KEGG_LYSOSOME | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | CD63 | CD63 antigen | [1] | -2.82[2] | -2.99[3] | -3.34[4] | -1.95[5] | -2.15[6] | -2.79[7] |
2 | PSAP | Prosaposin | [8] | 0.40[9] | 0.30[10] | 0.49[11] | 1.11[12] | 0.75[13] | 0.43[14] |
3 | CTSB | Cathepsin B | [15] | 0.55[16] | 0.24[17] | -0.76[18] | -1.00[19] | -0.13[20] | 0.20[21] |
4 | CTSD | Cathepsin D | [22] | 0.02[23] | -0.38[24] | -0.30[25] | 0.53[26] | -1.36[27] | 0.78[28] |
5 | CLTA | Clathrin light chain A | [29] | -1.85[30] | -1.77[31] | -1.61[32] | -2.04[33] | -1.65[34] | -3.05[35] |
6 | CTSZ | Cathepsin Z | [36] | -10.30[37] | -9.66[38] | -2.58[39] | -1.86[40] | -1.90[41] | -2.18[42] |
7 | LAPTM4A | Lysosomal-associated transmembrane protein 4A | [43] | -0.50[44] | 0.03[45] | -0.68[46] | -0.66[47] | -1.04[48] | -0.75[49] |
8 | ATP6V0B | V-type proton ATPase 21 kDa proteolipid subunit | [50] | -1.51[51] | -1.07[52] | -1.58[53] | -1.29[54] | -0.91[55] | -0.49[56] |
9 | LAMP1 | Lysosome-associated membrane glycoprotein 1 | [57] | 0.21[58] | -0.81[59] | -1.20[60] | -0.21[61] | 0.23[62] | -1.40[63] |
10 | NPC2 | Epididymal secretory protein E1 | [64] | -1.29[65] | -0.22[66] | -1.87[67] | -1.45[68] | -0.91[69] | -2.06[70] |
11 | ATP6V0C | V-type proton ATPase 16 kDa proteolipid subunit | [71] | -1.09[72] | -1.27[73] | -1.30[74] | -1.45[75] | -0.64[76] | -1.39[77] |
12 | CD68 | Macrosialin | [78] | -1.74[79] | -1.92[80] | -2.05[81] | -1.21[82] | -1.27[83] | -2.04[84] |
13 | HYAL1 | Hyaluronidase-1 | [85] | -0.48[86] | 0.03[87] | -5.71[88] | -8.79[89] | -6.56[90] | 0.01[91] |
14 | CLTB | Clathrin light chain B | [92] | -0.54[93] | -2.28[94] | -2.43[95] | -2.23[96] | -1.85[97] | -2.08[98] |
15 | LIPA | Lysosomal acid lipase/cholesteryl ester hydrolase | [99] | -0.66[100] | -0.39[101] | -1.41[102] | -1.50[103] | -1.09[104] | -0.06[105] |
16 | CD164 | Sialomucin core protein 24 | [106] | -0.03[107] | 1.24[108] | 0.83[109] | 0.87[110] | 1.11[111] | 1.04[112] |
17 | M6PR | Cation-dependent mannose-6-phosphate receptor | [113] | -0.48[114] | -1.17[115] | -0.38[116] | -1.39[117] | -0.21[118] | -1.21[119] |
18 | AP3S1 | AP-3 complex subunit sigma-1 | [120] | -1.12[121] | -0.43[122] | -1.73[123] | -1.47[124] | -1.21[125] | -1.58[126] |
19 | CTSA | Lysosomal protective protein | [127] | 1.39[128] | 0.30[129] | -0.27[130] | 0.99[131] | 0.02[132] | 0.24[133] |
20 | NEU1 | Sialidase-1 | [134] | 0.94[135] | 0.59[136] | -0.70[137] | -1.04[138] | -1.12[139] | -1.39[140] |
21 | CTSH | Pro-cathepsin H | [141] | 0.74[142] | 1.46[143] | -1.21[144] | -2.89[145] | -2.52[146] | -0.57[147] |
22 | HEXB | Beta-hexosaminidase subunit beta | [148] | -0.20[149] | -0.33[150] | 0.28[151] | -0.32[152] | 0.47[153] | -0.09[154] |
23 | LAMP2 | Lysosome-associated membrane glycoprotein 2 | [155] | 0.15[156] | -0.06[157] | 1.61[158] | 1.29[159] | 1.42[160] | 1.45[161] |
24 | ASAH1 | Acid ceramidase | [162] | 0.13[163] | 0.23[164] | 0.53[165] | -0.34[166] | -0.42[167] | -0.20[168] |
25 | CLTC | Clathrin heavy chain 1 | [169] | 1.64[170] | 2.00[171] | 2.22[172] | 2.10[173] | 2.26[174] | 2.67[175] |
26 | SCARB2 | Lysosome membrane protein 2 | [176] | 0.07[177] | 0.22[178] | 0.94[179] | 0.72[180] | 1.52[181] | 1.63[182] |
27 | GNPTG | N-acetylglucosamine-1-phosphotransferase subunit gamma | [183] | -1.40[184] | -1.58[185] | -1.73[186] | -2.61[187] | -1.57[188] | -0.44[189] |
28 | AP1S1 | AP-1 complex subunit sigma-1A | [190] | -0.98[191] | -1.03[192] | -0.59[193] | -0.58[194] | -0.79[195] | -2.58[196] |
29 | GUSB | Beta-glucuronidase | [197] | -1.59[198] | -1.02[199] | -0.46[200] | -0.46[201] | -0.95[202] | 0.44[203] |
30 | ATP6AP1 | V-type proton ATPase subunit S1 | [204] | 0.55[205] | 0.54[206] | 0.81[207] | 0.32[208] | 0.84[209] | -0.20[210] |
31 | ATP6V0D1 | V-type proton ATPase subunit d 1 | [211] | -0.25[212] | -0.46[213] | -0.03[214] | 0.36[215] | 0.20[216] | 0.23[217] |
32 | AP1M1 | AP-1 complex subunit mu-1 | [218] | 0.01[219] | -0.08[220] | 1.02[221] | -0.11[222] | 0.04[223] | 0.13[224] |
33 | LGMN | Legumain | [225] | -0.29[226] | -0.83[227] | -0.16[228] | 0.35[229] | -0.15[230] | 0.44[231] |
34 | FUCA1 | Tissue alpha-L-fucosidase | [232] | -0.68[233] | 0.23[234] | -2.25[235] | -1.37[236] | -1.71[237] | 0.36[238] |
35 | ACP2 | Lysosomal acid phosphatase | [239] | -1.49[240] | -1.45[241] | -1.07[242] | -1.64[243] | -1.30[244] | 0.40[245] |
36 | TPP1 | Tripeptidyl-peptidase 1 | [246] | 1.17[247] | 0.38[248] | 1.19[249] | 0.81[250] | 0.89[251] | 1.41[252] |
37 | CTSF | Cathepsin F | [253] | -10.18[254] | -8.89[255] | -1.92[256] | -0.46[257] | -0.24[258] | -0.41[259] |
38 | SMPD1 | Sphingomyelin phosphodiesterase | [260] | -2.09[261] | -2.46[262] | -2.61[263] | -1.05[264] | -0.54[265] | 0.69[266] |
39 | AP3D1 | AP-3 complex subunit delta-1 | [267] | 1.61[268] | 1.37[269] | 1.53[270] | 1.24[271] | 1.47[272] | 1.17[273] |
40 | GLB1 | Beta-galactosidase | [274] | 0.68[275] | 0.57[276] | 1.66[277] | -0.09[278] | 0.72[279] | 0.33[280] |
41 | HEXA | Beta-hexosaminidase subunit alpha | [281] | 1.47[282] | 1.06[283] | 0.80[284] | 1.28[285] | 1.22[286] | 0.46[287] |
42 | PPT1 | Palmitoyl-protein thioesterase 1 | [288] | 1.60[289] | 1.54[290] | 0.63[291] | 0.73[292] | 1.92[293] | -0.04[294] |
43 | IGF2R | Cation-independent mannose-6-phosphate receptor | [295] | 3.33[296] | 2.16[297] | 1.74[298] | 2.21[299] | 3.04[300] | 2.42[301] |
44 | CTSC | Dipeptidyl peptidase 1 | [302] | 2.43[303] | 2.28[304] | 2.65[305] | 0.89[306] | 1.75[307] | -0.08[308] |
45 | LAPTM4B | Lysosomal-associated transmembrane protein 4B | [309] | 1.94[310] | 2.36[311] | 3.53[312] | 2.41[313] | 2.16[314] | -1.21[315] |
46 | NAGLU | Alpha-N-acetylglucosaminidase | [316] | 0.17[317] | 0.12[318] | 0.62[319] | -0.62[320] | -0.90[321] | -0.05[322] |
47 | GNS | N-acetylglucosamine-6-sulfatase | [323] | 1.81[324] | 1.71[325] | 2.52[326] | 2.58[327] | 2.87[328] | 2.45[329] |
48 | GAA | Lysosomal alpha-glucosidase | [330] | 2.08[331] | 1.69[332] | 2.30[333] | 0.58[334] | 1.20[335] | 1.20[336] |
49 | AP1B1 | AP-1 complex subunit beta-1 | [337] | 1.14[338] | 0.73[339] | 2.69[340] | 1.62[341] | 1.45[342] | 1.70[343] |
50 | TCIRG1 | V-type proton ATPase 116 kDa subunit a isoform 3 | [344] | 0.07[345] | 0.83[346] | 0.80[347] | 2.75[348] | 1.00[349] | 1.03[350] |
51 | ATP6V1H | V-type proton ATPase subunit H | [351] | -0.29[352] | -0.14[353] | -0.93[354] | 1.04[355] | 0.96[356] | -0.34[357] |
52 | MAN2B1 | Lysosomal alpha-mannosidase | [358] | 1.14[359] | 0.73[360] | 2.43[361] | 0.47[362] | 0.47[363] | 0.55[364] |
53 | GLA | Alpha-galactosidase A | [365] | -0.04[366] | -0.44[367] | 0.77[368] | 0.62[369] | 0.45[370] | -1.34[371] |
54 | CTSS | Cathepsin S | [372] | -2.52[373] | -1.60[374] | -3.87[375] | -0.50[376] | -3.32[377] | 0.87[378] |
55 | GBA | Glucosylceramidase | [379] | 0.13[380] | -1.13[381] | 0.71[382] | 1.26[383] | 1.43[384] | -0.69[385] |
56 | DNASE2 | Deoxyribonuclease-2-alpha | [386] | -0.12[387] | 0.48[388] | 1.24[389] | -0.39[390] | 0.59[391] | -0.90[392] |
57 | SLC17A5 | Sialin | [393] | 0.15[394] | 0.39[395] | 1.30[396] | 0.68[397] | -0.18[398] | 0.58[399] |
58 | SUMF1 | Sulfatase-modifying factor 1 | [400] | 0.02[401] | 0.15[402] | 0.10[403] | -0.54[404] | 0.37[405] | 0.33[406] |
59 | CLN3 | Battenin | [407] | 0.65[408] | 0.49[409] | 1.19[410] | -0.65[411] | -0.62[412] | 0.01[413] |
60 | AP1G1 | AP-1 complex subunit gamma-1 | [414] | 1.43[415] | 1.97[416] | 2.44[417] | 2.13[418] | 1.99[419] | 2.14[420] |
61 | GM2A | Ganglioside GM2 activator | [421] | 1.08[422] | 0.49[423] | 0.63[424] | 0.40[425] | 1.09[426] | -0.04[427] |
62 | SLC11A2 | Natural resistance-associated macrophage protein 2 | [428] | 1.69[429] | 2.75[430] | 0.95[431] | 0.42[432] | 1.20[433] | 1.89[434] |
63 | AP3B1 | AP-3 complex subunit beta-1 | [435] | 0.76[436] | 1.60[437] | 1.57[438] | 1.62[439] | 1.52[440] | 0.82[441] |
64 | CTSO | Cathepsin O | [442] | -6.84[443] | -7.69[444] | -1.64[445] | -0.95[446] | -1.09[447] | 1.82[448] |
65 | GGA1 | ADP-ribosylation factor-binding protein GGA1 | [449] | 0.31[450] | 3.35[451] | 1.53[452] | -0.52[453] | 0.59[454] | 0.56[455] |
66 | IDS | Iduronate 2-sulfatase | [456] | 0.24[457] | -0.06[458] | -0.57[459] | 2.44[460] | 1.63[461] | 1.40[462] |
67 | AP3S2 | AP-3 complex subunit sigma-2 | [463] | -3.00[464] | -2.46[465] | -2.77[466] | -2.92[467] | -2.70[468] | -3.25[469] |
68 | AP1S2 | AP-1 complex subunit sigma-2 | [470] | -2.03[471] | -1.10[472] | -2.24[473] | 0.13[474] | 0.17[475] | -0.59[476] |
69 | AGA | N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase | [477] | -0.11[478] | 0.14[479] | 2.43[480] | -0.68[481] | -0.11[482] | 0.49[483] |
70 | ATP6V0A1 | V-type proton ATPase 116 kDa subunit a isoform 1 | [484] | 0.50[485] | 0.64[486] | 2.20[487] | 1.08[488] | 0.85[489] | 1.94[490] |
71 | CLN5 | Ceroid-lipofuscinosis neuronal protein 5 | [491] | -0.01[492] | 0.12[493] | 0.34[494] | 0.03[495] | 0.60[496] | 0.54[497] |
72 | AP3M1 | AP-3 complex subunit mu-1 | [498] | 0.88[499] | 2.20[500] | 1.31[501] | 1.99[502] | 1.99[503] | 1.24[504] |
73 | GGA2 | ADP-ribosylation factor-binding protein GGA2 | [505] | 2.72[506] | 2.57[507] | 2.37[508] | 1.68[509] | 1.69[510] | 1.09[511] |
74 | MANBA | Beta-mannosidase | [512] | 1.19[513] | 1.02[514] | 0.79[515] | -0.61[516] | 0.58[517] | 0.25[518] |
75 | LAPTM5 | Lysosomal-associated transmembrane protein 5 | [519] | -1.83[520] | -7.78[521] | -7.31[522] | -5.80[523] | -4.74[524] | 1.15[525] |
76 | ARSA | Arylsulfatase A | [526] | 0.88[527] | 0.57[528] | 1.01[529] | 0.54[530] | 0.10[531] | 0.94[532] |
77 | NAGPA | N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase | 1.57[533] | 0.42[534] | 0.54[535] | -1.05[536] | -0.06[537] | -0.39[538] | |
78 | NPC1 | Niemann-Pick C1 protein | [539] | 1.99[540] | 2.60[541] | 2.62[542] | 2.43[543] | 1.94[544] | 1.16[545] |
79 | NAGA | Alpha-N-acetylgalactosaminidase | [546] | 0.75[547] | 0.76[548] | 1.56[549] | 0.33[550] | 0.29[551] | 1.57[552] |
80 | PLA2G15 | Group XV phospholipase A2 | [553] | 1.32[554] | 1.50[555] | -0.05[556] | 1.01[557] | 1.21[558] | 0.27[559] |
81 | HGSNAT | Heparan-alpha-glucosaminide N-acetyltransferase | [560] | 0.51[561] | 0.58[562] | 0.91[563] | 1.02[564] | 1.06[565] | 1.43[566] |
82 | MCOLN1 | Mucolipin-1 | [567] | -0.79[568] | -1.18[569] | -0.32[570] | -0.14[571] | 0.62[572] | 0.28[573] |
83 | SGSH | N-sulphoglucosamine sulphohydrolase | [574] | 1.76[575] | 1.23[576] | -0.22[577] | 0.63[578] | 0.74[579] | 0.68[580] |
84 | GGA3 | ADP-ribosylation factor-binding protein GGA3 | [581] | 1.52[582] | 1.93[583] | 1.92[584] | 1.18[585] | 1.47[586] | 0.51[587] |
85 | ENTPD4 | Ectonucleoside triphosphate diphosphohydrolase 4 | [588] | 1.37[589] | 2.11[590] | 1.69[591] | 1.89[592] | 2.26[593] | 2.51[594] |
86 | PPT2 | Lysosomal thioesterase PPT2 | [595] | -0.14[596] | 0.62[597] | 0.21[598] | -1.81[599] | -0.44[600] | -0.83[601] |
87 | AP4B1 | AP-4 complex subunit beta-1 | [602] | -0.81[603] | -0.22[604] | -0.65[605] | 0.22[606] | 0.74[607] | 0.10[608] |
88 | GALNS | N-acetylgalactosamine-6-sulfatase | [609] | 1.62[610] | 0.99[611] | 1.10[612] | 1.10[613] | 1.23[614] | 0.99[615] |
89 | ACP5 | Tartrate-resistant acid phosphatase type 5 | [616] | -0.91[617] | 0.43[618] | -1.37[619] | -3.44[620] | -7.23[621] | 0.86[622] |
90 | SORT1 | Sortilin | [623] | 3.45[624] | 4.13[625] | 2.74[626] | 4.37[627] | 3.02[628] | 0.23[629] |
91 | CTNS | Cystinosin | [630] | 1.06[631] | 0.97[632] | 0.98[633] | 0.94[634] | 1.32[635] | 1.29[636] |
92 | MFSD8 | Major facilitator superfamily domain-containing protein 8 | [637] | -0.26[638] | 1.75[639] | 1.61[640] | 0.24[641] | 0.94[642] | 1.81[643] |
93 | AP1S3 | AP-1 complex subunit sigma-3 | [644] | 1.33[645] | 1.21[646] | -0.83[647] | 0.37[648] | 0.56[649] | -1.09[650] |
94 | AP3M2 | AP-3 complex subunit mu-2 | [651] | 0.61[652] | 0.96[653] | 1.44[654] | 1.03[655] | 1.65[656] | 0.47[657] |
95 | ARSB | Arylsulfatase B | [658] | 3.66[659] | 2.52[660] | 1.94[661] | 1.93[662] | 2.45[663] | 2.36[664] |
96 | GNPTAB | N-acetylglucosamine-1-phosphotransferase subunits alpha/beta | [665] | 2.17[666] | 2.92[667] | 2.86[668] | 2.93[669] | 3.39[670] | 2.09[671] |
97 | AP1M2 | AP-1 complex subunit mu-2 | [672] | 1.37[673] | 2.32[674] | 3.70[675] | 0.32[676] | -0.01[677] | -2.39[678] |
98 | ATP6V0A2 | V-type proton ATPase 116 kDa subunit a isoform 2 | [679] | 1.37[680] | 2.45[681] | 1.83[682] | 1.62[683] | 2.17[684] | 2.39[685] |
99 | AP4M1 | AP-4 complex subunit mu-1 | [686] | 0.43[687] | 0.84[688] | 1.15[689] | 0.79[690] | 1.06[691] | -0.36[692] |
100 | AP4S1 | AP-4 complex subunit sigma-1 | [693] | 1.10[694] | -0.03[695] | 1.02[696] | 0.53[697] | 0.58[698] | 0.26[699] |
101 | GALC | Galactocerebrosidase | [700] | -6.03[701] | -5.20[702] | 3.47[703] | 3.02[704] | 2.30[705] | 2.81[706] |
102 | IDUA | Alpha-L-iduronidase | [707] | -2.37[708] | -1.55[709] | -1.13[710] | 1.16[711] | -0.49[712] | 0.29[713] |
103 | ABCA2 | ATP-binding cassette sub-family A member 2 | [714] | 3.33[715] | 3.34[716] | 3.73[717] | 3.20[718] | 3.36[719] | 3.15[720] |
104 | AP4E1 | AP-4 complex subunit epsilon-1 | [721] | 1.20[722] | 2.35[723] | 2.05[724] | 3.11[725] | 3.27[726] | 2.29[727] |
105 | ATP6V0D2 | V-type proton ATPase subunit d 2 | [728] | -4.26[729] | -4.16[730] | -4.13[731] | -5.54[732] | -2.68[733] | -6.63[734] |
106 | CLTCL1 | Clathrin heavy chain 2 | [735] | 2.10[736] | 1.92[737] | 1.82[738] | 2.32[739] | 1.78[740] | 1.96[741] |
107 | CTSG | Cathepsin G | [742] | [743] | [744] | [745] | [746] | [747] | -1.95[748] |
108 | NAPSA | Napsin-A | [749] | -6.54[750] | -3.79[751] | -0.75[752] | -1.16[753] | -1.67[754] | -1.53[755] |
109 | ABCB9 | ATP-binding cassette sub-family B member 9 | [756] | 2.21[757] | 3.18[758] | 2.45[759] | 2.21[760] | 2.56[761] | -0.17[762] |
110 | ARSG | Arylsulfatase G | [763] | 2.74[764] | 2.51[765] | 2.73[766] | 0.15[767] | -2.24[768] | 2.03[769] |
111 | CTSW | Cathepsin W | [770] | -6.03[771] | [772] | -5.85[773] | -5.13[774] | -2.39[775] | 0.95[776] |
112 | SLC11A1 | Natural resistance-associated macrophage protein 1 | [777] | 0.57[778] | 1.69[779] | -0.39[780] | -3.17[781] | -1.12[782] | 2.90[783] |
113 | LAMP3 | Lysosome-associated membrane glycoprotein 3 | [784] | 0.39[785] | -0.18[786] | 1.56[787] | -1.03[788] | 1.88[789] | -1.34[790] |
114 | CTSK | Cathepsin K | [791] | 1.00[792] | 3.25[793] | 2.85[794] | 3.50[795] | 3.39[796] | 3.33[797] |
115 | CTSE | Cathepsin E | [798] | 6.08[799] | -2.17[800] | -3.50[801] | -2.67[802] | -3.05[803] | -1.25[804] |
116 | DNASE2B | Deoxyribonuclease-2-beta | [805] | [806] | [807] | -2.77[808] | [809] | [810] | -3.44[811] |
117 | AP3B2 | AP-3 complex subunit beta-2 | [812] | -0.82[813] | [814] | 0.72[815] | 3.02[816] | 4.83[817] | 2.03[818] |
118 | ATP6V0A4 | V-type proton ATPase 116 kDa subunit a isoform 4 | [819] | [820] | [821] | [822] | [823] | [824] | [825] |
119 | CTSL | Cathepsin L1 | [826] | [827] | [828] | [829] | [830] | [831] | [832] |
120 | PSAPL1 | Proactivator polypeptide-like 1 | [833] | [834] | [835] | [836] | [837] | [838] | [839] |
121 | CTSV | Cathepsin L2 | [840] | [841] | [842] | [843] | [844] | [845] | [846] |