KEGG_NEUROTROPHIN_SIGNALING_PATHWAY | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | CALM2 | Calmodulin-2 | [1] | -1.26[2] | -0.47[3] | -1.85[4] | -1.73[5] | -1.23[6] | -1.05[7] |
2 | ATF4 | Cyclic AMP-dependent transcription factor ATF-4 | [8] | -0.91[9] | 0.10[10] | 0.10[11] | -3.00[12] | -1.36[13] | -1.55[14] |
3 | YWHAE | 14-3-3 protein epsilon | [15] | -0.98[16] | -0.96[17] | -0.51[18] | -0.84[19] | -0.60[20] | -0.89[21] |
4 | RHOA | Transforming protein RhoA | [22] | -0.69[23] | -1.27[24] | -0.95[25] | -1.20[26] | -0.54[27] | -0.66[28] |
5 | YWHAZ | 14-3-3 protein zeta/delta | [29] | -0.32[30] | -0.55[31] | -0.14[32] | 0.93[33] | -0.29[34] | -0.98[35] |
6 | CDC42 | Cell division control protein 42 homolog | [36] | -0.57[37] | 0.06[38] | -0.85[39] | -0.51[40] | -1.03[41] | -1.42[42] |
7 | RAP1B | Ras-related protein Rap-1b | [43] | -2.05[44] | -1.52[45] | -1.65[46] | -0.50[47] | -0.54[48] | -1.23[49] |
8 | ARHGDIA | Rho GDP-dissociation inhibitor 1 | [50] | -0.27[51] | -1.03[52] | -1.68[53] | -0.98[54] | -0.41[55] | -1.17[56] |
9 | NFKBIA | NF-kappa-B inhibitor alpha | [57] | -0.80[58] | -2.68[59] | -2.96[60] | -3.50[61] | -1.41[62] | -0.47[63] |
10 | CALM3 | Calmodulin-3 | [64] | 0.19[65] | -0.15[66] | 1.14[67] | -0.31[68] | -0.26[69] | -1.45[70] |
11 | YWHAH | 14-3-3 protein eta | [71] | -1.11[72] | -1.61[73] | -1.54[74] | -1.17[75] | -1.37[76] | -1.30[77] |
12 | YWHAQ | 14-3-3 protein theta | [78] | 0.52[79] | 0.25[80] | 0.05[81] | 1.38[82] | 0.91[83] | 0.06[84] |
13 | RAC1 | Ras-related C3 botulinum toxin substrate 1 | [85] | -0.14[86] | -0.55[87] | 0.25[88] | 0.04[89] | 0.22[90] | -0.30[91] |
14 | YWHAG | 14-3-3 protein gamma | [92] | 0.46[93] | -0.16[94] | -0.01[95] | 0.74[96] | 0.25[97] | -0.68[98] |
15 | JUN | Transcription factor AP-1 | [99] | -0.24[100] | -1.86[101] | -1.50[102] | -1.68[103] | -0.91[104] | -1.14[105] |
16 | YWHAB | 14-3-3 protein beta/alpha | [106] | 1.29[107] | 0.92[108] | 0.29[109] | 1.32[110] | 0.96[111] | 0.57[112] |
17 | AKT1 | RAC-alpha serine/threonine-protein kinase | [113] | 0.33[114] | 0.02[115] | -0.97[116] | -0.03[117] | 0.20[118] | 0.42[119] |
18 | CALM1 | Calmodulin-1 | [120] | 0.33[121] | 0.28[122] | 0.84[123] | 1.61[124] | 1.08[125] | 2.28[126] |
19 | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1 | [127] | -0.68[128] | -1.09[129] | -0.41[130] | -0.52[131] | 0.19[132] | -0.53[133] |
20 | MAP2K2 | Dual specificity mitogen-activated protein kinase kinase 2 | [134] | 0.31[135] | -0.10[136] | 0.86[137] | -0.82[138] | -0.13[139] | -1.04[140] |
21 | BAX | Apoptosis regulator BAX | [141] | 0.58[142] | -0.29[143] | -0.66[144] | -1.58[145] | -0.99[146] | -3.29[147] |
22 | PTPN11 | Tyrosine-protein phosphatase non-receptor type 11 | [148] | 0.70[149] | 1.05[150] | 1.10[151] | 0.91[152] | 1.75[153] | 1.92[154] |
23 | MAGED1 | Melanoma-associated antigen D1 | [155] | 1.66[156] | 1.34[157] | -7.56[158] | 1.90[159] | 0.59[160] | 0.86[161] |
24 | IRAK1 | Interleukin-1 receptor-associated kinase 1 | [162] | 1.67[163] | 0.98[164] | 0.05[165] | 0.82[166] | 1.39[167] | -0.02[168] |
25 | GRB2 | Growth factor receptor-bound protein 2 | [169] | 1.45[170] | 1.20[171] | 1.42[172] | 0.58[173] | 0.69[174] | 0.96[175] |
26 | CRK | Adapter molecule crk | [176] | 0.05[177] | -0.10[178] | 0.06[179] | -0.22[180] | 0.38[181] | 1.51[182] |
27 | RAP1A | Ras-related protein Rap-1A | [183] | -0.80[184] | -0.94[185] | -0.01[186] | -0.19[187] | -0.23[188] | -0.63[189] |
28 | BAD | Bcl2-associated agonist of cell death | [190] | -1.42[191] | -1.37[192] | -2.22[193] | -1.04[194] | -0.44[195] | -0.76[196] |
29 | SHC1 | SHC-transforming protein 1 | [197] | 1.42[198] | 1.55[199] | 1.72[200] | 2.67[201] | 2.36[202] | 1.44[203] |
30 | RELA | Transcription factor p65 | [204] | 0.39[205] | -0.20[206] | 0.03[207] | -0.03[208] | 0.08[209] | -0.22[210] |
31 | RAF1 | RAF proto-oncogene serine/threonine-protein kinase | [211] | 0.19[212] | 0.51[213] | 1.87[214] | -0.16[215] | 0.90[216] | 1.76[217] |
32 | NRAS | GTPase NRas | [218] | 0.88[219] | 1.23[220] | 1.74[221] | 1.02[222] | 0.79[223] | 0.41[224] |
33 | NFKBIB | NF-kappa-B inhibitor beta | [225] | -0.91[226] | -1.17[227] | -0.74[228] | -1.79[229] | -1.24[230] | -1.06[231] |
34 | MAPKAPK | MAP kinase-activated protein kinase 2 | [232] | 0.71[233] | -0.33[234] | 0.17[235] | 1.42[236] | 0.83[237] | -0.28[238] |
35 | HRAS | GTPase HRas | [239] | -0.75[240] | -1.54[241] | -2.24[242] | -0.93[243] | -0.94[244] | -2.00[245] |
36 | MAPK1 | Mitogen-activated protein kinase 1 | [246] | 1.96[247] | 2.02[248] | 1.94[249] | 1.87[250] | 1.72[251] | 2.44[252] |
37 | AKT2 | RAC-beta serine/threonine-protein kinase | [253] | 1.21[254] | 1.41[255] | 1.63[256] | 0.88[257] | 0.87[258] | 1.79[259] |
38 | CSK | Tyrosine-protein kinase CSK | [260] | 0.63[261] | 0.05[262] | 0.51[263] | 0.01[264] | -0.19[265] | -0.20[266] |
39 | SHC2 | SHC-transforming protein 2 | [267] | -1.13[268] | -0.86[269] | -1.61[270] | -4.64[271] | -4.07[272] | 0.29[273] |
40 | RPS6KA3 | Ribosomal protein S6 kinase alpha-3 | [274] | [275] | [276] | [277] | [278] | [279] | [280] |
41 | KRAS | GTPase KRas | [281] | -0.26[282] | -0.36[283] | 1.33[284] | 0.82[285] | 0.69[286] | 1.34[287] |
42 | MAPK14 | Mitogen-activated protein kinase 14 | [288] | 1.73[289] | 1.71[290] | 1.38[291] | 1.71[292] | 1.38[293] | 1.95[294] |
43 | IRAK2 | Interleukin-1 receptor-associated kinase-like 2 | [295] | 0.18[296] | 0.20[297] | 0.07[298] | -2.41[299] | -0.66[300] | -0.36[301] |
44 | CRKL | Crk-like protein | [302] | 1.96[303] | 1.97[304] | 2.67[305] | 1.15[306] | 1.55[307] | 2.12[308] |
45 | PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha | [309] | -0.22[310] | -0.18[311] | 1.00[312] | 2.09[313] | 1.79[314] | 3.67[315] |
46 | MAPK8 | Mitogen-activated protein kinase 8 | [316] | -1.19[317] | 0.14[318] | -0.90[319] | -0.88[320] | -0.82[321] | 0.15[322] |
47 | SOS1 | Son of sevenless homolog 1 | [323] | 0.15[324] | 1.60[325] | 1.20[326] | 0.87[327] | 0.30[328] | 1.20[329] |
48 | PSEN1 | Presenilin-1 | [330] | 1.31[331] | 1.45[332] | 1.11[333] | 1.28[334] | 1.36[335] | 1.66[336] |
49 | NFKB1 | Nuclear factor NF-kappa-B p105 subunit | [337] | 0.92[338] | 0.52[339] | 0.40[340] | -0.22[341] | 0.89[342] | 1.12[343] |
50 | ARHGDIB | Rho GDP-dissociation inhibitor 2 | [344] | -4.79[345] | -5.08[346] | -5.94[347] | -1.58[348] | -0.95[349] | 1.39[350] |
51 | CAMK2D | Calcium/calmodulin-dependent protein kinase type II subunit delta | [351] | 0.38[352] | 0.61[353] | 2.23[354] | 0.70[355] | 0.09[356] | 2.07[357] |
52 | MAPK13 | Mitogen-activated protein kinase 13 | [358] | 2.59[359] | 2.92[360] | 0.33[361] | -1.86[362] | -0.14[363] | -1.05[364] |
53 | TP53 | Cellular tumor antigen p53 | [365] | 1.89[366] | 1.37[367] | 2.22[368] | 1.31[369] | 1.18[370] | 0.62[371] |
54 | PIK3R2 | Phosphatidylinositol 3-kinase regulatory subunit beta | [372] | 2.13[373] | 2.27[374] | 2.97[375] | 0.73[376] | 1.49[377] | 0.37[378] |
55 | RPS6KA4 | Ribosomal protein S6 kinase alpha-4 | [379] | [380] | [381] | [382] | [383] | [384] | [385] |
56 | RAPGEF1 | Rap guanine nucleotide exchange factor 1 | [386] | 2.34[387] | 2.09[388] | 1.90[389] | 1.28[390] | 1.15[391] | 1.84[392] |
57 | RPS6KA1 | Ribosomal protein S6 kinase alpha-1 | [393] | [394] | [395] | [396] | [397] | [398] | [399] |
58 | RIPK2 | Receptor-interacting serine/threonine-protein kinase 2 | [400] | -0.32[401] | 0.20[402] | 0.30[403] | -0.18[404] | -0.01[405] | -0.47[406] |
59 | MAPK9 | Mitogen-activated protein kinase 9 | [407] | 1.48[408] | 1.62[409] | 1.78[410] | 1.74[411] | 1.40[412] | 1.17[413] |
60 | ZNF274 | Neurotrophin receptor-interacting factor homolog | [414] | 0.37[415] | 0.42[416] | 1.01[417] | 0.15[418] | -0.19[419] | 0.74[420] |
61 | MAPK3 | Mitogen-activated protein kinase 3 | [421] | 2.10[422] | 2.07[423] | 2.20[424] | 0.45[425] | 0.67[426] | -0.38[427] |
62 | GSK3B | Glycogen synthase kinase-3 beta | [428] | 1.52[429] | 1.07[430] | 1.74[431] | 1.84[432] | 1.87[433] | 1.83[434] |
63 | NFKBIE | NF-kappa-B inhibitor epsilon | [435] | 0.29[436] | 1.13[437] | -0.64[438] | -0.76[439] | -0.10[440] | -0.60[441] |
64 | ABL1 | Tyrosine-protein kinase ABL1 | [442] | 2.48[443] | 1.80[444] | 2.68[445] | 2.09[446] | 2.98[447] | 1.61[448] |
65 | MAP2K7 | Dual specificity mitogen-activated protein kinase kinase 7 | [449] | 1.21[450] | 1.28[451] | 1.95[452] | 0.31[453] | 1.06[454] | -0.09[455] |
66 | MAP2K5 | Dual specificity mitogen-activated protein kinase kinase 5 | [456] | -0.19[457] | -0.04[458] | 1.06[459] | -0.74[460] | -0.14[461] | 0.21[462] |
67 | PRKCD | Protein kinase C delta type | [463] | 1.35[464] | 1.52[465] | 1.09[466] | -0.48[467] | 0.88[468] | -0.40[469] |
68 | PDPK1 | 3-phosphoinositide-dependent protein kinase 1 | [470] | 2.59[471] | 3.69[472] | 2.50[473] | 1.46[474] | 2.06[475] | 3.17[476] |
69 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 3.74[477] | 3.28[478] | 2.70[479] | 2.84[480] | 2.54[481] | 1.00[482] | |
70 | IKBKB | Inhibitor of nuclear factor kappa-B kinase subunit beta | [483] | 0.77[484] | 0.75[485] | 0.95[486] | 0.28[487] | 0.58[488] | 1.85[489] |
71 | SH2B1 | SH2B adapter protein 1 | [490] | 1.40[491] | 2.03[492] | 1.79[493] | 0.34[494] | 1.24[495] | 0.75[496] |
72 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 1.46[497] | 1.89[498] | 2.14[499] | 1.07[500] | 1.43[501] | 1.82[502] | |
73 | IRS1 | Insulin receptor substrate 1 | [503] | 2.34[504] | 1.71[505] | 3.23[506] | 1.73[507] | 1.51[508] | 2.78[509] |
74 | SH2B3 | SH2B adapter protein 3 | [510] | 1.37[511] | 0.88[512] | 1.19[513] | 1.58[514] | 2.61[515] | 2.07[516] |
75 | CAMK2G | Calcium/calmodulin-dependent protein kinase type II subunit gamma | 1.03[517] | 2.16[518] | 1.86[519] | 1.71[520] | 1.47[521] | 1.62[522] | |
76 | FOXO3 | Forkhead box protein O3 | [523] | 0.71[524] | 0.72[525] | 1.45[526] | 0.42[527] | 1.86[528] | 3.00[529] |
77 | KIDINS220 | Kinase D-interacting substrate of 220 kDa | [530] | 1.84[531] | 2.39[532] | 2.09[533] | 2.94[534] | 2.60[535] | 3.93[536] |
78 | SORT1 | Sortilin | [537] | 3.67[538] | 4.02[539] | 2.67[540] | 3.98[541] | 2.81[542] | 0.68[543] |
79 | SOS2 | Son of sevenless homolog 2 | [544] | 0.23[545] | 1.27[546] | 0.59[547] | 1.71[548] | 1.78[549] | 2.50[550] |
80 | PRDM4 | PR domain zinc finger protein 4 | [551] | 1.48[552] | 1.81[553] | 1.22[554] | 1.77[555] | 2.13[556] | 1.22[557] |
81 | IRS2 | Insulin receptor substrate 2 | [558] | -5.40[559] | [560] | -2.53[561] | -0.64[562] | 3.39[563] | 3.05[564] |
82 | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | -0.13[565] | 1.43[566] | 1.71[567] | 1.15[568] | 1.56[569] | 2.58[570] | |
83 | PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | 2.14[571] | 3.15[572] | -0.58[573] | 0.30[574] | 1.27[575] | 0.96[576] | |
84 | MAP3K3 | Mitogen-activated protein kinase kinase kinase 3 | [577] | 1.87[578] | 2.28[579] | 1.65[580] | 2.10[581] | 2.56[582] | 2.81[583] |
85 | IRAK4 | Interleukin-1 receptor-associated kinase 4 | [584] | 0.51[585] | 1.79[586] | 2.16[587] | 1.44[588] | 1.40[589] | 2.44[590] |
86 | RPS6KA2 | Ribosomal protein S6 kinase alpha-2 | [591] | [592] | [593] | [594] | [595] | [596] | [597] |
87 | MAP3K5 | Mitogen-activated protein kinase kinase kinase 5 | [598] | -4.05[599] | -7.05[600] | -1.07[601] | -1.84[602] | 2.76[603] | 3.72[604] |
88 | MAP3K1 | Mitogen-activated protein kinase kinase kinase 1 | [605] | 2.90[606] | 2.54[607] | 2.36[608] | 2.35[609] | 1.43[610] | 3.46[611] |
89 | FRS2 | Fibroblast growth factor receptor substrate 2 | [612] | 1.54[613] | 2.55[614] | 3.14[615] | 2.93[616] | 2.76[617] | 4.01[618] |
90 | MAPK7 | Mitogen-activated protein kinase 7 | [619] | 1.69[620] | 0.91[621] | 1.00[622] | 1.83[623] | 2.12[624] | 1.00[625] |
91 | BRAF | Serine/threonine-protein kinase B-raf | [626] | 0.50[627] | 0.15[628] | 2.27[629] | 0.76[630] | 0.66[631] | 2.52[632] |
92 | NTF3 | Neurotrophin-3 | [633] | -5.62[634] | -8.48[635] | 0.27[636] | -6.31[637] | [638] | -0.29[639] |
93 | PLCG2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 | -1.03[640] | -6.86[641] | 0.68[642] | -2.71[643] | -1.36[644] | 3.38[645] | |
94 | TRAF6 | TNF receptor-associated factor 6 | [646] | 1.34[647] | 1.15[648] | 1.81[649] | 1.68[650] | 1.34[651] | 3.57[652] |
95 | GAB1 | GRB2-associated-binding protein 1 | [653] | 1.55[654] | 2.56[655] | 2.78[656] | 1.96[657] | 2.02[658] | 3.54[659] |
96 | MAPK12 | Mitogen-activated protein kinase 12 | [660] | 3.07[661] | 2.65[662] | 3.86[663] | 1.51[664] | 2.96[665] | -0.24[666] |
97 | CAMK2B | Calcium/calmodulin-dependent protein kinase type II subunit beta | [667] | -2.28[668] | -3.69[669] | -6.56[670] | -2.84[671] | -2.00[672] | 1.81[673] |
98 | PIK3R3 | Phosphatidylinositol 3-kinase regulatory subunit gamma | [674] | 1.97[675] | 1.90[676] | 2.84[677] | 3.19[678] | 2.41[679] | 3.34[680] |
99 | AKT3 | RAC-gamma serine/threonine-protein kinase | [681] | -1.59[682] | -4.23[683] | -3.45[684] | 5.86[685] | 5.02[686] | 4.27[687] |
100 | RPS6KA5 | Ribosomal protein S6 kinase alpha-5 | [688] | [689] | [690] | [691] | [692] | [693] | [694] |
101 | MAPK11 | Mitogen-activated protein kinase 11 | [695] | 0.08[696] | -0.10[697] | -0.90[698] | 0.38[699] | 2.58[700] | 0.83[701] |
102 | PIK3R5 | Phosphoinositide 3-kinase regulatory subunit 5 | [702] | -6.91[703] | [704] | -2.27[705] | -3.90[706] | -3.35[707] | 3.00[708] |
103 | SH2B2 | SH2B adapter protein 2 | [709] | 0.26[710] | -0.48[711] | 0.43[712] | 0.56[713] | 0.07[714] | -0.45[715] |
104 | RPS6KA6 | Ribosomal protein S6 kinase alpha-6 | [716] | [717] | [718] | [719] | [720] | [721] | [722] |
105 | TP73 | Tumor protein p73 | [723] | 0.98[724] | 3.45[725] | 2.46[726] | 0.70[727] | 2.04[728] | 1.31[729] |
106 | BCL2 | Apoptosis regulator Bcl-2 | [730] | -2.60[731] | 2.72[732] | -4.59[733] | 1.80[734] | 1.71[735] | 3.90[736] |
107 | CALML3 | Calmodulin-like protein 3 | [737] | -2.35[738] | -2.27[739] | -4.71[740] | [741] | -2.94[742] | -1.68[743] |
108 | IRAK3 | Interleukin-1 receptor-associated kinase 3 | [744] | -1.20[745] | -0.29[746] | 1.67[747] | 6.06[748] | 8.51[749] | 6.55[750] |
109 | FASLG | Tumor necrosis factor ligand superfamily member 6 | [751] | -3.56[752] | -1.77[753] | -5.65[754] | [755] | [756] | 1.25[757] |
110 | PIK3CG | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | [758] | [759] | [760] | 1.36[761] | -3.32[762] | 4.76[763] | |
111 | SHC4 | SHC-transforming protein 4 | [764] | -2.01[765] | [766] | -1.44[767] | 2.55[768] | 3.13[769] | -0.03[770] |
112 | BDNF | Brain-derived neurotrophic factor | [771] | -1.41[772] | -4.26[773] | -2.24[774] | 6.77[775] | 5.73[776] | 2.76[777] |
113 | SHC3 | SHC-transforming protein 3 | [778] | 2.36[779] | 4.66[780] | -2.74[781] | 3.48[782] | 7.59[783] | 2.48[784] |
114 | NTRK3 | NT-3 growth factor receptor | [785] | [786] | [787] | [788] | 3.79[789] | -0.56[790] | 4.51[791] |
115 | NGFR | Tumor necrosis factor receptor superfamily member 16 | [792] | 8.72[793] | 1.79[794] | -2.12[795] | 1.77[796] | 2.92[797] | 8.27[798] |
116 | CAMK4 | Calcium/calmodulin-dependent protein kinase type IV | [799] | [800] | -1.59[801] | -2.16[802] | 1.47[803] | 3.74[804] | 4.91[805] |
117 | IRS4 | Insulin receptor substrate 4 | [806] | [807] | [808] | [809] | -1.54[810] | -2.43[811] | [812] |
118 | MAPK10 | Mitogen-activated protein kinase 10 | [813] | -1.23[814] | [815] | [816] | 8.93[817] | 4.87[818] | 7.91[819] |
119 | NGF | Beta-nerve growth factor | [820] | [821] | [822] | [823] | [824] | [825] | [826] |
120 | CAMK2A | Calcium/calmodulin-dependent protein kinase type II subunit alpha | [827] | [828] | [829] | [830] | [831] | [832] | [833] |
121 | NTRK2 | BDNF/NT-3 growth factors receptor | [834] | [835] | [836] | [837] | [838] | [839] | [840] |
122 | NTRK1 | High affinity nerve growth factor receptor | [841] | [842] | [843] | [844] | [845] | [846] | [847] |
123 | NTF4 | Neurotrophin-4 | [848] | [849] | [850] | [851] | [852] | [853] | [854] |
124 | CALML6 | Calmodulin-like protein 6 | [855] | [856] | [857] | [858] | [859] | [860] | [861] |
125 | BEX3 | Protein BEX3 | [862] | [863] | [864] | [865] | [866] | [867] | [868] |
126 | CALML5 | Calmodulin-like protein 5 | [869] | [870] | [871] | [872] | [873] | [874] | [875] |