [339] | 0.35[340] | -2.68[341] | 3.02[342] | 5.00[343] | 3.64[344] | 4.03[345] |
51 | PIK3CG | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | [346] | [347] | [348] | 0.52[349] | -4.29[350] | 3.36[351] | |
52 | PRKCG | Protein kinase C gamma type | [352] | -1.91[353] | -1.05[354] | -3.57[355] | -1.88[356] | -1.90[357] | [358] |
53 | RXRG | Retinoic acid receptor RXR-gamma | [359] | -4.82[360] | [361] | [362] | -2.88[363] | [364] | 1.77[365] |
54 | EGF | Pro-epidermal growth factor | [366] | 0.88[367] | 2.85[368] | 6.33[369] | 8.20[370] | 5.70[371] | 0.84[372] |