KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 NNMT Nicotinamide N-methyltransferase [1] -11.06[2] -12.86[3] -5.32[4] -3.11[5] -1.77[6] -1.05[7]
2 AOX1 Aldehyde oxidase [8] -1.41[9] -2.06[10] -8.20[11] -2.65[12] -2.30[13] 1.52[14]
3 NAMPT Nicotinamide phosphoribosyltransferase [15] -0.45[16] -0.33[17] 0.50[18] 1.77[19] 2.85[20] 0.25[21]
4 QPRT Nicotinate-nucleotide pyrophosphorylase [carboxylating] [22] 2.72[23] 2.32[24] 2.34[25] 1.31[26] -1.69[27] -1.19[28]
5 PNP Purine nucleoside phosphorylase [29] 1.61[30] 0.39[31] 1.29[32] 0.81[33] 0.90[34] -2.67[35]
6 NADK NAD kinase [36] 2.20[37] 2.17[38] 1.27[39] 2.14[40] 0.45[41] 0.23[42]
7 NNT NAD(P) transhydrogenase, mitochondrial [43] 1.12[44] 1.30[45] 0.97[46] 1.64[47] 0.63[48] 1.11[49]
8 NT5C 5'(3')-deoxyribonucleotidase, cytosolic type [50] 0.87[51] 1.39[52] 0.57[53] 1.20[54] -0.09[55] -2.68[56]
9 NT5C2 Cytosolic purine 5'-nucleotidase [57] 2.83[58] 2.88[59] 3.76[60] 3.42[61] 1.93[62] -0.42[63]
10 NADSYN1 Glutamine-dependent NAD(+) synthetase [64] 3.40[65] 2.79[66] 1.70[67] 2.54[68] 1.01[69] -0.23[70]
11 ENPP1 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 3.26[71] 3.84[72] 4.06[73] 2.45[74] -1.11[75] 2.16[76]
12 NT5E 5'-nucleotidase [77] 0.96[78] 3.95[79] 4.22[80] 1.99[81] 2.69[82] 0.66[83]
13 NUDT12 Peroxisomal NADH pyrophosphatase NUDT12 [84] -0.34[85] 0.55[86] 2.60[87] 1.81[88] 1.23[89] 0.27[90]
14 ENPP3 Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 2.33[91] 3.97[92] -1.14[93] -1.40[94] -4.83[95] -2.71[96]
15 NMNAT1 Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 [97] 2.55[98] 3.64[99] 1.79[100] 3.24[101] 1.44[102] -0.42[103]
16 NMNAT3 Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 [104] 2.48[105] 2.53[106] -5.16[107] 0.50[108] -3.61[109] -1.65[110]
17 BST1 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 [111] -3.45[112] -3.55[113] 0.06[114] -1.56[115] 1.30[116] 0.38[117]
18 CD38 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [118] -6.20[119] [120] -2.96[121] -0.98[122] -1.17[123] 0.18[124]
19 NT5M 5'(3')-deoxyribonucleotidase, mitochondrial [125] 1.74[126] 2.82[127] 2.61[128] 4.00[129] 1.55[130] -1.99[131]
20 NMNAT2 Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2 [132] -0.58[133] -1.13[134] -1.64[135] 7.64[136] 6.38[137] 0.07[138]
21 NT5C3A Cytosolic 5'-nucleotidase 3A [139] [140] [141] [142] [143] [144] [145]
22 NMRK1 Nicotinamide riboside kinase 1 [146] [147] [148] [149] [150] [151] [152]
23 NT5C1A Cytosolic 5'-nucleotidase 1A [153] [154] [155] [156] [157] [158] [159]
24 NT5C1B Cytosolic 5'-nucleotidase 1B [160] [161] [162] [163] [164] [165] [166]
[1]
ref_hepatocyte NNMT
Mean 598
Standard deviation 7.3e+02
Values 0 59 1.5e+03 1.3e+02 1.3e+03
[2]
HepG2 NNMT
Mean 0.129
Standard deviation 0.13
Values 0.22 0.034
[3]
HepG2.C3A NNMT
Mean 0.0458
Standard deviation 0.004
Values 0.049 0.043
[4]
HuH.7 NNMT
Mean 6.86
Standard deviation 2.3
Values 7.3 4.3 8.9
[5]
SNU475 NNMT
Mean 20.1
Standard deviation 7.5
Values 15 25
[6]
THLE NNMT
Mean 139
Standard deviation 16
Values 1.5e+02 1.3e+02
[7]
liver NNMT
Mean 680
Standard deviation 4.7e+02
Values 2.7e+02 1.1e+03 1.1e+03 2.7e+02
[8]
ref_hepatocyte AOX1
Mean 166
Standard deviation 2e+02
Values 12 68 2.5e+02 25 4.8e+02
[9]
HepG2 AOX1
Mean 28.7
Standard deviation 3.3
Values 26 31
[10]
HepG2.C3A AOX1
Mean 22.6
Standard deviation 2.4
Values 21 24
[11]
HuH.7 AOX1
Mean 0.258
Standard deviation 0.25
Values 0.16 0.55 0.066
[12]
SNU475 AOX1
Mean 7.67
Standard deviation 6.2
Values 3.3 12
[13]
THLE AOX1
Mean 26.7
Standard deviation 2.8
Values 29 25
[14]
liver AOX1
Mean 1.12e+03
Standard deviation 5.3e+02
Values 1.8e+03 5.6e+02 9.6e+02 1.1e+03
[15]
ref_hepatocyte NAMPT
Mean 74.5
Standard deviation 39
Values 16 1.2e+02 95 57 89
[16]
HepG2 NAMPT
Mean 25.1
Standard deviation 8.5
Values 19 31
[17]
HepG2.C3A NAMPT
Mean 33.9
Standard deviation 3.2
Values 32 36
[18]
HuH.7 NAMPT
Mean 48.4
Standard deviation 12
Values 44 62 38
[19]
SNU475 NAMPT
Mean 74.1
Standard deviation 15
Values 63 85
[20]
THLE NAMPT
Mean 427
Standard deviation 55
Values 4.7e+02 3.9e+02
[21]
liver NAMPT
Mean 209
Standard deviation 33
Values 2.5e+02 1.8e+02 2.2e+02 1.9e+02
[22]
ref_hepatocyte QPRT
Mean 54.6
Standard deviation 24
Values 66 46 60 18 83
[23]
HepG2 QPRT
Mean 166
Standard deviation 13
Values 1.6e+02 1.8e+02
[24]
HepG2.C3A QPRT
Mean 155
Standard deviation 28
Values 1.7e+02 1.4e+02
[25]
HuH.7 QPRT
Mean 127
Standard deviation 6.4
Values 1.2e+02 1.3e+02 1.2e+02
[26]
SNU475 QPRT
Mean 39.2
Standard deviation 20
Values 54 25
[27]
THLE QPRT
Mean 13.5
Standard deviation 0.43
Values 13 14
[28]
liver QPRT
Mean 56.2
Standard deviation 29
Values 31 92 68 34
[29]
ref_hepatocyte PNP
Mean 30
Standard deviation 33
Values 2.3 23 26 86 12
[30]
HepG2 PNP
Mean 42.3
Standard deviation 2.8
Values 44 40
[31]
HepG2.C3A PNP
Mean 22.5
Standard deviation 12
Values 14 31
[32]
HuH.7 PNP
Mean 33.5
Standard deviation 12
Values 31 23 46
[33]
SNU475 PNP
Mean 15.3
Standard deviation 6.3
Values 11 20
[34]
THLE PNP
Mean 44.5
Standard deviation 6.2
Values 40 49
[35]
liver PNP
Mean 11
Standard deviation 6
Values 6.1 20 8.7 9.7
[36]
ref_hepatocyte NADK
Mean 25.5
Standard deviation 12
Values 16 24 37 13 38
[37]
HepG2 NADK
Mean 54.2
Standard deviation 7.3
Values 59 49
[38]
HepG2.C3A NADK
Mean 65.3
Standard deviation 11
Values 73 58
[39]
HuH.7 NADK
Mean 28.3
Standard deviation 4.5
Values 28 24 33
[40]
SNU475 NADK
Mean 32.6
Standard deviation 7.7
Values 38 27
[41]
THLE NADK
Mean 27.6
Standard deviation 0.52
Values 27 28
[42]
liver NADK
Mean 70.2
Standard deviation 28
Values 47 95 94 45
[43]
ref_hepatocyte NNT
Mean 22.4
Standard deviation 15
Values 24 22 18 3.2 45
[44]
HepG2 NNT
Mean 22.4
Standard deviation 9.3
Values 16 29
[45]
HepG2.C3A NNT
Mean 31.4
Standard deviation 5.1
Values 28 35
[46]
HuH.7 NNT
Mean 20.1
Standard deviation 2.4
Values 21 22 17
[47]
SNU475 NNT
Mean 20.3
Standard deviation 12
Values 29 12
[48]
THLE NNT
Mean 27.6
Standard deviation 0.58
Values 28 27
[49]
liver NNT
Mean 114
Standard deviation 15
Values 1.3e+02 1.3e+02 1.1e+02 98
[50]
ref_hepatocyte NT5C
Mean 14.1
Standard deviation 2
Values 12 16 12 16 14
[51]
HepG2 NT5C
Mean 11.9
Standard deviation 0.64
Values 12 11
[52]
HepG2.C3A NT5C
Mean 21
Standard deviation 3.6
Values 24 19
[53]
HuH.7 NT5C
Mean 9.58
Standard deviation 3.9
Values 8.1 6.7 14
[54]
SNU475 NT5C
Mean 9.37
Standard deviation 2.2
Values 11 7.8
[55]
THLE NT5C
Mean 10.5
Standard deviation 0.81
Values 9.9 11
[56]
liver NT5C
Mean 5.18
Standard deviation 4
Values 1.9 8.2 9.2 1.5
[57]
ref_hepatocyte NT5C2
Mean 10.7
Standard deviation 5.7
Values 14 19 6.7 7.1 6.3
[58]
HepG2 NT5C2
Mean 35
Standard deviation 8.8
Values 29 41
[59]
HepG2.C3A NT5C2
Mean 44.8
Standard deviation 0.63
Values 45 44
[60]
HuH.7 NT5C2
Mean 66
Standard deviation 5.7
Values 62 73 63
[61]
SNU475 NT5C2
Mean 33.1
Standard deviation 12
Values 42 25
[62]
THLE NT5C2
Mean 32.4
Standard deviation 5.7
Values 28 36
[63]
liver NT5C2
Mean 18.8
Standard deviation 2.6
Values 21 15 21 18
[64]
ref_hepatocyte NADSYN1
Mean 6.84
Standard deviation 2.5
Values 8.9 6.1 9.5 3.2 6.5
[65]
HepG2 NADSYN1
Mean 33.2
Standard deviation 0.013
Values 33 33
[66]
HepG2.C3A NADSYN1
Mean 27
Standard deviation 8
Values 33 21
[67]
HuH.7 NADSYN1
Mean 10.2
Standard deviation 0.43
Values 11 9.8 10
[68]
SNU475 NADSYN1
Mean 11.5
Standard deviation 5
Values 15 8
[69]
THLE NADSYN1
Mean 11
Standard deviation 0.13
Values 11 11
[70]
liver NADSYN1
Mean 13.7
Standard deviation 3.8
Values 12 19 14 10
[71]
ref_hepatocyte ENPP1
Mean 6.12
Standard deviation 3.9
Values 9.8 2.9 6.7 1.4 9.9
[72]
HepG2 ENPP1
Mean 27.1
Standard deviation 7.8
Values 22 33
[73]
HepG2.C3A ENPP1
Mean 50
Standard deviation 14
Values 60 40
[74]
HuH.7 ENPP1
Mean 46.7
Standard deviation 8.1
Values 46 55 39
[75]
SNU475 ENPP1
Mean 9.73
Standard deviation 5.5
Values 14 5.8
[76]
THLE ENPP1
Mean 2.26
Standard deviation 0.11
Values 2.2 2.3
[77]
liver ENPP1
Mean 64.2
Standard deviation 27
Values 56 1e+02 38 61
[78]
ref_hepatocyte NT5E
Mean 5.59
Standard deviation 3.2
Values 0.3 5.8 5.6 8.3 8
[79]
HepG2 NT5E
Mean 5.01
Standard deviation 1.5
Values 4 6
[80]
HepG2.C3A NT5E
Mean 49.3
Standard deviation 7.9
Values 55 44
[81]
HuH.7 NT5E
Mean 47.8
Standard deviation 5.7
Values 53 42 49
[82]
SNU475 NT5E
Mean 6.43
Standard deviation 1.3
Values 5.5 7.4
[83]
THLE NT5E
Mean 28.7
Standard deviation 11
Values 21 36
[84]
liver NT5E
Mean 20.8
Standard deviation 5.2
Values 19 23 14 26
[85]
ref_hepatocyte NUDT12
Mean 4.91
Standard deviation 4.7
Values 0.54 6.8 3.3 1.7 12
[86]
HepG2 NUDT12
Mean 1.79
Standard deviation 0.41
Values 1.5 2.1
[87]
HepG2.C3A NUDT12
Mean 4.11
Standard deviation 0.49
Values 3.8 4.5
[88]
HuH.7 NUDT12
Mean 13.6
Standard deviation 0.93
Values 15 13 14
[89]
SNU475 NUDT12
Mean 4.99
Standard deviation 1.7
Values 6.2 3.8
[90]
THLE NUDT12
Mean 9.17
Standard deviation 0.94
Values 8.5 9.8
[91]
liver NUDT12
Mean 14
Standard deviation 2.9
Values 14 18 13 11
[92]
ref_hepatocyte ENPP3
Mean 3.1
Standard deviation 5.7
Values 13 0.18 0.48 0 1.7
[93]
HepG2 ENPP3
Mean 7.2
Standard deviation 2.6
Values 5.4 9
[94]
HepG2.C3A ENPP3
Mean 27.8
Standard deviation 0.8
Values 28 27
[95]
HuH.7 ENPP3
Mean 0.644
Standard deviation 0.37
Values 0.5 1.1 0.37
[96]
SNU475 ENPP3
Mean 0.341
Standard deviation 0.03
Values 0.36 0.32
[97]
THLE ENPP3
Mean 0.0866
Standard deviation 0.0054
Values 0.083 0.09
[98]
liver ENPP3
Mean 1.12
Standard deviation 0.72
Values 1.2 2.1 0.69 0.46
[99]
ref_hepatocyte NMNAT1
Mean 2.87
Standard deviation 1.2
Values 4.6 3.6 2.6 1.6 2
[100]
HepG2 NMNAT1
Mean 7.76
Standard deviation 0.7
Values 7.3 8.2
[101]
HepG2.C3A NMNAT1
Mean 20.4
Standard deviation 2.1
Values 19 22
[102]
HuH.7 NMNAT1
Mean 4.53
Standard deviation 0.81
Values 4.9 3.6 5.1
[103]
SNU475 NMNAT1
Mean 7.88
Standard deviation 1.8
Values 9.2 6.6
[104]
THLE NMNAT1
Mean 6.18
Standard deviation 0.82
Values 5.6 6.8
[105]
liver NMNAT1
Mean 5.02
Standard deviation 0.66
Values 5.3 4.9 5.8 4.2
[106]
ref_hepatocyte NMNAT3
Mean 1.31
Standard deviation 1.8
Values 4.5 0.13 1.1 0 0.87
[107]
HepG2 NMNAT3
Mean 3.36
Standard deviation 0.041
Values 3.3 3.4
[108]
HepG2.C3A NMNAT3
Mean 4.31
Standard deviation 0.33
Values 4.5 4.1
[109]
HuH.7 NMNAT3
Mean 0.0168
Standard deviation 0.015
Values 0.025 0.026 0
[110]
SNU475 NMNAT3
Mean 0.536
Standard deviation 0.28
Values 0.73 0.34
[111]
THLE NMNAT3
Mean 0.0855
Standard deviation 0.038
Values 0.11 0.059
[112]
liver NMNAT3
Mean 0.977
Standard deviation 0.36
Values 0.91 1.5 0.64 0.87
[113]
ref_hepatocyte BST1
Mean 0.849
Standard deviation 0.79
Values 0 1.4 1.2 0 1.6
[114]
HepG2 BST1
Mean 0.0358
Standard deviation 0.034
Values 0.011 0.06
[115]
HepG2.C3A BST1
Mean 0.0414
Standard deviation 0.017
Values 0.029 0.054
[116]
HuH.7 BST1
Mean 0.407
Standard deviation 0.086
Values 0.44 0.31 0.47
[117]
SNU475 BST1
Mean 0.0836
Standard deviation 0.039
Values 0.056 0.11
[118]
THLE BST1
Mean 1.66
Standard deviation 0.7
Values 1.2 2.1
[119]
liver BST1
Mean 2.6
Standard deviation 2.4
Values 0.88 6.2 1.4 1.9
[120]
ref_hepatocyte CD38
Mean 0.801
Standard deviation 1.1
Values 0 0.08 1.5 0 2.4
[121]
HepG2 CD38
Mean 0.00501
Standard deviation 0.001
Values 0.0057 0.0043
[122]
HepG2.C3A CD38
Mean 0
Standard deviation 0
Values 0 0
[123]
HuH.7 CD38
Mean 0.0471
Standard deviation 0.038
Values 0.033 0.09 0.019
[124]
SNU475 CD38
Mean 0.118
Standard deviation 0.1
Values 0.19 0.046
[125]
THLE CD38
Mean 0.283
Standard deviation 0.15
Values 0.39 0.18
[126]
liver CD38
Mean 2.14
Standard deviation 0.61
Values 2.2 1.8 3 1.6
[127]
ref_hepatocyte NT5M
Mean 0.313
Standard deviation 0.22
Values 0.073 0.075 0.53 0.43 0.46
[128]
HepG2 NT5M
Mean 0.483
Standard deviation 0.34
Values 0.72 0.24
[129]
HepG2.C3A NT5M
Mean 1.26
Standard deviation 0.57
Values 1.7 0.86
[130]
HuH.7 NT5M
Mean 0.875
Standard deviation 0.27
Values 0.89 0.6 1.1
[131]
SNU475 NT5M
Mean 1.45
Standard deviation 0.43
Values 1.8 1.1
[132]
THLE NT5M
Mean 0.729
Standard deviation 0.32
Values 0.96 0.5
[133]
liver NT5M
Mean 0.186
Standard deviation 0.11
Values 0.13 0.33 0.21 0.079
[134]
ref_hepatocyte NMNAT2
Mean 0.0372
Standard deviation 0.07
Values 0 0 0.026 0.16 0
[135]
HepG2 NMNAT2
Mean 0.0114
Standard deviation 0.0081
Values 0.0057 0.017
[136]
HepG2.C3A NMNAT2
Mean 0.00972
Standard deviation 0.014
Values 0.019 0
[137]
HuH.7 NMNAT2
Mean 0.00547
Standard deviation 0.0095
Values 0.016 0 0
[138]
SNU475 NMNAT2
Mean 2.15
Standard deviation 1.4
Values 1.1 3.2
[139]
THLE NMNAT2
Mean 2.47
Standard deviation 0.39
Values 2.2 2.8
[140]
liver NMNAT2
Mean 0.092
Standard deviation 0.085
Values 0.2 0.024 0.026 0.12
[141]
ref_hepatocyte NT5C3A
Missing
[142]
HepG2 NT5C3A
Missing
[143]
HepG2.C3A NT5C3A
Missing
[144]
HuH.7 NT5C3A
Missing
[145]
SNU475 NT5C3A
Missing
[146]
THLE NT5C3A
Missing
[147]
liver NT5C3A
Missing
[148]
ref_hepatocyte NMRK1
Missing
[149]
HepG2 NMRK1
Mean 1.99
Standard deviation 0.23
Values 1.8 2.1
[150]
HepG2.C3A NMRK1
Mean 5.23
Standard deviation 1.4
Values 6.2 4.3
[151]
HuH.7 NMRK1
Mean 6.35
Standard deviation 1.5
Values 4.8 6.3 7.9
[152]
SNU475 NMRK1
Mean 1.52
Standard deviation 0.84
Values 2.1 0.93
[153]
THLE NMRK1
Mean 4.92
Standard deviation 0.086
Values 4.9 5
[154]
liver NMRK1
Mean 7.63
Standard deviation 5.5
Values 2.9 14 10 3.3
[155]
ref_hepatocyte NT5C1A
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[156]
HepG2 NT5C1A
Mean 0
Standard deviation 0
Values 0 0
[157]
HepG2.C3A NT5C1A
Mean 0
Standard deviation 0
Values 0 0
[158]
HuH.7 NT5C1A
Mean 0.00273
Standard deviation 0.0047
Values 0.0082 0 0
[159]
SNU475 NT5C1A
Mean 0.00507
Standard deviation 0.0072
Values 0 0.01
[160]
THLE NT5C1A
Mean 0.0787
Standard deviation 0.0059
Values 0.083 0.074
[161]
liver NT5C1A
Mean 0.00688
Standard deviation 0.008
Values 0.014 0 0 0.013
[162]
ref_hepatocyte NT5C1B
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[163]
HepG2 NT5C1B
Mean 0.00429
Standard deviation 0.0061
Values 0 0.0086
[164]
HepG2.C3A NT5C1B
Mean 0.00536
Standard deviation 0.0076
Values 0 0.011
[165]
HuH.7 NT5C1B
Mean 0
Standard deviation 0
Values 0 0 0
[166]
SNU475 NT5C1B
Mean 0.0217
Standard deviation 0.0021
Values 0.023 0.02
[167]
THLE NT5C1B
Mean 0.0364
Standard deviation 0.0012
Values 0.035 0.037
[168]
liver NT5C1B
Mean 0.18
Standard deviation 0.11
Values 0.24 0.094 0.077 0.3