KEGG_GNRH_SIGNALING_PATHWAY |
Return to index |
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Order |
Gene |
Description |
ref_hepatocyte |
HepG2 |
HepG2.C3A |
HuH.7 |
SNU475 |
THLE |
liver |
1 |
PLA2G2A |
Phospholipase A2, membrane associated |
[1] |
-4.22[2] |
-8.16[3] |
-15.63[4] |
-15.09[5] |
-14.60[6] |
-0.79[7] |
2 |
CALM2 |
Calmodulin-2 |
[8] |
-0.78[9] |
-0.19[10] |
-1.53[11] |
-0.92[12] |
-0.69[13] |
-1.01[14] |
3 |
ATF4 |
Cyclic AMP-dependent transcription factor ATF-4 |
[15] |
-0.44[16] |
0.39[17] |
0.42[18] |
-2.19[19] |
-0.82[20] |
-1.50[21] |
4 |
CDC42 |
Cell division control protein 42 homolog |
[22] |
-0.10[23] |
0.35[24] |
-0.53[25] |
0.30[26] |
-0.49[27] |
-1.37[28] |
5 |
GNAS |
Guanine nucleotide-binding protein
G(s) subunit alpha isoforms XLas |
1.16[29] |
0.92[30] |
0.70[31] |
1.68[32] |
0.85[33] |
-0.63[34] |
6 |
CALM3 |
Calmodulin-3 |
[35] |
0.66[36] |
0.13[37] |
1.46[38] |
0.50[39] |
0.28[40] |
-1.41[41] |
7 |
JUN |
Transcription factor AP-1 |
[42] |
0.24[43] |
-1.58[44] |
-1.18[45] |
-0.87[46] |
-0.37[47] |
-1.10[48] |
8 |
MAP2K3 |
Dual specificity mitogen-activated protein kinase kinase 3 |
[49] |
-0.49[50] |
-0.47[51] |
-1.43[52] |
-0.99[53] |
-1.20[54] |
-0.73[55] |
9 |
CALM1 |
Calmodulin-1 |
[56] |
0.81[57] |
0.57[58] |
1.16[59] |
2.42[60] |
1.62[61] |
2.33[62] |
10 |
MAP2K1 |
Dual specificity mitogen-activated protein kinase kinase 1 |
[63] |
-0.20[64] |
-0.80[65] |
-0.09[66] |
0.29[67] |
0.73[68] |
-0.48[69] |
11 |
MAP2K2 |
Dual specificity mitogen-activated protein kinase kinase 2 |
[70] |
0.78[71] |
0.19[72] |
1.19[73] |
-0.01[74] |
0.41[75] |
-0.99[76] |
12 |
GRB2 |
Growth factor receptor-bound protein 2 |
[77] |
1.92[78] |
1.49[79] |
1.74[80] |
1.39[81] |
1.23[82] |
1.01[83] |
13 |
PLA2G12B |
Group XIIB secretory phospholipase A2-like protein |
[84] |
-2.02[85] |
-0.51[86] |
-1.43[87] |
-9.43[88] |
-9.36[89] |
-0.02[90] |
14 |
PRKACA |
cAMP-dependent protein kinase catalytic subunit alpha |
[91] |
0.57[92] |
0.12[93] |
0.25[94] |
0.36[95] |
0.88[96] |
-0.07[97] |
15 |
RAF1 |
RAF proto-oncogene serine/threonine-protein kinase |
[98] |
0.67[99] |
0.80[100] |
2.20[101] |
0.65[102] |
1.44[103] |
1.81[104] |
16 |
NRAS |
GTPase NRas |
[105] |
1.36[106] |
1.52[107] |
2.06[108] |
1.83[109] |
1.33[110] |
0.46[111] |
17 |
HRAS |
GTPase HRas |
[112] |
-0.28[113] |
-1.26[114] |
-1.92[115] |
-0.12[116] |
-0.40[117] |
-1.95[118] |
18 |
MAPK1 |
Mitogen-activated protein kinase 1 |
[119] |
2.44[120] |
2.30[121] |
2.26[122] |
2.68[123] |
2.26[124] |
2.49[125] |
19 |
GNA11 |
Guanine nucleotide-binding protein subunit alpha-11 |
[126] |
0.06[127] |
-0.29[128] |
-0.21[129] |
-0.35[130] |
0.38[131] |
-0.55[132] |
20 |
KRAS |
GTPase KRas |
[133] |
0.21[134] |
-0.08[135] |
1.65[136] |
1.63[137] |
1.22[138] |
1.39[139] |
21 |
MAPK14 |
Mitogen-activated protein kinase 14 |
[140] |
2.20[141] |
2.00[142] |
1.71[143] |
2.51[144] |
1.92[145] |
1.99[146] |
22 |
MAPK8 |
Mitogen-activated protein kinase 8 |
[147] |
-0.72[148] |
0.42[149] |
-0.58[150] |
-0.07[151] |
-0.28[152] |
0.20[153] |
23 |
SOS1 |
Son of sevenless homolog 1 |
[154] |
0.63[155] |
1.89[156] |
1.52[157] |
1.68[158] |
0.84[159] |
1.25[160] |
24 |
ELK1 |
ETS domain-containing protein Elk-1 |
[161] |
0.41[162] |
-2.00[163] |
0.56[164] |
1.11[165] |
1.62[166] |
0.54[167] |
25 |
CAMK2D |
Calcium/calmodulin-dependent protein kinase type II subunit delta |
[168] |
0.86[169] |
0.89[170] |
2.55[171] |
1.51[172] |
0.63[173] |
2.12[174] |
26 |
ITPR2 |
Inositol 1,4,5-trisphosphate receptor type 2 |
[175] |
1.64[176] |
2.82[177] |
1.41[178] |
0.84[179] |
0.91[180] |
4.58[181] |
27 |
EGFR |
Epidermal growth factor receptor |
[182] |
0.03[183] |
-0.61[184] |
2.40[185] |
1.27[186] |
1.82[187] |
3.36[188] |
28 |
MAPK13 |
Mitogen-activated protein kinase 13 |
[189] |
3.07[190] |
3.20[191] |
0.65[192] |
-1.05[193] |
0.40[194] |
-1.01[195] |
29 |
MAP2K4 |
Dual specificity mitogen-activated protein kinase kinase 4 |
[196] |
1.43[197] |
1.79[198] |
1.12[199] |
2.04[200] |
1.37[201] |
1.78[202] |
30 |
MAPK9 |
Mitogen-activated protein kinase 9 |
[203] |
1.96[204] |
1.91[205] |
2.10[206] |
2.55[207] |
1.94[208] |
1.22[209] |
31 |
MAPK3 |
Mitogen-activated protein kinase 3 |
[210] |
2.58[211] |
2.35[212] |
2.52[213] |
1.26[214] |
1.21[215] |
-0.33[216] |
32 |
MAP2K7 |
Dual specificity mitogen-activated protein kinase kinase 7 |
[217] |
1.69[218] |
1.57[219] |
2.27[220] |
1.11[221] |
1.60[222] |
-0.05[223] |
33 |
SRC |
Proto-oncogene tyrosine-protein kinase Src |
[224] |
3.75[225] |
3.46[226] |
2.60[227] |
3.23[228] |
2.34[229] |
-0.14[230] |
34 |
PRKCD |
Protein kinase C delta type |
[231] |
1.83[232] |
1.80[233] |
1.41[234] |
0.33[235] |
1.42[236] |
-0.36[237] |
35 |
PLA2G12A |
Group XIIA secretory phospholipase A2 |
[238] |
0.87[239] |
1.50[240] |
1.77[241] |
1.17[242] |
2.28[243] |
3.36[244] |
36 |
MMP14 |
Matrix metalloproteinase-14 |
[245] |
1.78[246] |
0.93[247] |
3.05[248] |
1.55[249] |
6.02[250] |
0.20[251] |
37 |
CAMK2G |
Calcium/calmodulin-dependent protein
kinase type II subunit gamma |
1.50[252] |
2.44[253] |
2.19[254] |
2.52[255] |
2.01[256] |
1.66[257] |
38 |
MAP3K4 |
Mitogen-activated protein kinase kinase kinase 4 |
[258] |
1.68[259] |
2.08[260] |
1.35[261] |
1.69[262] |
1.92[263] |
2.10[264] |
39 |
PRKACB |
cAMP-dependent protein kinase catalytic subunit beta |
[265] |
-0.10[266] |
0.40[267] |
1.81[268] |
3.06[269] |
1.86[270] |
2.42[271] |
40 |
ADCY9 |
Adenylate cyclase type 9 |
[272] |
3.35[273] |
2.26[274] |
2.82[275] |
1.79[276] |
1.27[277] |
3.12[278] |
41 |
SOS2 |
Son of sevenless homolog 2 |
[279] |
0.70[280] |
1.55[281] |
0.92[282] |
2.52[283] |
2.32[284] |
2.55[285] |
42 |
PRKCA |
Protein kinase C alpha type |
[286] |
3.57[287] |
3.33[288] |
3.82[289] |
2.98[290] |
3.27[291] |
2.63[292] |
43 |
MAP3K2 |
Mitogen-activated protein kinase kinase kinase 2 |
[293] |
2.16[294] |
3.10[295] |
2.95[296] |
3.91[297] |
3.12[298] |
4.53[299] |
44 |
ITPR3 |
Inositol 1,4,5-trisphosphate receptor type 3 |
[300] |
6.02[301] |
4.60[302] |
3.21[303] |
3.18[304] |
5.29[305] |
0.94[306] |
45 |
PLD1 |
Phospholipase D1 |
[307] |
3.15[308] |
3.59[309] |
4.21[310] |
1.88[311] |
2.41[312] |
2.77[313] |
46 |
PLD2 |
Phospholipase D2 |
[314] |
1.68[315] |
1.94[316] |
1.96[317] |
1.59[318] |
1.37[319] |
1.61[320] |
47 |
GNAQ |
Guanine nucleotide-binding protein G(q) subunit alpha |
[321] |
0.80[322] |
1.31[323] |
1.95[324] |
2.42[325] |
2.57[326] |
2.15[327] |
48 |
ADCY6 |
Adenylate cyclase type 6 |
[328] |
2.78[329] |
2.97[330] |
3.06[331] |
3.34[332] |
3.94[333] |
3.34[334] |
49 |
HBEGF |
Proheparin-binding EGF-like growth factor |
[335] |
-0.26[336] |
-1.34[337] |
-2.28[338] |
1.14[339] |
0.76[340] |
-1.72[341] |
50 |
PLCB3 |
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 |
[342] |
2.73[343] |
1.94[344] |
2.54[345] |
3.54[346] |
3.12[347] |
1.44[348] |
51 |
PTK2B |
Protein-tyrosine kinase 2-beta |
[349] |
-0.08[350] |
1.00[351] |
2.10[352] |
-0.95[353] |
1.61[354] |
2.48[355] |
52 |
MAP2K6 |
Dual specificity mitogen-activated protein kinase kinase 6 |
[356] |
1.02[357] |
-2.47[358] |
2.52[359] |
1.84[360] |
-2.26[361] |
-0.91[362] |
53 |
MAP3K3 |
Mitogen-activated protein kinase kinase kinase 3 |
[363] |
2.35[364] |
2.56[365] |
1.98[366] |
2.91[367] |
3.10[368] |
2.85[369] |
54 |
MAP3K1 |
Mitogen-activated protein kinase kinase kinase 1 |
[370] |
3.38[371] |
2.82[372] |
2.68[373] |
3.16[374] |
1.97[375] |
3.51[376] |
55 |
MAPK7 |
Mitogen-activated protein kinase 7 |
[377] |
2.16[378] |
1.19[379] |
1.32[380] |
2.64[381] |
2.66[382] |
1.05[383] |
56 |
PLCB1 |
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 |
[384] |
3.52[385] |
4.87[386] |
4.43[387] |
1.61[388] |
2.03[389] |
3.20[390] |
57 |
ADCY1 |
Adenylate cyclase type 1 |
[391] |
-0.11[392] |
-2.25[393] |
-2.32[394] |
-1.28[395] |
-1.36[396] |
5.70[397] |
58 |
MAPK12 |
Mitogen-activated protein kinase 12 |
[398] |
3.55[399] |
2.94[400] |
4.18[401] |
2.32[402] |
3.50[403] |
-0.19[404] |
59 |
PLA2G6 |
85/88 kDa calcium-independent phospholipase A2 |
[405] |
0.78[406] |
2.94[407] |
3.41[408] |
0.68[409] |
0.67[410] |
2.36[411] |
60 |
PRKX |
cAMP-dependent protein kinase catalytic subunit PRKX |
[412] |
-0.92[413] |
-1.42[414] |
3.64[415] |
2.08[416] |
3.55[417] |
2.15[418] |
61 |
CAMK2B |
Calcium/calmodulin-dependent protein kinase type II subunit beta |
[419] |
-1.81[420] |
-3.40[421] |
-6.23[422] |
-2.03[423] |
-1.46[424] |
1.86[425] |
62 |
PLA2G4B |
Cytosolic phospholipase A2 beta |
[426] |
-5.83[427] |
-7.12[428] |
-4.41[429] |
-3.81[430] |
-4.21[431] |
[432] |
63 |
ADCY7 |
Adenylate cyclase type 7 |
[433] |
4.24[434] |
3.59[435] |
2.68[436] |
4.14[437] |
3.55[438] |
3.63[439] |
64 |
PLCB2 |
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 |
[440] |
-0.89[441] |
-5.95[442] |
-7.66[443] |
-1.10[444] |
-1.88[445] |
2.94[446] |
65 |
ITPR1 |
Inositol 1,4,5-trisphosphate receptor type 1 |
[447] |
3.87[448] |
3.48[449] |
4.76[450] |
3.68[451] |
4.48[452] |
5.36[453] |
66 |
MAPK11 |
Mitogen-activated protein kinase 11 |
[454] |
0.56[455] |
0.18[456] |
-0.58[457] |
1.19[458] |
3.11[459] |
0.87[460] |
67 |
PLA2G1B |
Phospholipase A2 |
[461] |
-1.27[462] |
-2.23[463] |
-3.10[464] |
-3.35[465] |
-6.19[466] |
0.03[467] |
68 |
JMJD7-PLA2G4B |
JMJD7-PLA2G4B readthrough (Fragment) |
[468] |
-5.40[469] |
-4.33[470] |
-4.23[471] |
-5.61[472] |
-7.28[473] |
-3.90[474] |
69 |
PRKCB |
Protein kinase C beta type |
[475] |
-6.08[476] |
-5.16[477] |
[478] |
3.31[479] |
-2.06[480] |
4.25[481] |
70 |
CACNA1D |
Voltage-dependent L-type calcium channel subunit alpha-1D |
[482] |
-2.99[483] |
-0.25[484] |
2.18[485] |
-0.64[486] |
-3.35[487] |
5.22[488] |
71 |
MMP2 |
72 kDa type IV collagenase |
[489] |
4.16[490] |
-3.10[491] |
-1.69[492] |
8.27[493] |
7.75[494] |
4.64[495] |
72 |
ADCY3 |
Adenylate cyclase type 3 |
[496] |
2.19[497] |
0.67[498] |
4.13[499] |
5.57[500] |
7.03[501] |
4.23[502] |
73 |
ADCY2 |
Adenylate cyclase type 2 |
[503] |
-4.65[504] |
-2.99[505] |
-4.12[506] |
-1.90[507] |
-3.09[508] |
-3.41[509] |
74 |
CGA |
Glycoprotein hormones alpha chain |
[510] |
[511] |
[512] |
-1.77[513] |
-2.68[514] |
-4.06[515] |
-3.39[516] |
75 |
CALML3 |
Calmodulin-like protein 3 |
[517] |
-1.88[518] |
-1.98[519] |
-4.38[520] |
[521] |
-2.40[522] |
-1.63[523] |
76 |
PLA2G2D |
Group IID secretory phospholipase A2 |
[524] |
-2.56[525] |
[526] |
[527] |
[528] |
[529] |
-1.63[530] |
77 |
GNRH1 |
Progonadoliberin-1 |
[531] |
2.17[532] |
4.72[533] |
3.48[534] |
3.45[535] |
3.66[536] |
4.04[537] |
78 |
PLA2G3 |
Group 3 secretory phospholipase A2 |
[538] |
-0.60[539] |
2.70[540] |
-4.94[541] |
-4.41[542] |
-1.42[543] |
-2.78[544] |
79 |
GNRH2 |
Progonadoliberin-2 |
[545] |
-3.55[546] |
-2.55[547] |
-4.69[548] |
-1.84[549] |
-1.58[550] |
-0.19[551] |
80 |
ADCY5 |
Adenylate cyclase type 5 |
[552] |
0.88[553] |
1.61[554] |
2.77[555] |
1.48[556] |
2.54[557] |
7.08[558] |
81 |
PLA2G10 |
Group 10 secretory phospholipase A2 |
[559] |
1.45[560] |
1.02[561] |
0.11[562] |
-0.04[563] |
-2.58[564] |
1.48[565] |
82 |
PLA2G4A |
Cytosolic phospholipase A2 |
[566] |
1.00[567] |
-1.83[568] |
6.41[569] |
4.33[570] |
8.03[571] |
5.06[572] |
83 |
PLA2G4E |
Cytosolic phospholipase A2 epsilon |
[573] |
3.73[574] |
3.80[575] |
4.57[576] |
4.12[577] |
3.87[578] |
1.83[579] |
84 |
PLCB4 |
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 |
[580] |
0.98[581] |
0.55[582] |
1.69[583] |
10.46[584] |
8.11[585] |
4.50[586] |
85 |
ADCY4 |
Adenylate cyclase type 4 |
[587] |
0.82[588] |
-0.53[589] |
2.25[590] |
[591] |
[592] |
9.08[593] |
86 |
MAPK10 |
Mitogen-activated protein kinase 10 |
[594] |
-0.76[595] |
[596] |
[597] |
9.74[598] |
5.41[599] |
7.96[600] |
87 |
CACNA1C |
Voltage-dependent L-type calcium channel subunit alpha-1C |
[601] |
5.45[602] |
2.68[603] |
5.67[604] |
6.55[605] |
8.72[606] |
9.02[607] |
88 |
PLA2G2F |
Group IIF secretory phospholipase A2 |
[608] |
[609] |
[610] |
[611] |
[612] |
[613] |
[614] |
89 |
CAMK2A |
Calcium/calmodulin-dependent protein kinase type II subunit alpha |
[615] |
[616] |
[617] |
[618] |
[619] |
[620] |
[621] |
90 |
PLA2G5 |
Calcium-dependent phospholipase A2 |
[622] |
[623] |
[624] |
[625] |
[626] |
[627] |
[628] |
91 |
CACNA1S |
Voltage-dependent L-type calcium channel subunit alpha-1S |
[629] |
[630] |
[631] |
[632] |
[633] |
[634] |
[635] |
92 |
LHB |
Lutropin subunit beta |
[636] |
[637] |
[638] |
[639] |
[640] |
[641] |
[642] |
93 |
PLA2G2C |
Putative inactive group IIC secretory phospholipase A2 |
[643] |
[644] |
[645] |
[646] |
[647] |
[648] |
[649] |
94 |
CALML6 |
Calmodulin-like protein 6 |
[650] |
[651] |
[652] |
[653] |
[654] |
[655] |
[656] |
95 |
FSHB |
Follitropin subunit beta |
[657] |
[658] |
[659] |
[660] |
[661] |
[662] |
[663] |
96 |
PRKACG |
cAMP-dependent protein kinase catalytic subunit gamma |
[664] |
[665] |
[666] |
[667] |
[668] |
[669] |
[670] |
97 |
CACNA1F |
Voltage-dependent L-type calcium channel subunit alpha-1F |
[671] |
[672] |
[673] |
[674] |
[675] |
[676] |
[677] |
98 |
PLA2G2E |
Group IIE secretory phospholipase A2 |
[678] |
[679] |
[680] |
[681] |
[682] |
[683] |
[684] |
99 |
GNRHR |
Gonadotropin-releasing hormone receptor |
[685] |
[686] |
[687] |
[688] |
[689] |
[690] |
[691] |
100 |
ADCY8 |
Adenylate cyclase type 8 |
[692] |
[693] |
[694] |
[695] |
[696] |
[697] |
[698] |
101 |
CALML5 |
Calmodulin-like protein 5 |
[699] |
[700] |
[701] |
[702] |
[703] |
[704] |
[705] |
|
|
|
|
|
|
|
|
|
|