KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | PLA2G2A | Phospholipase A2, membrane associated | [1] | -4.06[2] | -7.88[3] | -15.42[4] | -14.89[5] | -14.33[6] | -0.96[7] |
2 | RAC1 | Ras-related C3 botulinum toxin substrate 1 | [8] | 0.50[9] | 0.01[10] | 0.78[11] | 1.05[12] | 1.04[13] | -0.43[14] |
3 | AKT1 | RAC-alpha serine/threonine-protein kinase | [15] | 0.97[16] | 0.58[17] | -0.44[18] | 0.98[19] | 1.02[20] | 0.30[21] |
4 | MAP2K3 | Dual specificity mitogen-activated protein kinase kinase 3 | [22] | -0.33[23] | -0.18[24] | -1.23[25] | -0.80[26] | -0.92[27] | -0.90[28] |
5 | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1 | [29] | -0.04[30] | -0.52[31] | 0.12[32] | 0.49[33] | 1.01[34] | -0.65[35] |
6 | MAP2K2 | Dual specificity mitogen-activated protein kinase kinase 2 | [36] | 0.95[37] | 0.47[38] | 1.40[39] | 0.19[40] | 0.69[41] | -1.16[42] |
7 | GRB2 | Growth factor receptor-bound protein 2 | [43] | 2.09[44] | 1.77[45] | 1.95[46] | 1.58[47] | 1.51[48] | 0.84[49] |
8 | PLA2G12B | Group XIIB secretory phospholipase A2-like protein | [50] | -1.86[51] | -0.23[52] | -1.23[53] | -9.23[54] | -9.08[55] | -0.19[56] |
9 | RAF1 | RAF proto-oncogene serine/threonine-protein kinase | [57] | 0.83[58] | 1.08[59] | 2.41[60] | 0.85[61] | 1.72[62] | 1.64[63] |
10 | NRAS | GTPase NRas | [64] | 1.52[65] | 1.80[66] | 2.27[67] | 2.03[68] | 1.61[69] | 0.29[70] |
11 | HRAS | GTPase HRas | [71] | -0.12[72] | -0.98[73] | -1.71[74] | 0.08[75] | -0.12[76] | -2.12[77] |
12 | FCER1G | High affinity immunoglobulin epsilon receptor subunit gamma | [78] | -4.18[79] | -3.45[80] | -6.36[81] | -7.43[82] | -5.39[83] | -0.43[84] |
13 | MAPK1 | Mitogen-activated protein kinase 1 | [85] | 2.60[86] | 2.58[87] | 2.47[88] | 2.88[89] | 2.54[90] | 2.32[91] |
14 | AKT2 | RAC-beta serine/threonine-protein kinase | [92] | 1.85[93] | 1.97[94] | 2.16[95] | 1.89[96] | 1.69[97] | 1.67[98] |
15 | KRAS | GTPase KRas | [99] | 0.38[100] | 0.20[101] | 1.86[102] | 1.83[103] | 1.50[104] | 1.21[105] |
16 | MAPK14 | Mitogen-activated protein kinase 14 | [106] | 2.37[107] | 2.28[108] | 1.92[109] | 2.71[110] | 2.20[111] | 1.82[112] |
17 | VAV2 | Guanine nucleotide exchange factor VAV2 | [113] | 2.19[114] | 2.29[115] | 1.84[116] | 0.50[117] | 0.93[118] | 1.05[119] |
18 | PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha | [120] | 0.42[121] | 0.38[122] | 1.53[123] | 3.10[124] | 2.61[125] | 3.54[126] |
19 | MAPK8 | Mitogen-activated protein kinase 8 | [127] | -0.55[128] | 0.70[129] | -0.37[130] | 0.13[131] | 0.00[132] | 0.03[133] |
20 | SOS1 | Son of sevenless homolog 1 | [134] | 0.79[135] | 2.17[136] | 1.73[137] | 1.88[138] | 1.12[139] | 1.08[140] |
21 | MAPK13 | Mitogen-activated protein kinase 13 | [141] | 3.23[142] | 3.48[143] | 0.86[144] | -0.85[145] | 0.68[146] | -1.18[147] |
22 | LYN | Tyrosine-protein kinase Lyn | [148] | 0.03[149] | -0.30[150] | 0.29[151] | 2.09[152] | 0.86[153] | 0.56[154] |
23 | PIK3R2 | Phosphatidylinositol 3-kinase regulatory subunit beta | [155] | 2.77[156] | 2.83[157] | 3.50[158] | 1.74[159] | 2.31[160] | 0.25[161] |
24 | MAP2K4 | Dual specificity mitogen-activated protein kinase kinase 4 | [162] | 1.60[163] | 2.07[164] | 1.33[165] | 2.24[166] | 1.65[167] | 1.60[168] |
25 | MAPK9 | Mitogen-activated protein kinase 9 | [169] | 2.12[170] | 2.19[171] | 2.31[172] | 2.74[173] | 2.22[174] | 1.05[175] |
26 | MAPK3 | Mitogen-activated protein kinase 3 | [176] | 2.74[177] | 2.63[178] | 2.73[179] | 1.45[180] | 1.49[181] | -0.50[182] |
27 | MAP2K7 | Dual specificity mitogen-activated protein kinase kinase 7 | [183] | 1.85[184] | 1.85[185] | 2.48[186] | 1.31[187] | 1.88[188] | -0.22[189] |
28 | RAC2 | Ras-related C3 botulinum toxin substrate 2 | [190] | -0.82[191] | -6.97[192] | -7.51[193] | -0.36[194] | 3.46[195] | -0.69[196] |
29 | PRKCD | Protein kinase C delta type | [197] | 1.99[198] | 2.08[199] | 1.62[200] | 0.53[201] | 1.70[202] | -0.53[203] |
30 | PDPK1 | 3-phosphoinositide-dependent protein kinase 1 | [204] | 3.22[205] | 4.26[206] | 3.03[207] | 2.47[208] | 2.88[209] | 3.04[210] |
31 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 4.38[211] | 3.85[212] | 3.24[213] | 3.85[214] | 3.36[215] | 0.88[216] | |
32 | PLA2G12A | Group XIIA secretory phospholipase A2 | [217] | 1.04[218] | 1.78[219] | 1.98[220] | 1.37[221] | 2.56[222] | 3.19[223] |
33 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 2.10[224] | 2.45[225] | 2.68[226] | 2.08[227] | 2.25[228] | 1.70[229] | |
34 | RAC3 | Ras-related C3 botulinum toxin substrate 3 | [230] | 0.52[231] | 3.43[232] | 2.32[233] | 1.14[234] | -0.33[235] | -2.93[236] |
35 | SOS2 | Son of sevenless homolog 2 | [237] | 0.87[238] | 1.84[239] | 1.13[240] | 2.72[241] | 2.60[242] | 2.38[243] |
36 | PRKCA | Protein kinase C alpha type | [244] | 3.73[245] | 3.61[246] | 4.03[247] | 3.18[248] | 3.55[249] | 2.46[250] |
37 | FYN | Tyrosine-protein kinase Fyn | [251] | 1.84[252] | -6.92[253] | 1.70[254] | 2.50[255] | 4.04[256] | 1.51[257] |
38 | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | 0.51[258] | 1.99[259] | 2.24[260] | 2.16[261] | 2.38[262] | 2.45[263] | |
39 | PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | 2.78[264] | 3.71[265] | -0.04[266] | 1.31[267] | 2.09[268] | 0.84[269] | |
40 | MAP2K6 | Dual specificity mitogen-activated protein kinase kinase 6 | [270] | 1.18[271] | -2.19[272] | 2.73[273] | 2.04[274] | -1.98[275] | -1.08[276] |
41 | GAB2 | GRB2-associated-binding protein 2 | [277] | 2.46[278] | 2.09[279] | 2.39[280] | 1.95[281] | 2.05[282] | 1.08[283] |
42 | INPP5D | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 | [284] | 4.74[285] | 4.98[286] | -5.15[287] | -4.63[288] | -1.67[289] | 1.82[290] |
43 | PLCG2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 | -0.39[291] | -6.29[292] | 1.22[293] | -1.70[294] | -0.54[295] | 3.26[296] | |
44 | MAPK12 | Mitogen-activated protein kinase 12 | [297] | 3.71[298] | 3.22[299] | 4.39[300] | 2.52[301] | 3.78[302] | -0.37[303] |
45 | LCP2 | Lymphocyte cytosolic protein 2 | [304] | [305] | [306] | [307] | -2.68[308] | [309] | 1.69[310] |
46 | PRKCE | Protein kinase C epsilon type | [311] | 1.53[312] | -0.13[313] | 2.42[314] | 2.01[315] | 2.39[316] | 4.10[317] |
47 | PLA2G6 | 85/88 kDa calcium-independent phospholipase A2 | [318] | 0.95[319] | 3.22[320] | 3.62[321] | 0.88[322] | 0.95[323] | 2.19[324] |
48 | LAT | Linker for activation of T-cells family member 1 | [325] | -0.56[326] | 0.83[327] | -0.71[328] | -0.33[329] | 0.26[330] | 0.12[331] |
49 | VAV3 | Guanine nucleotide exchange factor VAV3 | [332] | 2.70[333] | 0.83[334] | 3.07[335] | 4.72[336] | -1.25[337] | 1.89[338] |
50 | PLA2G4B | Cytosolic phospholipase A2 beta | [339] | -5.67[340] | -6.84[341] | -4.20[342] | -3.61[343] | -3.93[344] | [345] |
51 | VAV1 | Proto-oncogene vav | [346] | -7.61[347] | -2.93[348] | -4.58[349] | -5.06[350] | -6.31[351] | 1.72[352] |
52 | PIK3R3 | Phosphatidylinositol 3-kinase regulatory subunit gamma | [353] | 2.61[354] | 2.47[355] | 3.37[356] | 4.20[357] | 3.23[358] | 3.22[359] |
53 | AKT3 | RAC-gamma serine/threonine-protein kinase | [360] | -0.95[361] | -3.67[362] | -2.92[363] | 6.87[364] | 5.84[365] | 4.15[366] |
54 | MAPK11 | Mitogen-activated protein kinase 11 | [367] | 0.72[368] | 0.46[369] | -0.37[370] | 1.39[371] | 3.39[372] | 0.70[373] |
55 | PIK3R5 | Phosphoinositide 3-kinase regulatory subunit 5 | [374] | -6.28[375] | [376] | -1.74[377] | -2.89[378] | -2.54[379] | 2.88[380] |
56 | PLA2G1B | Phospholipase A2 | [381] | -1.11[382] | -1.95[383] | -2.89[384] | -3.15[385] | -5.91[386] | -0.14[387] |
57 | JMJD7-PL | JMJD7-PLA2G4B readthrough (Fragment) | [388] | -5.24[389] | -4.05[390] | -4.02[391] | -5.41[392] | -7.00[393] | -4.07[394] |
58 | SYK | Tyrosine-protein kinase SYK | [395] | -7.27[396] | -1.56[397] | -4.51[398] | 1.13[399] | -2.37[400] | 3.90[401] |
59 | PRKCB | Protein kinase C beta type | [402] | -5.92[403] | -4.88[404] | [405] | 3.51[406] | -1.78[407] | 4.07[408] |
60 | BTK | Tyrosine-protein kinase BTK | [409] | -6.49[410] | [411] | 0.26[412] | -1.98[413] | -4.19[414] | 2.37[415] |
61 | FCER1A | High affinity immunoglobulin epsilon receptor subunit alpha | [416] | [417] | [418] | [419] | [420] | -2.88[421] | -1.32[422] |
62 | TNF | Tumor necrosis factor | [423] | 1.99[424] | -0.30[425] | -4.84[426] | -1.19[427] | -4.40[428] | -1.35[429] |
63 | PIK3CG | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | [430] | [431] | [432] | 2.37[433] | -2.50[434] | 4.64[435] | |
64 | PLA2G2D | Group IID secretory phospholipase A2 | [436] | -2.39[437] | [438] | [439] | [440] | [441] | -1.80[442] |
65 | PLA2G3 | Group 3 secretory phospholipase A2 | [443] | -0.44[444] | 2.98[445] | -4.73[446] | -4.21[447] | -1.14[448] | -2.95[449] |
66 | MS4A2 | High affinity immunoglobulin epsilon receptor subunit beta | [450] | -0.03[451] | 1.73[452] | 0.25[453] | 0.91[454] | -0.15[455] | 3.05[456] |
67 | CSF2 | Granulocyte-macrophage colony-stimulating factor | [457] | 1.36[458] | -2.75[459] | -2.05[460] | -0.68[461] | 7.23[462] | -0.94[463] |
68 | PLA2G10 | Group 10 secretory phospholipase A2 | [464] | 1.61[465] | 1.30[466] | 0.32[467] | 0.16[468] | -2.30[469] | 1.31[470] |
69 | PLA2G4A | Cytosolic phospholipase A2 | [471] | 1.16[472] | -1.55[473] | 6.62[474] | 4.53[475] | 8.31[476] | 4.89[477] |
70 | PLA2G4E | Cytosolic phospholipase A2 epsilon | [478] | 3.90[479] | 4.08[480] | 4.77[481] | 4.31[482] | 4.15[483] | 1.66[484] |
71 | MAPK10 | Mitogen-activated protein kinase 10 | [485] | -0.59[486] | [487] | [488] | 9.94[489] | 5.69[490] | 7.79[491] |
72 | IL4 | Interleukin-4 | [492] | [493] | [494] | [495] | [496] | [497] | [498] |
73 | PLA2G2F | Group IIF secretory phospholipase A2 | [499] | [500] | [501] | [502] | [503] | [504] | [505] |
74 | IL3 | Interleukin-3 | [506] | [507] | [508] | [509] | [510] | [511] | [512] |
75 | PLA2G5 | Calcium-dependent phospholipase A2 | [513] | [514] | [515] | [516] | [517] | [518] | [519] |
76 | IL5 | Interleukin-5 | [520] | [521] | [522] | [523] | [524] | [525] | [526] |
77 | PLA2G2C | Putative inactive group IIC secretory phospholipase A2 | [527] | [528] | [529] | [530] | [531] | [532] | [533] |
78 | IL13 | Interleukin-13 | [534] | [535] | [536] | [537] | [538] | [539] | [540] |
79 | PLA2G2E | Group IIE secretory phospholipase A2 | [541] | [542] | [543] | [544] | [545] | [546] | [547] |