KEGG_MELANOMA | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | CDKN1A | Cyclin-dependent kinase inhibitor 1 | [1] | -0.07[2] | -1.24[3] | -4.03[4] | -2.61[5] | -0.14[6] | -2.52[7] |
2 | AKT1 | RAC-alpha serine/threonine-protein kinase | [8] | -0.83[9] | -0.84[10] | -2.02[11] | -0.68[12] | -0.74[13] | -0.93[14] |
3 | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1 | [15] | -1.84[16] | -1.94[17] | -1.47[18] | -1.17[19] | -0.74[20] | -1.88[21] |
4 | MAP2K2 | Dual specificity mitogen-activated protein kinase kinase 2 | [22] | -0.85[23] | -0.95[24] | -0.19[25] | -1.47[26] | -1.06[27] | -2.39[28] |
5 | CCND1 | G1/S-specific cyclin-D1 | [29] | 2.14[30] | -0.14[31] | 0.59[32] | 1.25[33] | -0.31[34] | 0.37[35] |
6 | CDK4 | Cyclin-dependent kinase 4 | [36] | 0.42[37] | 1.23[38] | 0.75[39] | -0.45[40] | 0.12[41] | -1.52[42] |
7 | IGF1 | Insulin-like growth factor I | [43] | -9.33[44] | -10.04[45] | -8.36[46] | -2.17[47] | -10.08[48] | 0.23[49] |
8 | BAD | Bcl2-associated agonist of cell death | [50] | -2.58[51] | -2.23[52] | -3.28[53] | -1.69[54] | -1.37[55] | -2.11[56] |
9 | RAF1 | RAF proto-oncogene serine/threonine-protein kinase | [57] | -0.97[58] | -0.34[59] | 0.82[60] | -0.81[61] | -0.03[62] | 0.41[63] |
10 | NRAS | GTPase NRas | [64] | -0.28[65] | 0.38[66] | 0.68[67] | 0.37[68] | -0.14[69] | -0.94[70] |
11 | MET | Hepatocyte growth factor receptor | [71] | -0.82[72] | -0.57[73] | -0.05[74] | 0.91[75] | -0.45[76] | 0.28[77] |
12 | ARAF | Serine/threonine-protein kinase A-Raf | [78] | -1.36[79] | -1.45[80] | -1.28[81] | -0.72[82] | -0.77[83] | 0.19[84] |
13 | CDH1 | Cadherin-1 | [85] | 0.21[86] | 0.92[87] | 1.34[88] | -3.80[89] | -8.13[90] | 0.88[91] |
14 | HRAS | GTPase HRas | [92] | -1.91[93] | -2.40[94] | -3.30[95] | -1.58[96] | -1.87[97] | -3.35[98] |
15 | MAPK1 | Mitogen-activated protein kinase 1 | [99] | 0.80[100] | 1.16[101] | 0.88[102] | 1.22[103] | 0.79[104] | 1.09[105] |
16 | AKT2 | RAC-beta serine/threonine-protein kinase | [106] | 0.05[107] | 0.55[108] | 0.57[109] | 0.23[110] | -0.06[111] | 0.44[112] |
17 | KRAS | GTPase KRas | [113] | -1.42[114] | -1.22[115] | 0.27[116] | 0.17[117] | -0.25[118] | -0.01[119] |
18 | FGF21 | Fibroblast growth factor 21 | [120] | -9.62[121] | -11.40[122] | -7.89[123] | -9.88[124] | -10.44[125] | -2.90[126] |
19 | PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha | [127] | -1.38[128] | -1.04[129] | -0.05[130] | 1.44[131] | 0.86[132] | 2.32[133] |
20 | PTEN | Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protei | -1.45[134] | 0.17[135] | 0.26[136] | -1.19[137] | -0.02[138] | 1.79[139] | |
21 | MDM2 | E3 ubiquitin-protein ligase Mdm2 | [140] | 1.20[141] | 2.84[142] | -0.03[143] | -0.12[144] | 0.68[145] | 1.48[146] |
22 | EGFR | Epidermal growth factor receptor | [147] | -1.60[148] | -1.76[149] | 1.02[150] | -0.19[151] | 0.34[152] | 1.97[153] |
23 | TP53 | Cellular tumor antigen p53 | [154] | 0.73[155] | 0.51[156] | 1.17[157] | 0.66[158] | 0.25[159] | -0.73[160] |
24 | PIK3R2 | Phosphatidylinositol 3-kinase regulatory subunit beta | [161] | 0.97[162] | 1.41[163] | 1.91[164] | 0.08[165] | 0.56[166] | -0.98[167] |
25 | PDGFC | Platelet-derived growth factor C | [168] | -2.18[169] | -1.02[170] | -1.19[171] | 0.27[172] | 0.43[173] | -0.48[174] |
26 | MAPK3 | Mitogen-activated protein kinase 3 | [175] | 0.94[176] | 1.21[177] | 1.14[178] | -0.20[179] | -0.26[180] | -1.73[181] |
27 | CDK6 | Cyclin-dependent kinase 6 | [182] | 1.14[183] | 2.06[184] | 0.36[185] | 0.29[186] | 1.01[187] | 1.39[188] |
28 | FGF2 | Fibroblast growth factor 2 | [189] | -7.59[190] | -7.12[191] | -3.07[192] | 0.31[193] | 1.81[194] | -2.35[195] |
29 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 0.30[196] | 1.03[197] | 1.09[198] | 0.42[199] | 0.50[200] | 0.47[201] | |
30 | RB1 | Retinoblastoma-associated protein | [202] | 0.31[203] | 1.03[204] | 1.49[205] | 1.65[206] | 1.89[207] | 0.79[208] |
31 | E2F1 | Transcription factor E2F1 | [209] | 1.04[210] | 1.12[211] | 1.14[212] | 1.24[213] | 1.60[214] | -4.30[215] |
32 | MITF | Microphthalmia-associated transcription factor | [216] | -5.24[217] | -5.94[218] | -7.91[219] | 0.65[220] | -1.17[221] | -1.44[222] |
33 | E2F3 | Transcription factor E2F3 | [223] | 0.81[224] | 0.86[225] | 0.01[226] | 2.00[227] | 1.37[228] | -0.85[229] |
34 | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | -1.29[230] | 0.57[231] | 0.65[232] | 0.50[233] | 0.62[234] | 1.23[235] | |
35 | PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | 0.98[236] | 2.29[237] | -1.63[238] | -0.35[239] | 0.34[240] | -0.39[241] | |
36 | PDGFA | Platelet-derived growth factor subunit A | [242] | -1.91[243] | -1.48[244] | 0.50[245] | -0.97[246] | -1.96[247] | -1.44[248] |
37 | BRAF | Serine/threonine-protein kinase B-raf | [249] | -0.66[250] | -0.71[251] | 1.22[252] | 0.11[253] | -0.27[254] | 1.17[255] |
38 | FGF13 | Fibroblast growth factor 13 | [256] | -4.52[257] | -5.61[258] | [259] | -8.94[260] | -8.90[261] | -1.94[262] |
39 | FGFR1 | Fibroblast growth factor receptor 1 | [263] | 3.67[264] | 2.21[265] | 3.75[266] | 4.43[267] | 3.62[268] | 0.97[269] |
40 | IGF1R | Insulin-like growth factor 1 receptor | [270] | 3.84[271] | 3.37[272] | 1.93[273] | 3.84[274] | 3.31[275] | 1.40[276] |
41 | PDGFB | Platelet-derived growth factor subunit B | [277] | 2.15[278] | 2.23[279] | -0.69[280] | -0.56[281] | -1.07[282] | -0.31[283] |
42 | FGF7 | Fibroblast growth factor 7 | [284] | -10.20[285] | -6.28[286] | [287] | -6.00[288] | -1.81[289] | -2.14[290] |
43 | PDGFRA | Platelet-derived growth factor receptor alpha | [291] | -4.53[292] | -5.28[293] | 2.24[294] | -0.10[295] | 4.49[296] | 4.63[297] |
44 | PDGFRB | Platelet-derived growth factor receptor beta | [298] | 0.39[299] | 1.01[300] | -1.55[301] | 1.23[302] | 1.71[303] | 2.73[304] |
45 | PIK3R3 | Phosphatidylinositol 3-kinase regulatory subunit gamma | [305] | 0.81[306] | 1.05[307] | 1.79[308] | 2.54[309] | 1.48[310] | 1.99[311] |
46 | AKT3 | RAC-gamma serine/threonine-protein kinase | [312] | -2.75[313] | -5.09[314] | -4.50[315] | 5.21[316] | 4.09[317] | 2.92[318] |
47 | PIK3R5 | Phosphoinositide 3-kinase regulatory subunit 5 | [319] | -8.07[320] | [321] | -3.32[322] | -4.55[323] | -4.29[324] | 1.65[325] |
48 | CDKN2A | Cyclin-dependent kinase inhibitor 2A | [326] | 3.18[327] | 1.16[328] | 4.46[329] | 4.58[330] | 6.28[331] | -2.84[332] |
49 | FGF5 | Fibroblast growth factor 5 | [333] | -1.90[334] | -0.36[335] | -0.54[336] | 0.86[337] | 0.46[338] | 2.45[339] |
50 | FGF11 | Fibroblast growth factor 11 | [340] | 3.04[341] | 3.09[342] | 3.94[343] | 1.89[344] | 0.35[345] | -1.22[346] |
51 | FGF14 | Fibroblast growth factor 14 | [347] | [348] | [349] | [350] | -3.94[351] | -2.31[352] | 1.26[353] |
52 | E2F2 | Transcription factor E2F2 | [354] | 3.34[355] | 4.45[356] | 3.86[357] | 3.42[358] | 3.67[359] | 0.73[360] |
53 | FGF1 | Fibroblast growth factor 1 | [361] | -3.67[362] | -2.66[363] | -7.23[364] | -0.04[365] | 1.46[366] | -0.65[367] |
54 | FGF19 | Fibroblast growth factor 19 | [368] | -2.97[369] | -1.59[370] | 5.04[371] | 0.20[372] | -3.35[373] | [374] |
55 | PIK3CG | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | [375] | [376] | [377] | 0.71[378] | -4.25[379] | 3.41[380] | |
56 | FGF12 | Fibroblast growth factor 12 | [381] | [382] | [383] | 1.90[384] | -2.33[385] | 2.76[386] | 1.91[387] |
57 | PDGFD | Platelet-derived growth factor D | [388] | 1.46[389] | -3.12[390] | -5.43[391] | 2.20[392] | 3.68[393] | 5.39[394] |
58 | HGF | Hepatocyte growth factor | [395] | [396] | [397] | -2.44[398] | 3.97[399] | 0.92[400] | 8.21[401] |
59 | FGF8 | Fibroblast growth factor 8 | [402] | -4.24[403] | -3.67[404] | 0.72[405] | -2.54[406] | [407] | 2.01[408] |
60 | FGF18 | Fibroblast growth factor 18 | [409] | 0.87[410] | -3.02[411] | -0.96[412] | -0.01[413] | 0.50[414] | -0.10[415] |
61 | FGF9 | Fibroblast growth factor 9 | [416] | 1.35[417] | -2.08[418] | [419] | 2.16[420] | -3.04[421] | -0.58[422] |
62 | EGF | Pro-epidermal growth factor | [423] | 1.06[424] | 3.07[425] | 6.58[426] | 8.40[427] | 5.74[428] | 0.89[429] |
63 | FGF16 | Fibroblast growth factor 16 | [430] | [431] | [432] | [433] | [434] | [435] | [436] |
64 | FGF6 | Fibroblast growth factor 6 | [437] | [438] | [439] | [440] | [441] | [442] | [443] |
65 | FGF17 | Fibroblast growth factor 17 | [444] | [445] | [446] | [447] | [448] | [449] | [450] |
66 | FGF3 | Fibroblast growth factor 3 | [451] | [452] | [453] | [454] | [455] | [456] | [457] |
67 | FGF10 | Fibroblast growth factor 10 | [458] | [459] | [460] | [461] | [462] | [463] | [464] |
68 | FGF22 | Fibroblast growth factor 22 | [465] | [466] | [467] | [468] | [469] | [470] | [471] |
69 | FGF20 | Fibroblast growth factor 20 | [472] | [473] | [474] | [475] | [476] | [477] | [478] |
70 | FGF23 | Fibroblast growth factor 23 | [479] | [480] | [481] | [482] | [483] | [484] | [485] |
71 | FGF4 | Fibroblast growth factor 4 | [486] | [487] | [488] | [489] | [490] | [491] | [492] |