KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 CYP2E1 Cytochrome P450 2E1 [1] -10.65[2] -10.88[3] -7.32[4] -13.62[5] -10.45[6] 0.17[7]
2 AKR1C1 Aldo-keto reductase family 1 member C1 [8] 1.09[9] 0.68[10] -2.71[11] -0.05[12] -3.23[13] -3.66[14]
3 MGST1 Microsomal glutathione S-transferase 1 [15] -0.41[16] -0.83[17] 0.38[18] -1.42[19] 0.89[20] -0.30[21]
4 ADH1B Alcohol dehydrogenase 1B [22] -9.83[23] [24] -5.86[25] [26] [27] 0.64[28]
5 GSTA1 Glutathione S-transferase A1 [29] -1.79[30] -5.65[31] 0.87[32] -5.22[33] -8.42[34] -3.04[35]
6 ADH4 Alcohol dehydrogenase 4 [36] -2.62[37] -3.21[38] -7.09[39] -12.11[40] -8.53[41] -1.89[42]
7 ADH1A Alcohol dehydrogenase 1A [43] -11.25[44] [45] -6.45[46] -15.19[47] [48] -1.35[49]
8 CYP2C8 Cytochrome P450 2C8 [50] -12.64[51] -8.00[52] -5.48[53] -10.71[54] [55] 1.10[56]
9 EPHX1 Epoxide hydrolase 1 [57] 0.80[58] -0.76[59] -1.30[60] 1.62[61] -0.05[62] -0.37[63]
10 CYP2C9 Cytochrome P450 2C9 [64] [65] -12.91[66] -5.70[67] -13.40[68] -10.98[69] 1.60[70]
11 CYP3A4 Cytochrome P450 3A4 [71] -7.90[72] -8.11[73] -9.51[74] -13.71[75] -10.55[76] 1.31[77]
12 AKR1C3 Aldo-keto reductase family 1 member C3 [78] 1.57[79] 2.11[80] -4.22[81] 3.19[82] -2.26[83] -1.61[84]
13 UGT1A6 UDP-glucuronosyltransferase 1-6 [85] -4.99[86] -12.82[87] -6.61[88] -5.06[89] -9.28[90] -3.31[91]
14 UGT2B4 UDP-glucuronosyltransferase 2B4 [92] -5.60[93] -5.86[94] -0.30[95] -8.30[96] -10.18[97] 1.35[98]
15 GSTA2 Glutathione S-transferase A2 [99] -2.90[100] -5.48[101] -0.77[102] -6.64[103] -8.56[104] -2.85[105]
16 AKR1C2 Aldo-keto reductase family 1 member C2 [106] 2.96[107] 0.83[108] -1.49[109] 2.30[110] -2.04[111] -0.59[112]
17 GSTO1 Glutathione S-transferase omega-1 [113] 1.90[114] 2.53[115] 2.32[116] -1.37[117] 2.43[118] -0.63[119]
18 CYP3A5 Cytochrome P450 3A5 [120] -2.97[121] -0.82[122] -3.26[123] -6.28[124] -6.88[125] 1.68[126]
19 ADH1C Alcohol dehydrogenase 1C [127] -11.62[128] -9.53[129] -7.84[130] -9.01[131] -9.74[132] -0.54[133]
20 UGT2B7 UDP-glucuronosyltransferase 2B7 [134] 0.50[135] 0.56[136] -4.59[137] -9.51[138] -9.47[139] 0.06[140]
21 AKR1C4 Aldo-keto reductase family 1 member C4 [141] -5.22[142] -2.94[143] -3.22[144] -7.86[145] -11.73[146] -0.30[147]
22 GSTK1 Glutathione S-transferase kappa 1 [148] 0.82[149] 1.31[150] 1.87[151] -0.32[152] 0.72[153] -0.45[154]
23 UGT2B10 UDP-glucuronosyltransferase 2B10 [155] 0.08[156] 2.62[157] -4.72[158] -9.64[159] -11.50[160] -1.03[161]
24 CYP1A2 Cytochrome P450 1A2 [162] -7.07[163] -5.86[164] -6.21[165] -7.28[166] -6.08[167] -1.07[168]
25 MGST2 Microsomal glutathione S-transferase 2 [169] 1.77[170] 3.07[171] 1.69[172] -1.17[173] 0.43[174] -1.35[175]
26 ADH6 Alcohol dehydrogenase 6 [176] 0.30[177] 0.98[178] 1.38[179] -8.01[180] -6.57[181] -0.12[182]
27 UGT2B15 UDP-glucuronosyltransferase 2B15 [183] -7.84[184] -6.37[185] -5.34[186] -9.38[187] -8.31[188] -0.40[189]
28 UGT1A1 UDP-glucuronosyltransferase 1-1 [190] -2.52[191] -8.86[192] -3.39[193] 0.46[194] -7.92[195] 0.53[196]
29 ADH5 Alcohol dehydrogenase class-3 [197] 3.56[198] 3.45[199] 4.29[200] 1.73[201] 3.61[202] 0.22[203]
30 UGT1A4 UDP-glucuronosyltransferase 1-4 [204] -9.90[205] [206] -9.29[207] -8.81[208] [209] 0.72[210]
31 GSTT1 Glutathione S-transferase theta-1 [211] 1.81[212] 1.91[213] -8.06[214] -10.20[215] -0.19[216] -0.42[217]
32 CYP2B6 Cytochrome P450 2B6 [218] -5.80[219] -2.45[220] -0.76[221] -8.26[222] -7.65[223] 2.98[224]
33 GSTZ1 Maleylacetoacetate isomerase [225] -0.12[226] 0.58[227] 0.50[228] -1.56[229] 0.10[230] -1.23[231]
34 CYP1A1 Cytochrome P450 1A1 [232] -0.62[233] -2.29[234] 1.68[235] -2.68[236] -1.61[237] -5.22[238]
35 CYP2C18 Cytochrome P450 2C18 [239] -7.62[240] -9.18[241] -3.02[242] -10.54[243] -6.99[244] 0.12[245]
36 MGST3 Microsomal glutathione S-transferase 3 [246] 1.66[247] 1.61[248] 2.65[249] 1.96[250] 3.54[251] 0.37[252]
37 CYP3A7 Cytochrome P450 3A7 [253] -3.08[254] -0.90[255] -5.31[256] [257] -8.35[258] -1.09[259]
38 CYP2C19 Cytochrome P450 2C19 [260] [261] [262] -2.84[263] -11.08[264] -9.28[265] 2.16[266]
39 UGT1A9 UDP-glucuronosyltransferase 1-9 [267] -3.87[268] -8.82[269] -4.70[270] -3.87[271] -7.51[272] -0.06[273]
40 GSTA4 Glutathione S-transferase A4 [274] 2.66[275] 2.86[276] 4.35[277] 2.88[278] 2.64[279] -0.90[280]
41 UGT2B17 UDP-glucuronosyltransferase 2B17 [281] -7.18[282] -6.65[283] -9.15[284] [285] [286] -0.78[287]
42 GSTM4 Glutathione S-transferase Mu 4 [288] 3.04[289] 2.40[290] 2.90[291] 2.58[292] 1.01[293] 0.33[294]
43 UGT2A3 UDP-glucuronosyltransferase 2A3 [295] 5.12[296] 6.90[297] -0.19[298] -4.24[299] -5.47[300] 2.08[301]
44 GSTP1 Glutathione S-transferase P [302] -0.12[303] 0.68[304] 8.68[305] 8.52[306] 7.89[307] 0.52[308]
45 UGT1A3 UDP-glucuronosyltransferase 1-3 [309] 0.88[310] [311] -5.55[312] -3.61[313] -7.10[314] 1.82[315]
46 GSTT2 Glutathione S-transferase theta-2 [316] -3.48[317] -5.51[318] -6.05[319] -2.16[320] 1.12[321] -3.00[322]
47 GSTM3 Glutathione S-transferase Mu 3 [323] 6.21[324] 5.47[325] 3.47[326] 5.67[327] 7.12[328] 2.10[329]
48 CYP1B1 Cytochrome P450 1B1 [330] -3.20[331] -2.72[332] 1.70[333] 4.31[334] 8.53[335] 1.59[336]
49 ALDH3A1 Aldehyde dehydrogenase, dimeric NADP-preferring [337] 1.34[338] -2.87[339] 0.03[340] 1.04[341] -0.40[342] -2.00[343]
50 CYP3A43 Cytochrome P450 3A43 [344] -1.01[345] 1.80[346] 1.93[347] [348] -5.72[349] 1.96[350]
51 GSTO2 Glutathione S-transferase omega-2 [351] 2.61[352] 5.19[353] 3.07[354] -2.03[355] 1.76[356] -0.66[357]
52 ALDH3B1 Aldehyde dehydrogenase family 3 member B1 [358] 5.71[359] 5.72[360] 5.58[361] 7.57[362] 7.30[363] 0.50[364]
53 GSTM2 Glutathione S-transferase Mu 2 [365] 4.23[366] 2.90[367] 5.00[368] 4.28[369] 5.25[370] 0.59[371]
54 CYP2S1 Cytochrome P450 2S1 [372] 6.76[373] 5.54[374] 5.04[375] 3.99[376] 5.68[377] -0.07[378]
55 GSTM1 Glutathione S-transferase Mu 1 [379] 1.53[380] 0.16[381] 6.63[382] 6.90[383] 0.10[384] 7.13[385]
56 UGT1A5 UDP-glucuronosyltransferase 1-5 [386] -2.40[387] [388] -3.37[389] -0.47[390] [391] 1.89[392]
57 UGT2B11 UDP-glucuronosyltransferase 2B11 [393] 4.06[394] 2.62[395] 4.18[396] -3.47[397] [398] 1.40[399]
58 DHDH Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase [400] 3.55[401] 5.00[402] 3.36[403] 1.04[404] 3.18[405] -3.89[406]
59 UGT2B28 UDP-glucuronosyltransferase 2B28 [407] 3.83[408] 4.26[409] 0.32[410] -4.06[411] [412] 1.35[413]
60 GSTA5 Glutathione S-transferase A5 [414] -3.23[415] [416] -2.42[417] [418] [419] [420]
61 ALDH1A3 Aldehyde dehydrogenase family 1 member A3 [421] 3.99[422] -0.10[423] 2.80[424] 6.85[425] 13.59[426] 4.28[427]
62 GSTA3 Glutathione S-transferase A3 [428] -2.49[429] [430] 0.47[431] 0.81[432] [433] [434]
63 UGT1A7 UDP-glucuronosyltransferase 1-7 [435] 3.02[436] [437] 2.52[438] 7.51[439] 3.75[440] 3.83[441]
64 ADH7 Alcohol dehydrogenase class 4 mu/sigma chain [442] [443] [444] [445] [446] [447] -2.43[448]
65 CYP2F1 Cytochrome P450 2F1 [449] 3.07[450] 1.37[451] 5.99[452] 4.24[453] 4.75[454] 1.55[455]
66 ALDH3B2 Aldehyde dehydrogenase family 3 member B2 [456] [457] [458] [459] [460] [461] [462]
67 UGT2A1 UDP-glucuronosyltransferase 2A1 [463] [464] [465] [466] [467] [468] [469]
68 GSTM5 Glutathione S-transferase Mu 5 [470] [471] [472] [473] [474] [475] [476]
69 UGT1A8 UDP-glucuronosyltransferase 1-8 [477] [478] [479] [480] [481] [482] [483]
70 UGT1A10 UDP-glucuronosyltransferase 1-10 [484] [485] [486] [487] [488] [489] [490]
[1]
ref_hepatocyte CYP2E1
Mean 1.39e+03
Standard deviation 1.9e+03
Values 0 4.6 2.7e+03 90 4.1e+03
[2]
HepG2 CYP2E1
Mean 0.133
Standard deviation 0.1
Values 0.21 0.06
[3]
HepG2.C3A CYP2E1
Mean 0.107
Standard deviation 0.15
Values 0.21 0
[4]
HuH.7 CYP2E1
Mean 0.975
Standard deviation 0.29
Values 0.67 1.3 0.99
[5]
SNU475 CYP2E1
Mean 0.0289
Standard deviation 0.005
Values 0.032 0.025
[6]
THLE CYP2E1
Mean 0.0955
Standard deviation 0.082
Values 0.15 0.037
[7]
liver CYP2E1
Mean 1.49e+03
Standard deviation 8.2e+02
Values 1e+03 2.6e+03 1.7e+03 6.9e+02
[8]
ref_hepatocyte AKR1C1
Mean 1e+03
Standard deviation 4.3e+02
Values 1.4e+03 1.3e+03 1e+03 9.2e+02 3.2e+02
[9]
HepG2 AKR1C1
Mean 329
Standard deviation 2.6e+02
Values 5.1e+02 1.5e+02
[10]
HepG2.C3A AKR1C1
Mean 233
Standard deviation 65
Values 2.8e+02 1.9e+02
[11]
HuH.7 AKR1C1
Mean 17.1
Standard deviation 16
Values 7.8 35 8.5
[12]
SNU475 AKR1C1
Mean 254
Standard deviation 82
Values 2e+02 3.1e+02
[13]
THLE AKR1C1
Mean 10.3
Standard deviation 0.06
Values 10 10
[14]
liver AKR1C1
Mean 75.6
Standard deviation 54
Values 67 63 1.5e+02 21
[15]
ref_hepatocyte MGST1
Mean 720
Standard deviation 4.5e+02
Values 2.4e+02 7.2e+02 7.8e+02 4.4e+02 1.4e+03
[16]
HepG2 MGST1
Mean 83.4
Standard deviation 3.7
Values 86 81
[17]
HepG2.C3A MGST1
Mean 58.5
Standard deviation 26
Values 40 77
[18]
HuH.7 MGST1
Mean 105
Standard deviation 17
Values 97 93 1.2e+02
[19]
SNU475 MGST1
Mean 70.5
Standard deviation 6
Values 66 75
[20]
THLE MGST1
Mean 128
Standard deviation 3.8
Values 1.3e+02 1.3e+02
[21]
liver MGST1
Mean 558
Standard deviation 6e+02
Values 62 9.8e+02 1.2e+03 31
[22]
ref_hepatocyte ADH1B
Mean 512
Standard deviation 8.3e+02
Values 0.096 0.69 6.3e+02 6.9 1.9e+03
[23]
HepG2 ADH1B
Mean 0.0866
Standard deviation 0.017
Values 0.074 0.099
[24]
HepG2.C3A ADH1B
Mean 0
Standard deviation 0
Values 0 0
[25]
HuH.7 ADH1B
Mean 0.991
Standard deviation 1.6
Values 0.049 2.9 0.028
[26]
SNU475 ADH1B
Mean 0
Standard deviation 0
Values 0 0
[27]
THLE ADH1B
Mean 0
Standard deviation 0
Values 0 0
[28]
liver ADH1B
Mean 756
Standard deviation 3.8e+02
Values 5.3e+02 1.3e+03 5.5e+02 6.2e+02
[29]
ref_hepatocyte GSTA1
Mean 456
Standard deviation 5.8e+02
Values 1.3e+02 2.2e+02 4.8e+02 8.4 1.4e+03
[30]
HepG2 GSTA1
Mean 20.3
Standard deviation 5.9
Values 16 24
[31]
HepG2.C3A GSTA1
Mean 1.31
Standard deviation 0.69
Values 0.83 1.8
[32]
HuH.7 GSTA1
Mean 93.3
Standard deviation 39
Values 95 53 1.3e+02
[33]
SNU475 GSTA1
Mean 3.21
Standard deviation 3.3
Values 5.5 0.88
[34]
THLE GSTA1
Mean 0.127
Standard deviation 0.11
Values 0.21 0.048
[35]
liver GSTA1
Mean 52.8
Standard deviation 52
Values 29 48 1.3e+02 6.8
[36]
ref_hepatocyte ADH4
Mean 397
Standard deviation 7e+02
Values 29 4.9 3.3e+02 1.5 1.6e+03
[37]
HepG2 ADH4
Mean 9.95
Standard deviation 0.32
Values 9.7 10
[38]
HepG2.C3A ADH4
Mean 6.21
Standard deviation 2.8
Values 4.3 8.2
[39]
HuH.7 ADH4
Mean 0.326
Standard deviation 0.33
Values 0.2 0.71 0.075
[40]
SNU475 ADH4
Mean 0.0236
Standard deviation 0.019
Values 0.037 0.01
[41]
THLE ADH4
Mean 0.103
Standard deviation 0.02
Values 0.089 0.12
[42]
liver ADH4
Mean 102
Standard deviation 66
Values 40 1.9e+02 58 1.2e+02
[43]
ref_hepatocyte ADH1A
Mean 362
Standard deviation 6e+02
Values 0 0.45 4.1e+02 9.8 1.4e+03
[44]
HepG2 ADH1A
Mean 0.0229
Standard deviation 0.016
Values 0.011 0.034
[45]
HepG2.C3A ADH1A
Mean 0
Standard deviation 0
Values 0 0
[46]
HuH.7 ADH1A
Mean 0.465
Standard deviation 0.75
Values 0.057 1.3 0.0094
[47]
SNU475 ADH1A
Mean 0.00253
Standard deviation 0.0036
Values 0 0.0051
[48]
THLE ADH1A
Mean 0
Standard deviation 0
Values 0 0
[49]
liver ADH1A
Mean 135
Standard deviation 1.5e+02
Values 47 3.6e+02 93 38
[50]
ref_hepatocyte CYP2C8
Mean 328
Standard deviation 4.4e+02
Values 0 1.2 7.1e+02 19 9.1e+02
[51]
HepG2 CYP2C8
Mean 0.00788
Standard deviation 0.0051
Values 0.011 0.0043
[52]
HepG2.C3A CYP2C8
Mean 0.186
Standard deviation 0.071
Values 0.14 0.24
[53]
HuH.7 CYP2C8
Mean 0.822
Standard deviation 1
Values 0.16 2 0.3
[54]
SNU475 CYP2C8
Mean 0.0515
Standard deviation 0.02
Values 0.037 0.066
[55]
THLE CYP2C8
Mean 0
Standard deviation 0
Values 0 0
[56]
liver CYP2C8
Mean 666
Standard deviation 3.9e+02
Values 6.2e+02 6.8e+02 1.2e+03 2e+02
[57]
ref_hepatocyte EPHX1
Mean 300
Standard deviation 3.6e+02
Values 43 21 7.2e+02 48 6.7e+02
[58]
HepG2 EPHX1
Mean 80.5
Standard deviation 9
Values 87 74
[59]
HepG2.C3A EPHX1
Mean 25.6
Standard deviation 6.3
Values 30 21
[60]
HuH.7 EPHX1
Mean 13.6
Standard deviation 1.2
Values 14 14 12
[61]
SNU475 EPHX1
Mean 243
Standard deviation 68
Values 2.9e+02 2e+02
[62]
THLE EPHX1
Mean 27.8
Standard deviation 0.14
Values 28 28
[63]
liver EPHX1
Mean 220
Standard deviation 1.4e+02
Values 3.1e+02 1.4e+02 3.7e+02 61
[64]
ref_hepatocyte CYP2C9
Mean 285
Standard deviation 4.1e+02
Values 0.064 20 4.7e+02 21 9.2e+02
[65]
HepG2 CYP2C9
Mean 0
Standard deviation 0
Values 0 0
[66]
HepG2.C3A CYP2C9
Mean 0.00536
Standard deviation 0.0076
Values 0 0.011
[67]
HuH.7 CYP2C9
Mean 0.616
Standard deviation 0.63
Values 0.25 1.3 0.25
[68]
SNU475 CYP2C9
Mean 0.00696
Standard deviation 0.0098
Values 0.014 0
[69]
THLE CYP2C9
Mean 0.0136
Standard deviation 0.011
Values 0.0059 0.021
[70]
liver CYP2C9
Mean 822
Standard deviation 5.3e+02
Values 6.1e+02 8.6e+02 1.5e+03 2.9e+02
[71]
ref_hepatocyte CYP3A4
Mean 259
Standard deviation 4.1e+02
Values 0.24 11 3.2e+02 11 9.6e+02
[72]
HepG2 CYP3A4
Mean 0.167
Standard deviation 0.098
Values 0.097 0.24
[73]
HepG2.C3A CYP3A4
Mean 0.136
Standard deviation 0.096
Values 0.068 0.2
[74]
HuH.7 CYP3A4
Mean 0.0397
Standard deviation 0.029
Values 0.0082 0.064 0.047
[75]
SNU475 CYP3A4
Mean 0.00507
Standard deviation 0.0072
Values 0 0.01
[76]
THLE CYP3A4
Mean 0.0166
Standard deviation 0.0067
Values 0.012 0.021
[77]
liver CYP3A4
Mean 610
Standard deviation 5.3e+02
Values 6.4e+02 4.3e+02 1.3e+03 49
[78]
ref_hepatocyte AKR1C3
Mean 242
Standard deviation 1.8e+02
Values 99 4.4e+02 4.3e+02 1.1e+02 1.2e+02
[79]
HepG2 AKR1C3
Mean 111
Standard deviation 53
Values 1.5e+02 74
[80]
HepG2.C3A AKR1C3
Mean 152
Standard deviation 34
Values 1.8e+02 1.3e+02
[81]
HuH.7 AKR1C3
Mean 1.46
Standard deviation 0.83
Values 1.1 2.4 0.84
[82]
SNU475 AKR1C3
Mean 580
Standard deviation 2.8e+02
Values 7.8e+02 3.9e+02
[83]
THLE AKR1C3
Mean 4.84
Standard deviation 0.00088
Values 4.8 4.8
[84]
liver AKR1C3
Mean 75.4
Standard deviation 53
Values 67 51 1.5e+02 32
[85]
ref_hepatocyte UGT1A6
Mean 242
Standard deviation 2.6e+02
Values 0.45 1.7e+02 4.3e+02 11 5.9e+02
[86]
HepG2 UGT1A6
Mean 1.17
Standard deviation 0.86
Values 1.8 0.56
[87]
HepG2.C3A UGT1A6
Mean 0.00486
Standard deviation 0.0069
Values 0.0097 0
[88]
HuH.7 UGT1A6
Mean 0.277
Standard deviation 0.33
Values 0.041 0.65 0.14
[89]
SNU475 UGT1A6
Mean 1.9
Standard deviation 0.11
Values 2 1.8
[90]
THLE UGT1A6
Mean 0.0372
Standard deviation 0.053
Values 0 0.074
[91]
liver UGT1A6
Mean 23.2
Standard deviation 17
Values 34 9 42 8.2
[92]
ref_hepatocyte UGT2B4
Mean 210
Standard deviation 2.5e+02
Values 0.056 68 4.6e+02 15 5e+02
[93]
HepG2 UGT2B4
Mean 0.666
Standard deviation 0.42
Values 0.96 0.37
[94]
HepG2.C3A UGT2B4
Mean 0.523
Standard deviation 0.23
Values 0.36 0.69
[95]
HuH.7 UGT2B4
Mean 19.1
Standard deviation 13
Values 11 34 12
[96]
SNU475 UGT2B4
Mean 0.176
Standard deviation 0.04
Values 0.2 0.15
[97]
THLE UGT2B4
Mean 0.0175
Standard deviation 0.017
Values 0.03 0.0053
[98]
liver UGT2B4
Mean 509
Standard deviation 93
Values 5.3e+02 4.5e+02 6.3e+02 4.3e+02
[99]
ref_hepatocyte GSTA2
Mean 199
Standard deviation 3.4e+02
Values 27 48 1.2e+02 1.1 8e+02
[100]
HepG2 GSTA2
Mean 4.11
Standard deviation 1.5
Values 3.1 5.2
[101]
HepG2.C3A GSTA2
Mean 0.647
Standard deviation 0.13
Values 0.55 0.74
[102]
HuH.7 GSTA2
Mean 13.1
Standard deviation 7.6
Values 7.6 22 10
[103]
SNU475 GSTA2
Mean 0.525
Standard deviation 0.65
Values 0.98 0.066
[104]
THLE GSTA2
Mean 0.0506
Standard deviation 0.0038
Values 0.053 0.048
[105]
liver GSTA2
Mean 26.3
Standard deviation 39
Values 20 0.73 84 0.29
[106]
ref_hepatocyte AKR1C2
Mean 167
Standard deviation 1.2e+02
Values 1.2e+02 3.4e+02 2.3e+02 1.1e+02 40
[107]
HepG2 AKR1C2
Mean 199
Standard deviation 1.3e+02
Values 2.9e+02 1e+02
[108]
HepG2.C3A AKR1C2
Mean 42.9
Standard deviation 7.5
Values 48 38
[109]
HuH.7 AKR1C2
Mean 6.67
Standard deviation 6.9
Values 3 15 2.5
[110]
SNU475 AKR1C2
Mean 215
Standard deviation 34
Values 2.4e+02 1.9e+02
[111]
THLE AKR1C2
Mean 3.9
Standard deviation 0.29
Values 4.1 3.7
[112]
liver AKR1C2
Mean 106
Standard deviation 92
Values 1.1e+02 64 2.3e+02 19
[113]
ref_hepatocyte GSTO1
Mean 150
Standard deviation 1e+02
Values 51 1.2e+02 2.1e+02 79 3e+02
[114]
HepG2 GSTO1
Mean 86.3
Standard deviation 4.3
Values 83 89
[115]
HepG2.C3A GSTO1
Mean 126
Standard deviation 39
Values 98 1.5e+02
[116]
HuH.7 GSTO1
Mean 84.1
Standard deviation 20
Values 84 65 1e+02
[117]
SNU475 GSTO1
Mean 15.2
Standard deviation 0.17
Values 15 15
[118]
THLE GSTO1
Mean 77.6
Standard deviation 17
Values 66 90
[119]
liver GSTO1
Mean 92.1
Standard deviation 75
Values 39 1.4e+02 1.7e+02 19
[120]
ref_hepatocyte CYP3A5
Mean 139
Standard deviation 1.6e+02
Values 22 55 2e+02 35 3.9e+02
[121]
HepG2 CYP3A5
Mean 2.75
Standard deviation 2.1
Values 1.3 4.2
[122]
HepG2.C3A CYP3A5
Mean 11.4
Standard deviation 3.8
Values 14 8.7
[123]
HuH.7 CYP3A5
Mean 1.63
Standard deviation 1.6
Values 0.58 3.5 0.83
[124]
SNU475 CYP3A5
Mean 0.471
Standard deviation 0.12
Values 0.56 0.39
[125]
THLE CYP3A5
Mean 0.113
Standard deviation 0.032
Values 0.14 0.09
[126]
liver CYP3A5
Mean 424
Standard deviation 3.2e+02
Values 2.7e+02 9e+02 2.5e+02 2.8e+02
[127]
ref_hepatocyte ADH1C
Mean 132
Standard deviation 2e+02
Values 0.14 2.1 2e+02 4 4.5e+02
[128]
HepG2 ADH1C
Mean 0.00643
Standard deviation 0.0091
Values 0 0.013
[129]
HepG2.C3A ADH1C
Mean 0.0258
Standard deviation 0.009
Values 0.019 0.032
[130]
HuH.7 ADH1C
Mean 0.0645
Standard deviation 0.029
Values 0.041 0.096 0.056
[131]
SNU475 ADH1C
Mean 0.0673
Standard deviation 0.062
Values 0.023 0.11
[132]
THLE ADH1C
Mean 0.0148
Standard deviation 0.021
Values 0.03 0
[133]
liver ADH1C
Mean 86.2
Standard deviation 1.1e+02
Values 32 2.6e+02 44 13
[134]
ref_hepatocyte UGT2B7
Mean 122
Standard deviation 1.9e+02
Values 3.3 8.1 1.6e+02 5.3 4.3e+02
[135]
HepG2 UGT2B7
Mean 26.6
Standard deviation 9
Values 33 20
[136]
HepG2.C3A UGT2B7
Mean 26.2
Standard deviation 13
Values 17 35
[137]
HuH.7 UGT2B7
Mean 0.568
Standard deviation 0.44
Values 0.3 1.1 0.34
[138]
SNU475 UGT2B7
Mean 0.0439
Standard deviation 0.0096
Values 0.037 0.051
[139]
THLE UGT2B7
Mean 0.0166
Standard deviation 0.0067
Values 0.012 0.021
[140]
liver UGT2B7
Mean 121
Standard deviation 61
Values 77 1.7e+02 1.7e+02 61
[141]
ref_hepatocyte AKR1C4
Mean 105
Standard deviation 1.4e+02
Values 0 3.6 2.3e+02 1.7 2.8e+02
[142]
HepG2 AKR1C4
Mean 0.432
Standard deviation 0.36
Values 0.69 0.18
[143]
HepG2.C3A AKR1C4
Mean 1.97
Standard deviation 0.48
Values 1.6 2.3
[144]
HuH.7 AKR1C4
Mean 1.26
Standard deviation 0.56
Values 0.75 1.9 1.2
[145]
SNU475 AKR1C4
Mean 0.118
Standard deviation 0.055
Values 0.079 0.16
[146]
THLE AKR1C4
Mean 0.00296
Standard deviation 0.0042
Values 0.0059 0
[147]
liver AKR1C4
Mean 80.8
Standard deviation 62
Values 66 56 1.7e+02 30
[148]
ref_hepatocyte GSTK1
Mean 94
Standard deviation 81
Values 43 51 1.6e+02 16 2e+02
[149]
HepG2 GSTK1
Mean 25.5
Standard deviation 6
Values 21 30
[150]
HepG2.C3A GSTK1
Mean 33.8
Standard deviation 0.97
Values 34 33
[151]
HuH.7 GSTK1
Mean 38.4
Standard deviation 8.4
Values 40 30 46
[152]
SNU475 GSTK1
Mean 19.8
Standard deviation 7.5
Values 25 14
[153]
THLE GSTK1
Mean 14.9
Standard deviation 0.92
Values 16 14
[154]
liver GSTK1
Mean 65.4
Standard deviation 45
Values 28 1.1e+02 95 26
[155]
ref_hepatocyte UGT2B10
Mean 89.2
Standard deviation 1.3e+02
Values 13 1.3 1.2e+02 2.6 3.1e+02
[156]
HepG2 UGT2B10
Mean 14.5
Standard deviation 5.1
Values 11 18
[157]
HepG2.C3A UGT2B10
Mean 79.3
Standard deviation 33
Values 56 1e+02
[158]
HuH.7 UGT2B10
Mean 0.379
Standard deviation 0.38
Values 0.098 0.82 0.22
[159]
SNU475 UGT2B10
Mean 0.0293
Standard deviation 0.0087
Values 0.023 0.035
[160]
THLE UGT2B10
Mean 0.00296
Standard deviation 0.0042
Values 0.0059 0
[161]
liver UGT2B10
Mean 41.7
Standard deviation 22
Values 68 16 33 50
[162]
ref_hepatocyte CYP1A2
Mean 78.9
Standard deviation 1.3e+02
Values 0.4 18 71 0.97 3e+02
[163]
HepG2 CYP1A2
Mean 0.0901
Standard deviation 0.055
Values 0.052 0.13
[164]
HepG2.C3A CYP1A2
Mean 0.197
Standard deviation 0.066
Values 0.24 0.15
[165]
HuH.7 CYP1A2
Mean 0.12
Standard deviation 0.026
Values 0.11 0.1 0.15
[166]
SNU475 CYP1A2
Mean 0.134
Standard deviation 0.091
Values 0.07 0.2
[167]
THLE CYP1A2
Mean 0.112
Standard deviation 0.068
Values 0.16 0.064
[168]
liver CYP1A2
Mean 35.7
Standard deviation 24
Values 12 55 58 19
[169]
ref_hepatocyte MGST2
Mean 73.6
Standard deviation 69
Values 20 29 1.2e+02 25 1.7e+02
[170]
HepG2 MGST2
Mean 38.6
Standard deviation 7.7
Values 33 44
[171]
HepG2.C3A MGST2
Mean 89.8
Standard deviation 3.2
Values 88 92
[172]
HuH.7 MGST2
Mean 26.6
Standard deviation 6.5
Values 24 22 34
[173]
SNU475 MGST2
Mean 8.62
Standard deviation 2.3
Values 10 7
[174]
THLE MGST2
Mean 9.5
Standard deviation 0.2
Values 9.4 9.6
[175]
liver MGST2
Mean 27.6
Standard deviation 24
Values 7.8 59 35 8.6
[176]
ref_hepatocyte ADH6
Mean 72.8
Standard deviation 92
Values 50 11 72 1.2 2.3e+02
[177]
HepG2 ADH6
Mean 13.8
Standard deviation 5.3
Values 10 17
[178]
HepG2.C3A ADH6
Mean 20.8
Standard deviation 0.45
Values 21 20
[179]
HuH.7 ADH6
Mean 21.2
Standard deviation 7
Values 19 29 15
[180]
SNU475 ADH6
Mean 0.0743
Standard deviation 0.053
Values 0.037 0.11
[181]
THLE ADH6
Mean 0.0733
Standard deviation 0.013
Values 0.083 0.064
[182]
liver ADH6
Mean 63.7
Standard deviation 33
Values 30 1.1e+02 46 74
[183]
ref_hepatocyte UGT2B15
Mean 72.3
Standard deviation 99
Values 0.2 13 1.2e+02 3.3 2.3e+02
[184]
HepG2 UGT2B15
Mean 0.0487
Standard deviation 0.004
Values 0.046 0.051
[185]
HepG2.C3A UGT2B15
Mean 0.127
Standard deviation 0.013
Values 0.14 0.12
[186]
HuH.7 UGT2B15
Mean 0.2
Standard deviation 0.22
Values 0.066 0.45 0.084
[187]
SNU475 UGT2B15
Mean 0.0285
Standard deviation 0.019
Values 0.042 0.015
[188]
THLE UGT2B15
Mean 0.0219
Standard deviation 0.014
Values 0.012 0.032
[189]
liver UGT2B15
Mean 52
Standard deviation 21
Values 56 66 64 21
[190]
ref_hepatocyte UGT1A1
Mean 67.2
Standard deviation 89
Values 0.52 12 2.1e+02 15 96
[191]
HepG2 UGT1A1
Mean 1.8
Standard deviation 0.2
Values 1.9 1.7
[192]
HepG2.C3A UGT1A1
Mean 0.0209
Standard deviation 0.016
Values 0.0097 0.032
[193]
HuH.7 UGT1A1
Mean 0.72
Standard deviation 0.5
Values 0.57 1.3 0.31
[194]
SNU475 UGT1A1
Mean 24.4
Standard deviation 21
Values 39 9.8
[195]
THLE UGT1A1
Mean 0.0266
Standard deviation 0.038
Values 0 0.053
[196]
liver UGT1A1
Mean 92.4
Standard deviation 46
Values 83 1.1e+02 1.4e+02 34
[197]
ref_hepatocyte ADH5
Mean 65.9
Standard deviation 32
Values 84 59 61 19 1.1e+02
[198]
HepG2 ADH5
Mean 119
Standard deviation 17
Values 1.1e+02 1.3e+02
[199]
HepG2.C3A ADH5
Mean 104
Standard deviation 26
Values 86 1.2e+02
[200]
HuH.7 ADH5
Mean 144
Standard deviation 17
Values 1.3e+02 1.4e+02 1.6e+02
[201]
SNU475 ADH5
Mean 57.2
Standard deviation 13
Values 66 48
[202]
THLE ADH5
Mean 77.4
Standard deviation 11
Values 69 85
[203]
liver ADH5
Mean 73.2
Standard deviation 37
Values 49 1.2e+02 76 43
[204]
ref_hepatocyte UGT1A4
Mean 53.1
Standard deviation 73
Values 0 4.2 99 2.5 1.6e+02
[205]
HepG2 UGT1A4
Mean 0.00858
Standard deviation 0.012
Values 0 0.017
[206]
HepG2.C3A UGT1A4
Mean 0
Standard deviation 0
Values 0 0
[207]
HuH.7 UGT1A4
Mean 0.00954
Standard deviation 0.0096
Values 0 0.019 0.0094
[208]
SNU475 UGT1A4
Mean 0.031
Standard deviation 0.015
Values 0.042 0.02
[209]
THLE UGT1A4
Mean 0
Standard deviation 0
Values 0 0
[210]
liver UGT1A4
Mean 83.1
Standard deviation 65
Values 95 36 1.7e+02 32
[211]
ref_hepatocyte GSTT1
Mean 52
Standard deviation 58
Values 17 5 86 14 1.4e+02
[212]
HepG2 GSTT1
Mean 28
Standard deviation 9.8
Values 21 35
[213]
HepG2.C3A GSTT1
Mean 28.3
Standard deviation 1.1
Values 28 29
[214]
HuH.7 GSTT1
Mean 0.0218
Standard deviation 0.015
Values 0.0082 0.039 0.019
[215]
SNU475 GSTT1
Mean 0.0116
Standard deviation 0.016
Values 0.023 0
[216]
THLE GSTT1
Mean 4.36
Standard deviation 0.38
Values 4.6 4.1
[217]
liver GSTT1
Mean 36.9
Standard deviation 41
Values 8.6 50 89 0
[218]
ref_hepatocyte CYP2B6
Mean 49.6
Standard deviation 62
Values 0 4.1 1.3e+02 12 1e+02
[219]
HepG2 CYP2B6
Mean 0.138
Standard deviation 0.15
Values 0.24 0.034
[220]
HepG2.C3A CYP2B6
Mean 1.32
Standard deviation 0.56
Values 1.7 0.92
[221]
HuH.7 CYP2B6
Mean 3.27
Standard deviation 2.3
Values 2.1 5.9 1.9
[222]
SNU475 CYP2B6
Mean 0.0424
Standard deviation 0.04
Values 0.014 0.071
[223]
THLE CYP2B6
Mean 0.0237
Standard deviation 0.033
Values 0.047 0
[224]
liver CYP2B6
Mean 372
Standard deviation 5.3e+02
Values 3.2e+02 23 1.1e+03 7.4
[225]
ref_hepatocyte GSTZ1
Mean 46.1
Standard deviation 60
Values 4.8 6.8 66 9 1.4e+02
[226]
HepG2 GSTZ1
Mean 6.52
Standard deviation 0.28
Values 6.7 6.3
[227]
HepG2.C3A GSTZ1
Mean 9.98
Standard deviation 2.1
Values 11 8.5
[228]
HuH.7 GSTZ1
Mean 7.32
Standard deviation 1
Values 6.6 6.9 8.5
[229]
SNU475 GSTZ1
Mean 4.11
Standard deviation 1.9
Values 5.4 2.8
[230]
THLE GSTZ1
Mean 4.72
Standard deviation 0.55
Values 4.3 5.1
[231]
liver GSTZ1
Mean 18.6
Standard deviation 9.1
Values 7.5 28 16 23
[232]
ref_hepatocyte CYP1A1
Mean 43.8
Standard deviation 36
Values 77 43 17 0.06 82
[233]
HepG2 CYP1A1
Mean 4.39
Standard deviation 2.6
Values 6.2 2.6
[234]
HepG2.C3A CYP1A1
Mean 1.3
Standard deviation 0.1
Values 1.4 1.2
[235]
HuH.7 CYP1A1
Mean 15.8
Standard deviation 1.4
Values 14 17 17
[236]
SNU475 CYP1A1
Mean 1.8
Standard deviation 1.8
Values 0.49 3.1
[237]
THLE CYP1A1
Mean 1.38
Standard deviation 0.04
Values 1.4 1.4
[238]
liver CYP1A1
Mean 1.12
Standard deviation 0.58
Values 0.47 1.2 0.92 1.8
[239]
ref_hepatocyte CYP2C18
Mean 43
Standard deviation 35
Values 0 90 51 18 56
[240]
HepG2 CYP2C18
Mean 0.0336
Standard deviation 0.017
Values 0.046 0.021
[241]
HepG2.C3A CYP2C18
Mean 0.0107
Standard deviation 0.015
Values 0 0.021
[242]
HuH.7 CYP2C18
Mean 0.593
Standard deviation 0.1
Values 0.53 0.71 0.53
[243]
SNU475 CYP2C18
Mean 0.0076
Standard deviation 0.011
Values 0 0.015
[244]
THLE CYP2C18
Mean 0.0325
Standard deviation 0.029
Values 0.012 0.053
[245]
liver CYP2C18
Mean 44.5
Standard deviation 13
Values 57 36 54 31
[246]
ref_hepatocyte MGST3
Mean 29.9
Standard deviation 13
Values 15 35 48 20 33
[247]
HepG2 MGST3
Mean 14.5
Standard deviation 2.5
Values 13 16
[248]
HepG2.C3A MGST3
Mean 13.2
Standard deviation 1.3
Values 12 14
[249]
HuH.7 MGST3
Mean 21
Standard deviation 3.7
Values 19 19 25
[250]
SNU475 MGST3
Mean 30.6
Standard deviation 11
Values 38 23
[251]
THLE MGST3
Mean 33.4
Standard deviation 7.3
Values 28 39
[252]
liver MGST3
Mean 36.8
Standard deviation 33
Values 10 56 73 7.7
[253]
ref_hepatocyte CYP3A7
Mean 29.1
Standard deviation 41
Values 8.7 0.12 1e+02 5 32
[254]
HepG2 CYP3A7
Mean 0.531
Standard deviation 0.38
Values 0.26 0.8
[255]
HepG2.C3A CYP3A7
Mean 2.26
Standard deviation 0.013
Values 2.3 2.3
[256]
HuH.7 CYP3A7
Mean 0.0822
Standard deviation 0.074
Values 0.033 0.17 0.047
[257]
SNU475 CYP3A7
Mean 0
Standard deviation 0
Values 0 0
[258]
THLE CYP3A7
Mean 0.00858
Standard deviation 0.0046
Values 0.012 0.0053
[259]
liver CYP3A7
Mean 13
Standard deviation 12
Values 5.2 30 11 5.1
[260]
ref_hepatocyte CYP2C19
Mean 19.2
Standard deviation 30
Values 0 5.9 18 0 72
[261]
HepG2 CYP2C19
Mean 0
Standard deviation 0
Values 0 0
[262]
HepG2.C3A CYP2C19
Mean 0
Standard deviation 0
Values 0 0
[263]
HuH.7 CYP2C19
Mean 0.3
Standard deviation 0.27
Values 0.098 0.6 0.2
[264]
SNU475 CYP2C19
Mean 0.00232
Standard deviation 0.0033
Values 0.0046 0
[265]
THLE CYP2C19
Mean 0.00296
Standard deviation 0.0042
Values 0.0059 0
[266]
liver CYP2C19
Mean 81.4
Standard deviation 39
Values 92 65 1.3e+02 38
[267]
ref_hepatocyte UGT1A9
Mean 15.2
Standard deviation 13
Values 0 21 26 2.6 27
[268]
HepG2 UGT1A9
Mean 0.16
Standard deviation 0.057
Values 0.2 0.12
[269]
HepG2.C3A UGT1A9
Mean 0.00486
Standard deviation 0.0069
Values 0.0097 0
[270]
HuH.7 UGT1A9
Mean 0.0656
Standard deviation 0.056
Values 0.066 0.12 0.0094
[271]
SNU475 UGT1A9
Mean 0.273
Standard deviation 0.34
Values 0.51 0.03
[272]
THLE UGT1A9
Mean 0.00798
Standard deviation 0.011
Values 0 0.016
[273]
liver UGT1A9
Mean 13.9
Standard deviation 9.6
Values 22 8.7 22 3
[274]
ref_hepatocyte GSTA4
Mean 11.5
Standard deviation 10
Values 29 9.2 8 0.55 11
[275]
HepG2 GSTA4
Mean 11.2
Standard deviation 1.3
Values 10 12
[276]
HepG2.C3A GSTA4
Mean 12.1
Standard deviation 1.1
Values 11 13
[277]
HuH.7 GSTA4
Mean 26.2
Standard deviation 3.6
Values 25 24 30
[278]
SNU475 GSTA4
Mean 22.2
Standard deviation 8.7
Values 28 16
[279]
THLE GSTA4
Mean 6.87
Standard deviation 0.55
Values 6.5 7.3
[280]
liver GSTA4
Mean 5.88
Standard deviation 4
Values 2.3 11 7.6 2.9
[281]
ref_hepatocyte UGT2B17
Mean 10.8
Standard deviation 16
Values 0 1.3 15 1.3 37
[282]
HepG2 UGT2B17
Mean 0.0114
Standard deviation 0.0081
Values 0.0057 0.017
[283]
HepG2.C3A UGT2B17
Mean 0.0156
Standard deviation 0.0083
Values 0.0097 0.021
[284]
HuH.7 UGT2B17
Mean 0.00214
Standard deviation 0.0037
Values 0 0.0064 0
[285]
SNU475 UGT2B17
Mean 0
Standard deviation 0
Values 0 0
[286]
THLE UGT2B17
Mean 0
Standard deviation 0
Values 0 0
[287]
liver UGT2B17
Mean 6
Standard deviation 4.8
Values 8.6 3.7 11 0.5
[288]
ref_hepatocyte GSTM4
Mean 9.44
Standard deviation 5.5
Values 11 5.2 14 2.4 15
[289]
HepG2 GSTM4
Mean 11.9
Standard deviation 5
Values 8.4 15
[290]
HepG2.C3A GSTM4
Mean 7.23
Standard deviation 1
Values 8 6.5
[291]
HuH.7 GSTM4
Mean 7.9
Standard deviation 0.7
Values 8.4 7.1 8.2
[292]
SNU475 GSTM4
Mean 14.8
Standard deviation 7.9
Values 20 9.2
[293]
THLE GSTM4
Mean 1.82
Standard deviation 0.44
Values 2.1 1.5
[294]
liver GSTM4
Mean 11.3
Standard deviation 5.6
Values 5.7 18 14 7.7
[295]
ref_hepatocyte UGT2A3
Mean 7.91
Standard deviation 6.4
Values 18 5.7 9.3 0.33 6.3
[296]
HepG2 UGT2A3
Mean 42.4
Standard deviation 14
Values 33 52
[297]
HepG2.C3A UGT2A3
Mean 137
Standard deviation 28
Values 1.2e+02 1.6e+02
[298]
HuH.7 UGT2A3
Mean 0.775
Standard deviation 0.72
Values 0.33 1.6 0.39
[299]
SNU475 UGT2A3
Mean 0.11
Standard deviation 0.13
Values 0.2 0.02
[300]
THLE UGT2A3
Mean 0.0172
Standard deviation 0.0092
Values 0.024 0.011
[301]
liver UGT2A3
Mean 31.9
Standard deviation 15
Values 24 55 25 24
[302]
ref_hepatocyte GSTP1
Mean 6.16
Standard deviation 5.2
Values 0 2.2 6 13 9.9
[303]
HepG2 GSTP1
Mean 0.872
Standard deviation 0.24
Values 0.7 1
[304]
HepG2.C3A GSTP1
Mean 1.43
Standard deviation 0.0018
Values 1.4 1.4
[305]
HuH.7 GSTP1
Mean 283
Standard deviation 1e+02
Values 2.9e+02 1.8e+02 3.8e+02
[306]
SNU475 GSTP1
Mean 592
Standard deviation 1.2e+02
Values 6.7e+02 5.1e+02
[307]
THLE GSTP1
Mean 140
Standard deviation 16
Values 1.3e+02 1.5e+02
[308]
liver GSTP1
Mean 8.38
Standard deviation 7.4
Values 2 17 12 2.6
[309]
ref_hepatocyte UGT1A3
Mean 4.24
Standard deviation 4.8
Values 0 2.3 7.9 0.37 11
[310]
HepG2 UGT1A3
Mean 1.2
Standard deviation 0.2
Values 1.3 1.1
[311]
HepG2.C3A UGT1A3
Mean 0
Standard deviation 0
Values 0 0
[312]
HuH.7 UGT1A3
Mean 0.0101
Standard deviation 0.0024
Values 0.0082 0.013 0.0094
[313]
SNU475 UGT1A3
Mean 0.0911
Standard deviation 0.029
Values 0.11 0.071
[314]
THLE UGT1A3
Mean 0.00296
Standard deviation 0.0042
Values 0.0059 0
[315]
liver UGT1A3
Mean 14.2
Standard deviation 12
Values 21 2.5 28 5.8
[316]
ref_hepatocyte GSTT2
Mean 3.22
Standard deviation 3.2
Values 0 1.1 7.8 2.2 5.1
[317]
HepG2 GSTT2
Mean 0.0444
Standard deviation 0.022
Values 0.029 0.06
[318]
HepG2.C3A GSTT2
Mean 0.0102
Standard deviation 0.00071
Values 0.0097 0.011
[319]
HuH.7 GSTT2
Mean 0.00547
Standard deviation 0.0095
Values 0.016 0 0
[320]
SNU475 GSTT2
Mean 0.19
Standard deviation 0.13
Values 0.28 0.1
[321]
THLE GSTT2
Mean 0.671
Standard deviation 0.33
Values 0.44 0.9
[322]
liver GSTT2
Mean 0.384
Standard deviation 0.24
Values 0.16 0.73 0.36 0.29
[323]
ref_hepatocyte GSTM3
Mean 2.88
Standard deviation 2.5
Values 6.2 4.8 1.6 0.21 1.6
[324]
HepG2 GSTM3
Mean 32.9
Standard deviation 4.6
Values 30 36
[325]
HepG2.C3A GSTM3
Mean 18.6
Standard deviation 2.4
Values 17 20
[326]
HuH.7 GSTM3
Mean 3.57
Standard deviation 0.4
Values 3.4 3.3 4
[327]
SNU475 GSTM3
Mean 38.7
Standard deviation 3.4
Values 41 36
[328]
THLE GSTM3
Mean 38.5
Standard deviation 4.1
Values 41 36
[329]
liver GSTM3
Mean 11.7
Standard deviation 7.4
Values 4.8 22 13 7.3
[330]
ref_hepatocyte CYP1B1
Mean 2.62
Standard deviation 3.2
Values 0.024 8 2.7 0.92 1.4
[331]
HepG2 CYP1B1
Mean 0.0437
Standard deviation 0.019
Values 0.057 0.03
[332]
HepG2.C3A CYP1B1
Mean 0.0575
Standard deviation 0.04
Values 0.029 0.086
[333]
HuH.7 CYP1B1
Mean 0.95
Standard deviation 0.082
Values 0.87 1 0.95
[334]
SNU475 CYP1B1
Mean 13.6
Standard deviation 3.1
Values 16 11
[335]
THLE CYP1B1
Mean 93
Standard deviation 14
Values 1e+02 83
[336]
liver CYP1B1
Mean 7.5
Standard deviation 1.4
Values 7.4 6.9 9.5 6.2
[337]
ref_hepatocyte ALDH3A1
Mean 2.58
Standard deviation 5.2
Values 12 0.4 0.24 0 0.37
[338]
HepG2 ALDH3A1
Mean 1
Standard deviation 0.21
Values 1.2 0.85
[339]
HepG2.C3A ALDH3A1
Mean 0.0511
Standard deviation 0.0036
Values 0.049 0.054
[340]
HuH.7 ALDH3A1
Mean 0.294
Standard deviation 0.089
Values 0.36 0.19 0.33
[341]
SNU475 ALDH3A1
Mean 1.39
Standard deviation 0.1
Values 1.3 1.5
[342]
THLE ALDH3A1
Mean 0.187
Standard deviation 0.07
Values 0.24 0.14
[343]
liver ALDH3A1
Mean 0.614
Standard deviation 0.76
Values 0.59 0.071 1.7 0.11
[344]
ref_hepatocyte CYP3A43
Mean 1.46
Standard deviation 2.7
Values 0.059 0 1.1 0 6.1
[345]
HepG2 CYP3A43
Mean 0.112
Standard deviation 0.061
Values 0.069 0.15
[346]
HepG2.C3A CYP3A43
Mean 0.735
Standard deviation 0.42
Values 1 0.44
[347]
HuH.7 CYP3A43
Mean 0.622
Standard deviation 0.91
Values 0.057 1.7 0.14
[348]
SNU475 CYP3A43
Mean 0
Standard deviation 0
Values 0 0
[349]
THLE CYP3A43
Mean 0.00266
Standard deviation 0.0038
Values 0 0.0053
[350]
liver CYP3A43
Mean 5.41
Standard deviation 4.2
Values 2.9 12 3.4 3.6
[351]
ref_hepatocyte GSTO2
Mean 1.37
Standard deviation 1.2
Values 0.43 0.34 3.3 0.98 1.8
[352]
HepG2 GSTO2
Mean 1.28
Standard deviation 0.51
Values 1.6 0.92
[353]
HepG2.C3A GSTO2
Mean 7.24
Standard deviation 0.65
Values 7.7 6.8
[354]
HuH.7 GSTO2
Mean 1.29
Standard deviation 0.42
Values 1.1 0.96 1.8
[355]
SNU475 GSTO2
Mean 0.0882
Standard deviation 0.033
Values 0.065 0.11
[356]
THLE GSTO2
Mean 0.444
Standard deviation 0.026
Values 0.43 0.46
[357]
liver GSTO2
Mean 0.821
Standard deviation 0.41
Values 0.81 0.63 1.4 0.45
[358]
ref_hepatocyte ALDH3B1
Mean 1.3
Standard deviation 0.3
Values 1.8 1.2 1.1 1.2 1.2
[359]
HepG2 ALDH3B1
Mean 10.5
Standard deviation 1.5
Values 12 9.5
[360]
HepG2.C3A ALDH3B1
Mean 9.94
Standard deviation 4.7
Values 13 6.6
[361]
HuH.7 ALDH3B1
Mean 6.99
Standard deviation 0.87
Values 8 6.4 6.6
[362]
SNU475 ALDH3B1
Mean 64.9
Standard deviation 36
Values 91 39
[363]
THLE ALDH3B1
Mean 19.7
Standard deviation 1.7
Values 18 21
[364]
liver ALDH3B1
Mean 1.75
Standard deviation 0.18
Values 1.6 2 1.8 1.7
[365]
ref_hepatocyte GSTM2
Mean 0.961
Standard deviation 0.9
Values 1.9 0 1.3 0 1.7
[366]
HepG2 GSTM2
Mean 2.78
Standard deviation 0.68
Values 2.3 3.3
[367]
HepG2.C3A GSTM2
Mean 1.04
Standard deviation 0.29
Values 1.2 0.84
[368]
HuH.7 GSTM2
Mean 3.46
Standard deviation 0.18
Values 3.4 3.3 3.7
[369]
SNU475 GSTM2
Mean 4.89
Standard deviation 2.9
Values 7 2.8
[370]
THLE GSTM2
Mean 3.5
Standard deviation 0.29
Values 3.7 3.3
[371]
liver GSTM2
Mean 1.38
Standard deviation 0.62
Values 0.53 1.9 1.8 1.3
[372]
ref_hepatocyte CYP2S1
Mean 0.536
Standard deviation 0.51
Values 0.27 0.31 0.1 1.4 0.61
[373]
HepG2 CYP2S1
Mean 8.91
Standard deviation 2.7
Values 11 7
[374]
HepG2.C3A CYP2S1
Mean 3.61
Standard deviation 0.85
Values 4.2 3
[375]
HuH.7 CYP2S1
Mean 1.97
Standard deviation 1.2
Values 3 0.73 2.2
[376]
SNU475 CYP2S1
Mean 2.23
Standard deviation 1.5
Values 1.2 3.3
[377]
THLE CYP2S1
Mean 2.64
Standard deviation 0.9
Values 2 3.3
[378]
liver CYP2S1
Mean 0.486
Standard deviation 0.16
Values 0.4 0.38 0.72 0.45
[379]
ref_hepatocyte GSTM1
Mean 0.404
Standard deviation 0.25
Values 0.52 0.62 0.52 0 0.36
[380]
HepG2 GSTM1
Mean 0.18
Standard deviation 0.14
Values 0.08 0.28
[381]
HepG2.C3A GSTM1
Mean 0.0657
Standard deviation 0.017
Values 0.078 0.054
[382]
HuH.7 GSTM1
Mean 4.5
Standard deviation 1.1
Values 5.5 3.3 4.7
[383]
SNU475 GSTM1
Mean 12.6
Standard deviation 6.3
Values 17 8.2
[384]
THLE GSTM1
Mean 0.0417
Standard deviation 0.0088
Values 0.035 0.048
[385]
liver GSTM1
Mean 54
Standard deviation 35
Values 15 93 70 38
[386]
ref_hepatocyte UGT1A5
Mean 0.393
Standard deviation 0.32
Values 0 0.38 0.82 0.19 0.58
[387]
HepG2 UGT1A5
Mean 0.0114
Standard deviation 0.0081
Values 0.0057 0.017
[388]
HepG2.C3A UGT1A5
Mean 0
Standard deviation 0
Values 0 0
[389]
HuH.7 UGT1A5
Mean 0.00428
Standard deviation 0.0074
Values 0 0.013 0
[390]
SNU475 UGT1A5
Mean 0.0747
Standard deviation 0.012
Values 0.083 0.066
[391]
THLE UGT1A5
Mean 0
Standard deviation 0
Values 0 0
[392]
liver UGT1A5
Mean 1.38
Standard deviation 1.4
Values 3.4 0.31 0.98 0.85
[393]
ref_hepatocyte UGT2B11
Mean 0.391
Standard deviation 0.65
Values 0 0 1.5 0 0.46
[394]
HepG2 UGT2B11
Mean 1
Standard deviation 0.2
Values 0.86 1.1
[395]
HepG2.C3A UGT2B11
Mean 0.348
Standard deviation 0.19
Values 0.21 0.48
[396]
HuH.7 UGT2B11
Mean 0.795
Standard deviation 0.79
Values 0.31 1.7 0.37
[397]
SNU475 UGT2B11
Mean 0.00928
Standard deviation 0.013
Values 0.019 0
[398]
THLE UGT2B11
Mean 0
Standard deviation 0
Values 0 0
[399]
liver UGT2B11
Mean 0.98
Standard deviation 0.68
Values 0.59 2 0.49 0.87
[400]
ref_hepatocyte DHDH
Mean 0.294
Standard deviation 0.37
Values 0.88 0.44 0 0 0.15
[401]
HepG2 DHDH
Mean 0.532
Standard deviation 0.33
Values 0.77 0.3
[402]
HepG2.C3A DHDH
Mean 1.37
Standard deviation 0.57
Values 1.8 0.97
[403]
HuH.7 DHDH
Mean 0.34
Standard deviation 0.11
Values 0.29 0.26 0.47
[404]
SNU475 DHDH
Mean 0.16
Standard deviation 0.011
Values 0.17 0.15
[405]
THLE DHDH
Mean 0.257
Standard deviation 0.055
Values 0.3 0.22
[406]
liver DHDH
Mean 0.0189
Standard deviation 0.013
Values 0 0.024 0.026 0.026
[407]
ref_hepatocyte UGT2B28
Mean 0.294
Standard deviation 0.52
Values 0 0 0.28 0 1.2
[408]
HepG2 UGT2B28
Mean 0.642
Standard deviation 0.23
Values 0.81 0.48
[409]
HepG2.C3A UGT2B28
Mean 0.816
Standard deviation 0.45
Values 0.5 1.1
[410]
HuH.7 UGT2B28
Mean 0.0413
Standard deviation 0.043
Values 0.025 0.09 0.0094
[411]
SNU475 UGT2B28
Mean 0.00464
Standard deviation 0.0066
Values 0.0093 0
[412]
THLE UGT2B28
Mean 0
Standard deviation 0
Values 0 0
[413]
liver UGT2B28
Mean 0.714
Standard deviation 0.87
Values 1.1 0 1.8 0.013
[414]
ref_hepatocyte GSTA5
Mean 0.13
Standard deviation 0.18
Values 0 0.32 0 0 0.33
[415]
HepG2 GSTA5
Mean 0.00214
Standard deviation 0.003
Values 0 0.0043
[416]
HepG2.C3A GSTA5
Mean 0
Standard deviation 0
Values 0 0
[417]
HuH.7 GSTA5
Mean 0.00273
Standard deviation 0.0047
Values 0.0082 0 0
[418]
SNU475 GSTA5
Mean 0
Standard deviation 0
Values 0 0
[419]
THLE GSTA5
Mean 0
Standard deviation 0
Values 0 0
[420]
liver GSTA5
Mean 0
Standard deviation 0
Values 0 0 0 0
[421]
ref_hepatocyte ALDH1A3
Mean 0.115
Standard deviation 0.2
Values 0 0.47 0.043 0 0.065
[422]
HepG2 ALDH1A3
Mean 0.283
Standard deviation 0.2
Values 0.42 0.14
[423]
HepG2.C3A ALDH1A3
Mean 0.0156
Standard deviation 0.0083
Values 0.0097 0.021
[424]
HuH.7 ALDH1A3
Mean 0.0903
Standard deviation 0.069
Values 0.16 0.096 0.019
[425]
SNU475 ALDH1A3
Mean 3.5
Standard deviation 1.1
Values 2.7 4.3
[426]
THLE ALDH1A3
Mean 136
Standard deviation 53
Values 99 1.7e+02
[427]
liver ALDH1A3
Mean 2.13
Standard deviation 0.67
Values 2.4 1.3 1.9 2.9
[428]
ref_hepatocyte GSTA3
Mean 0.0781
Standard deviation 0.11
Values 0 0 0.15 0 0.24
[429]
HepG2 GSTA3
Mean 0.00214
Standard deviation 0.003
Values 0 0.0043
[430]
HepG2.C3A GSTA3
Mean 0
Standard deviation 0
Values 0 0
[431]
HuH.7 GSTA3
Mean 0.0121
Standard deviation 0.014
Values 0.0082 0 0.028
[432]
SNU475 GSTA3
Mean 0.0359
Standard deviation 0.015
Values 0.046 0.025
[433]
THLE GSTA3
Mean 0
Standard deviation 0
Values 0 0
[434]
liver GSTA3
Mean 0
Standard deviation 0
Values 0 0 0 0
[435]
ref_hepatocyte UGT1A7
Mean 0.0431
Standard deviation 0.096
Values 0 0 0.22 0 0
[436]
HepG2 UGT1A7
Mean 0.0537
Standard deviation 0.021
Values 0.069 0.039
[437]
HepG2.C3A UGT1A7
Mean 0
Standard deviation 0
Values 0 0
[438]
HuH.7 UGT1A7
Mean 0.0277
Standard deviation 0.011
Values 0.016 0.039 0.028
[439]
SNU475 UGT1A7
Mean 2.06
Standard deviation 1.2
Values 1.2 2.9
[440]
THLE UGT1A7
Mean 0.0556
Standard deviation 0.012
Values 0.047 0.064
[441]
liver UGT1A7
Mean 0.582
Standard deviation 0.83
Values 1.8 0.094 0.1 0.32
[442]
ref_hepatocyte ADH7
Mean 0.0374
Standard deviation 0.084
Values 0 0 0 0 0.19
[443]
HepG2 ADH7
Mean 0
Standard deviation 0
Values 0 0
[444]
HepG2.C3A ADH7
Mean 0
Standard deviation 0
Values 0 0
[445]
HuH.7 ADH7
Mean 0
Standard deviation 0
Values 0 0 0
[446]
SNU475 ADH7
Mean 0
Standard deviation 0
Values 0 0
[447]
THLE ADH7
Mean 0
Standard deviation 0
Values 0 0
[448]
liver ADH7
Mean 0.00662
Standard deviation 0.013
Values 0 0 0 0.026
[449]
ref_hepatocyte CYP2F1
Mean 0.026
Standard deviation 0.058
Values 0 0 0 0 0.13
[450]
HepG2 CYP2F1
Mean 0.0336
Standard deviation 0.007
Values 0.029 0.039
[451]
HepG2.C3A CYP2F1
Mean 0.00972
Standard deviation 0.014
Values 0.019 0
[452]
HuH.7 CYP2F1
Mean 0.185
Standard deviation 0.058
Values 0.16 0.25 0.14
[453]
SNU475 CYP2F1
Mean 0.129
Standard deviation 0.047
Values 0.16 0.096
[454]
THLE CYP2F1
Mean 0.0674
Standard deviation 0.0051
Values 0.071 0.064
[455]
liver CYP2F1
Mean 0.0726
Standard deviation 0.035
Values 0.071 0.024 0.1 0.093
[456]
ref_hepatocyte ALDH3B2
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[457]
HepG2 ALDH3B2
Mean 0.00214
Standard deviation 0.003
Values 0 0.0043
[458]
HepG2.C3A ALDH3B2
Mean 0.00486
Standard deviation 0.0069
Values 0.0097 0
[459]
HuH.7 ALDH3B2
Mean 0.00214
Standard deviation 0.0037
Values 0 0.0064 0
[460]
SNU475 ALDH3B2
Mean 0.0312
Standard deviation 0.0083
Values 0.037 0.025
[461]
THLE ALDH3B2
Mean 0.0112
Standard deviation 0.00084
Values 0.012 0.011
[462]
liver ALDH3B2
Mean 0.00331
Standard deviation 0.0066
Values 0 0 0 0.013
[463]
ref_hepatocyte UGT2A1
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[464]
HepG2 UGT2A1
Mean 0.00214
Standard deviation 0.003
Values 0 0.0043
[465]
HepG2.C3A UGT2A1
Mean 0.00536
Standard deviation 0.0076
Values 0 0.011
[466]
HuH.7 UGT2A1
Mean 0
Standard deviation 0
Values 0 0 0
[467]
SNU475 UGT2A1
Mean 0.015
Standard deviation 0.015
Values 0.0046 0.025
[468]
THLE UGT2A1
Mean 0
Standard deviation 0
Values 0 0
[469]
liver UGT2A1
Mean 0.00999
Standard deviation 0.012
Values 0.014 0 0.026 0
[470]
ref_hepatocyte GSTM5
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[471]
HepG2 GSTM5
Mean 0.00429
Standard deviation 0.0061
Values 0 0.0086
[472]
HepG2.C3A GSTM5
Mean 0
Standard deviation 0
Values 0 0
[473]
HuH.7 GSTM5
Mean 0.00273
Standard deviation 0.0047
Values 0.0082 0 0
[474]
SNU475 GSTM5
Mean 0.0127
Standard deviation 0.018
Values 0 0.025
[475]
THLE GSTM5
Mean 0
Standard deviation 0
Values 0 0
[476]
liver GSTM5
Mean 0.506
Standard deviation 0.46
Values 0.16 1.1 0.62 0.15
[477]
ref_hepatocyte UGT1A8
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[478]
HepG2 UGT1A8
Mean 0
Standard deviation 0
Values 0 0
[479]
HepG2.C3A UGT1A8
Mean 0
Standard deviation 0
Values 0 0
[480]
HuH.7 UGT1A8
Mean 0.0407
Standard deviation 0.027
Values 0.033 0.071 0.019
[481]
SNU475 UGT1A8
Mean 0.152
Standard deviation 0.028
Values 0.17 0.13
[482]
THLE UGT1A8
Mean 0
Standard deviation 0
Values 0 0
[483]
liver UGT1A8
Mean 0.0104
Standard deviation 0.014
Values 0.029 0 0 0.013
[484]
ref_hepatocyte UGT1A10
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[485]
HepG2 UGT1A10
Mean 0.00788
Standard deviation 0.0051
Values 0.011 0.0043
[486]
HepG2.C3A UGT1A10
Mean 0
Standard deviation 0
Values 0 0
[487]
HuH.7 UGT1A10
Mean 0.115
Standard deviation 0.078
Values 0.066 0.21 0.075
[488]
SNU475 UGT1A10
Mean 0.012
Standard deviation 0.0027
Values 0.014 0.01
[489]
THLE UGT1A10
Mean 0
Standard deviation 0
Values 0 0
[490]
liver UGT1A10
Mean 0.0104
Standard deviation 0.014
Values 0.029 0 0 0.013