KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 SLC2A2 Solute carrier family 2, facilitated glucose transporter member 2 [1] -2.84[2] -2.58[3] -2.38[4] -3.07[5] -6.81[6] 0.50[7]
2 HNF4A Hepatocyte nuclear factor 4-alpha [8] 1.44[9] 1.40[10] 0.85[11] -3.31[12] -3.32[13] 0.50[14]
3 HHEX Hematopoietically-expressed homeobox protein HHEX [15] 0.11[16] 0.35[17] 0.43[18] 0.24[19] 0.54[20] -1.37[21]
4 FOXA3 Hepatocyte nuclear factor 3-gamma [22] -0.72[23] -0.06[24] -0.02[25] -3.79[26] -4.16[27] -2.38[28]
5 FOXA2 Hepatocyte nuclear factor 3-beta [29] 0.87[30] 0.66[31] 0.62[32] -3.83[33] -3.84[34] -1.82[35]
6 PKLR Pyruvate kinase PKLR [36] -1.51[37] -0.15[38] -2.32[39] -6.47[40] -5.75[41] -0.38[42]
7 HES1 Transcription factor HES-1 [43] -0.07[44] -3.09[45] -1.29[46] 2.43[47] 2.22[48] -2.74[49]
8 HNF1A Hepatocyte nuclear factor 1-alpha [50] 1.27[51] 1.08[52] 1.32[53] 0.34[54] 0.11[55] -1.15[56]
9 NR5A2 Nuclear receptor subfamily 5 group A member 2 [57] -3.52[58] -3.75[59] 1.33[60] -0.48[61] 4.47[62] 1.43[63]
10 BHLHA15 Class A basic helix-loop-helix protein 15 [64] -1.28[65] -2.11[66] -2.30[67] -2.89[68] -2.65[69] -2.22[70]
11 HNF1B Hepatocyte nuclear factor 1-beta [71] 0.17[72] -2.65[73] 1.01[74] 2.87[75] -2.93[76] -1.15[77]
12 HNF4G Hepatocyte nuclear factor 4-gamma [78] -0.60[79] 1.51[80] 1.24[81] 2.96[82] -1.76[83] 0.40[84]
13 ONECUT1 Hepatocyte nuclear factor 6 [85] -0.63[86] -0.02[87] 2.34[88] -4.01[89] -2.13[90] 1.73[91]
14 GCK Glucokinase [92] -7.59[93] -6.10[94] -9.75[95] -3.21[96] -0.65[97] 0.58[98]
15 IAPP Islet amyloid polypeptide [99] -1.52[100] -1.33[101] -1.61[102] 1.80[103] 2.49[104] -2.81[105]
16 MAFA Transcription factor MafA [106] 0.77[107] -1.39[108] -1.12[109] 0.28[110] 2.91[111] [112]
17 PAX6 Paired box protein Pax-6 [113] 6.03[114] 3.85[115] 5.06[116] 8.46[117] 5.92[118] 1.02[119]
18 PDX1 Pancreas/duodenum homeobox protein 1 [120] 0.76[121] -2.44[122] 5.02[123] 1.44[124] [125] 1.10[126]
19 MNX1 Motor neuron and pancreas homeobox protein 1 [127] 6.52[128] 6.02[129] 7.28[130] 6.50[131] 2.95[132] [133]
20 NKX2-2 Homeobox protein Nkx-2.2 [134] [135] [136] [137] [138] [139] [140]
21 PAX4 Paired box protein Pax-4 [141] [142] [143] [144] [145] [146] [147]
22 NEUROD1 Neurogenic differentiation factor 1 [148] [149] [150] [151] [152] [153] [154]
23 NKX6-1 Homeobox protein Nkx-6.1 [155] [156] [157] [158] [159] [160] [161]
24 INS Insulin [162] [163] [164] [165] [166] [167] [168]
25 NEUROG3 Neurogenin-3 [169] [170] [171] [172] [173] [174] [175]
[1]
ref_hepatocyte SLC2A2
Mean 50.4
Standard deviation 77
Values 3.6 23 39 0.5 1.9e+02
[2]
HepG2 SLC2A2
Mean 12.1
Standard deviation 6.3
Values 7.6 17
[3]
HepG2.C3A SLC2A2
Mean 18.4
Standard deviation 9.8
Values 11 25
[4]
HuH.7 SLC2A2
Mean 27.9
Standard deviation 5.4
Values 29 32 22
[5]
SNU475 SLC2A2
Mean 0.843
Standard deviation 0.21
Values 0.99 0.69
[6]
THLE SLC2A2
Mean 0.0458
Standard deviation 0.027
Values 0.065 0.027
[7]
liver SLC2A2
Mean 257
Standard deviation 32
Values 2.6e+02 2.5e+02 2.2e+02 2.9e+02
[8]
ref_hepatocyte HNF4A
Mean 22.2
Standard deviation 11
Values 30 11 30 9.6 30
[9]
HepG2 HNF4A
Mean 104
Standard deviation 5.9
Values 1e+02 1.1e+02
[10]
HepG2.C3A HNF4A
Mean 128
Standard deviation 15
Values 1.4e+02 1.2e+02
[11]
HuH.7 HNF4A
Mean 115
Standard deviation 13
Values 1.2e+02 1.2e+02 1e+02
[12]
SNU475 HNF4A
Mean 0.314
Standard deviation 0.14
Values 0.21 0.42
[13]
THLE HNF4A
Mean 0.228
Standard deviation 0.1
Values 0.3 0.15
[14]
liver HNF4A
Mean 113
Standard deviation 8.7
Values 1.1e+02 1.2e+02 1e+02 1.2e+02
[15]
ref_hepatocyte HHEX
Mean 14.9
Standard deviation 11
Values 16 3.5 21 4.7 29
[16]
HepG2 HHEX
Mean 27.6
Standard deviation 5.8
Values 24 32
[17]
HepG2.C3A HHEX
Mean 41.6
Standard deviation 0.72
Values 41 42
[18]
HuH.7 HHEX
Mean 57.8
Standard deviation 12
Values 48 71 54
[19]
SNU475 HHEX
Mean 2.46
Standard deviation 0.093
Values 2.4 2.5
[20]
THLE HHEX
Mean 2.22
Standard deviation 0.067
Values 2.2 2.3
[21]
liver HHEX
Mean 20.8
Standard deviation 17
Values 8.9 26 42 6.5
[22]
ref_hepatocyte FOXA3
Mean 12.4
Standard deviation 15
Values 0.59 1.2 18 5.3 37
[23]
HepG2 FOXA3
Mean 13
Standard deviation 1.4
Values 12 14
[24]
HepG2.C3A FOXA3
Mean 26.1
Standard deviation 5.7
Values 30 22
[25]
HuH.7 FOXA3
Mean 35.3
Standard deviation 3
Values 33 38 35
[26]
SNU475 FOXA3
Mean 0.126
Standard deviation 0.087
Values 0.065 0.19
[27]
THLE FOXA3
Mean 0.0713
Standard deviation 0.033
Values 0.095 0.048
[28]
liver FOXA3
Mean 8.61
Standard deviation 3.6
Values 6.9 10 13 4.6
[29]
ref_hepatocyte FOXA2
Mean 7.53
Standard deviation 2.5
Values 7.1 4.1 11 8.6 6.8
[30]
HepG2 FOXA2
Mean 23.7
Standard deviation 12
Values 32 15
[31]
HepG2.C3A FOXA2
Mean 26.1
Standard deviation 10
Values 33 19
[32]
HuH.7 FOXA2
Mean 33.3
Standard deviation 2.6
Values 31 36 33
[33]
SNU475 FOXA2
Mean 0.074
Standard deviation 0.033
Values 0.097 0.051
[34]
THLE FOXA2
Mean 0.0538
Standard deviation 0.016
Values 0.065 0.043
[35]
liver FOXA2
Mean 7.66
Standard deviation 5
Values 3.8 15 6.3 5.6
[36]
ref_hepatocyte PKLR
Mean 7.45
Standard deviation 8
Values 8.4 0.078 8.7 0.38 20
[37]
HepG2 PKLR
Mean 4.51
Standard deviation 1.3
Values 3.6 5.4
[38]
HepG2.C3A PKLR
Mean 14.7
Standard deviation 7.4
Values 20 9.5
[39]
HuH.7 PKLR
Mean 4.29
Standard deviation 1.9
Values 3.3 6.5 3.1
[40]
SNU475 PKLR
Mean 0.0118
Standard deviation 0.0095
Values 0.019 0.0051
[41]
THLE PKLR
Mean 0.0142
Standard deviation 0.005
Values 0.018 0.011
[42]
liver PKLR
Mean 20.6
Standard deviation 18
Values 5 46 9.8 22
[43]
ref_hepatocyte HES1
Mean 7.15
Standard deviation 5.3
Values 9.1 1 15 3.7 7
[44]
HepG2 HES1
Mean 11.7
Standard deviation 5.7
Values 16 7.7
[45]
HepG2.C3A HES1
Mean 1.84
Standard deviation 0.56
Values 2.2 1.4
[46]
HuH.7 HES1
Mean 8.41
Standard deviation 1.4
Values 6.9 8.7 9.7
[47]
SNU475 HES1
Mean 5.42
Standard deviation 0.41
Values 5.7 5.1
[48]
THLE HES1
Mean 3.42
Standard deviation 0.023
Values 3.4 3.4
[49]
liver HES1
Mean 3.86
Standard deviation 1.7
Values 3 6.2 4.1 2.2
[50]
ref_hepatocyte HNF1A
Mean 5.57
Standard deviation 2.4
Values 3.4 2.6 6.4 7.8 7.6
[51]
HepG2 HNF1A
Mean 23.2
Standard deviation 1.9
Values 24 22
[52]
HepG2.C3A HNF1A
Mean 25.8
Standard deviation 0.61
Values 26 25
[53]
HuH.7 HNF1A
Mean 40
Standard deviation 1.9
Values 38 41 41
[54]
SNU475 HNF1A
Mean 0.99
Standard deviation 0.31
Values 1.2 0.77
[55]
THLE HNF1A
Mean 0.614
Standard deviation 0.01
Values 0.62 0.61
[56]
liver HNF1A
Mean 9.06
Standard deviation 1.3
Values 7.4 9.8 10 8.6
[57]
ref_hepatocyte NR5A2
Mean 2.95
Standard deviation 1.8
Values 0.12 4.2 4 2.1 4.3
[58]
HepG2 NR5A2
Mean 0.442
Standard deviation 0.21
Values 0.29 0.59
[59]
HepG2.C3A NR5A2
Mean 0.482
Standard deviation 0.23
Values 0.64 0.32
[60]
HuH.7 NR5A2
Mean 21.3
Standard deviation 11
Values 17 34 13
[61]
SNU475 NR5A2
Mean 0.296
Standard deviation 0.025
Values 0.28 0.31
[62]
THLE NR5A2
Mean 6.69
Standard deviation 1.7
Values 5.5 7.9
[63]
liver NR5A2
Mean 28.7
Standard deviation 5.9
Values 28 37 24 26
[64]
ref_hepatocyte BHLHA15
Mean 2.23
Standard deviation 2.4
Values 0 1.5 2.9 6.1 0.59
[65]
HepG2 BHLHA15
Mean 1.58
Standard deviation 0.65
Values 2 1.1
[66]
HepG2.C3A BHLHA15
Mean 1.13
Standard deviation 0.14
Values 1.2 1
[67]
HuH.7 BHLHA15
Mean 1.3
Standard deviation 0.53
Values 0.96 1.9 1
[68]
SNU475 BHLHA15
Mean 0.042
Standard deviation 0.027
Values 0.023 0.061
[69]
THLE BHLHA15
Mean 0.0364
Standard deviation 0.0012
Values 0.035 0.037
[70]
liver BHLHA15
Mean 1.72
Standard deviation 1.1
Values 2.4 0.33 1.3 2.9
[71]
ref_hepatocyte HNF1B
Mean 2.16
Standard deviation 1.2
Values 0.97 1.2 2.6 4.1 2
[72]
HepG2 HNF1B
Mean 4.18
Standard deviation 0.91
Values 3.5 4.8
[73]
HepG2.C3A HNF1B
Mean 0.755
Standard deviation 0.14
Values 0.86 0.65
[74]
HuH.7 HNF1B
Mean 12.5
Standard deviation 0.66
Values 13 13 12
[75]
SNU475 HNF1B
Mean 2.21
Standard deviation 1.2
Values 3.1 1.3
[76]
THLE HNF1B
Mean 0.029
Standard deviation 0.026
Values 0.047 0.011
[77]
liver HNF1B
Mean 3.51
Standard deviation 2.7
Values 1.2 6 5.6 1.3
[78]
ref_hepatocyte HNF4G
Mean 2.02
Standard deviation 1.6
Values 1.8 1.1 1.4 4.8 1
[79]
HepG2 HNF4G
Mean 2.3
Standard deviation 0.24
Values 2.1 2.5
[80]
HepG2.C3A HNF4G
Mean 12.6
Standard deviation 0.36
Values 12 13
[81]
HuH.7 HNF4G
Mean 13.7
Standard deviation 4.6
Values 12 19 9.9
[82]
SNU475 HNF4G
Mean 2.21
Standard deviation 1.1
Values 3 1.4
[83]
THLE HNF4G
Mean 0.0612
Standard deviation 0.011
Values 0.053 0.069
[84]
liver HNF4G
Mean 9.62
Standard deviation 3.1
Values 13 7.3 7 11
[85]
ref_hepatocyte ONECUT1
Mean 1.06
Standard deviation 0.6
Values 1.1 0.85 1.5 0.18 1.7
[86]
HepG2 ONECUT1
Mean 1.19
Standard deviation 0.62
Values 0.75 1.6
[87]
HepG2.C3A ONECUT1
Mean 2.29
Standard deviation 0.26
Values 2.1 2.5
[88]
HuH.7 ONECUT1
Mean 15.6
Standard deviation 12
Values 14 28 4.7
[89]
SNU475 ONECUT1
Mean 0.00928
Standard deviation 0.013
Values 0.019 0
[90]
THLE ONECUT1
Mean 0.0248
Standard deviation 0.01
Values 0.018 0.032
[91]
liver ONECUT1
Mean 12.7
Standard deviation 2
Values 15 12 10 13
[92]
ref_hepatocyte GCK
Mean 0.642
Standard deviation 1.1
Values 0 0 0.7 0 2.5
[93]
HepG2 GCK
Mean 0.00573
Standard deviation 0.0081
Values 0.011 0
[94]
HepG2.C3A GCK
Mean 0.0204
Standard deviation 0.0014
Values 0.019 0.021
[95]
HuH.7 GCK
Mean 0.00214
Standard deviation 0.0037
Values 0 0.0064 0
[96]
SNU475 GCK
Mean 0.00971
Standard deviation 0.00061
Values 0.0093 0.01
[97]
THLE GCK
Mean 0.042
Standard deviation 0.00081
Values 0.041 0.043
[98]
liver GCK
Mean 3.47
Standard deviation 6.5
Values 0.17 13 0.13 0.38
[99]
ref_hepatocyte IAPP
Mean 0.301
Standard deviation 0.42
Values 0.52 0.94 0 0.03 0.0081
[100]
HepG2 IAPP
Mean 0.18
Standard deviation 0.012
Values 0.19 0.17
[101]
HepG2.C3A IAPP
Mean 0.263
Standard deviation 0.068
Values 0.31 0.21
[102]
HuH.7 IAPP
Mean 0.285
Standard deviation 0.091
Values 0.26 0.39 0.21
[103]
SNU475 IAPP
Mean 0.147
Standard deviation 0.015
Values 0.16 0.14
[104]
THLE IAPP
Mean 0.174
Standard deviation 0.0028
Values 0.17 0.18
[105]
liver IAPP
Mean 0.155
Standard deviation 0.059
Values 0.19 0.21 0.077 0.15
[106]
ref_hepatocyte MAFA
Mean 0.0832
Standard deviation 0.19
Values 0 0 0 0.42 0
[107]
HepG2 MAFA
Mean 0.245
Standard deviation 0.16
Values 0.36 0.13
[108]
HepG2.C3A MAFA
Mean 0.0696
Standard deviation 0.053
Values 0.11 0.032
[109]
HuH.7 MAFA
Mean 0.11
Standard deviation 0.033
Values 0.11 0.14 0.075
[110]
SNU475 MAFA
Mean 0.0141
Standard deviation 0.013
Values 0.023 0.0051
[111]
THLE MAFA
Mean 0.0639
Standard deviation 0.015
Values 0.053 0.074
[112]
liver MAFA
Mean 0
Standard deviation 0
Values 0 0 0 0
[113]
ref_hepatocyte PAX6
Mean 0.0716
Standard deviation 0.088
Values 0 0 0.095 0.052 0.21
[114]
HepG2 PAX6
Mean 8.03
Standard deviation 2.9
Values 10 6
[115]
HepG2.C3A PAX6
Mean 2.25
Standard deviation 0.65
Values 2.7 1.8
[116]
HuH.7 PAX6
Mean 6.86
Standard deviation 0.41
Values 7.3 6.8 6.5
[117]
SNU475 PAX6
Mean 3.54
Standard deviation 0.9
Values 2.9 4.2
[118]
THLE PAX6
Mean 0.444
Standard deviation 0.12
Values 0.53 0.36
[119]
liver PAX6
Mean 0.523
Standard deviation 0.14
Values 0.4 0.73 0.46 0.5
[120]
ref_hepatocyte PDX1
Mean 0.0133
Standard deviation 0.02
Values 0.045 0 0 0.022 0
[121]
HepG2 PDX1
Mean 0.0386
Standard deviation 0.006
Values 0.034 0.043
[122]
HepG2.C3A PDX1
Mean 0.00536
Standard deviation 0.0076
Values 0 0.011
[123]
HuH.7 PDX1
Mean 1.24
Standard deviation 0.28
Values 1.3 0.93 1.5
[124]
SNU475 PDX1
Mean 0.00507
Standard deviation 0.0072
Values 0 0.01
[125]
THLE PDX1
Mean 0
Standard deviation 0
Values 0 0
[126]
liver PDX1
Mean 0.103
Standard deviation 0.045
Values 0.057 0.12 0.077 0.16
[127]
ref_hepatocyte MNX1
Mean 0.0108
Standard deviation 0.024
Values 0.054 0 0 0 0
[128]
HepG2 MNX1
Mean 1.72
Standard deviation 0.22
Values 1.9 1.6
[129]
HepG2.C3A MNX1
Mean 1.53
Standard deviation 0.48
Values 1.9 1.2
[130]
HuH.7 MNX1
Mean 4.85
Standard deviation 1.1
Values 4.2 4.2 6.2
[131]
SNU475 MNX1
Mean 0.138
Standard deviation 0.015
Values 0.15 0.13
[132]
THLE MNX1
Mean 0.00858
Standard deviation 0.0046
Values 0.012 0.0053
[133]
liver MNX1
Mean 0
Standard deviation 0
Values 0 0 0 0
[134]
ref_hepatocyte NKX2-2
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[135]
HepG2 NKX2-2
Mean 0
Standard deviation 0
Values 0 0
[136]
HepG2.C3A NKX2-2
Mean 0
Standard deviation 0
Values 0 0
[137]
HuH.7 NKX2-2
Mean 0
Standard deviation 0
Values 0 0 0
[138]
SNU475 NKX2-2
Mean 0.027
Standard deviation 0.012
Values 0.019 0.035
[139]
THLE NKX2-2
Mean 0
Standard deviation 0
Values 0 0
[140]
liver NKX2-2
Mean 0
Standard deviation 0
Values 0 0 0 0
[141]
ref_hepatocyte PAX4
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[142]
HepG2 PAX4
Missing
[143]
HepG2.C3A PAX4
Missing
[144]
HuH.7 PAX4
Missing
[145]
SNU475 PAX4
Missing
[146]
THLE PAX4
Missing
[147]
liver PAX4
Missing
[148]
ref_hepatocyte NEUROD1
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[149]
HepG2 NEUROD1
Mean 0
Standard deviation 0
Values 0 0
[150]
HepG2.C3A NEUROD1
Mean 0
Standard deviation 0
Values 0 0
[151]
HuH.7 NEUROD1
Mean 0.00312
Standard deviation 0.0054
Values 0 0 0.0094
[152]
SNU475 NEUROD1
Mean 0
Standard deviation 0
Values 0 0
[153]
THLE NEUROD1
Mean 0
Standard deviation 0
Values 0 0
[154]
liver NEUROD1
Mean 0.185
Standard deviation 0.02
Values 0.2 0.16 0.21 0.17
[155]
ref_hepatocyte NKX6-1
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[156]
HepG2 NKX6-1
Mean 0.00573
Standard deviation 0.0081
Values 0.011 0
[157]
HepG2.C3A NKX6-1
Mean 0
Standard deviation 0
Values 0 0
[158]
HuH.7 NKX6-1
Mean 0.143
Standard deviation 0.079
Values 0.057 0.21 0.16
[159]
SNU475 NKX6-1
Mean 0.61
Standard deviation 0.29
Values 0.4 0.82
[160]
THLE NKX6-1
Mean 0.00266
Standard deviation 0.0038
Values 0 0.0053
[161]
liver NKX6-1
Mean 0
Standard deviation 0
Values 0 0 0 0
[162]
ref_hepatocyte INS
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[163]
HepG2 INS
Mean 0.00287
Standard deviation 0.0041
Values 0.0057 0
[164]
HepG2.C3A INS
Mean 0
Standard deviation 0
Values 0 0
[165]
HuH.7 INS
Mean 0
Standard deviation 0
Values 0 0 0
[166]
SNU475 INS
Mean 0
Standard deviation 0
Values 0 0
[167]
THLE INS
Mean 0
Standard deviation 0
Values 0 0
[168]
liver INS
Mean 0.0838
Standard deviation 0.13
Values 0.057 0 0 0.28
[169]
ref_hepatocyte NEUROG3
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[170]
HepG2 NEUROG3
Missing
[171]
HepG2.C3A NEUROG3
Missing
[172]
HuH.7 NEUROG3
Missing
[173]
SNU475 NEUROG3
Missing
[174]
THLE NEUROG3
Missing
[175]
liver NEUROG3
Missing