KEGG_MELANOGENESIS | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | CALM2 | Calmodulin-2 | [1] | -1.52[2] | -0.74[3] | -2.42[4] | -1.90[5] | -1.47[6] | -1.60[7] |
2 | GNAS | Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas | 0.42[8] | 0.37[9] | -0.19[10] | 0.70[11] | 0.07[12] | -1.22[13] | |
3 | CREB3L3 | Cyclic AMP-responsive element-binding protein 3-like protein 3 | [14] | -5.18[15] | -3.36[16] | -2.07[17] | -10.03[18] | -8.60[19] | -0.01[20] |
4 | CALM3 | Calmodulin-3 | [21] | -0.07[22] | -0.42[23] | 0.57[24] | -0.48[25] | -0.50[26] | -2.00[27] |
5 | CTNNB1 | Catenin beta-1 | [28] | 1.61[29] | 1.02[30] | 1.70[31] | 0.61[32] | 0.97[33] | 1.22[34] |
6 | GNAI2 | Guanine nucleotide-binding protein G(i) subunit alpha-2 | [35] | 0.06[36] | -1.09[37] | -1.13[38] | -0.32[39] | 0.89[40] | -0.08[41] |
7 | CALM1 | Calmodulin-1 | [42] | 0.07[43] | 0.02[44] | 0.27[45] | 1.44[46] | 0.84[47] | 1.73[48] |
8 | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1 | [49] | -0.94[50] | -1.35[51] | -0.98[52] | -0.69[53] | -0.05[54] | -1.08[55] |
9 | MAP2K2 | Dual specificity mitogen-activated protein kinase kinase 2 | [56] | 0.05[57] | -0.36[58] | 0.30[59] | -0.99[60] | -0.37[61] | -1.58[62] |
10 | CREB3 | Cyclic AMP-responsive element-binding protein 3 | [63] | -0.64[64] | -0.83[65] | -1.54[66] | -1.32[67] | -0.70[68] | -1.00[69] |
11 | PRKACA | cAMP-dependent protein kinase catalytic subunit alpha | [70] | -0.17[71] | -0.44[72] | -0.64[73] | -0.62[74] | 0.11[75] | -0.66[76] |
12 | GNAI3 | Guanine nucleotide-binding protein G(k) subunit alpha | [77] | 0.12[78] | 0.57[79] | 0.46[80] | 0.96[81] | 0.72[82] | 0.35[83] |
13 | RAF1 | RAF proto-oncogene serine/threonine-protein kinase | [84] | -0.07[85] | 0.25[86] | 1.31[87] | -0.33[88] | 0.67[89] | 1.21[90] |
14 | NRAS | GTPase NRas | [91] | 0.62[92] | 0.97[93] | 1.17[94] | 0.85[95] | 0.56[96] | -0.13[97] |
15 | DVL1 | Segment polarity protein dishevelled homolog DVL-1 | [98] | 0.80[99] | 1.16[100] | -0.16[101] | -0.08[102] | 0.09[103] | -0.64[104] |
16 | HRAS | GTPase HRas | [105] | -1.02[106] | -1.81[107] | -2.81[108] | -1.10[109] | -1.18[110] | -2.54[111] |
17 | MAPK1 | Mitogen-activated protein kinase 1 | [112] | 1.70[113] | 1.75[114] | 1.37[115] | 1.70[116] | 1.48[117] | 1.89[118] |
18 | KRAS | GTPase KRas | [119] | -0.52[120] | -0.63[121] | 0.76[122] | 0.65[123] | 0.45[124] | 0.79[125] |
19 | WNT11 | Protein Wnt-11 | [126] | -1.43[127] | -7.23[128] | -6.41[129] | -6.68[130] | -6.97[131] | -2.97[132] |
20 | GNAI1 | Guanine nucleotide-binding protein G(i) subunit alpha-1 | [133] | -1.66[134] | -2.68[135] | -0.75[136] | 1.07[137] | 0.57[138] | 0.95[139] |
21 | CAMK2D | Calcium/calmodulin-dependent protein kinase type II subunit delta | [140] | 0.12[141] | 0.34[142] | 1.66[143] | 0.53[144] | -0.15[145] | 1.53[146] |
22 | FZD5 | Frizzled-5 | [147] | 0.96[148] | 1.74[149] | 2.53[150] | -1.28[151] | -2.46[152] | 2.70[153] |
23 | DVL3 | Segment polarity protein dishevelled homolog DVL-3 | [154] | 1.48[155] | 1.61[156] | 0.79[157] | 1.32[158] | 1.53[159] | 0.43[160] |
24 | MAPK3 | Mitogen-activated protein kinase 3 | [161] | 1.84[162] | 1.80[163] | 1.63[164] | 0.27[165] | 0.43[166] | -0.92[167] |
25 | GSK3B | Glycogen synthase kinase-3 beta | [168] | 1.26[169] | 0.81[170] | 1.17[171] | 1.67[172] | 1.63[173] | 1.28[174] |
26 | CREB3L2 | Cyclic AMP-responsive element-binding protein 3-like protein 2 | [175] | 2.39[176] | 2.66[177] | 2.50[178] | 1.76[179] | 1.53[180] | 1.82[181] |
27 | EDN1 | Endothelin-1 | [182] | -0.79[183] | -4.42[184] | -0.49[185] | -0.63[186] | -3.98[187] | -1.92[188] |
28 | CAMK2G | Calcium/calmodulin-dependent protein kinase type II subunit gamma | 0.77[189] | 1.89[190] | 1.30[191] | 1.54[192] | 1.23[193] | 1.07[194] | |
29 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | [195] | -0.84[196] | -0.15[197] | 0.92[198] | 2.08[199] | 1.08[200] | 1.83[201] |
30 | FZD4 | Frizzled-4 | [202] | 4.08[203] | 2.93[204] | 1.76[205] | 0.55[206] | 0.01[207] | 3.06[208] |
31 | ADCY9 | Adenylate cyclase type 9 | [209] | 2.61[210] | 1.71[211] | 1.93[212] | 0.81[213] | 0.49[214] | 2.53[215] |
32 | GNAO1 | Guanine nucleotide-binding protein G(o) subunit alpha | [216] | -6.44[217] | -8.10[218] | -7.47[219] | -2.73[220] | -6.46[221] | 0.60[222] |
33 | CREB3L4 | Cyclic AMP-responsive element-binding protein 3-like protein 4 | [223] | -0.59[224] | 0.28[225] | 1.28[226] | 0.23[227] | -0.47[228] | -0.56[229] |
34 | EP300 | Histone acetyltransferase p300 | [230] | 2.71[231] | 2.22[232] | 2.91[233] | 2.42[234] | 2.61[235] | 2.87[236] |
35 | PRKCA | Protein kinase C alpha type | [237] | 2.83[238] | 2.78[239] | 2.93[240] | 2.00[241] | 2.50[242] | 2.04[243] |
36 | TCF7L2 | Transcription factor 7-like 2 | [244] | 0.86[245] | 1.54[246] | 1.53[247] | 0.55[248] | 0.66[249] | 1.84[250] |
37 | DVL2 | Segment polarity protein dishevelled homolog DVL-2 | [251] | 2.11[252] | 1.77[253] | 2.55[254] | 2.08[255] | 1.86[256] | 0.13[257] |
38 | MITF | Microphthalmia-associated transcription factor | [258] | -4.35[259] | -5.35[260] | -7.43[261] | 1.13[262] | -0.48[263] | -0.64[264] |
39 | GNAQ | Guanine nucleotide-binding protein G(q) subunit alpha | [265] | 0.07[266] | 0.76[267] | 1.06[268] | 1.44[269] | 1.79[270] | 1.56[271] |
40 | ADCY6 | Adenylate cyclase type 6 | [272] | 2.04[273] | 2.42[274] | 2.17[275] | 2.36[276] | 3.16[277] | 2.75[278] |
41 | CREB1 | Cyclic AMP-responsive element-binding protein 1 | [279] | 1.71[280] | 2.78[281] | 3.06[282] | 2.39[283] | 2.47[284] | 2.46[285] |
42 | TCF7L1 | Transcription factor 7-like 1 | [286] | -3.06[287] | -1.34[288] | 0.65[289] | -1.97[290] | -1.71[291] | 0.41[292] |
43 | CREBBP | CREB-binding protein | [293] | 2.89[294] | 2.02[295] | 2.42[296] | 2.61[297] | 2.75[298] | 3.35[299] |
44 | TCF7 | Transcription factor 7 | [300] | 2.43[301] | 1.00[302] | -0.15[303] | 0.01[304] | -0.16[305] | -0.25[306] |
45 | PLCB3 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 | [307] | 2.00[308] | 1.39[309] | 1.65[310] | 2.56[311] | 2.34[312] | 0.84[313] |
46 | FZD6 | Frizzled-6 | [314] | 1.77[315] | 2.51[316] | -0.20[317] | 4.58[318] | 3.48[319] | 1.23[320] |
47 | PLCB1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 | [321] | 2.78[322] | 4.32[323] | 3.54[324] | 0.63[325] | 1.26[326] | 2.61[327] |
48 | FZD8 | Frizzled-8 | [328] | -3.14[329] | -8.56[330] | -1.39[331] | -3.11[332] | -1.77[333] | -0.08[334] |
49 | WNT3 | Proto-oncogene Wnt-3 | [335] | -0.39[336] | 0.47[337] | -1.66[338] | -0.72[339] | -1.92[340] | 0.30[341] |
50 | POMC | Pro-opiomelanocortin | [342] | [343] | -8.46[344] | [345] | [346] | -7.13[347] | -2.07[348] |
51 | ADCY1 | Adenylate cyclase type 1 | [349] | -0.84[350] | -2.80[351] | -3.21[352] | -2.26[353] | -2.14[354] | 5.11[355] |
52 | WNT5B | Protein Wnt-5b | [356] | -4.95[357] | -6.21[358] | 0.14[359] | 1.42[360] | -2.25[361] | -1.09[362] |
53 | PRKX | cAMP-dependent protein kinase catalytic subunit PRKX | [363] | -1.65[364] | -1.97[365] | 2.75[366] | 1.10[367] | 2.78[368] | 1.56[369] |
54 | CAMK2B | Calcium/calmodulin-dependent protein kinase type II subunit beta | [370] | -2.54[371] | -3.95[372] | -7.12[373] | -3.01[374] | -2.24[375] | 1.26[376] |
55 | ADCY7 | Adenylate cyclase type 7 | [377] | 3.50[378] | 3.04[379] | 1.79[380] | 3.16[381] | 2.77[382] | 3.04[383] |
56 | PLCB2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 | [384] | -1.63[385] | -6.50[386] | -8.55[387] | -2.08[388] | -2.66[389] | 2.35[390] |
57 | FZD7 | Frizzled-7 | [391] | 2.19[392] | -1.93[393] | 3.87[394] | 4.41[395] | 1.95[396] | 0.14[397] |
58 | EDNRB | Endothelin receptor type B | [398] | -4.40[399] | -2.84[400] | -6.44[401] | -2.58[402] | -3.61[403] | 5.78[404] |
59 | WNT4 | Protein Wnt-4 | [405] | -3.70[406] | -2.92[407] | -4.24[408] | -1.51[409] | -2.70[410] | 0.33[411] |
60 | FZD1 | Frizzled-1 | [412] | 1.54[413] | -0.51[414] | 2.96[415] | 2.27[416] | 3.53[417] | 2.90[418] |
61 | WNT5A | Protein Wnt-5a | [419] | -3.20[420] | -3.28[421] | -2.32[422] | 6.45[423] | 8.15[424] | 1.43[425] |
62 | PRKCB | Protein kinase C beta type | [426] | -6.82[427] | -5.71[428] | [429] | 2.33[430] | -2.84[431] | 3.65[432] |
63 | WNT7B | Protein Wnt-7b | [433] | 2.68[434] | 0.78[435] | 0.32[436] | 0.18[437] | -0.63[438] | -0.71[439] |
64 | FZD3 | Frizzled-3 | [440] | 2.92[441] | 3.77[442] | 5.26[443] | 3.65[444] | 3.01[445] | 3.76[446] |
65 | ASIP | Agouti-signaling protein | [447] | -1.97[448] | -2.18[449] | -2.46[450] | -2.24[451] | [452] | -1.65[453] |
66 | WNT9B | Protein Wnt-9b | [454] | -4.06[455] | -4.97[456] | -1.62[457] | [458] | [459] | -4.73[460] |
67 | FZD2 | Frizzled-2 | [461] | 1.14[462] | -0.56[463] | 1.94[464] | 6.74[465] | 4.33[466] | -0.24[467] |
68 | ADCY3 | Adenylate cyclase type 3 | [468] | 1.45[469] | 0.12[470] | 3.24[471] | 4.59[472] | 6.25[473] | 3.63[474] |
69 | CREB3L1 | Cyclic AMP-responsive element-binding protein 3-like protein 1 | [475] | -0.02[476] | -3.03[477] | 6.44[478] | 5.16[479] | 5.58[480] | -0.12[481] |
70 | MC1R | Melanocyte-stimulating hormone receptor | [482] | 5.48[483] | 5.97[484] | 1.94[485] | 3.30[486] | 2.95[487] | 1.22[488] |
71 | WNT9A | Protein Wnt-9a | [489] | 0.04[490] | -3.17[491] | -4.16[492] | 1.09[493] | -0.99[494] | -2.51[495] |
72 | KITLG | Kit ligand | [496] | 5.44[497] | 1.57[498] | 7.09[499] | 6.58[500] | 4.91[501] | 3.15[502] |
73 | FZD9 | Frizzled-9 | [503] | 1.41[504] | 1.51[505] | 1.05[506] | 1.99[507] | -0.18[508] | -0.28[509] |
74 | ADCY2 | Adenylate cyclase type 2 | [510] | -5.39[511] | -3.55[512] | -5.01[513] | -2.88[514] | -3.87[515] | -4.00[516] |
75 | KIT | Mast/stem cell growth factor receptor Kit | [517] | -3.00[518] | -4.97[519] | [520] | 2.35[521] | -3.04[522] | 3.75[523] |
76 | CALML3 | Calmodulin-like protein 3 | [524] | -2.62[525] | -2.53[526] | -5.27[527] | [528] | -3.18[529] | -2.23[530] |
77 | WNT2B | Protein Wnt-2b | [531] | -0.64[532] | 0.06[533] | -0.17[534] | 2.45[535] | 1.90[536] | 1.04[537] |
78 | LEF1 | Lymphoid enhancer-binding factor 1 | [538] | 2.64[539] | -4.37[540] | 3.34[541] | 0.93[542] | -0.64[543] | 1.20[544] |
79 | WNT16 | Protein Wnt-16 | [545] | [546] | [547] | [548] | 1.19[549] | -2.54[550] | 0.27[551] |
80 | TYRP1 | 5,6-dihydroxyindole-2-carboxylic acid oxidase | [552] | 0.76[553] | -2.09[554] | -1.60[555] | 7.70[556] | 3.54[557] | [558] |
81 | ADCY5 | Adenylate cyclase type 5 | [559] | 0.14[560] | 1.06[561] | 1.88[562] | 0.50[563] | 1.76[564] | 6.49[565] |
82 | WNT10A | Protein Wnt-10a | [566] | 1.24[567] | -2.19[568] | -5.10[569] | 3.40[570] | -2.24[571] | -1.37[572] |
83 | PRKCG | Protein kinase C gamma type | [573] | -0.83[574] | -0.24[575] | -2.83[576] | -1.21[577] | -1.17[578] | [579] |
84 | PLCB4 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 | [580] | 0.25[581] | 0.00[582] | 0.80[583] | 9.48[584] | 7.33[585] | 3.91[586] |
85 | WNT2 | Protein Wnt-2 | [587] | [588] | [589] | -2.31[590] | 0.79[591] | -3.01[592] | 6.34[593] |
86 | ADCY4 | Adenylate cyclase type 4 | [594] | 0.08[595] | -1.08[596] | 1.36[597] | [598] | [599] | 8.48[600] |
87 | CAMK2A | Calcium/calmodulin-dependent protein kinase type II subunit alpha | [601] | [602] | [603] | [604] | [605] | [606] | [607] |
88 | FZD10 | Frizzled-10 | [608] | [609] | [610] | [611] | [612] | [613] | [614] |
89 | WNT7A | Protein Wnt-7a | [615] | [616] | [617] | [618] | [619] | [620] | [621] |
90 | WNT8A | Protein Wnt-8a | [622] | [623] | [624] | [625] | [626] | [627] | [628] |
91 | WNT1 | Proto-oncogene Wnt-1 | [629] | [630] | [631] | [632] | [633] | [634] | [635] |
92 | WNT3A | Protein Wnt-3a | [636] | [637] | [638] | [639] | [640] | [641] | [642] |
93 | WNT10B | Protein Wnt-10b | [643] | [644] | [645] | [646] | [647] | [648] | [649] |
94 | WNT8B | Protein Wnt-8b | [650] | [651] | [652] | [653] | [654] | [655] | [656] |
95 | TYR | Tyrosinase | [657] | [658] | [659] | [660] | [661] | [662] | [663] |
96 | WNT6 | Protein Wnt-6 | [664] | [665] | [666] | [667] | [668] | [669] | [670] |
97 | CALML5 | Calmodulin-like protein 5 | [671] | [672] | [673] | [674] | [675] | [676] | [677] |
98 | ADCY8 | Adenylate cyclase type 8 | [678] | [679] | [680] | [681] | [682] | [683] | [684] |
99 | PRKACG | cAMP-dependent protein kinase catalytic subunit gamma | [685] | [686] | [687] | [688] | [689] | [690] | [691] |
100 | CALML6 | Calmodulin-like protein 6 | [692] | [693] | [694] | [695] | [696] | [697] | [698] |
101 | DCT | L-dopachrome tautomerase | [699] | [700] | [701] | [702] | [703] | [704] | [705] |