KEGG_GLYCOSAMINOGLYCAN_DEGRADATION Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 HYAL1 Hyaluronidase-1 [1] -1.03[2] -0.48[3] -6.17[4] -9.11[5] -7.09[6] -0.61[7]
2 HEXB Beta-hexosaminidase subunit beta [8] -0.75[9] -0.84[10] -0.18[11] -0.64[12] -0.07[13] -0.72[14]
3 GUSB Beta-glucuronidase [15] -2.14[16] -1.53[17] -0.92[18] -0.78[19] -1.48[20] -0.19[21]
4 GLB1 Beta-galactosidase [22] 0.13[23] 0.06[24] 1.20[25] -0.42[26] 0.18[27] -0.29[28]
5 HEXA Beta-hexosaminidase subunit alpha [29] 0.92[30] 0.55[31] 0.34[32] 0.96[33] 0.69[34] -0.17[35]
6 NAGLU Alpha-N-acetylglucosaminidase [36] -0.38[37] -0.39[38] 0.16[39] -0.95[40] -1.44[41] -0.67[42]
7 GNS N-acetylglucosamine-6-sulfatase [43] 1.26[44] 1.20[45] 2.06[46] 2.26[47] 2.34[48] 1.83[49]
8 IDS Iduronate 2-sulfatase [50] -0.31[51] -0.57[52] -1.03[53] 2.11[54] 1.09[55] 0.77[56]
9 HYAL2 Hyaluronidase-2 [57] 1.81[58] 2.33[59] 1.30[60] -0.25[61] 0.52[62] 0.71[63]
10 HGSNAT Heparan-alpha-glucosaminide N-acetyltransferase [64] -0.04[65] 0.07[66] 0.45[67] 0.69[68] 0.53[69] 0.81[70]
11 SGSH N-sulphoglucosamine sulphohydrolase [71] 1.21[72] 0.72[73] -0.68[74] 0.31[75] 0.20[76] 0.05[77]
12 HS3ST3B1 Heparan sulfate glucosamine 3-O-sulfotransferase 3B1 [78] -1.48[79] -0.78[80] -1.94[81] -4.61[82] -2.63[83] 0.28[84]
13 GALNS N-acetylgalactosamine-6-sulfatase [85] 1.08[86] 0.48[87] 0.64[88] 0.77[89] 0.69[90] 0.36[91]
14 ARSB Arylsulfatase B [92] 3.11[93] 2.01[94] 1.48[95] 1.61[96] 1.91[97] 1.73[98]
15 IDUA Alpha-L-iduronidase [99] -2.92[100] -2.06[101] -1.58[102] 0.84[103] -1.02[104] -0.34[105]
16 HYAL3 Hyaluronidase-3 [106] 1.45[107] 0.81[108] 1.23[109] -0.75[110] -0.05[111] -1.38[112]
17 HPSE Heparanase [113] -1.59[114] -1.22[115] -0.20[116] 2.27[117] 4.69[118] 1.23[119]
18 HS3ST3A1 Heparan sulfate glucosamine 3-O-sulfotransferase 3A1 [120] -1.21[121] -1.61[122] 1.09[123] 4.03[124] 3.23[125] 1.22[126]
19 HYAL4 Hyaluronidase-4 [127] -4.84[128] -2.06[129] -3.66[130] 0.52[131] -3.70[132] -0.68[133]
20 SPAM1 Hyaluronidase PH-20 [134] [135] [136] [137] [138] [139] [140]
21 HPSE2 Inactive heparanase-2 [141] [142] [143] [144] [145] [146] [147]
[1]
ref_hepatocyte HYAL1
Mean 53.9
Standard deviation 39
Values 18 24 90 36 1e+02
[2]
HepG2 HYAL1
Mean 83.6
Standard deviation 4.4
Values 81 87
[3]
HepG2.C3A HYAL1
Mean 88.6
Standard deviation 33
Values 1.1e+02 65
[4]
HuH.7 HYAL1
Mean 1.54
Standard deviation 0.96
Values 0.95 2.7 1
[5]
SNU475 HYAL1
Mean 0.168
Standard deviation 0.058
Values 0.21 0.13
[6]
THLE HYAL1
Mean 0.868
Standard deviation 0.069
Values 0.92 0.82
[7]
liver HYAL1
Mean 66.7
Standard deviation 12
Values 54 80 73 59
[8]
ref_hepatocyte HEXB
Mean 33.9
Standard deviation 11
Values 39 33 44 16 38
[9]
HepG2 HEXB
Mean 64.1
Standard deviation 5.9
Values 68 60
[10]
HepG2.C3A HEXB
Mean 43.4
Standard deviation 2.1
Values 45 42
[11]
HuH.7 HEXB
Mean 61.5
Standard deviation 15
Values 46 77 61
[12]
SNU475 HEXB
Mean 37.4
Standard deviation 0.5
Values 37 38
[13]
THLE HEXB
Mean 71.3
Standard deviation 17
Values 59 83
[14]
liver HEXB
Mean 39
Standard deviation 15
Values 34 42 57 22
[15]
ref_hepatocyte GUSB
Mean 25.3
Standard deviation 23
Values 7 7.5 52 11 49
[16]
HepG2 GUSB
Mean 18.3
Standard deviation 3.5
Values 21 16
[17]
HepG2.C3A GUSB
Mean 20.1
Standard deviation 2
Values 22 19
[18]
HuH.7 GUSB
Mean 27.5
Standard deviation 3.9
Values 26 25 32
[19]
SNU475 GUSB
Mean 25.3
Standard deviation 2.9
Values 23 27
[20]
THLE GUSB
Mean 20
Standard deviation 0.097
Values 20 20
[21]
liver GUSB
Mean 42.1
Standard deviation 30
Values 22 54 79 14
[22]
ref_hepatocyte GLB1
Mean 15.3
Standard deviation 5.7
Values 22 9.9 18 8.6 18
[23]
HepG2 GLB1
Mean 53.1
Standard deviation 4.7
Values 56 50
[24]
HepG2.C3A GLB1
Mean 36.7
Standard deviation 8.2
Values 42 31
[25]
HuH.7 GLB1
Mean 72.4
Standard deviation 9.9
Values 62 81 75
[26]
SNU475 GLB1
Mean 19.7
Standard deviation 1.4
Values 19 21
[27]
THLE GLB1
Mean 38.2
Standard deviation 4.9
Values 35 42
[28]
liver GLB1
Mean 23.6
Standard deviation 8.2
Values 20 23 35 16
[29]
ref_hepatocyte HEXA
Mean 15.3
Standard deviation 8.5
Values 11 11 25 6.1 24
[30]
HepG2 HEXA
Mean 91.6
Standard deviation 1.4
Values 93 91
[31]
HepG2.C3A HEXA
Mean 51.3
Standard deviation 2.1
Values 53 50
[32]
HuH.7 HEXA
Mean 39.8
Standard deviation 6.4
Values 37 35 47
[33]
SNU475 HEXA
Mean 51.2
Standard deviation 9
Values 58 45
[34]
THLE HEXA
Mean 54.1
Standard deviation 9.1
Values 48 61
[35]
liver HEXA
Mean 25.8
Standard deviation 15
Values 17 28 46 12
[36]
ref_hepatocyte NAGLU
Mean 11.6
Standard deviation 11
Values 4.4 2.3 22 5.1 24
[37]
HepG2 NAGLU
Mean 28.5
Standard deviation 0.22
Values 28 29
[38]
HepG2.C3A NAGLU
Mean 20.4
Standard deviation 4
Values 23 18
[39]
HuH.7 NAGLU
Mean 26.8
Standard deviation 6.6
Values 26 20 34
[40]
SNU475 NAGLU
Mean 10.4
Standard deviation 3.9
Values 13 7.6
[41]
THLE NAGLU
Mean 9.46
Standard deviation 2.1
Values 7.9 11
[42]
liver NAGLU
Mean 13.8
Standard deviation 2.3
Values 11 16 15 14
[43]
ref_hepatocyte GNS
Mean 10.7
Standard deviation 4.8
Values 17 13 12 4 8.4
[44]
HepG2 GNS
Mean 81.3
Standard deviation 7.9
Values 87 76
[45]
HepG2.C3A GNS
Mean 56.4
Standard deviation 4.7
Values 60 53
[46]
HuH.7 GNS
Mean 91.4
Standard deviation 13
Values 1e+02 97 77
[47]
SNU475 GNS
Mean 87.8
Standard deviation 16
Values 99 77
[48]
THLE GNS
Mean 119
Standard deviation 32
Values 96 1.4e+02
[49]
liver GNS
Mean 71.6
Standard deviation 24
Values 1e+02 44 66 76
[50]
ref_hepatocyte IDS
Mean 6.6
Standard deviation 4
Values 1.7 8.7 5 12 5.4
[51]
HepG2 IDS
Mean 16.9
Standard deviation 2.4
Values 19 15
[52]
HepG2.C3A IDS
Mean 10.2
Standard deviation 0.54
Values 9.8 11
[53]
HuH.7 IDS
Mean 6.65
Standard deviation 2.1
Values 5.9 9 5
[54]
SNU475 IDS
Mean 49.1
Standard deviation 1.7
Values 50 48
[55]
THLE IDS
Mean 30.9
Standard deviation 4
Values 28 34
[56]
liver IDS
Mean 21.3
Standard deviation 4.6
Values 15 27 22 22
[57]
ref_hepatocyte HYAL2
Mean 5.55
Standard deviation 2.1
Values 4.6 3.2 8.7 6.6 4.7
[58]
HepG2 HYAL2
Mean 61.5
Standard deviation 5.1
Values 65 58
[59]
HepG2.C3A HYAL2
Mean 64
Standard deviation 2.5
Values 66 62
[60]
HuH.7 HYAL2
Mean 28.1
Standard deviation 10
Values 28 18 39
[61]
SNU475 HYAL2
Mean 8
Standard deviation 0.042
Values 8 8
[62]
THLE HYAL2
Mean 17.5
Standard deviation 3.3
Values 15 20
[63]
liver HYAL2
Mean 17.2
Standard deviation 2.7
Values 13 18 19 18
[64]
ref_hepatocyte HGSNAT
Mean 4.04
Standard deviation 1.6
Values 5.4 2.4 4 2.6 5.8
[65]
HepG2 HGSNAT
Mean 12.5
Standard deviation 3.7
Values 9.8 15
[66]
HepG2.C3A HGSNAT
Mean 9.74
Standard deviation 2.6
Values 12 7.9
[67]
HuH.7 HGSNAT
Mean 11.4
Standard deviation 1.7
Values 12 12 9.4
[68]
SNU475 HGSNAT
Mean 11.2
Standard deviation 4.7
Values 15 7.9
[69]
THLE HGSNAT
Mean 12.8
Standard deviation 2.9
Values 11 15
[70]
liver HGSNAT
Mean 13.4
Standard deviation 1.5
Values 14 12 15 13
[71]
ref_hepatocyte SGSH
Mean 3.8
Standard deviation 3.4
Values 9.9 1.8 1.9 2.8 2.6
[72]
HepG2 SGSH
Mean 27.9
Standard deviation 0.23
Values 28 28
[73]
HepG2.C3A SGSH
Mean 14.4
Standard deviation 5.6
Values 18 10
[74]
HuH.7 SGSH
Mean 4.87
Standard deviation 0.69
Values 5.2 4.1 5.4
[75]
SNU475 SGSH
Mean 8.08
Standard deviation 1.6
Values 9.2 6.9
[76]
THLE SGSH
Mean 9.61
Standard deviation 1.2
Values 8.8 10
[77]
liver SGSH
Mean 7.46
Standard deviation 5.8
Values 2.3 15 9 3.6
[78]
ref_hepatocyte HS3ST3B1
Mean 2.81
Standard deviation 3.1
Values 2.2 0.68 1.5 8.2 1.4
[79]
HepG2 HS3ST3B1
Mean 3.2
Standard deviation 0.5
Values 2.8 3.5
[80]
HepG2.C3A HS3ST3B1
Mean 3.74
Standard deviation 0.11
Values 3.7 3.8
[81]
HuH.7 HS3ST3B1
Mean 1.5
Standard deviation 0.7
Values 1.5 2.2 0.82
[82]
SNU475 HS3ST3B1
Mean 0.198
Standard deviation 0.12
Values 0.11 0.28
[83]
THLE HS3ST3B1
Mean 0.998
Standard deviation 0.027
Values 1 0.98
[84]
liver HS3ST3B1
Mean 6.44
Standard deviation 2
Values 7.1 6.4 3.7 8.5
[85]
ref_hepatocyte GALNS
Mean 2.75
Standard deviation 1
Values 2.3 1.7 4 2 3.7
[86]
HepG2 GALNS
Mean 18.4
Standard deviation 5.4
Values 22 15
[87]
HepG2.C3A GALNS
Mean 8.83
Standard deviation 1.2
Values 9.7 8
[88]
HuH.7 GALNS
Mean 8.79
Standard deviation 1.8
Values 9.7 6.7 9.9
[89]
SNU475 GALNS
Mean 8.1
Standard deviation 4.4
Values 11 5
[90]
THLE GALNS
Mean 9.76
Standard deviation 0.35
Values 9.5 10
[91]
liver GALNS
Mean 6.69
Standard deviation 2.6
Values 5.2 8.1 9.6 3.9
[92]
ref_hepatocyte ARSB
Mean 1.85
Standard deviation 1.5
Values 4.3 0.43 1.1 1.1 2.3
[93]
HepG2 ARSB
Mean 50.8
Standard deviation 1.2
Values 50 52
[94]
HepG2.C3A ARSB
Mean 17.1
Standard deviation 4.2
Values 14 20
[95]
HuH.7 ARSB
Mean 10.6
Standard deviation 2.5
Values 12 7.7 12
[96]
SNU475 ARSB
Mean 9.69
Standard deviation 3.6
Values 12 7.1
[97]
THLE ARSB
Mean 15.3
Standard deviation 3.2
Values 13 18
[98]
liver ARSB
Mean 11.6
Standard deviation 6.3
Values 11 7.9 6.6 21
[99]
ref_hepatocyte IDUA
Mean 1.21
Standard deviation 1.4
Values 0 0.052 3.2 0.69 2.1
[100]
HepG2 IDUA
Mean 0.506
Standard deviation 0.019
Values 0.49 0.52
[101]
HepG2.C3A IDUA
Mean 0.666
Standard deviation 0.49
Values 1 0.32
[102]
HuH.7 IDUA
Mean 0.828
Standard deviation 0.42
Values 0.39 1.2 0.85
[103]
SNU475 IDUA
Mean 3.72
Standard deviation 1.5
Values 4.8 2.7
[104]
THLE IDUA
Mean 1.31
Standard deviation 0.3
Values 1.5 1.1
[105]
liver IDUA
Mean 1.81
Standard deviation 0.66
Values 1.1 2.7 1.9 1.6
[106]
ref_hepatocyte HYAL3
Mean 1.18
Standard deviation 1
Values 0.37 0.22 0.75 2.6 2
[107]
HepG2 HYAL3
Mean 10.2
Standard deviation 1.5
Values 9.2 11
[108]
HepG2.C3A HYAL3
Mean 4.74
Standard deviation 0.039
Values 4.8 4.7
[109]
HuH.7 HYAL3
Mean 5.68
Standard deviation 0.29
Values 5.4 5.7 6
[110]
SNU475 HYAL3
Mean 1.21
Standard deviation 0.21
Values 1.1 1.4
[111]
THLE HYAL3
Mean 2.51
Standard deviation 0.14
Values 2.4 2.6
[112]
liver HYAL3
Mean 0.856
Standard deviation 0.5
Values 0.26 1.4 1.1 0.65
[113]
ref_hepatocyte HPSE
Mean 0.271
Standard deviation 0.14
Values 0.35 0.15 0.24 0.47 0.15
[114]
HepG2 HPSE
Mean 0.286
Standard deviation 0.017
Values 0.3 0.27
[115]
HepG2.C3A HPSE
Mean 0.267
Standard deviation 0.062
Values 0.22 0.31
[116]
HuH.7 HPSE
Mean 0.483
Standard deviation 0.063
Values 0.41 0.51 0.52
[117]
SNU475 HPSE
Mean 2.25
Standard deviation 0.14
Values 2.3 2.1
[118]
THLE HPSE
Mean 15.4
Standard deviation 1.3
Values 14 16
[119]
liver HPSE
Mean 1.2
Standard deviation 0.48
Values 1.8 0.63 1.2 1.1
[120]
ref_hepatocyte HS3ST3A1
Mean 0.154
Standard deviation 0.14
Values 0.32 0.098 0 0.29 0.065
[121]
HepG2 HS3ST3A1
Mean 0.212
Standard deviation 0.2
Values 0.36 0.069
[122]
HepG2.C3A HS3ST3A1
Mean 0.116
Standard deviation 0.028
Values 0.14 0.097
[123]
HuH.7 HS3ST3A1
Mean 0.673
Standard deviation 0.16
Values 0.57 0.85 0.59
[124]
SNU475 HS3ST3A1
Mean 4.34
Standard deviation 1.2
Values 3.5 5.2
[125]
THLE HS3ST3A1
Mean 3.18
Standard deviation 1
Values 2.4 3.9
[126]
liver HS3ST3A1
Mean 0.679
Standard deviation 0.36
Values 0.94 0.33 0.41 1
[127]
ref_hepatocyte HYAL4
Mean 0.0841
Standard deviation 0.12
Values 0.29 0.098 0 0 0.033
[128]
HepG2 HYAL4
Mean 0.0093
Standard deviation 0.005
Values 0.0057 0.013
[129]
HepG2.C3A HYAL4
Mean 0.0463
Standard deviation 0.01
Values 0.039 0.054
[130]
HuH.7 HYAL4
Mean 0.0137
Standard deviation 0.014
Values 0 0.013 0.028
[131]
SNU475 HYAL4
Mean 0.208
Standard deviation 0.14
Values 0.11 0.3
[132]
THLE HYAL4
Mean 0.0142
Standard deviation 0.005
Values 0.018 0.011
[133]
liver HYAL4
Mean 0.0989
Standard deviation 0.088
Values 0.19 0 0.051 0.16
[134]
ref_hepatocyte SPAM1
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[135]
HepG2 SPAM1
Missing
[136]
HepG2.C3A SPAM1
Missing
[137]
HuH.7 SPAM1
Missing
[138]
SNU475 SPAM1
Missing
[139]
THLE SPAM1
Missing
[140]
liver SPAM1
Missing
[141]
ref_hepatocyte HPSE2
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[142]
HepG2 HPSE2
Mean 0.17
Standard deviation 0.13
Values 0.26 0.077
[143]
HepG2.C3A HPSE2
Mean 0.0302
Standard deviation 0.012
Values 0.039 0.021
[144]
HuH.7 HPSE2
Mean 2.68
Standard deviation 1.4
Values 3.7 1.1 3.1
[145]
SNU475 HPSE2
Mean 0.0173
Standard deviation 0.011
Values 0.0093 0.025
[146]
THLE HPSE2
Mean 0
Standard deviation 0
Values 0 0
[147]
liver HPSE2
Mean 0
Standard deviation 0
Values 0 0 0 0